Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters

Feuerer, Markus; Herrero, Laura; Cipolletta, Daniela; Naaz, Afia; Wong, Jamie; Nayer, Ali; Lee, Jongsoon; Goldfine, Allison B; Benoist, Christophe; Shoelson, Steven; Mathis, Diane

doi:10.1038/nm.2002

Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters

Obesity is accompanied by chronic, low-grade inflammation of adipose tissue, which promotes insulin resistance and type-2 diabetes. These findings raise the question of how fat inflammation can escape the powerful armamentarium of cells and molecules normally responsible for guarding against a ru…