GIT1 is associated with ADHD in humans and ADHD-like behaviors in mice

Won, Hyejung, Mah, Won, Kim, Eunjin, Kim, Jae-Won, Hahm, Eun-Kyoung, Kim, Myoung-Hwan, Cho, Sukhee, Kim, Jeongjin +10 more·2011·Nature Medicine

DOI 10.1038/nm.2330

Cited by (153)

Items 101–153 of 153

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Genome-wide DNA methylation alteration in prenatally stressed Brahman heifer calves with the advancement of age
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T Tian, Xiping Xu, Junke Song, Xiaoling Zhang, Hongwen Yuan, F Zhong, Jia Li, Youli Hu, Dao‐Lu Zhang · 2024 · Physiological Research
Mice with reduced glutamate transporter GLT1 expression exhibit behaviors related to attention-deficit/hyperactivity disorder
Yuichi Hiraoka, Kaori Sugiyama, Daiki Nagaoka, Iku Tsutsui‐Kimura, Kenji F. Tanaka, Kohichi Tanaka · 2021 · Biochemical and Biophysical Research Communications
The ATP6V1B2 DDOD/DOORS-Associated p.Arg506* Variant Causes Hyperactivity and Seizures in Mice
Justine Rousseau, Samuel Boris Tene Tadoum, Marisol Lavertu-Jolin, Thi Tuyet Mai Nguyen, Norbert Fonya Ajeawung, Ann Marie Flenniken, Lauryl M. J. Nutter, Igor Vukobradovic, Elsa Rossignol, Philippe M. Campeau · 2023 · Genes
GIT1 is an untolerized autoantigen involved in immunologic disturbance of spermatogenesis
Kenta Nagahori, Miyuki Kuramasu, Shinichi Kawata, Tomiko Yakura, Zhong‐Lian Li, Shuichi Hirai, Ning Qu, Masahiro Itoh · 2022 · Histochemistry and Cell Biology
Neuron tracing and quantitative analyses of dendritic architecture reveal symmetrical three-way-junctions and phenotypes of git-1 in C. elegans
Omer Yuval, Yael Iosilevskii, Anna Meledin, Benjamin Podbilewicz, Tom Shemesh · 2021 · PLoS Computational Biology
A mouse model for too much TV?
Parizad M. Bilimoria, Takao K. Hensch, Daphné Bavelier · 2012 · Trends in Cognitive Sciences
BiallelicELMO3mutations and loss of function for DOCK-mediated RAC1 activation result in intellectual disability
Viviane Tran, Marie-Anne Goyette, Mónica Mártinez‐García, Ana Jiménez de Domingo, Daniel Martı́n Fernández-Mayoralas, Ana Laura Fernández‐Perrone, Pilar Tirado, Beatriz Calleja‐Pérez, Sara Álvarez, Jean‐François Côté et al. · 2021 · Small GTPases
Sapap4deficiency leads to postsynaptic defects and abnormal behaviors relevant to hyperkinetic neuropsychiatric disorder in mice
Tianhua Wang, Yunxia Bai, Xianjie Zheng, Xinxia Liu, Shuang Jun Xing, Linbin Wang, Huimin Wang, Guoping Feng, Chunxia Li · 2022 · Cerebral Cortex
GIT1 is associated with ADHD in humans and ADHD-like behaviors in mice
J.A. Stockman · 2012 · Yearbook of Pediatrics
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Samet Çetin, Serap Uysal, Dilara Girgin, Ayşenur Alp, Ecem Kiliç, Remzi Oğulcan Çıray · 2025 · Neuroglia
Loss of neuronal βPix isoforms impairs neuronal morphology in the hippocampus and causes behavioral defects
Younghee Kwon, Seung Joon Lee, Yoon Kyung Shin, June-Seek Choi, Dong Eun Park, Jung Eun Shin · 2025 · Animal Cells and Systems
Sex and Age-Dependent Olfactory Memory Dysfunction in ADHD Model Mice
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ADHD, New Developed or Newly Found : Historical Review
Geon Ho Bahn, Jae-Ho Bae, Su-Jin Moon, Jungwon Min · 2011 · Journal of korean Academy of Child and Adolescent Psychiatry
GPCR systems coordinate cellular resilience against aging-associated stress
Tabitha Boeringer, Mia Pardo, Carter J Craig, Ainhoa Nieto Gutierrez, Derek R. Duckett, Patricia H. McDonald, Stuart R. Maudsley · 2026 · Frontiers in Molecular Biosciences
Different Alterations of Hippocampal and Reticulo-Thalamic GABAergic Parvalbumin-Expressing Interneurons Underlie Different States of Unconsciousness
Ljiljana T. Radovanovic, Andrea Novakovic, Jelena Petrović, Jasna Šaponjić · 2023 · International Journal of Molecular Sciences
Aberrant Thalamocortical Synchrony Associated with Behavioral Manifestations in Git1−/− Mice
Won Mah · 2015 · Experimental Neurobiology
Downregulation of integrin α3 in ADHD mirrored in mutant mouse model by dopamine-dependent hippocampal AMPAR expression
Xiaojuan Yao, Ruiying Chen, Jiayi Zhu, Ruiqing Hou, Shitong Xiang, Tianye Jia, Yuelin Gu, Zhenyu Wang, Han Hu, Hongting Chen et al. · 2025 · Molecular Psychiatry
Principles Driving the Spatial Organization of Rho GTPase Signaling at Synapses
Scott H. Soderling, Linda Van Aelst · 2014 · Springer eBooks
Aniracetam Ameliorates Attention Deficit Hyperactivity Disorder Behavior in Adolescent Mice
Xiao-Li Sun, Jie Cui, Hui Bai, Wei Zhang, Wanjun Bai · 2025 · eNeuro
Epigenetics in Child Psychiatry
Josephine Elia, Richard S. Kingsley, Oliver Yost, Charles Bongiorno, Carolyn Green Bernacki, Alexander P. Ambrosini, Makiko Okuyama, Hakon H. Hakonarson · 2014 · Elsevier eBooks
Orexin action on the dopaminergic system modulates theta during REM sleep and wakefulness
Mojtaba Bandarabadi, Sha Li, Mehdi Tafti, Giulia Colombo, Andrea Becchetti, Anne Vassalli · 2022 · bioRxiv (Cold Spring Harbor Laboratory)
ArfGAPs: Not Only for the Termination
Shigeru Hashimoto, Ari Hashimoto, Hirokazu Sugino, Ayumu Yoshikawa, Haruka Handa, Masanao Yoshino, Yutaro Otsuka, Hisataka Sabe · 2014 · Springer eBooks
CYP2C19 and brain development : implications for susceptibility to anxiety in a transgenic mouse model
Anna Persson · 2013 · Figshare
CIN85 defect in brain and neurobehavioral disorder: involvement in excess dopamine signaling
Noriaki Shimokawa, Shinnosuke Masuda, Hiroko Masuda, Noriyuki Koibuchi · 2013 · Hormonal Studies
Social dysfunction and mental retardation
Susanna Pietropaolo, Frans Sluyter, Wim E. Crusio · 2014 · Cambridge University Press eBooks
Form follows function: actin-binding proteins as critical regulators of excitatory synapses
Marco B. Rust, Kristin Michaelsen‐Preusse · 2016 · e-Neuroforum
Etiology of Attention Deficit Hyperactivity Disorder: Genetical Factors
Hesna Gül, Bedriye Öncü · 2018 · Turkiye Klinikleri Journal of Pediatrics
Biologische Grundlagen der Aufmerksamkeitsdefizits-/Hyperaktivitätsstörung (ADHS) des Erwachsenenalters
Sarah Kittel‐Schneider · 2018 · Springer eBooks
GIT2 is dispensable for normal learning and memory function due to a predominant brain GIT2 splice variant that evades GIT/PIX complexes
Krisztián Tóth, Amanda C. Martyn, Natalia Bastrikova, Woojoo Kim, Ramona M. Rodriguiz, Umer Ahmed, Robert Schmalzigaug, Serena M. Dudek, William C. Wetsel, Richard T. Premont · 2019 · bioRxiv (Cold Spring Harbor Laboratory)
ADHD (주의력결핍 과잉행동장애) 생쥐 모델에서의 별아교세포 유래 신경전달물질 분석
김가연, 박재원, 윤보은 · 2018 · JoLS Journal of Life Sciences
Another Genetic Factor in ADHD
Barbara Geller · 2011 · Journal watch
Epigenetics in child psychiatry
Josephine Elia, Yumiko Izaki, Kristin L. Borreggine, Oliver Yost, Amanda Castro, Connie Y. Chang, Alexander P. Ambrosini, Samuel Fels, Karuna Poddar, Jessica Rayfield et al. · 2021 · Elsevier eBooks
Animal and Cellular Models of Pediatric Psychiatric Disorders
Elodie Drapeau, Hala Harony‐Nicolas, Jacqueline N. Crawley · 2017 · Oxford University Press eBooks
Proximity based proteomics reveals Git1 as a regulator of Smoothened signaling
Jingyi Zhang, Gurleen Kaur, Eva Cai, Oscar Torres Gutierrez, Xiaoliang Liu, Sabyasachi Baboo, Jolene K. Diedrich, Ju‐Fen Zhu, Benjamin R. Myers, John R. Yates et al. · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
JNK regulates β3-containing GABAAR expression at the cell surface via the receptor clustering protein GIT1 (ArfGAP1)
Artemis Varidaki, Prasannakumar Deshpande, Elina I. Nagaeva, Annika Schäfer, Christel Sourander, Ye Hong, Soroush Abyari, Valentina Siino, Christoffer Lagerholm, Peter James et al. · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
Bioinformatics Analysis of Persistent Dysregulated Expression of Genes Involved in HCV‐Induced Neurological Disorders and Liver Injuries After DAA Treatment Through Weighted Gene Co‐Expression Network Analysis
Mohadeseh Zarei Ghobadi, Mohammad Amin Nooraniyan Esfehani, Shohreh Shahmahmoodi, Ahmad Nejati, Abolfazl Keshavarz, Katayoun Samimi‐Rad · 2025 · Health Science Reports
Additional file 4 of Biomarker discovery in attention deficit hyperactivity disorder: RNA sequencing of whole blood in discordant twin and case-controlled cohorts
McCaffrey, Timothy A., St. Laurent, Georges, Shtokalo, Dmitry, Денис Антонец, Vyatkin, Yuri, Jones, Daniel, Eleanor Battison, Joel T. Nigg · 2020 · Figshare
Additional file 1 of Biomarker discovery in attention deficit hyperactivity disorder: RNA sequencing of whole blood in discordant twin and case-controlled cohorts
McCaffrey, Timothy A., St. Laurent, Georges, Shtokalo, Dmitry, Денис Антонец, Vyatkin, Yuri, Jones, Daniel, Eleanor Battison, Joel T. Nigg · 2020 · Figshare
Additional file 3 of Biomarker discovery in attention deficit hyperactivity disorder: RNA sequencing of whole blood in discordant twin and case-controlled cohorts
McCaffrey, Timothy A., St. Laurent, Georges, Shtokalo, Dmitry, Денис Антонец, Yuri Vyatkin, Jones, Daniel, Eleanor Battison, Joel T. Nigg · 2020 · Figshare
Aniracetam restores the excitation-inhibition balance of neurotransmitters in the prefrontal cortex of mice with ADHD
Jie Cui, Xiao-Li Sun, Shuo Shi, Hui Bai, Wen Zhang, Wanjun Bai · 2026 · Scientific Reports
Exploratory study of plasma GFAP and GAD65-Ab levels in children with ADHD
Rui-Liang Li, Yu-Dong Shan, Peng Lu, Tingting Liu, Zhi-Fang Yu, Ge-Ge Lv, Na-Na Liu, Weiya Zhang, Lei Zhang, Weijuan Gao et al. · 2026 · The Italian Journal of Pediatrics/Italian journal of pediatrics
GIT1 loss of function causes a recognizable syndromic neurodevelopmental disorder
Pinella Failla, Valentina Muto, Antonella Lauri, Lucia Saccuzzo, Alessia Arena, Giulia Fasano, Anne‐Marie Guerrot, François Lecoquierre, Andrea Ciolfi, Cecilia Mancini et al. · 2026 · Brain
α6GABAA receptors as novel targets for ADHD therapy: A proof-of-concept study in MK-801-treated juvenile mice
Chia-Chi Lu, Yu-Hsuan Lee, Hsin-Jung Lee, Akihiro Mouri, Dishary Sharmin, James Minton Cook, Toshitaka Nabeshima, Werner Sieghart, Lih‐Chu Chiou · 2026 · European Journal of Pharmacology
Prenatal stress selectively enhances locomotor hyperactivity in male mice with embryonic loss of Fgfr2
Michelle X. Chen, Polona Jager, Abigail Sawyer, Hanna E. Stevens · 2026 · Frontiers in Psychiatry
Transcranial photobiomodulation rebalances cortical excitation/inhibition in young adults with attention deficit/hyperactivity disorder
Xuye Yuan, Yiyang Wang, Chen Dang, Hongyu Liu, Lili Yang, Dongwei Li, Li Sun, Yan Song · 2026 · medRxiv
Revealing the Shared Genetic Architecture of Metabolic Dysfunction–Associated Steatotic Liver Disease–Related Traits Through Genomic Structural Equation Modeling
Hao Dong, Yufeng Li, Qiang Ding, Miaoxin Zhang, Shuaipeng Gu, Mei Liu · 2026 · Genetic Epidemiology
Podocyte GIT1 and GIT2 ArfGAPs cooperatively sustain the ARHGEF7-Cdc42 axis and glomerular permselectivity
Jun Matsuda, Maho Tokuchi, Naoyuki Shimada, Kana Asano-Matsuda, Hiromitsu Miyakawa, Lamine Aoudjit, Claire Emilie Martin, Tomoko Takano, Yoshitaka Isaka · 2026 · Kidney International