BCAT1 promotes cell proliferation through amino acid catabolism in gliomas carrying wild-type IDH1

Tönjes, Martje, Barbus, Sebastian, Park, Yoon Jung, Wang, Wei, Schlotter, Magdalena, Lindroth, Anders M, Pleier, Sabrina V, Bai, Alfa H C +26 more·2013·Nature Medicine

DOI 10.1038/nm.3217

Cited by (487)

Items 201–300 of 487

Methylation and Gene Expression of BCAT1 and IKZF1 in Colorectal Cancer Tissues
Maher Jedi, Graeme Paul Young, Susanne Kartin Pedersen, Erin Leigh Symonds · 2018 · Clinical Medicine Insights Oncology
Dietary intake of branched‐chain amino acids and survival after colorectal cancer diagnosis
Lü Long, Wanshui Yang, Li Liu, Deirdre Kay Tobias, Ryoko Katagiri, Kana Wu, Lina Jin, Fang‐Fang Zhang, Xiao Luo, Xing Liu et al. · 2020 · International Journal of Cancer
A Transient Metabolic State in Melanoma Persister Cells Mediated by Chemotherapeutic Treatments
Prashant Karki, Vahideh Angardi, Juan Carlos Mier, Mehmet A. Orman · 2022 · Frontiers in Molecular Biosciences
Human acute leukemia uses branched-chain amino acid catabolism to maintain stemness through regulating PRC2 function
Yoshikane Kikushige, Toshihiro Miyamoto, Yu Kochi, Yuichiro Semba, Maki Ohishi, Hidetoshi Irifune, Kiwamu Hatakeyama, Yuya Kunisaki, Takeshi Sugio, Teppei Sakoda et al. · 2022 · Blood Advances
11C-Methionine positron emission tomography delineates non-contrast enhancing tumor regions at high risk for recurrence in pediatric high-grade glioma
John Thomas Lucas, Nick Serrano, Hyun Kim, Xingyu Li, Scott E. Snyder, Scott N. Hwang, Yimei Li, Chia-Ho Hua, Alberto Broniscer, Thomas E. Merchant et al. · 2017 · Journal of Neuro-Oncology
Inhibiting CREPT reduces the proliferation and migration of non-small cell lung cancer cells by down-regulating cell cycle related protein.
Tao Liu, Weimiao Li, Wu-Ping Wang, Ying Sun, Yunfeng Ni, Hao Xing, Jinghua Xia, Xuejiao Wang, Zhipei Zhang, Xiaofei Li · 2016 · PubMed Central
Nuclear Magnetic Resonance-Based Metabolomics Approach to Evaluate the Prevention Effect of Camellia nitidissima Chi on Colitis-Associated Carcinogenesis
Minghui Li, Hongzhi Du, Gui-Ju Kong, Li-Bao Liu, Xinxin Li, Sensen Lin, Ai‐Qun Jia, Shengtao Yuan, Li Sun, Junsong Wang · 2017 · Frontiers in Pharmacology
An overview of branched-chain amino acid aminotransferases: functional differences between mitochondrial and cytosolic isozymes in yeast and human
Yoichi Toyokawa, Jirasin Koonthongkaew, Hiroshi Takagi · 2021 · Applied Microbiology and Biotechnology
L-type amino acid transporter 1 as a target for inflammatory disease and cancer immunotherapy
Keitaro Hayashi, Naohiko Anzai · 2021 · Journal of Pharmacological Sciences
Metabolic rewiring during bone development underlies tRNA m7G–associated primordial dwarfism
Qiwen Li, Shuang Jiang, Kexin Lei, Hui Ling Han, Yaqian Chen, Weimin Lin, Qiuchan Xiong, Xingying Qi, Xinyan Gan, Rui Sheng et al. · 2024 · Journal of Clinical Investigation
Baicalein Delays H 2 O 2 -Induced Astrocytic Senescence through Inhibition of Senescence-Associated Secretory Phenotype (SASP), Suppression of JAK2/STAT1/NF-κB Pathway, and Regulation of Leucine Metabolism
Li Gao, Wen-ge Zheng, Xingkang Wu, Guanhua Du, Xuemei Qin · 2021 · ACS Chemical Neuroscience
BCAT1 redox function maintains mitotic fidelity
Liliana Francois, Pavle Boskovic, Julian Knerr, Wei He, Gianluca Sigismondo, Carsten Schwan, Tushar H. More, Magdalena Schlotter, Myra E. Conway, Jeroen Krijgsveld et al. · 2022 · Cell Reports
Association of plasma branched-chain amino acid with multiple cancers: A mendelian randomization analysis
Huan Xu, Xuanyang Wang, Xiaoqing Xu, Lin Liu, Yuntao Zhang, Xuemin Yan, Yingfeng Zhang, Keke Dang, Ying Li · 2023 · Clinical Nutrition
Does Neuronal Activity Promote Glioma Progression?
Hans‐Georg Wirsching, Michael Weller · 2019 · Trends in cancer
Synthesis of 2-oxoglutarate derivatives and their evaluation as cosubstrates and inhibitors of human aspartate/asparagine-β-hydroxylase
Lennart Brewitz, Yu Nakashima, Christopher John Schofield · 2020 · Chemical Science
Insights on Metabolic Reprogramming and Its Therapeutic Potential in Acute Leukemia
Ludovica Di Martino, Valeria Tosello, Edoardo Peroni, Erich Piovan · 2021 · International Journal of Molecular Sciences
BAY-069, a Novel (Trifluoromethyl)pyrimidinedione-Based BCAT1/2 Inhibitor and Chemical Probe
Judith Günther, Roman Christian Hillig, Katja C. Zimmermann, Stefan Kaulfuß, Clara Lemos, Duy Nguyen, Hartmut Rehwinkel, Matthew Habgood, Christian Lechner, Roland Neuhaus et al. · 2022 · Journal of Medicinal Chemistry
Inhibition of branched-chain alpha-keto acid dehydrogenase kinase augments the sensitivity of ovarian and breast cancer cells to paclitaxel
Suad Lateef Ibrahim, Mohammed Najim Abed, Gehad Genidy Mohamed, Joshua C. Price, Marwan Ibrahim Abdullah, Alan Richardson · 2022 · British Journal of Cancer
Wild-Type IDH1 and Mutant IDH1 Opposingly Regulate Podoplanin Expression in Glioma
Chao Sun, Liming Xiao, Yuanlin Zhao, Jiankuan Shi, Yuan Yuan, Yu Gu, Feng Zhang, Xing Gao, Ying Yang, Risheng Yang et al. · 2020 · Translational Oncology
Translation of branched-chain aminotransferase-1 transcripts is impaired in cells haploinsufficient for ribosomal protein genes
Tamara C. Pereboom, Albert Bondt, Paschalina Pallaki, Timothy D. Klasson, Yvonne J. Goos, Paul Essers, Marian J.A. Groot Koerkamp, Hanna T. Gazda, Frank C. P. Holstege, Lydie M. Da Costa et al. · 2014 · Experimental Hematology
Effect of policosanol from insect wax on amyloid β-peptide-induced toxicity in a transgenic Caenorhabditis elegans model of Alzheimer’s disease
Xin Zhang, Chenjing Ma, Long Sun, Zhao He, Ying Feng, Xian Li, Jin Gan, Xiaoming Chen · 2021 · BMC Complementary Medicine and Therapies
Dietary Manipulation of Amino Acids for Cancer Therapy
Julio José Jiménez‐Alonso, Miguel López‐Lázaro · 2023 · Nutrients
Investigational new drugs for brain cancer
Verena Staedtke, Ren-Yuan Bai, John Laterra · 2016 · Expert Opinion on Investigational Drugs
Emerging Moonlighting Functions of the Branched-Chain Aminotransferase Proteins
Myra E. Conway · 2020 · Antioxidants and Redox Signaling
One-Carbon Metabolism Associated Vulnerabilities in Glioblastoma: A Review
Kimia Ghannad‐Zadeh, Sunit Das · 2021 · Cancers
BCAT1 binds the RNA-binding protein ZNF423 to activate autophagy via the IRE1-XBP-1-RIDD axis in hypoxic PASMCs
Wei Xin, Min Zhang, Yang Yu, Songlin Li, Cui Ma, Junting Zhang, Yuan Jiang, Yiying Li, Xiaodong Zheng, Lixin Zhang et al. · 2020 · Cell Death and Disease
BCAT1 overexpression regulates proliferation and c‑Myc/GLUT1 signaling in head and neck squamous cell carcinoma
Hongming Wang, Fei Wang, Wenyu Ouyang, Xuejun Jiang, Yan Wang · 2021 · Oncology Reports
Metabolic partitioning in the brain and its hijacking by glioblastoma
Jed de Ruiter Swain, Evdokia Michalopoulou, Evan Noch, Michael J. Lukey, Linda Van Aelst · 2023 · Genes & Development
Further understanding of glioma mechanisms of pathogenesis: implications for therapeutic development
Michael W. Ruff, Sani Haider Kizilbash, Jan C. Buckner · 2020 · Expert Review of Anticancer Therapy
Epigenetic Regulators of DNA Cytosine Modification: Promising Targets for Cancer Therapy
Inkyung Jung, Jungeun An, Myunggon Ko · 2023 · Biomedicines
Bioenergetic dysfunction in a zebrafish model of acute hyperammonemic decompensation
Matthias Zielonka, Joris Probst, Matthias Carl, Georg Friedrich Hoffmann, Stefan Kölker, Jürgen G. Okun · 2019 · Experimental Neurology
Branched-Chain Amino Acids and Seizures: A Systematic Review of the Literature
Shaun Evan Gruenbaum, Eric C. Chen, Mani Ratnesh S. Sandhu, Ketaki Deshpande, Roni Dhaher, Denise Hersey, Tore Eid · 2019 · CNS Drugs
Perampanel Add-on to Standard Radiochemotherapy in vivo Promotes Neuroprotection in a Rodent F98 Glioma Model
Falko Lange, Jens Hartung, Clara Liebelt, Julius Boisserée, Tobias Resch, Katrin Porath, Max Frederik Hörnschemeyer, Gesine Reichart, Tina Sellmann, Valentin Neubert et al. · 2020 · Frontiers in Neuroscience
A Set of Cell Lines Derived from a Genetic Murine Glioblastoma Model Recapitulates Molecular and Morphological Characteristics of Human Tumors
Barbara Costa, Michael N. C. Fletcher, Pavle Boskovic, Ekaterina L. Ivanova, Tanja Eisemann, Sabrina Lohr, Lukas Bunse, Martin Löwer, Stefanie Burchard, Andrey Korshunov et al. · 2021 · Cancers
1H NMR metabolic profiling of gastric cancer patients with lymph node metastasis
Hailong Zhang, Longzhen Cui, Wen Liu, Zhenfeng Wang, Ye Yang, Xue Li, Huijuan Wang · 2018 · Metabolomics
Silencing of Long Noncoding RNA LINC00324 Interacts with MicroRNA-3200-5p to Attenuate the Tumorigenesis of Gastric Cancer via Regulating BCAT1
Shuang Wang, Yuanyuan Cheng, Pingping Yang, Guang Qin · 2020 · Gastroenterology Research and Practice
Oridonin impedes breast cancer growth by blocking cells in S phase and inhibiting the PI3K/AKT/mTOR signaling pathway
Weijie Zhang, Lei Shi, Wei Zhou, Xin Liu, Yuan Xi, Xinyin Wang, Ya Li, Xia Xu, Youcai Tang · 2023 · Heliyon
Mitochondrial phosphoenolpyruvate carboxykinase (PEPCK-M) regulates the cell metabolism of pancreatic neuroendocrine tumors (pNET) and de-sensitizes pNET to mTOR inhibitors
Pei‐Yi Chu, Shih Sheng Jiang, Yan‐Shen Shan, Wen-Chun Hung, Ming‐Huang Chen, Hui-You Lin, Yulin Chen, Hui‐Jen Tsai, Li‐Tzong Chen · 2017 · Oncotarget
LINC00963 Confers Oncogenic Properties in Glioma by Regulating the miR-506/BCAT1 Axis
Feng Ye, Ronghua Xu, Yuanhong Ge, Yi Zheng, Xiaowei Liu, Pingfu Deng, Xuejun Xu · 2020 · Cancer Management and Research
Integrative analysis of DNA methylation and gene expression profiles to identify biomarkers of glioblastoma
Mohammad Reza Alivand, Sajad Najafi, Sajjad Esmaeili, Dara Rahmanpour, Hossein Zhaleh, Yazdan Rahmati · 2021 · Cancer Genetics
An amino acid-defined diet impairs tumour growth in mice by promoting endoplasmic reticulum stress and mTOR inhibition
Maurizio Ragni, Chiara Ruocco, Laura Tedesco, Michele O. Carruba, Alessandra Valerio, Enzo Nisoli · 2022 · Molecular Metabolism
BCAT2 binding to PCBP1 regulates the PI3K/AKT signaling pathway to inhibit autophagy-related apoptosis and ferroptosis in prostate cancer
Wangli Mei, Mengyu Wei, Chaozhi Tang, Weiyi Li, Bowen Ye, Shiyong Xin, Weiguo Ma, Lin Ye · 2025 · Cell Death and Disease
Isocitrate dehydrogenase 1 and 2 mutations in gliomas
Magdalena Megova Houdova, Jir̆ı́ Drábek, Vladimíra Koudeláková, Radek Trojanec, Ondřej Kalita, Marián Hajdúch · 2014 · Journal of Neuroscience Research
Mapping actionable pathways and mutations in brain tumours using targeted RNA next generation sequencing
Krissie Lenting, Corina N. A. M. van den Heuvel, Anne van Ewijk, Duaa Elmelik, Remco de Boer, Elizabeth A. Tindall, Wei Ge, Benno Küsters, Maarten te Dorsthorst, Mark ter Laan et al. · 2019 · Acta Neuropathologica Communications
Targeting oncometabolism to maximize immunotherapy in malignant brain tumors
Joshua D. Bernstock, Kyung‐Don Kang, Neil V. Klinger, Hannah E. Olsen, Sam E. Gary, Stacie K. Totsch, Gelare Ghajar-Rahimi, David J. Segar, Eric M. Thompson, Victor M. Darley-Usmar et al. · 2022 · Oncogene
The emerging role of the branched chain aminotransferases, BCATc and BCATm, for anti-tumor T-cell immunity
Tanner J. Wetzel, Sheila C. Erfan, Elitsa Antonova Ananieva · 2023 · Immunometabolism
Antitumor Potential of Antiepileptic Drugs in Human Glioblastoma: Pharmacological Targets and Clinical Benefits
Manuela Stella, Giammarco Baiardi, Stefano Pasquariello, Fabio Sacco, Irene Dellacasagrande, Alessandro Corsaro, Francesca Mattioli, Federica Barbieri · 2023 · Biomedicines
Targeted inhibition of branched-chain amino acid metabolism drives apoptosis of glioblastoma by facilitating ubiquitin degradation of Mfn2 and oxidative stress
Zhuo Lü, Guifeng Sun, Kai-Yi He, Zhen Zhang, Xin‐Hao Han, Xin-Hui Qu, Deng-Feng Wan, Deng-Feng Wan, Fangfang Tou, Xiao-Jian Han et al. · 2024 · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
BCATc modulates crosstalk between the PI3K/Akt and the Ras/ERK pathway regulating proliferation in triple negative breast cancer
Mai Ahmed Shafei, Tom E. Forshaw, Jasmine Davis, Arwa F. Flemban, David Qualtrough, Sarah Dean, Claire M. Perks, Ming Dong, Robert Howard Newman, Myra E. Conway · 2020 · Oncotarget
Central nervous system regulation of diffuse glioma growth and invasion: from single unit physiology to circuit remodeling
Thiébaud Picart, Shawn L. Hervey‐Jumper · 2024 · Journal of Neuro-Oncology
Validation of a Circulating Tumor-Derived DNA Blood Test for Detection of Methylated BCAT1 and IKZF1 DNA
David H. Murray, Rohan T. Baker, Snigdha Gaur, Graeme Paul Young, Susanne Kartin Pedersen · 2017 · The Journal of Applied Laboratory Medicine
Mice deficient in the mitochondrial branched-chain aminotransferase (BCATm) respond with delayed tumour growth to a challenge with EL-4 lymphoma
Elitsa Antonova Ananieva, Joshua N. Bostic, Ashley Torres, Hannah R. Glanz, Sean M. McNitt, Michelle K. Brenner, Michael P. Boyer, Adele K. Addington, Susan M. Hutson · 2018 · British Journal of Cancer
Enrichment of branched chain amino acid transaminase 1 correlates with multiple biological processes and contributes to poor survival of IDH1 wild-type gliomas
Yi Li, Xiaoguang Fan, Jiabo Li, Feng Yuan, Jian Zhao, Monica Nistér, Xuejun Yang · 2021 · Aging
BCAT1 defines gliomas by IDH status
Jared R. Mayers, Matthew G. Vander Heiden · 2013 · Nature Medicine
Branched-chain amino acid transaminase 1 regulates glioblastoma cell plasticity and contributes to immunosuppression
Pavle Boskovic, Nathalie Wilke, Ka-Hou Man, Peter Lichter, Liliana Francois, Bernhard Radlwimmer · 2023 · Neuro-Oncology
Fueling the fight against cancer: Exploring the impact of branched-chain amino acid catalyzation on cancer and cancer immune microenvironment
Qianquan Ma, Haoyu Li, Zhihao Song, Zhili Deng, Wei Huang, Qing Liu · 2024 · Metabolism
Nuclear Translocation of LDHA Promotes the Catabolism of BCAAs to Sustain GBM Cell Proliferation through the TxN Antioxidant Pathway
Zhujun Li, Zhiyan Gu, Lan Wang, Yun Guan, Yingying Lyu, Jialong Zhang, Yin Wang, Xin Wang, Ji Xiong, Ying Liu · 2023 · International Journal of Molecular Sciences
Cross-talk between BCKDK-mediated phosphorylation and STUB1-dependent ubiquitination degradation of BCAT1 promotes GBM progression
Wei Wang, Youwei Li, Liu Tang, Yue Shi, Wensheng Li, Ling Zou, Liyuan Zhang, Yue Cheng, Yuan Zheng, Feng Zhu et al. · 2024 · Cancer Letters
Gabapentin Can Suppress Cell Proliferation Independent of the Cytosolic Branched-Chain Amino Acid Transferase 1 (BCAT1)
Nina Grankvist, Kim A. Lagerborg, Mohit Jain, Roland Nilsson · 2018 · Biochemistry
Rapid Determination of Amino Acids of Nitraria tangutorum Bobr. from the Qinghai-Tibet Plateau Using HPLC-FLD-MS/MS and a Highly Selective and Sensitive Pre-Column Derivatization Method
Wu Zhou, Yuwei Wang, Fang Yang, Qi Dong, Honglun Wang, Na Hu · 2019 · Molecules
Amino Acid-Mediated Metabolism: A New Power to Influence Properties of Stem Cells
Jilan Liu, Xianyun Qin, Dongfeng Pan, Bin Zhang, Feng Jin · 2019 · Stem Cells International
Expression of 3-Methylcrotonyl-CoA Carboxylase in Brain Tumors and Capability to Catabolize Leucine by Human Neural Cancer Cells
Eduard Gondáš, Alzbeta Kralova Trancikova, Eva Baranovičová, Jakub Šofránko, Jozef Hatok, Bhavani S. Kowtharapu, Tomáš Galanda, Dušan Dobrota, Peter Kubatka, Dietrich Büsselberg et al. · 2022 · Cancers
Sex differences in transcriptomic profiles in aged kidney cells of renin lineage
Yuliang Wang, Diana G. Eng, Jeffrey W. Pippin, Sina A. Gharib, Aaron D. McClelland, Kenneth W. Gross, Stuart J. Shankland · 2018 · Aging
Flotillin-2 promotes cell proliferation via activating the c-Myc/BCAT1 axis by suppressing miR-33b-5p in nasopharyngeal carcinoma
Rong Liu, Jie Liu, Ping Wu, Hong Liang Yi, Bin Zhang, Wei Huang · 2021 · Aging
The promise of mitochondria in the treatment of glioblastoma: a brief review
Zhuo Liang, Songyun Zhao, Yuankun Liu, Chao Cheng · 2025 · Discover Oncology
Loss of BCAT1 Expression is a Sensitive Marker for IDH-Mutant Diffuse Glioma
Yen‐Ying Chen, Hsiang‐Ling Ho, Shih‐Chieh Lin, Chih‐Yi Hsu, Donald Ming‐Tak Ho · 2018 · Neurosurgery
Differential expression of the BCAT isoforms between breast cancer subtypes
Mai Ahmed Shafei, Arwa F. Flemban, Carl S. Daly, Paul Kendrick, Paul White, Sarah Dean, David Qualtrough, Myra E. Conway · 2020 · Breast Cancer
BCAT1 knockdown-mediated suppression of melanoma cell proliferation and migration is associated with reduced oxidative phosphorylation.
Bingxia Zhang, Fang Xu, Kaijuan Wang, Mengduan Liu, Jinxia Li, Qianwei Zhao, Liya Jiang, Zhendong Zhang, Yamei Li, Huiping Chen et al. · 2021 · PubMed Central
Contribution of branched chain amino acids to energy production and mevalonate synthesis in cancer cells
Valeryia Mikalayeva, Monika Pankevičiūtė, Vaidotas Žvikas, Vytenis Arvydas Skeberdis, Sergio Bordel · 2021 · Biochemical and Biophysical Research Communications
Genomic and transcriptomic analysis of pituitary adenomas reveals the impacts of copy number variations on gene expression and clinical prognosis among prolactin-secreting subtype
Yiyuan Chen, Hua Gao, Weiyan Xie, Jing Guo, Qiuyue Fang, Peng Zhao, Chunhui Liu, Haibo Zhu, Zhuang Wang, Jichao Wang et al. · 2020 · Aging
Plasma amino acids indicate glioblastoma with ATRX loss
Ernest Jan Bobeff, Dorota Szczęsna, Michał Bieńkowski, Karolina Janczar, Małgorzata Chmielewska-Kassassir, Karol Wiśniewski, Wielislaw Papierz, Lucyna A. Woźniak, Dariusz Jan Jaskólski · 2021 · Amino Acids
Rewired Metabolism of Amino Acids and Its Roles in Glioma Pathology
Sirui Chen, Jingjing Jiang, Ao Shen, Ying Miao, Yun‐Feng Cao, Ying Zhang, Peiyu Cong, Peng Gao · 2022 · Metabolites
Metabolic network modeling approaches for investigating the “hungry cancer”
Ashwini Kumar Sharma, Rainer König · 2013 · Seminars in Cancer Biology
Microbial metabolites in tumor epigenetic regulation
Wangzheqi Zhang, Haoling Zhang, Yan Liao, Shuya Jiang, Haolong Zhang, Chenwei Huang, ZhiJing Song, Rui Zhao, Ping Lü, Xiaohong Kang et al. · 2026 · iMeta
Fitting algorithms and baseline correction influence the results of non‐invasive in vivo quantitation of 2‐hydroxyglutarate with 1H‐MRS
Katharina Johanna Wenger, Elke Hattingen, Patrick N. Harter, Christian Paolo Richter, Kea Franz, Joachim Peter Steinbach, Oliver Bähr, Ulrich Pilatus · 2018 · NMR in Biomedicine
Abundance of d ‐2‐hydroxyglutarate in G2/M is determined by FOXM1 in mutant IDH1‐expressing cells
Balabhaskararao Kancharana, Kumar Katragunta, Uma Maheswara Sarma, Nishant Jain · 2019 · FEBS Letters
Data mining of the expression and regulatory role of BCAT1 in hepatocellular carcinoma
Haifan Zou, Minjun Liao, Wentao Xu, Renzhi Yao, Weijia Liao · 2019 · Oncology Letters
Assessment of bevacizumab resistance increased by expression of BCAT1 in IDH1 wild-type glioblastoma: application of DSC perfusion MR imaging
Hye Rim Cho, Bora Hong, Hyeonjin Kim, Chul‐Kee Park, Sung‐Hye Park, Sunghyouk Park, Seung Hong Choi · 2016 · Oncotarget
SIRT5-mediated BCAT1 desuccinylation and stabilization leads to ferroptosis insensitivity and promotes cell proliferation in glioma
Tao Wang, Xin‐Hao Han, Junjun Chen, Xing Wang, Zhen Zhang, Xiao‐Jian Han, Zhuo Lü · 2025 · Cell Death and Disease
Branched-chain amino acid aminotransferase-1 regulates self-renewal and pluripotency of mouse embryonic stem cells through Ras signaling
Shaohui Chen, Bohan Chen, Guangsong Su, Jun Chen, Dianhao Guo, Qingqing Yin, Wenbin Wang, Zhongfang Zhao, Lei Zhang, Jiandang Shi et al. · 2020 · Stem Cell Research
Curcumin induces apoptosis by inhibiting BCAT1 expression and mTOR signaling in cytarabine‑resistant myeloid leukemia cells
Yu‐Hsin Tseng, Rei‐Cheng Yang, Shyh‐Shin Chiou, Tzong‐Ming Shieh, Yin-Hwa Shih, Pei‐Chin Lin · 2021 · Molecular Medicine Reports
Dietary amylose:amylopectin ratio influences the expression of amino acid transporters and enzyme activities for amino acid metabolism in the gastrointestinal tract of goats
Xiaokang Lv, Chuanshe Zhou, Tao Ran, Jinzhen Jiao, Yong Liu, Zhiliang Tan, Shaoxun Tang, Jinhe Kang, Jingjing Xie, Liang Chen et al. · 2021 · British Journal Of Nutrition
Mutant IDH1 inhibitors activate pSTAT3-Y705 leading to an increase in BCAT1 and YKL-40 levels in mutant IDH1-expressing cells
Debanjan Bhattacharjee, Balabhaskararao Kancharana, Nishant Jain · 2021 · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
Measuring the Metabolic Evolution of Glioblastoma throughout Tumor Development, Regression, and Recurrence with Hyperpolarized Magnetic Resonance
Travis C. Salzillo, Vimbai Mawoneke, Joseph Weygand, Akaanksh Shetty, Joy Gumin, Niki Marie Zacharias, Seth T. Gammon, David R Piwnica-Worms, Gregory N. Fuller, Christopher J. Logothetis et al. · 2021 · Cells
Nuclear Receptor-Mediated Metabolic Reprogramming and the Impact on HR+ Breast Cancer
Shaimaa Hussein, Pooja Khanna, Neha Yunus, Michael L. Gatza · 2021 · Cancers
Quantitative Acetylomics Revealed Acetylation-Mediated Molecular Pathway Network Changes in Human Nonfunctional Pituitary Neuroendocrine Tumors
Siqi Wen, Jiajia Li, Jingru Yang, Biao Li, Na Li, Xianquan Zhan · 2021 · Frontiers in Endocrinology
BCAT1 promotes lung adenocarcinoma progression through enhanced mitochondrial function and NF-κB pathway activation
Mengdan Yu, Qianwei Zhao, Jinxia Li, Fang Xu, Zhibiao Zhang, Yixian Liu, Liping Dai, Bingxia Zhang, Jianying Zhang, Jintao Zhang · 2022 · Journal of Zhejiang University SCIENCE B
Prognostic value and their clinical implication of 89-gene signature in glioma
Muhammad Shahid, Kyoung Min Cho, Minh Nam Nguyen, Tae Gyu Choi, Yong Hwa Jo, Saurav Nath Aryal, Ji Youn Yoo, Hyeong Rok Yun, Jae Woong Lee, Young‐Gyu Eun et al. · 2016 · Oncotarget
Brief isoflurane anaesthesia affects differential gene expression, gene ontology and gene networks in rat brain
Damon A. Lowes, Helen F. Galley, Alessandro P. S. de Moura, Nigel R. Webster · 2016 · Behavioural Brain Research
Bioinformatics analysis of gene expression profiles to diagnose crucial and novel genes in glioblastoma multiform
Chanabasayya Mallikarjunayya Vastrad, Basavaraj Mallikarjunayya Vastrad · 2018 · Pathology - Research and Practice
Metabolic Adaptations in Cancer Progression: Optimization Strategies and Therapeutic Targets
Agnieszka Dominiak, Beata Chełstowska, Grażyna Nowicka · 2025 · Cancers
Redox Homeostasis and Beyond: The Role of Wild-Type Isocitrate Dehydrogenases for the Pathogenesis of Glioblastoma
Kevin Murnan, Craig Horbinski, Alexander H. Stegh · 2023 · Antioxidants and Redox Signaling
2‐Hydoxyglutarate: D/Riving Pathology in gLiomaS
Daniel Richard Wahl, Sriram Venneti · 2015 · Brain Pathology
IDH1 mutation correlates with a beneficial prognosis and suppresses tumor growth in IHCC
Jian Wang, Zhan-guo Zhang, Zeyang Ding, Wei Dong, Hui-fang Liang, Liang Chu, Bi-xiang Zhang, Xiaoping Chen · 2018 · Journal of Surgical Research
Identification of natural compounds tubercidin and lycorine HCl against small‐cell lung cancer and BCAT1 as a therapeutic target
Jungang Chen, Lindsey Barrett, Zhen Nan Lin, Samantha L. Kendrick, Shengyu Mu, Lu Dai, Zhiqiang Qin · 2022 · Journal of Cellular and Molecular Medicine
Individualized pathway activity algorithm identifies oncogenic pathways in pan-cancer analysis
Xin Ke, Hao Wu, Yi-Xiao Chen, Yan Ping Guo, Shi Yao, Mingrui Guo, Yuanyuan Duan, Naining Wang, Wei Shi, Chen Wang et al. · 2022 · EBioMedicine
Effects of CCN1 and Macrophage Content on Glioma Virotherapy: A Mathematical Model
Karly A. Jacobsen, Luke Russell, Balveen Kaur, Avner Friedman · 2015 · Bulletin of Mathematical Biology
Branched chain amino acid metabolism and cancer: the importance of keeping things in context
Elizabeth M. Selwan, Aimee L. Edinger · 2017 · Translational Cancer Research
Multiple roles of branched-chain amino acid metabolism in tumour progression
Lin Wang, Feng Shi, Ya Cao, Longlong Xie · 2025 · Journal of Biomedical Science
Targeting PERP promotes anti-tumor immunity in HNSCC by regulating tumor immune microenvironment and metabolic homeostasis
Xueying Wang, Yuxi Tian, Xiaohong Wu, Yewen Zhu, Huihong Chen, Zeyao Wang, Zihan Liu, Jiaqi Tan, Zhaoyu Pan, Jiaoyan Cao et al. · 2025 · Molecular Cancer