Preexisting influenza-specific CD4+ T cells correlate with disease protection against influenza challenge in humans

Wilkinson, Tom M, Li, Chris K F, Chui, Cecilia S C, Huang, Arthur K Y, Perkins, Molly, Liebner, Julia C, Lambkin-Williams, Rob, Gilbert, Anthony +7 more·2012·Nature Medicine
DOI 10.1038/nm.2612

Cited by (982)

Items 901–982 of 982

  1. A Framework for Measuring Population Immunity Against Influenza Using Individual Antibody Titers
    Weijia Xiong, Xiaotong Huang, Tran Thi Nhu Thao, Nguyen Thi Le Thanh, Liping Peng, Ranawaka A. P. M. Perera, Vicky J. Fang, Bingyi Yang, Sook‐San Wong, Nancy Leung et al. · 2025 · medRxiv
  2. An autologous human iPSC-derived 3D organoid infection model for preclinical testing of antiviral T cells
    Ugarit Daher, Valeria Beatriz Fernández Vallone, Morris Baumgardt, Benedikt Obermayer, Niklas Wiese, Achim K. Kirsch, Tanja Fisch, Anna Löwa, Michael Schmueck‐Henneresse, Andreas Christian Hocke et al. · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
  3. The Subtype Specific and Cross-Reactive T Cell Responses to Influenza Viruses in Humans: A Dissertation
    Jenny Aurielle B. Babon · 2012 · The Journal of the American Medical Association (JAMA) Network (American Medical Association)
  4. A Perspective of Influenza Pandemics
    JOHN S. OXFORD · 2014 · Encyclopedia of Life Sciences
  5. Influenza Specific T- and B-cell Responses in Immunosuppressed Patients
    Aditya Ambati · 2015 · Figshare
  6. No easy route to a pandemic influenza vaccine
    Sarah C. Gilbert · 2013 · The Lancet Infectious Diseases
  7. An influenza vaccine pill—can we swallow it?
    Patricia Fast, Josephine H. Cox · 2015 · The Lancet Infectious Diseases
  8. The potential for a controlled human infection platform
    Shobana Balasingam, Peter Horby, Annelies Wilder‐Smith · 2014
  9. Immune Response in Young Men to the 2014/15 Seasonal Influenza Vaccine
    Stewart, Andrew · 2016 · Libraries and Cultural Resources (University of Calgary)
  10. The Effects of Adiposity and Type II Diabetes on the Immune Response to Influenza Virus in Adults
    Heather A. Paich · 2019 · Carolina Digital Repository (University of North Carolina at Chapel Hill)
  11. Development of a chlamydial vaccine for koalas (Phascolarctos cinereus)
    Shahneaz Ali Khan · 2016 · Queensland University of Technology
  12. Defining T-cell immunity against rhinovirus species A and C
    Cibele Marina Gaido · 2017 · UWA Profiles and Research Repository (UWA)
  13. Application of Antigen Cross-Presentation Research into Patient Care
    2017 · Frontiers research topics
  14. Development of a conditionally-attenuated cytomegalovirus (CMV) vaccine vector platform, and initial investigations into use of CMV as a vaccine against pandemic influenza A virus
    Shirin Hama Salih · 2017
  15. Preclinical Animal Models for Developing Vaccines Against Influenza Infection for the Young and the Elderly
    Thomas Ebensen, Kai Schulze, Blair Prochnow, Carlos A. Guzmán · 2019 · Springer eBooks
  16. Late Antigen Regulates the Differentiation of Cytotoxic CD4 T Cells in Influenza Infection
    Allen M. Vong · 2017 · eScholarship@UMassChan
  17. Origins of recent pandemics and lessons for surveillance
    JOHN S. OXFORD · 2014
  18. Mechanisms of cross-protection and development of universal influenza vaccines
    Huan Huu Nguyen, De-chu Christopher Tang · 2015
  19. Efficacy of Prokaryotic and Eukaryotic Recombinant Fusion Proteins (M2e-carliticulin) As an Influenza Universal Vaccine in Mice C57Bl/6
    Hamidreza Attaran, Hassan Nili, Bahman Gholamhossein Gudarzi, Hongxuan He · 2018 · Future Virology
  20. T Cells in the Female Reproductive Tract Can Both Block and Facilitate HIV Transmission
    Christopher J. Miller, Ronald S. Veazey · 2018 · Current Immunology Reviews
  21. Lung-resident, M2e-specific CD4 T cells critically protect during influenza infection
    Ajibola Omokanye · 2018 · Gothenburg University Publications Electronic Archive (Gothenburg University)
  22. Making a bad relationship good
    Karl J. Staples · 2019 · Nature Microbiology
  23. Applications of Cutting-Edge Immunoproteomics Technology in Human Immunotherapy
    Joseph D. Comber, Ramila Philip · 2020 · Springer eBooks
  24. Blood gene expression-based prediction of lethality after respiratory infection by influenza A virus in mice
    Pedro Milanez‐Almeida, Andrew J. Martins, Parizad Torabi‐Parizi, Luis Miguel Franco, John S. Tsang, Ronald N. Germain · 2020 · bioRxiv (Cold Spring Harbor Laboratory)
  25. COVID-19: Balancing between Transmission Suppression and Immunity
    Duk‐Hee Lee · 2020 · Clinical Ultrasound
  26. Impact of cytomegalovirus-infection on ageing of the immune system
    Sara Berg · 2020
  27. Development of a non-invasive nanoparticle-based vaccination strategy protecting against influenza infection
    Simon Delandre · 2020 · Digitale Bibliothek Braunschweig (Verbundzentrale Göttingen (VZG))
  28. Mesenchimal stem cells in treatment of cancer patients with COVID-19 pneumonia
    Ирина Александровна Балдуева, Т. Л. Нехаева, А. М. Belyaev · 2021 · Voprosy Onkologii
  29. AGING WITH T CELLS
    Pieren, Daniël Kees Johan · 2021
  30. Nonlinear Hierarchical Models for Longitudinal Experimental Infection Studies
    Michael D. Singleton · 2015 · UKnowledge (University of Kentucky)
  31. Review of the British Thoracic Society Winter Meeting 2018, 5–7 December 2018, London, UK
    Amanda T. Goodwin, Aran Singanayagam, Gisli R. Jenkins · 2019 · Thorax
  32. Influenza Vaccination in Older Adults
    Janet E. McElhaney, Daniela Frasca · 2021 · Springer eBooks
  33. Pneumonia Severity and Phase Linked to Virus-Specific T Cell Responses with Distinct Immune Checkpoints during pH1N1 Infection
    Hui Li, Min Jie Zhao, Hangjie Zhang, Chuansong Quan, Dannie Zhang, Yingmei Liu, Meng Liu, Chunxue Xue, Shuguang Tan, Yaxin Guo et al. · 2022 · The Journal of Immunology
  34. Influenza Virus and Vaccination
    Marta L. DeDiego, Aitor Nogales · 2020 · MDPI eBooks
  35. Vaccines against viral infections
    Janet E. McElhaney · 2017 · Oxford University Press eBooks
  36. Influenza vaccines
    Åsne Jul‐Larsen, Rebecca Jane Cox · 2015
  37. Preclinical Animal Models for Developing Vaccines Against Influenza Infection for the Young and the Elderly
    Thomas Ebensen, Kai Schulze, Blair Prochnow, Carlos A. Guzmán · 2017 · Springer eBooks
  38. Influenza Vaccination in Older Adults
    Janet E. McElhaney, Daniela Frasca · 2019 · Springer eBooks
  39. Strategies to fight COVID-19: Beyond the difference between SARS-CoV-2 and Influenza virus
    Lin Huihui, Li Hequan · 2022 · International Journal of Sexual and Reproductive Health Care
  40. Enhanced survival and low proliferation marks multifunctional virus specific memory CD4 T cells
    Lotus M Westerhof, Jonathan Edward Noonan, Kerrie E Hargrave, Elizabeth T. Chimbayo, Zhiling Cheng, Thomas Purnell, Mark R. Jackson, Nicholas C. Borcherding, Megan K. L. MacLeod · 2022 · bioRxiv (Cold Spring Harbor Laboratory)
  41. Chasing the chains by testing them twice
    Peter C. de Greef · 2023
  42. Data from Preexisting and Post–COVID-19 Immune Responses to SARS-CoV-2 in Patients with Cancer
    Tatjana Bilich, Malte Roerden, Yacine Maringer, Annika Nelde, Jonas S. Heitmann, Marissa Lisa Dubbelaar, Andreas Peter, Sebastian Hörber, Jens Bauer, Jonas Rieth et al. · 2023
  43. Carbohydrate‐Based Antiviral Vaccines
    Adrián Plata, Alberto Fernández‐Tejada · 2023
  44. Regulação da expressão de Runx3 em linfócitos T CD4+ maduros durante a evolução da encefalomielite autoimune experimental
    Ana Maria Marques · 2022
  45. Contribución de las células T de memoria en la generación de inmunidad de larga duración contra COVID-19
    Alejandro Torres-Flores, Isabel Wong‐Baeza, Constantino III Roberto López-Macías · 2024 · Gaceta Médica de México
  46. Contribution of memory T cells to the generation of long-lasting immunity against COVID-19
    Alejandro Torres-Flores, Isabel Wong‐Baeza, Constantino III Roberto López-Macías · 2024 · Gaceta Médica de México
  47. Cross Protection and Sustained Immunity Against Influenza a Viruses in Mice Provided by Core-Shell Structured Lipopolyplex Delivered mRNA Vaccine with Optimized Sequences Coding HAstem-Na-Fused Antigens
    Tangqi Wang, Ruiwen Han, Zhanyihao Hao, Xueting Cheng, Jia Li, Chengcheng Zhai, Donghong Wang, Yao Liang Deng, Liang Zhang, Wenjie Tan · 2025 · SSRN Electronic Journal
  48. A Lymphocyte Subset-Based Prediction Model for Refractory Community-Acquired Pneumonia in Immunocompetent Patients
    Jingyuan Zhang, Xinyu Hu, Ailifeila Aili, Lei Pan, Xinying Xue, Xiaolan Chen · 2025 · Diagnostics
  49. Influenza strain-specific T cell responses longitudinally post-vaccination with FluZone
    Harry C. Pickering, Eduardo Valli, Michael A. Carlock, Monica Cappelletti, David W. Gjertson, Ted M. Ross, Elaine F. Reed · 2025 · Vaccine
  50. Immunomodulatory Role of Milk on Gut Microbiota: Implications for Enhancing Oral Vaccine Efficacy
    Nur Ain Mohd Asri, Solehah Mohd Rosdan Bushra, Amiratul Aifa Mohamad Asri, Rapeah Suppıan, Mohd Nor Norazmi · 2025 · Probiotics and Antimicrobial Proteins
  51. Distinct characteristics of T cell receptor repertoire associated with the SARS-CoV-2 reinfection
    Liling Zeng, Li Liu, Baolin Ren, Bing Feng, Xudong Lai, Xunxi Lai, Zhimin Chen, Yihui Huang, Wenxin Hong · 2025 · Frontiers in Immunology
  52. Individualized Mechanistic Modeling Reveals Viral Infectivity and CD8 + T cell Expansion as Drivers of Heterogeneous Influenza Dynamics
    Nicole Bruce, Jordan J.A. Weaver, Cailan Jeynes‐Smith, Fatemeh Beigmohammadi, Solene G.D. Hegarty-Cremer, Amanda Pfaff Smith, Morgan Craig, Amber M. Smith · 2025 · medRxiv
  53. An autologous human iPSC-derived 3D organoid infection model for preclinical testing of antiviral T cells
    Leila Amini, Ugarit Daher, Valeria Beatriz Fernández Vallone, Morris Baumgardt, Benedikt Obermayer, Niklas Wiese, Achim K. Kirsch, Tanja Fisch, Anna Löwa, Michael Schmueck‐Henneresse et al. · 2025 · Research Square
  54. Promiscuous class II-binding SARS-CoV-2-nuc derived vaccine-peptide induced extensive conventional, innate and unconventional T cell responses
    Naomi Krickeberg, Hans‐Georg Rammensee, Karin Schilbach · 2025 · Frontiers in Immunology
  55. Divergent Effects of Cytomegalovirus and Rheumatoid Arthritis on Senescent CD4 + T Cells
    Lea Williams, Ali O. Saber, Silina Awad, Xi Su, Asgar Ansari, Ruozhang Xu, Hannah Jung, Anupama Shahane, Joshua F. Baker, Laura F. Su · 2025 · European Journal of Immunology
  56. Role of the host genetic variability in the influenza-A virus susceptibility; a review
    Ana Carolina Arcanjo, Giovanni Mazzocco, Silviene Fabiana de Oliveira, Dariusz Plewczyński, Jan P. Radomski · 2014 · arXiv (Cornell University)
  57. Additional file 2 of A polyvalent virosomal influenza vaccine induces broad cellular and humoral immunity in pigs
    Vanessa Haach, Ana Paula Almeida Bastos, Danielle Gava, Francisco Noé da Fonseca, Morés, Marcos Antônio Zanella, Arlei Coldebella, Ana Cláudia Franco, Rejane Schaefer · 2023 · Figshare
  58. Additional file 1 of A polyvalent virosomal influenza vaccine induces broad cellular and humoral immunity in pigs
    Vanessa Haach, Ana Paula Almeida Bastos, Danielle Gava, Francisco Noé da Fonseca, Morés, Marcos Antônio Zanella, Arlei Coldebella, Ana Cláudia Franco, Rejane Schaefer · 2023 · Figshare
  59. Additional file 3 of A polyvalent virosomal influenza vaccine induces broad cellular and humoral immunity in pigs
    Vanessa Haach, Ana Paula Almeida Bastos, Danielle Gava, Francisco Noé da Fonseca, Morés, Marcos Antônio Zanella, Arlei Coldebella, Ana Cláudia Franco, Rejane Schaefer · 2023 · Figshare
  60. Additional file 4 of A polyvalent virosomal influenza vaccine induces broad cellular and humoral immunity in pigs
    Vanessa Haach, Ana Paula Almeida Bastos, Danielle Gava, Francisco Noé da Fonseca, Morés, Marcos Antônio Zanella, Arlei Coldebella, Ana Cláudia Franco, Rejane Schaefer · 2023 · Figshare
  61. Additional file 1 of Investigation of CD4 and CD8 T cell-mediated protection against influenza A virus in a cohort study
    Tim K. Tsang, Lam, Kwok-Tai, Yinping Liu, Vicky J. Fang, Xiaofeng Mu, Nancy Leung, Peiris, J. S. Malik, Leung, Gabriel M., Cowling, Benjamin J., Wenwei Tu · 2022 · Figshare
  62. Intranasal Vaccine Induces Broad and Long-Lasting Immunity Against the Hemagglutinin Stem of Group 2 Influenza a Viruses
    Abenaya Muralidharan, Jérémie Prévost, Angela M Sloan, Levi A. Tamming, Annabelle Pfeifle, Caroline Gravel, Sathya N. Thulasi Raman, Gary Van Domselaar, Michael Johnston, Lisheng Wang et al. · 2025 · SSRN Electronic Journal
  63. Adult mice with neonatal-like T cell subsets exhibit increased susceptibility to Bordetella pertussis and influenza infection
    Matthew R. Hansen, Colleen J. Sedney, Shiyun Xiao, Disha BR Prasad, Wen Zhang, Kalyan Kumar Dewan, Jillian Masters, Maiya Callender, Eric T. Harvill, Kimberly D. Klonowski et al. · 2026 · The Journal of Immunology
  64. Analyse de réponses lymphocytaires T par Elispot et Fluorospot au cours du suivi de protocoles de vaccination : mise en évidence de l’effet du thiomersal présent dans la préparation vaccinale
    Anne Chauvat · 2012
  65. Hemagglutination inhibition antibody titer as a correlate of protection against influenza infection : impact and dynamics
    Rosemary Markovic Delabre · 2016
  66. Broad heterologous protection against Influenza A viruses by an adjuvant-free modular mucosal T-cell vaccine platform
    Rajesh Thangavel Yadav, Mansi Sharma, Santhosh Kambaiah Nagaraj, Rohan Narayan, Abinaya Kaliappan, Uma Shanmugasundaram, Rahul Chavan, Akhila B Rai, Rashmi Rai, Thottethodi Subrahmanya Keshava Prasad et al. · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
  67. Dynamique des réponses lymphocytaires T locales et systémiques à l'injection d'un vaccin dans la peau
    Candie Joly · 2019
  68. Cross-reactive antibody and T-cell responses after influenza virus infection in community-dwelling older adults
    Lisa van Pul, Sietske K. Rosendahl Huber, Ronald H. J. Jacobi, Marion Hendriks, Roos van Schuijlenburg, Yannick van Sleen, Elske Bijvank, Jelle de Wit, Josine van Beek · 2026 · Journal of Virology
  69. Influenza Viruses
    John Jay Treanor · 2026 · Springer eBooks
  70. Innate immune responsiveness predicts enhanced cellular immunity and symptomatic disease after controlled human influenza infection
    Loukas Papargyris, Jiayun Xu, Claire M. Broderick, Ao Huang, Trupti Gore, Arnold Reynaldi, Pete Dayananda, Ashley M. Collins, Stephanie Ascough, Nathan Wong et al. · 2026 · Nature Medicine
  71. Cytotoxic CD4+ T cells across aging: a conceptual framework for health, protection, pathology, and age-associated diseases
    Tatsuya Hasegawa, Kosei Nishitani, Kenji Kabashima · 2026 · International Immunology
  72. Cytotoxic CD4 + T Cells in Visceral Leishmaniasis Patients
    Shashi Bhushan Chauhan, Siddharth Sankar Singh, Bhawana Singh, Shashi Bhushan Kumar, Rahul Tiwari, Vibhav Gautam, Fabian de Labastida Rivera, Susanne Nylén, Christian R. Engwerda, Shyam Sundar et al. · 2026 · Parasite Immunology
  73. Influenza A(H3N2) Subclade K During the 2025–26 Season and Differential Humoral Responses in Vaccinated Individuals Versus Vaccinated Convalescents in Israel
    Ital Nemet, Neta S. Zuckerman, Nofar Atari, Limor Kliker, Menucha Jurkowicz, Mayan Gilboa, Yael Weiss-Ottolenghi, Nathan Keller, Michal Stein, Gili Regev‐Yochay et al. · 2026 · Vaccines
  74. Double-Blind, Randomized, Phase 2a Study to Evaluate the Safety and Immunogenicity of OVX836, a Nucleoprotein-Based Universal Influenza Vaccine, Co-Administered with Fluarix Tetra® or Afluria Quad®
    Nicola Groth, Jacques Bruhwyler, Emilie Piat, Jessika Tourneur, Philippe Moris, Michael Penlington, Florence Nicolas, Alexandre Le Vert · 2026 · Vaccines
  75. Using interpretable machine learning models to predict the occurrence of severe influenza in hospitalized children: a retrospective cohort study
    Jinhuan Wu, Wenxian Qian, Shuqin Xie, Yi Yan, Gang Chen, Ye Wang, Xing Liu, Xiuchang Ma, Yuchen Du, Yaowen Liang et al. · 2026 · BMC Medical Informatics and Decision Making
  76. COBRA and cGAMP Microparticles Provide Active and Stable Vaccine Platform
    Kristy Ainslie · 2026 · ImmPort
  77. Immunogenicity of adjuvanted COBRA vaccine in immunocompromised and diverse populations
    Kristy Ainslie · 2025 · ImmPort
  78. T cell population correlates
    Paul Thomas · 2026 · ImmPort
  79. T and B cell responses to SARS-CoV-2 coronavirus
    Alessandro Sette · 2020 · ImmPort
  80. Influenza T cell response post-vaccination
    Elaine Reed · 2025 · ImmPort
  81. Analysis of cellular immune responses to Influenza vaccines
    Ted Ross · 2025 · ImmPort
  82. RNA-Sensing Pattern Recognition Receptors and Their Effects on T-Cell Immune Responses: A Dissertation
    Rachel Madera · 2012 · eScholarship@UMassChan