p38 MAPK signaling underlies a cell-autonomous loss of stem cell self-renewal in skeletal muscle of aged mice

Bernet, Jennifer D, Doles, Jason D, Hall, John K, Kelly Tanaka, Kathleen, Carter, Thomas A, Olwin, Bradley B·2014·Nature Medicine

DOI 10.1038/nm.3465

Cited by (573)

Items 401–500 of 573

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Constance E. Runyan, Lucy Luo, Lynn C. Welch, Ziyan Lu, Fei Chen, Maxwell J. Schleck, Radmila A. Nafikova, Rogan A. Grant, Raul Piseaux Aillon, Karolina J. Senkow et al. · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
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Zhijie Tian, Xiaozhen Dai · 2021 · Springer eBooks
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Vladimir P. Baklaushev, Ekaterina M. Samoilova, Кальсин Владимир Анатольевич, Gaukhar M. Yusubalieva · 2022 · Journal of clinical practice
Inactivating IL34 promotes regenerating muscle stem cell expansion and attenuates Duchenne muscular dystrophy in mouse models
Yang Su, Yuxin Cao, Chang Liu, Qing Xu, Na Li, Miaomiao Lan, Lei Li, Kun Wang, Zeyu Zhang, Qingyong Meng · 2023 · Theranostics
Chromatin organization of muscle stem cell
Philina Santarelli, Valentina Rosti, Maria Vivo, Chiara Lanzuolo · 2024 · Current topics in developmental biology/Current Topics in Developmental Biology
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Saifedine T. Rjaibi, Erik Jacques, Jiaru Ni, Bin Xu, Sonya Kouthouridis, Julie Sitolle, Heta Lad, Nitya Gulati, Nancy T. Li, Henry Ahn et al. · 2024 · Advanced Materials Interfaces
The role of different physical exercises as an anti-aging factor in different stem cells
Jiajia Xu, Zhe Song · 2025 · Biogerontology
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K. Sakamoto · 2017 · Folia Pharmacologica Japonica
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Francesco Castagnetti, Elisabetta Fiacco, Carol Imbriano, Lucia Latella · 2017 · Journal of Visualized Experiments
Epigenetic Regulation of Muscle Stem Cells During Skeletal Muscle Regeneration and Disease
Beatrice Biferali, Chiara Mozzetta · 2019 · Elsevier eBooks
Stem Cell-Based and Tissue Engineering Approaches for Skeletal Muscle Repair
Seraina A. Domenig, Andrew S. Palmer, Ori Bar‐Nur · 2020 · Repository for Publications and Research Data (ETH Zurich)
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Norio Motohashi, Katsura Minegishi, Michihiro Imamura, Yoshitsugu Aoki · 2023 · Methods in molecular biology
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Pei Zhu, Clara Bien Peek · 2024 · Current topics in developmental biology/Current Topics in Developmental Biology
The Potential Role of Stem Cell Reprogramming in Antiaging
Banu Orta Yılmaz, Melike Erkan · 2018 · Springer eBooks
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Zachary R. Hettinger, Sophia Hu, Hikaru Mamiya, Amrita Sahu, Hirotaka Iijima, Kai Wang, Gabrielle G. Gilmer, Amanda K. Miller, Gabriele Nasello, Antonio D’Amore et al. · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
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Quan-Qing Cui, Xianmin Li, Ying Xie · 2022 · Medicine
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Chanho Lee, Manho Kim, Ju Hyun Park · 2025 · Food Science and Biotechnology
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Yanping Xu, Jethro Wang Zih-Shuo, Z M Zhang, Peng Chen, Usman Alizai, Keerthika Sathish, Sakai Lilian, Zhiyu Yan, Bryan A. Whitson, Timothy Michael Pawlik et al. · 2026 · Cells
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Yanteng Wang, Yi Yang, Wenwei Guan, Wan Yu, Na Li, Difei Wang · 2026 · Ageing Research Reviews
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Aissa Benyoucef, Marjorie Brand · 2015 · Elsevier eBooks
Role of muscle stem cells in sarcopenia
Ryo Fujita · 2021 · Elsevier eBooks
Quantification of Muscle Satellite Stem Cell Divisions by High-Content Analysis
William C. Chen, Theodore J. Perkins, Michael A. Rudnicki · 2022 · Methods in molecular biology
Circadian Clocks in Ageing
Pei Zhu, Clara Bien Peek · 2024 · Royal Society of Chemistry eBooks
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Oksana A. Ivanova, Elena V. Ignatieva, Т. А. Lelyavina, В. Л. Галенко, Margarita Y. Komarova, М. А. Борцова, Maria Yu. Sitnikova, Anna Aleksandrovna Kostareva, Alexey Sergushichev, Renata I. Dmitrieva · 2020 · Russian Journal of Cardiology
Aging of Epidermal Stem Cells
Alexandra Charruyer, Ruby Ghadially · 2016 · Springer eBooks
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Eyal Bengal, Maali Odeh · 2019 · Springer eBooks
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Caroline E. Brun, Marie‐Claude Sincennes · 2022 · médecine/sciences
Scribble dictates orderly stem cell fate
Ryo Fujita, Daiki Seko, Yusuke Ono · 2015 · Oncotarget
The role of telomere damage in cardiomyocyte ageing
Rhys K. Anderson · 2016
Maintaining the stemness of satellite cells during long-term culture
Ding · 2019
Hydrogen Enhanced the Myogenic Differentiation of Adipose Mesenchymal Stem Cells Through P38 MAPK Signaling Pathway
Wenyong Fei, Erkai Pang, Lei Hou, Jihang Dai, Mingsheng Liu, Xuanqi Wang, Bin Xie, Jingcheng Wang · 2021 · Research Square
Stem Cells and Aging
Eusebio Perdiguero, Laura García‐Prat, Pedro Sousa‐Victor, Pura Muñoz‐Cánoves · 2022 · Elsevier eBooks
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Alexander D. Brown, Annarita Scaramozza, Hanzhi Zhang, Samiha Mahin, Nivedita Suresh, Takeshi Tsusaka, Susan Eliazer, Xuhui Liu, Brian Thomas Feeley, Andrew S. Brack · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
Stem Cells and Aging
Eusebio Perdiguero, Laura García‐Prat, Pedro Sousa‐Victor, Pura Muñoz‐Cánoves · 2015 · Elsevier eBooks
Role of vascular plasticity in muscle remodeling in the child
Cyril Gitiaux · 2015 · theses.fr (ABES)
Towards ‘Eternal Youth’ of cardiac and skeletal muscle
Magdi Habib Yacoub, Ahmed Mohamed ElGuindy · 2015 · Global Cardiology Science and Practice
Effects of Heregulin on Muscle: A Biochemical and Histological Analysis
Nicole Moss · 2014
Effec ts of Heregulin on Muscle: A Biochemical and Histological Analysis
Dominican Scholar · 2014
A Proof of Principle for Reversing Muscle Aging
Richard Robinson · 2014 · Neurology Today
Deteriorating Infrastructure in the Aged Muscle Stem Cell Niche
Joseph T. Rodgers · 2016 · Cell stem cell
New culture systems for mesenchymal stem cells
Cairnan R. E. Duffy · 2015 · ERA
The Relevance of Induced Pluripotent Stem Cells for the Study of Physiological and Premature Aging
Dido Carrero, Carlos López-Otı́n · 2018 · Springer eBooks
The Effect of DHT Treatment on Changes in Amino Acid Transport Occurring in Aged Muscle
Oskar Wendowski · 2018 · UEA Digital Repository (University of East Anglia)
Canonical nuclear factor-κB signaling in satellite stem cell homeostasis and function.
Alex R. Straughn · 2018
Altered secretory profile of dysfunctional endothelial cells impairs in vitro satellite cell activity in humans
J. Matthew Hinkley · 2019 · The Journal of Physiology