Early infection with respiratory syncytial virus impairs regulatory T cell function and increases susceptibility to allergic asthma

Krishnamoorthy, Nandini; Khare, Anupriya; Oriss, Timothy B; Raundhal, Mahesh; Morse, Christina; Yarlagadda, Manohar; Wenzel, Sally E; Moore, Martin L; Peebles, R Stokes; Ray, Anuradha; Ray, Prabir

doi:10.1038/nm.2896

Early infection with respiratory syncytial virus impairs regulatory T cell function and increases susceptibility to allergic asthma

Immune tolerance is instituted early in life, during which time regulatory T (Treg) cells have an important role. Recurrent infections with respiratory syncytial virus (RSV) in early life increase the risk for asthma in adult life. Repeated infection of infant mice tolerized to ovalbumin (OVA) th…