Profiling of residual breast cancers after neoadjuvant chemotherapy identifies DUSP4 deficiency as a mechanism of drug resistance
Balko, Justin M, Cook, Rebecca S, Vaught, David B, Kuba, María G, Miller, Todd W, Bhola, Neil E, Sanders, Melinda E, Granja-Ingram, Nara M +10 more·2012·Nature Medicine
DOI 10.1038/nm.2795
Cited by (264)
Items 101–200 of 264
- Genome-wide characterization of human minisatellite VNTRs: population-specific alleles and gene expression differencesMarzieh Eslami Rasekh, Yozen A. Hernandez, Samantha D. Drinan, Juan I. Fuxman Bass, Gary Benson · 2021 · Nucleic Acids Research
- Residual Prostate Cancer Cells after Docetaxel Therapy Increase the Tumorigenic Potential via Constitutive Signaling of CXCR4, ERK1/2 and c-MycKoji Hatano, Souhei Yamaguchi, Keisuke Nimura, Kouki Murakami, Akira Nagahara, Kazutoshi Fujita, Motohide Uemura, Yasutomo Nakai, Mutsumi Tsuchiya, Masashi Nakayama et al. · 2013 · Molecular Cancer Research
- Targeting the XIAP/caspase-7 complex selectively kills caspase-3–deficient malignanciesYuan‐Feng Lin, Tsung‐Ching Lai, Chih‐Kang Chang, Chi‐Long Chen, Ming-Shyan Huang, Chih‐Jen Yang, Hon-Ge Liu, Jhih-Jhong Dong, Yi-An Chou, Kuo-Hsun Teng et al. · 2013 · Journal of Clinical Investigation
- Changing the expression vector of multidrug resistance genes is related to neoadjuvant chemotherapy responseНиколай Васильевич Литвяков, Н. В. Чердынцева, Matvey Mikhailovich Tsyganov, Evgeny V. Denisov, Е. Yu. Garbukov, М К Мерзлякова, В. В. Волкоморов, Sergey Vladimirovich Vtorushin, Marina V. Zavyalova, Elena M. Slonimskaya et al. · 2012 · Cancer Chemotherapy and Pharmacology
- A novel triazole, NMK-T-057, induces autophagic cell death in breast cancer cells by inhibiting γ-secretase–mediated activation of Notch signalingAmlan Kumar Das, Maruthi Kumar Narayanam, Santanu Paul, Pritha Mukhnerjee, Suvranil Ghosh, Debabrata Ghosh Dastidar, Subhendu Chakrabarty, Arnab Ganguli, Biswarup Basu, Mahadeb Pal et al. · 2019 · Journal of Biological Chemistry
- A Transposon-based Analysis Reveals RASA1 Is Involved in Triple-Negative Breast CancerCristian Suárez-Cabrera, Rita M. Quintana, Ana Bravo, M. Casanova, Angustias Page, Josefa P. Alameda, Jesús María Paramio, Alicia Maroto, Javier Salamanca, Adam J. Dupuy et al. · 2017 · Cancer Research
- Strategic Developments & Future Perspective on Gene Therapy for Breast Cancer: Role of mTOR and Brk/ PTK6 as Molecular TargetsRoja Sahu, Shakti Prasad Pattanayak · 2020 · Current Gene Therapy
- Statins affect ETS1-overexpressing triple-negative breast cancer cells by restoring DUSP4 deficiencyHae Hyun Jung, Soo Hyun Lee, Ji‐Yeon Kim, Jin Seok Ahn, Yeon Hee Park, Young‐Hyuck Im · 2016 · Scientific Reports
- Post-neoadjuvant strategies in breast cancer: From risk assessment to treatment escalationGiacomo Pelizzari, Lorenzo Gerratana, Debora Basile, Valentina Fanotto, Michele Bartoletti, Alessia Liguori, Caterina Fontanella, Simon Spazzapan, Fabio Puglisi · 2018 · Cancer Treatment Reviews
- Single-Cell RNA Sequencing Reveals the Migration of Osteoclasts in Giant Cell Tumor of BoneWenyu Feng, Mingwei He, Xiaohong Jiang, Huijiang Liu, Tianyu Xie, Zhaojie Qin, Qian Huang, Shijie Liao, Chengsen Lin, Juliang He et al. · 2021 · Frontiers in Oncology
- Dual-specificity protein phosphatase DUSP4 regulates response to MEK inhibition in BRAF wild-type melanomaAvinash Gupta, Christopher Towers, F. Willenbrock, R. Brant, D. Hodgson, A. Sharpe, Philip Smith, A. Cutts, A. Schuh, R. Asher et al. · 2019 · British Journal of Cancer
- Downregulation of dual‐specificity phosphatase 4 enhances cell proliferation and invasiveness in colorectal carcinomasMichihiro Ichimanda, Naoki Hijiya, Yoshiyuki Tsukamoto, Tomohisa Uchida, Chisato Nakada, Tomonori Akagi, Tsuyoshi Etoh, Hidekatsu Iha, Masafumi Inomata, Mutsuhiro Takekawa et al. · 2017 · Cancer Science
- A Four-gene Decision Tree Signature Classification of Triple-negative Breast Cancer: Implications for Targeted TherapeuticsJelmar Quist, Hasan Mirza, Maggie C.U. Cheang, Melinda L. Telli, Joyce O’Shaughnessy, Christopher J. Lord, Andrew N.J. Tutt, Anita E. Grigoriadis · 2018 · Molecular Cancer Therapeutics
- GFAP alternative splicing regulates glioma cell–ECM interaction in a DUSP4‐dependent mannerEmma J. van Bodegraven, Jessy V. van Asperen, Jacqueline A. Sluijs, Coen Van Deursen, Miriam E. van Strien, Oscar M. J. A. Stassen, Pierre A. J. T. Robe, Elly M. Hol · 2019 · The FASEB Journal
- Predicting the clinical outcome of oral potentially malignant disorders using transcriptomic-based molecular pathologyHans Prakash Sathasivam, Ralf Kist, Philip Sloan, Peter James Thomson, Michael Nugent, John J. Alexander, Syed Aleem Haider, Max Robinson · 2021 · British Journal of Cancer
- Methylation of dual-specificity phosphatase 4 controls cell differentiationHairui Su, Ming Zuo Jiang, Chamara Senevirathne, Srinivas Aluri, Tuo Zhang, Han Guo, Juliana M. Xavier-Ferrucio, Shuiling Jin, Ngoc Tung Tran, Szumam Liu et al. · 2021 · Cell Reports
- Kinase inhibitors for precision therapy of triple-negative breast cancer: Progress, challenges, and new perspectives on targeting this heterogeneous diseaseDawid Mehlich, Anna A. Marusiak · 2022 · Cancer Letters
- Neuropeptide Y1 receptor inhibits cell growth through inactivating mitogen-activated protein kinase signal pathway in human hepatocellular carcinomaXiufang Lv, Fengbo Zhao, Xisong Huo, Weidong Tang, Baoying Hu, Xiu Gong, Juan Yang, Qiujin Shen, Wenxin Qin · 2016 · Medical Oncology
- DUSP4 promotes esophageal squamous cell carcinoma progression by dephosphorylating HSP90βLiting Zhou, Ning Yao, Lu Yang, Kangdong Liu, Yan Qiao, Chuntian Huang, Ruijuan Du, Yiu To Yeung, Wenting Liu, Dan Cheng et al. · 2023 · Cell Reports
- Research advances and new challenges in overcoming triple-negative breast cancerYu Zong, Mark Daniel Pegram · 2021 · Cancer Drug Resistance
- Post-diagnostic statin use and breast cancer-specific mortality: a population-based cohort studyOliver William Scott, Sandar Tin Tin, Sixten Harborg, Marion J J Kuper-Hommel, Ross A Lawrenson, Mark Elwood · 2023 · Breast Cancer Research and Treatment
- Resistance to Neoadjuvant Treatment in Breast Cancer: Clinicopathological and Molecular PredictorsMaría del Rosario Chica-Parrado, Ana Godoy-Ortíz, Begoña Jiménez, Nuria Ribelles, Isabel Barragán, Emilio Alba · 2020 · Cancers
- SIK2 attenuates proliferation and survival of breast cancer cells with simultaneous perturbation of MAPK and PI3K/Akt pathwaysNeslihan Zohrap, Özge Saatci, Burçak Özeş, İpek Çoban, Hasan Murat Atay, Esra Battaloğlu, Özgür Şahin, Kuyaş Buğra · 2018 · Oncotarget
- Genomic analysis of drug resistant gastric cancer cell lines by combining mRNA and microRNA expression profilingZhangqian Chen, Lin Zhang, Limin Xia, Yangsheng Jin, Qing Hua Wu, Hao Guo, Xin Chun Shang, Jianhua Dou, Kaichun Wu, Yongzhan Nie et al. · 2014 · Cancer Letters
- Regional methylome profiling reveals dynamic epigenetic heterogeneity and convergent hypomethylation of stem cell quiescence-associated genes in breast cancer following neoadjuvant chemotherapyYumei Luo, Juan Huang, Yi Tang, Xitu Luo, Lingxia Ge, Xiujie Sheng, Xiaofang Sun, Yaoyong Chen, Detu Zhu · 2019 · Cell & Bioscience
- Defining a Role and Predicting Benefit From Platinum-Based Therapy in Breast Cancer: An Evolving StoryJoseph A. Sparano · 2014 · Journal of Clinical Oncology
- DUSP 4 expression identifies a subset of colorectal cancer tumors that differ in MAPK activation, regardless of the genotypeVeerle de Vriendt, Wendy De Roock, Antonio Fabio Di Narzo, Sun Tian, Bart Biesmans, Bart Jacobs, Eva Budínská, Xavier Sagaert, Simona Rossi, Giovanni D’Ario et al. · 2013 · Biomarkers
- Dual specificity phosphatase 4 gene expression in association with triple-negative breast cancer outcomeMichelle L. Baglia, Qiuyin Cai, Ying Zheng, Jie Wu, Timothy Su, Fei Ye, Ping‐Ping Bao, Hui Cai, Zhiguo Zhao, Justin Micah Balko et al. · 2014 · Breast Cancer Research and Treatment
- Recent Advances of Nanotechnology in the Diagnosis and Therapy of Triple- Negative Breast Cancer (TNBC)Abhishek Kanugo, Rupesh Kumar Gautam, Mohammad Amjad Kamal · 2021 · Current Pharmaceutical Biotechnology
- Basal–epithelial subpopulations underlie and predict chemotherapy resistance in triple-negative breast cancerMohammed Inayatullah, Arun Mahesh, Arran Turnbull, J. Michael Dixon, Rachael Natrajan, Vijay Kumar Tiwari · 2024 · EMBO Molecular Medicine
- Loco-regional Control After Neo-adjuvant Chemotherapy and Conservative Treatment for Locally Advanced Breast Cancer PatientsAntonin Lévy, Isabelle Borget, Manel Bahri, Mónica Arnedos, Eleonor Rivin del Campo, Philippe R. Vielh, Corinne Balleyguier, Françoise Rimareix, C. Bourgier · 2014 · The Breast Journal
- Chemotherapy enriches for an invasive triple-negative breast tumor cell subpopulation expressing a precursor form of N-cadherin on the cell surfaceErik Russell Nelson, Shenduo Li, Margaret N. Kennedy, Sturgis Payne, Kelly Kilibarda, Jeffrey Groth, Michelle L. Bowie, Edgardo R. Parrilla Castellar, Gustaaf de Ridder, Paul Kelly Marcom et al. · 2016 · Oncotarget
- Enhanced O-linked Glcnacylation in Crohn's disease promotes intestinal inflammationQian-Hui Sun, Yi-Shu Wang, Guolong Liu, Hong-Lan Zhou, Yong‐Ping Jian, Ming-Di Liu, Dan Zhang, Qiang Ding, Rui–Xun Zhao, Jian-Feng Chen et al. · 2020 · EBioMedicine
- Subpathway Analysis of Transcriptome Profiles Reveals New Molecular Mechanisms of Acquired Chemotherapy Resistance in Breast CancerYang Huo, Shuai Shao, Enze Liu, Jin Li, Zhen Tian, Xue Wu, Shijun Zhang, Daniel G. Stover, Huanmei Wu, Lijun Cheng et al. · 2022 · Cancers
- Transcriptional CCND1 expression as a predictor of poor response to neoadjuvant chemotherapy with trastuzumab in HER2-positive/ER-positive breast cancerMaki Tanioka, Kazuko Sakai, Tamotsu Sudo, T. Sakuma, Kazuyoshi Kajimoto, Koichi Hirokaga, Shintaro Takao, Shunichi Negoro, Hironobu Minami, Kazuhiko Nakagawa et al. · 2014 · Breast Cancer Research and Treatment
- miR-1226-3p Promotes Sorafenib Sensitivity of Hepatocellular Carcinoma via Downregulation of DUSP4 ExpressionXianqing Chen, Wenliang Tan, Wenxin Li, Wenda Li, Sicong Zhu, Jinyi Zhong, Changzhen Shang, Yajin Chen · 2019 · Journal of Cancer
- Liver kinase B1 regulates the centrosome via PLK1Kaitlin D. Werle, J. Chen, H-G Xu, R-X Zhao, Q He, C Lu, Rutao Cui, Jiyong Liang, Y-L Li, Z-X Xu · 2014 · Cell Death and Disease
- Adding Adjuvant Systemic Treatment after Neoadjuvant Therapy in Breast Cancer: Review of the DataShetal Arvind Patel, Angela M. DeMichele · 2017 · Current Oncology Reports
- Supplementary Materials and MethodsFloris H. Groenendijk, Wilbert T. Zwart, Arno N. Floore, Stephanie Akbari, René Bernards · 2013
- Phosphatases and solid tumors: focus on glioblastoma initiation, progression and recurrencesMatthias Dedobbeleer, Estelle Willems, Stephen D. Freeman, Arnaud Lombard, Nicolas Goffart, Bernard Rogister · 2017 · Biochemical Journal
- A cellular automata model of chemotherapy effects on tumour growth: targeting cancer and immune cellsFateme Pourhasanzade, S. H. Sabzpoushan · 2019 · Mathematical and Computer Modelling of Dynamical Systems
- Chromosome 12p Amplification in Triple-Negative/ BRCA1- Mutated Breast Cancer Associates with Emergence of Docetaxel Resistance and Carboplatin SensitivityJorge Gomez Miragaya, Ander Díaz‐Navarro, Raúl Tonda, Sergi Beltrán, Luís Palomero, Marta Palafox, Lacey Elizabeth Dobrolecki, Chen Lu Huang, Suhas V. Vasaikar, Bing Zhang et al. · 2019 · Cancer Research
- Identification of miRNA Signature in Breast Cancer to Predict Neoadjuvant Chemotherapy ResponseAi‐Yan Xing, Bin Wang, Yu-Hong Li, Xu Chen, Ya‐Wen Wang, Haiting Liu, Peng Gao · 2021 · Pathology & Oncology Research
- The therapeutic significance of the novel photodynamic material TPE-IQ-2O in tumorsLiyu Wang, Yu Liu, Hengchang Liu, He Tian, Yalong Wang, Guochao Zhang, Yuanyuan Lei, Liyan Xue, Bo Jian Zheng, Tao T. Fan et al. · 2020 · Aging
- Molecular Targets and Promising Therapeutics of Triple-Negative Breast CancerWon‐Ji Ryu, Joohyuk Sohn · 2021 · Pharmaceuticals
- ERBB4-Mediated Signaling Is a Mediator of Resistance to PI3K and BTK Inhibitors in B-cell Lymphoid NeoplasmsAlberto J. Arribas, Sara Napoli, Luciano Cascione, Laura Barnabei, Giulio Sartori, Eleonora Cannas, Eugenio Gaudio, Chiara Tarantelli, Afua A. Mensah, Filippo Spriano et al. · 2023 · Molecular Cancer Therapeutics
- Targeting kinases that regulate programmed cell death: a new therapeutic strategy for breast cancerYun Chul Hong, Jun He, Dan Deng, Qinyue Liu, Xuyu Zu, Yingying Shen · 2025 · Journal of Translational Medicine
- DUSP4/MKP2 overexpression is associated with BRAFV600E mutation and aggressive behavior of papillary thyroid cancerYu Wang, Ben Ma, Rong‐Liang Shi, Shuwen Yang, Li Zhou, Ning Qu, Tian Liao, Yulong Wang, Qinghai Ji · 2016 · OncoTargets and Therapy
- Blockade of PDGFRβ circumvents resistance to MEK-JAK inhibition via intratumoral CD8+ T-cells infiltration in triple-negative breast cancerMurugan Kalimutho, Debottam Sinha, Deepak Mittal, Sriganesh Srihari, Devathri M. Nanayakkara, Shagufta Shafique, Prahlad V. Raninga, Purba Nag, Kate Parsons, Kum Kum Khanna · 2019 · Journal of Experimental & Clinical Cancer Research
- Lymphoma Microenvironment in DLBCL and PTCL-NOS: the key to uncovering heterogeneity and the potential for stratificationKohta Miyawaki, Takeshi Sugio · 2022 · Journal of the Japan Society of the Reticuloendothelial System
- Gene heterogeneity in metastasis of colorectal cancer to the lungJiayun Hou, Yong Zhang, Zhitu Zhu · 2016 · Seminars in Cell and Developmental Biology
- MIDAS: Mining differentially activated subpaths of KEGG pathways from multi-class RNA-seq dataSangseon Lee, Youngjun Park, Sun Kim · 2017 · Methods
- Microarray phosphatome profiling of breast cancer patients unveils a complex phosphatase regulatory role of the MAPK and PI3K pathways in estrogen receptor-negative breast cancersRamón González Manzano, E. Martinez-Navarro, Jerónimo Forteza, Antonio Brugarolas · 2014 · International Journal of Oncology
- Tumor Immune Microenvironment and Response to Neoadjuvant Chemotherapy in Hormone Receptor/HER2+ Early Stage Breast CancerRami Sesha Vanguri, Kathleen M. Fenn, Matthew Kearney, Qi Wang, Hua Guo, Douglas Kanter Marks, Christine Chin, Claire F. Alcus, Julia B Thompson, Cheng‐Shiun Leu et al. · 2022 · Clinical Breast Cancer
- Digital Quantification of Gene Expression in Sequential Breast Cancer Biopsies Reveals Activation of an Immune ResponseRinath M. Jeselsohn, Lillian L. Werner, Meredith M. Regan, Aquila Fatima, Lauren Gilmore, Laura C. Collins, Andrew H. Beck, Shannon Terrell Bailey, Housheng Hansen He, Gilles Buchwalter et al. · 2013 · PLoS ONE
- COGNITION: a prospective precision oncology trial for patients with early breast cancer at high risk following neoadjuvant chemotherapyConstantin Pixberg, Marc Zapatka, Mario Hlevnjak, S. Benedetto, Jan Philip Suppelna, Joerg Heil, Katharina Smetanay, Laura L. Michel, Carlo Fremd, V. Körber et al. · 2022 · ESMO Open
- MEK inhibition as a strategy for targeting residual breast cancer cells with low DUSP4 expressionSven Rottenberg, Jos Jonkers · 2012 · Breast Cancer Research
- Phase II study of MEK inhibitor trametinib alone and in combination with AKT inhibitor GSK2141795/uprosertib in patients with metastatic triple negative breast cancerVishnu Prasath, H. Boutrid, Robert Wesolowski, Mahmoud Abdel‐Rasoul, Cynthia Dawn Timmers, Maryam B. Lustberg, Rachel M. Layman, Erin Renee Macrae, Ewa Mrózek, Charles L. Shapiro et al. · 2024 · Breast Cancer Research and Treatment
- DUSP4 directly deubiquitinates and stabilizes Smad4 protein, promoting proliferation and metastasis of colorectal cancer cellsWeifeng Xu, Beibei Chen, Dianshan Ke, Xiaobing Chen · 2020 · Aging
- Functional analysis of MKP-1 and MKP-2 in breast cancer tamoxifen sensitivityKelly K. Haagenson, Jessica Wei Zhang, Zhengfan Xu, Malathy P.V. Shekhar, Gen Sheng Wu · 2014 · Oncotarget
- Tumor necrosis factor-α-mediated suppression of dual-specificity phosphatase 4: crosstalk between NFκB and MAPK regulates endothelial cell survivalDerrick D. Kao, Scott R. Oldebeken, Anjali Rai, Edith Lubos, Jane A. Leopold, Joseph Loscalzo, Diane E. Handy · 2013 · Molecular and Cellular Biochemistry
- Precision Breast Cancer Medicine: Early Stage Triple Negative Breast Cancer—A Review of Molecular Characterisation, Therapeutic Targets and Future TrendsKaren Pinilla, Lynsey M Drewett, Rebecca Lucey, Jean Abraham · 2022 · Frontiers in Oncology
- ERBB activation modulates sensitivity to MEK1/2 inhibition in a subset of driver-negative melanomaKatherine E. Hutchinson, Douglas Buckner Johnson, Adam S. Johnson, Violeta M. Sanchez, Maria Gabriela Kuba, Lu Wang, Xi Chen, Mark C. Kelley, Qingguo Wang, Zhongming Zhao et al. · 2015 · Oncotarget
- Dual-Specificity Protein Phosphatases Targeting Extracellular Signal-Regulated Kinases: Friends or Foes in the Biology of Cancer?Alessandro Tubita, Dimitri Papini, Ignazia Tusa, Elisabetta Rovida · 2025 · International Journal of Molecular Sciences
- Low-GPX4 drives a sustained drug-tolerant persister state in TNBC by a targetable adaptive FSP1 upregulationNazia Chaudhary, Dibita Mandal, Bhagya Shree Choudhary, Sushmita Patra, Darshan Jain, Pritam Poonia, Shagufa Shaikh, Siddhi Tekalkar, Shivani Malvankar, Anusha Shivashankar et al. · 2025 · Redox Biology
- DUSP4 Silencing Enhances the Sensitivity of Breast Cancer Cells to Doxorubicin through the Activation of the JNK/c-Jun Signalling PathwayMashael S. Al-Mutairi, Hany Onsy Habashy · 2022 · Molecules
- CREB1-BCL2 drives mitochondrial resilience in RAS GAP-dependent breast cancer chemoresistanceKi-Fong Man, Omeed Darweesh, Jinghui Hong, Alexandra Thompson, Charlotte O’Connor, Chiara Bonaldo, Mark N. Melkonyan, Mo Sun, Rajnikant Patel, Leif William Ellisen et al. · 2025 · Oncogene
- KDM4C inhibition blocks tumor growth in basal breast cancer by promoting cathepsin L-mediated histone H3 cleavageZheqi Li, Guillermo Peluffo, Laura E. Stevens, Xintao Qiu, Marco Seehawer, Amatullah Tawawalla, Xiao-Yun Huang, Shawn B. Egri, Shaunak Raval, Maeve McFadden et al. · 2025 · Nature Genetics
- Emerging strategies for TNBC with early clinical data: new chemoimmunotherapy strategiesPeter Edward Hall, Peter Schmid · 2022 · Breast Cancer Research and Treatment
- MicroRNA‐Based Therapeutic Strategies for Targeting Mutant and Wild Type RAS in CancerSriganesh B. Sharma, John Michael Ruppert · 2015 · Drug Development Research
- New Developments and Future Directions in Systemic TherapyAmna Sheri, Stephen R.D. Johnston · 2012 · Clinical Oncology
- Circulating Proteins Associated with Response and Resistance to Neoadjuvant Chemotherapy in HER2-Positive Breast CancerMaría del Pilar Chantada‐Vázquez, Mercedes Conde‐Amboage, L. Graña-López, Sergio Vázquez‐Estévez, Susana B. Bravo, Cristina Núñez · 2022 · Cancers
- Combined Dusp4 and p53 loss with Dbf4 amplification drives tumorigenesis via cell cycle restriction and replication stress escape in breast cancerAnn Hanna, Mellissa J. Nixon, Monica Valeria Estrada, Violeta M. Sanchez, Quanhu Sheng, Susan R. Opalenik, Abigail L. Toren, Joshua A. Bauer, Philip Owens, Frank M. Mason et al. · 2022 · Breast Cancer Research
- Proteolysis Targeting Chimera (PROTAC) as a promising novel therapeutic modality for the treatment of triple‐negative breast cancer (TNBC)Gaidaa M. Dogheim, Mohamed T. Amralla · 2023 · Drug Development Research
- Integration of multiomics data shows down regulation of mismatch repair and tubulin pathways in triple-negative chemotherapy-resistant breast tumorsXiaojia Tang, Kevin J. Thompson, Krishna R. Kalari, Jason P. Sinnwell, Vera Jean Suman, Peter T. Vedell, Sarah A. McLaughlin, DW Northfelt, Alvaro Moreno Aspitia, Richard J. Gray et al. · 2023 · Breast Cancer Research
- Shifting the Paradigm: The Transformative Role of Neoadjuvant Therapy in Early Breast CancerNader Hirmas, Johannes Holtschmidt, Sibylle Loibl · 2024 · Cancers
- FRET biosensor-based kinase inhibitor screen for ERK and AKT activity reveals differential kinase dependencies for proliferation in TNBC cellsJichao He, Steven Wink, Hans de Bont, Sylvia E. Le Dévédec, Ying-Hui Zhang, Bob van de Water · 2019 · Biochemical Pharmacology
- Neoadjuvant or Adjuvant Chemotherapy for Breast Cancer in Sub-Saharan Africa: A Retrospective Analysis of Recurrence and Survival in Women Treated for Breast Cancer at the Korle Bu Teaching Hospital in GhanaHannah Ayettey Anie, Joel Yarney, Olutobi Adekunle Sanuade, Shivanshu Awasthi, Tom Akuetteh Ndanu, Akash D. Parekh, Charles Akoto Aidoo, Mary Ann Dadzie, Verna D.N.K. Vanderpuye, Kosj Yamoah · 2021 · JCO Global Oncology
- Molecular-Genetic Portrait of Breast Cancer with Triple Negative PhenotypeMarina Konstantinovna Ibragimova, Matvey Mikhailovich Tsyganov, Николай Васильевич Литвяков · 2021 · Cancers
- Current therapeutics and treatment options in TNBCManzoor Ahmad Mir, Shariqa Aisha, Umar Mehraj · 2022 · Elsevier eBooks
- PKM splice-switching ASOs induce upregulation of dual-specificity phosphatases and dephosphorylation of ERK1/2 in hepatocellular carcinomaDillon M. Voss, Alexander J. Kral, GeunYoung Sim, Raditya Utama, Kuan‐Ting Lin, Chris Cizmeciyan, Balázs Schäfer, Patrick J. Cunniff, Christopher R. Vakoc, Marvin H. Caruthers et al. · 2025 · Journal of Biological Chemistry
- Risk factors of locoregional relapse in locally advanced breast cancer treated with neoadjuvant chemotherapy following mastectomy and radiotherapyLiang Huang, Sheng Chen, Wentao Yang, Zhi‐Ming Shao · 2016 · Oncotarget
- Aberrant expression of DUSP4 is a specific phenomenon in betel quid-related oral cancerBhoj Raj Adhikari, Koki Yoshida, Durga Paudel, Tetsuro Morikawa, Osamu Uehara, Jun Sato, Malsantha Muthumala, Prasad Amaratunga, Toshiya Arakawa, Itsuo Chiba et al. · 2020 · Medical Molecular Morphology
- DUSP4 inhibited tumor cell proliferation by downregulating glycolysis via p-ERK/p-PGK1 signaling in ovarian cancerYing Xiong, Xiaoqian Zhang, Weiwei Xie, Yujia Yin, Yujing Qian, Xiang Ying, Xiaocui Zheng, Xipeng Wang · 2025 · Cancer Cell International
- Low DUSP4 Expression Is Associated With Aggressive Phenotypes and Poor Prognosis in Gastric CancerSeongsik Bang, Seungyun Jee, Hyunsung Kim, KISEOK JANG, Hosub Park, Jae Kyung Myung, Dongho Choi, Su‐Jin Shin, Seung Sam Paik · 2021 · In Vivo
- DUSP4 enhances therapeutic sensitivity in HER2-positive breast cancer by inhibiting the G6PD pathway and ROS metabolism by interacting with ALDOBXuliren Wang, Weiru Chi, Yuwei Ma, Qi Zhang, Jingyan Xue, Zhi‐Ming Shao, Bingqiu Xiu, Jiong Wu, Yayun Chi · 2024 · Translational Oncology
- Cancer stem cell phosphatasesMajid Momeny, Tiina Arsiola, Jukka K. Westermarck · 2021 · Biochemical Journal
- Silencing circFTO inhibits malignant phenotype through modulating DUSP4 expression in clear cell renal cell carcinomaChen Yang, Yiwen Zang, Siqi Wu, Quan Zhou, Yuxi Ou, Qiang Ding, Hao Wang, Zuquan Xiong · 2022 · Cell Death Discovery
- Immuno-oncologic signature of malignant transformation in oral squamous cell carcinomaManar Elnaggar, Risa Chaisuparat, Ioana Ghita, Søren Møller Bentzen, Donita Dyalram, Robert Andrew Ord, Joshua Eli Lubek, Rania H. Younis · 2023 · Oral Surgery Oral Medicine Oral Pathology and Oral Radiology
- 682: Synergistic combination of valproic acid and oncolytic parvovirus H-1PV as a potential therapy against cervical and pancreatic carcinomasJ. Li, Serena Bonifati, Georgi Hristov, T. Marttila, Jean Rommelaere, Antonio Marchini · 2014 · European Journal of Cancer
- Dual-Specificity Phosphatase 11 Is a Prognostic Biomarker of Intrahepatic CholangiocarcinomaXu Lin, Peng Wang, Wei Zhang, Weiran Li, Tao Liu, Xu Che · 2021 · Frontiers in Oncology
- Short-Term Environmental Conditioning Enhances Tumorigenic Potential of Triple-Negative Breast Cancer CellsSamantha S. Eckley, Johanna M. Buschhaus, Brock A. Humphries, Tanner H. Robison, Kathryn E. Luker, Gary D. Luker · 2019 · Tomography
- Challenges in triple negative breast cancer treatment and therapeutic potential of the mitogen activated protein kinase pathwayPrettisha K. Nand, David R. Croucher, Levon Michael Khachigian · 2026 · Cancer Letters
- Patterns of Dual-Specific Phosphatase 4 mRNA Expression Before and after Neoadjuvant Chemotherapy in Breast CancerPrihantono Prihantono, Andi Nilawati Usman, Christian Binekada, Mochammad Hatta, Andi Asadul Islam · 2019 · Asian Pacific Journal of Cancer Prevention
- Loss of DUSP4 Expression as a Prognostic Biomarker in Clear Cell Renal Cell CarcinomaSeongsik Bang, Seungyun Jee, Hwangkyu Son, Young Chan Wi, Hyunsung Kim, Hosub Park, Jae Kyung Myung, Su‐Jin Shin, Seung Sam Paik · 2021 · Diagnostics
- Cancer stem cells and early stage basal-like breast cancerPang‐Kuo Lo, Benjamin Wolfson, Qun Yong Zhou · 2016 · World Journal of Obstetrics and Gynecology
- Preoperative Therapy for Operable Breast CancerYeşim Eralp · 2016 · Springer eBooks
- AR/ERK co-targeting triggers ferroptosis via FOXC2 in triple-negative breast cancerYuhan Zhao, Chi Xu, Yiqiu Liu, Ye Zhu, Lingling Fan, Fangyan Gao, Xiaojie Liang, Yaqin Shi, Yongbin Chen, Xiaoxiang Guan · 2025 · Science China Life Sciences
- Inhibition of UCH-L1 enhances immunotherapy efficacy in triple-negative breast cancer by stabilizing PD-L1Linhao He, Jiaying He, Ting Jiang, Rong Gong, Xiaoya Wan, Mingwu Duan, Zonglin Chen, Yan Cheng · 2025 · European Journal of Pharmacology
- Implementation of a High-Accuracy Targeted Gene Expression Panel for Clinical CareAileen Y. Alontaga, Pedro Cano, Hilal Özakıncı, John Puskas, Paul A. Stewart, Eric A. Welsh, Sean Yoder, James Kevin Hicks, Andreas Nicholas Saltos, Aaron Bossler et al. · 2024 · Journal of Molecular Diagnostics