The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Simultaneous two-photon imaging of oxygen and blood flow in deep cerebral vessels
Open accessAbstract
Uncovering principles that regulate energy metabolism in the brain requires mapping of partial pressure of oxygen (PO2) and blood flow with high spatial and temporal resolution. Using two-photon phosphorescence lifetime microscopy (2PLM) and the oxygen probe PtP-C343, we show that PO2 can be accurately measured in the brain at depths up to 300 μm with micron-scale resolution. In addition, 2PLM allowed simultaneous measurements of blood flow and of PO2 in capillaries with less than one-second temporal resolution. Using this approach, we detected erythrocyte-associated transients (EATs) in oxygen in the rat olfactory bulb and showed the existence of diffusion-based arterio-venous shunts. Sensory stimulation evoked functional hyperemia, accompanied by an increase in PO2 in capillaries and by a biphasic PO2 response in the neuropil, consisting of an 'initial dip' and a rebound. 2PLM of PO2 opens new avenues for studies of brain metabolism and blood flow regulation.
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Cites
Raichle, M. E., & Mintun, M. A. (2006) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.29.051605.112819 · Cited by 1,630
Kleinfeld, D., Mitra, P. P., Helmchen, F., & Denk, W. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.26.15741 · Cited by 832
Two-photon microscopy in brain tissue: parameters influencing the imaging depth
Oheim, M., Beaurepaire, E., Chaigneau, E., Mertz, J., & Charpak, S. (2001) · Journal of Neuroscience Methods · doi:10.1016/s0165-0270(01)00438-1 · Cited by 425
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Cited by
Direct measurement of local oxygen concentration in the bone marrow of live animals
Spencer, J. A., Ferraro, F., Roussakis, E., Klein, A., Wu, J., Runnels, J. M., Zaher, W., Mortensen, L. J., Alt, C., Turcotte, R., et al. (2014) · Nature · doi:10.1038/nature13034 · Cited by 1,167
Self-citationOptical methods for sensing and imaging oxygen: materials, spectroscopies and applications
Wang, X.-D., & Wolfbeis, O. S. (2014) · Chem. Soc. Rev. · doi:10.1039/c4cs00039k · Cited by 1,114
Two-Photon Microscopy as a Tool to Study Blood Flow and Neurovascular Coupling in the Rodent Brain
Shih, A. Y., Driscoll, J. D., Drew, P. J., Nishimura, N., Schaffer, C. B., & Kleinfeld, D. (2012) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2011.196 · Cited by 458
Biological detection by optical oxygen sensing
Papkovsky, D. B., & Dmitriev, R. I. (2013) · Chemical Society Reviews · doi:10.1039/c3cs60131e · Cited by 444
Understanding the role of the perivascular space in cerebral small vessel disease
Brown, R., Benveniste, H., Black, S. E., Charpak, S., Dichgans, M., Joutel, A., Nedergaard, M., Smith, K. J., Zlokovic, B. V., & Wardlaw, J. M. (2018) · Cardiovascular Research · doi:10.1093/cvr/cvy113 · Cited by 336
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Metadata
- Authors
- Lecoq, J., Parpaleix, A., Roussakis, E., Ducros, M., Houssen, Y. G., Vinogradov, S. A., & Charpak, S.
- Venue
- Nature Medicine
- Published
- 2011-06-05
- Volume
- 17
- Issue
- 7
- Pages
- 893-898
- ISSN
- 1078-8956 (ISSN-L)
- 1546-170X
- OpenAlex
- W2060172358
- Cited by
- 258
- References
- 3
- FWCI
- 13.36
- Type
- journal article
- Language
- en
- Open access
- green
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