The TAM receptor Mertk protects against neuroinvasive viral infection by maintaining blood-brain barrier integrity

Miner, Jonathan J, Daniels, Brian P, Shrestha, Bimmi, Proenca-Modena, Jose L, Lew, Erin D, Lazear, Helen M, Gorman, Matthew J, Lemke, Greg +2 more·2015·Nature Medicine
DOI 10.1038/nm.3974

Cited by (152)

Items 101–152 of 152

  1. In the Eyes of the Beholder—New Mertk Knockout Mouse and Re-Evaluation of Phagocytosis versus Anti-Inflammatory Functions of MERTK
    Sourav Ghosh, Silvia C. Finnemann, Douglas Vollrath, Carla Vanina Rothlin · 2024 · International Journal of Molecular Sciences
  2. Axl−/− neurons promote JEV infection by dampening the innate immunity
    Jiali Yang, Mengyuan Li, Mingcheng Yuan, Peiyu Bian, Yangchao Dong, Haijun Zhang, Chuanyu Luo, Zhifeng Xue, Yuan Wang, Fanglin Zhang et al. · 2021 · Virus Research
  3. NETs activate the GAS6-AXL-NLRP3 axis in macrophages to drive morphine tolerance
    Qingyan Tian, Haiyue Guo, Mengyao Zhang, Kunmao Jiang, Fan Hu, Yan Xu, Li Wan, Xiaokai Zhou, Yinbing Pan, Wentao Liu et al. · 2025 · Cell Communication and Signaling
  4. Chronic social defeat stress induces meningeal neutrophilia via type I interferon signaling in male mice
    Stacey L. Kigar, Mary-Ellen Lynall, Allison E. DePuyt, Robert Atkinson, Virginia H. Sun, Joshua D. Samuels, Nicole E. Eassa, Chelsie N. Poffenberger, Michael L. Lehmann, Samuel J. Listwak et al. · 2025 · Nature Communications
  5. Neuropsychiatric Burden of SARS-CoV-2: A Review of Its Physiopathology, Underlying Mechanisms, and Management Strategies
    Aliteia-Maria Pacnejer, Anca Butucă, Carmen Maximiliana Dobrea, Anca Maria Arseniu, Adina Frum, Felicia Gabriela Gligor, Rares Arseniu, Razvan Constantin Vonica, Andreea Loredana Vonica-Țincu, Cristian Iulian Oancea et al. · 2024 · Viruses
  6. TAM receptors mediate the Fpr2-driven pain resolution and fibrinolysis after nerve injury
    Beate Hartmannsberger, Adel Ben-Kraiem, Sofia Kramer, Carolina Guidolin, Ida Kazerani, Kathrin Doppler, Dominique Thomas, Robert Gurke, Marco Sisignano, Pranav P. Kalelkar et al. · 2024 · Acta Neuropathologica
  7. An Updated Review of Potential Drug Targets for Japanese Encephalitis
    Roshni Singh, Sayak Sanyal, Nikita Basant, Somali Sanyal · 2025 · Central Nervous System Agents in Medicinal Chemistry
  8. Pathogenic breaches: how viruses compromise blood-tissue barriers
    Apoorva, Sunit K. Singh · 2025 · Tissue Barriers
  9. GAS6 as a potential target to alleviate neuroinflammation during Japanese encephalitis in mouse models
    Peiyu Bian, Haijun Zhang, Chuantao Ye, Chuanyu Luo, Hong Jiang, Yuan Wang, Yangchao Dong, Jing Yang, Fanglin Zhang, Xiaoming Wang et al. · 2024 · Journal of Neuroinflammation
  10. Potential roles for efferocytosis in glioblastoma immune evasion
    Ian A.J. Lorimer · 2024 · Neuro-Oncology Advances
  11. A Review: The Potential Involvement of Growth Arrest-Specific 6 and Its Receptors in the Pathogenesis of Lung Damage and in Coronavirus Disease 2019
    Daria Apostolo, Luciana L. Ferreira, Alice Di Tizio, Barbara Ruaro, Filippo Patrucco, Mattia Bellan · 2023 · Microorganisms
  12. Cryptic etiopathological conditions of equine nervous system with special emphasis on viral diseases
    Rakesh Kumar, Rajendra Damu Patil · 2017 · Veterinary World
  13. RNA Interference Screening Reveals Requirement for Platelet-Derived Growth Factor Receptor Beta in Japanese Encephalitis Virus Infection
    Minmin Zhou, Shaobo Wang, Jiao Guo, Yang Liu, Junyuan Cao, Xiaohao Lan, Xiaoying Jia, Bo Zhang, Gengfu Xiao, Wei Wang · 2021 · Antimicrobial Agents and Chemotherapy
  14. Disruption of the Blood-Brain Barrier During Neuroinflammatory and Neuroinfectious Diseases
    Hamid Salimi, Robyn S. Klein · 2024 · Springer eBooks
  15. Viral apoptotic mimicry and the role of phosphatidylserine receptors
    Melinda Ann Brindley, Michael A. Pisciotta · 2025 · mSphere
  16. Neuroinflammation and blood–brain barrier disruption in Japanese encephalitis virus infection: mechanisms, therapeutic targets, and intervention strategies
    Xiaochun Ye, Ping Wang, Mengping Song, Jieying Zhang, Xiangmin Li, Xu Wang · 2026 · Archives of Pharmacal Research
  17. COVID-19 Infection and Recurrent Stroke in Young Patients With Protein S Deficiency
    Leila Ali, Héla Jamoussi, Nesrine Kouki, Saloua Fray, Slim Echebbi, Nadia Ali, Mohamed Fredj · 2021 · The Neurologist
  18. Sniffer restricts arboviral brain infections by regulating ROS levels and protecting blood-brain barrier integrity in Drosophila and mosquitoes
    Rui Hu, Mengzhu Li, Shulin Chen, Man Wang, Xinjun Tao, Yihan Zhu, Huan Yan, Yuan Liu · 2024 · PLoS Pathogens
  19. Zika virus: Critical crosstalk between pathogenesis, cytopathic effects, and macroautophagy
    Lucas Coêlho Bernardo‐Menezes, Almerinda Agrelli, Ana Sofia Lima Estevão de Oliveira, Elisa de Almeida Neves Azevedo, Clarice Neuenschwander Lins de Morais · 2023 · Journal of Cellular Biochemistry
  20. Características de la estructura molecular de las proteínas E del virus Zika y E1 del virus de la rubeola. Posibles implicaciones en el neurotropismo y en las alteraciones del sistema nervioso
    Luis Alberto Gómez, Gladis Montoya-Ortiz, Hernán Mauricio Rivera, Juan Carlos Hernández · 2016 · Biomédica
  21. Junin Virus Triggers Macrophage Activation and Modulates Polarization According to Viral Strain Pathogenicity
    María Florencia Ferrer, Pablo Thomas, Aída O López Ortiz, Andrea Emilse Errasti, Nancy L. Charó, Eugenio A Carrera Silva, Ricardo Martin Gomez · 2020 · Vide Leaf, Hyderabad eBooks
  22. The ameliorative effect of C-Kit+ hepatic endothelial cells with Mertk deficiency on nonalcoholic steatohepatitis
    Sengwang Fu, Yu-Xuan Gao, Huiyi Li, Jun-Cheng Wu, Zheng-Hong Li, Mingyi Xu · 2025 · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
  23. Suppression of cardiac allograft vasculopathy by a macrophage efferocytosis receptor
    Sahil Shah, Aparnaa Ananthakrishnan, Matthew DeBerge, Kristofor E. Glinton, Rebecca T.L. Jones, Mallory E. Filipp, Ivana R. Shen, Joey Lockhart, Connor W. Lantz, Edward Benjamin Thorp · 2025 · American Journal of Transplantation
  24. Bystander neuronal progenitors in forebrain organoids promote protective antiviral responses
    Seble G. Negatu, Christine Vazquez, Carl Bannerman, Kevin R. Amses, Guo‐li Ming, Kellie A. Jurado · 2025 · Journal of Neuroinflammation
  25. Plasma MERTK is causally associated with infection mortality
    Michael Drozd, Fergus Hamilton, Chew Weng Cheng, Patrick J. Lillie, Oliver Ian Brown, Natalie Chaddock, Sinisa Savic, Khalid M. Naseem, Mark Martin Iles, Ann Wendy Morgan et al. · 2024 · Journal of Infection
  26. The protective role of Mertk in JEV-induced encephalitis by maintaining the integrity of blood–brain barrier
    Chuanyu Luo, Mengyuan Li, Peiyu Bian, Jiali Yang, Xiamei Liao, Yangchao Dong, Chuantao Ye, Fanglin Zhang, Xin Lv, Qianqian Zhang et al. · 2024 · Virology Journal
  27. Endothelial MerTK impairment promotes cardiac dysfunction in the condition of high fat diet
    Hongye Huang, Shijie Liu, Jingke Yao, Xiaoyuan Bai, Zhicheng Jin, Bingzhong Xue, Hang Shi, Zufeng Ding · 2026 · Redox Biology
  28. TYRO3 , AXL , MERTK and Their Ligands in Brain Metastases From Colorectal Cancers
    Anaïs Noblanc, Fatima Dkhissi, Pierre‐Olivier Guichet, Lucie Lebeau, Serge Milin, Sheik Emambux, Pauline Roussille, Camille Evrard, Lucie Karayan, David Tougeron et al. · 2026 · Cancer Medicine
  29. Potential therapeutic strategies to halt viral neuroinvasion
    Luping Zhang, Usama Ashraf, Huanchun Chen, Shengbo Cao, Jing Ye · 2024 · Reviews in Medical Virology
  30. Contribution of protein-derived bioactive molecules (cytokines and chemokines) in neuroinflammation, resolution, and neuroprotection
    A. A. Farooqui · 2021 · Elsevier eBooks
  31. Neurotropism of influenza A virus
    Zhimin Jiang, Fanhua Wei, Jinhua Liu, Juan Pu, Xuxiao Zhang · 2018 · Scientia Sinica Vitae
  32. Encephalitic alphaviruses exploit caveolae-mediated transcytosis at the blood-brain barrier for CNS entry
    Hamid Salimi, Matthew D. Cain, Xiaoping Jiang, Robyn A. Roth, Wandy L. Beatty, Chengqun Sun, William B. Klimstra, Jianghui Hou, Robyn S. Klein · 2019 · bioRxiv (Cold Spring Harbor Laboratory)
  33. O papel dos receptores TAM e seu ligante, GAS6, durante a infecção por Zika vírus em camundongos SJL e C57BL/6
    Lilian Gomes de Oliveira · 2019
  34. Neuroinfección y patologías neurológicas por el virus Zika. Una revisión
    Rita Briones, Marcela Cobeña, Viviana Moreira · 2021 · Revista de la Universidad del Zulia
  35. Plasma proteomic associates of infection mortality in UK Biobank
    Michael Drozd, Fergus Hamilton, Chew Weng Cheng, Patrick J. Lillie, Oliver Ian Brown, Natalie Chaddock, Sinisa Savic, Khalid M. Naseem, Mark Martin Iles, Ann Wendy Morgan et al. · 2024 · medRxiv
  36. The ameliorative effect of C-Kit pos hepatic endothelial Mertk deficiency on nonalcoholic steatohepatitis
    Sengwang Fu, Yu-Xuan Gao, Huiyi Li, Yifan Ren, Jun-Cheng Wu, Zheng-Hong Li, Mingyi Xu · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
  37. The Ameliorative Effect of C-Kit+ Hepatic Endothelial Cells with Mertk Deficiency on Nonalcoholic Steatohepatitis
    Sengwang Fu, Yuxuan Gao, Huiyi Li, Jun-Cheng Wu, Zheng-Hong Li, Mingyi Xu · 2024 · SSRN Electronic Journal
  38. The role and function of specialized blood–neuronal barriers: Blood–CSF, blood–retinal, blood–spinal cord, blood–labyrinth, blood–nerve barriers, and blood–brain barrier (BBB)
    Fabricia Cardoso Petronilho, Amanda Della Giustina, Lucinéia Gainski Danielski · 2024 · Elsevier eBooks
  39. PROS1/AXL signaling protects mice from lethal influenza infection by inducing M2 macrophage polarization
    Wenbo Zhu, Shao Wang, Shuangquan Liu, Qiang Fu, Hongbo Zhang · 2025 · Acta Biochimica et Biophysica Sinica
  40. Additional file 4 of Mertk-expressing microglia influence oligodendrogenesis and myelin modelling in the CNS
    Nguyen, Linda T., Andrea Aprico, Eze C. Nwoke, Alexander D. Walsh, Farrah Blades, Raphael Avneri, Elodie Martin, Bernard Zalc, Trevor John Kilpatrick, Michele D. Binder · 2024 · Figshare
  41. Additional file 3 of Mertk-expressing microglia influence oligodendrogenesis and myelin modelling in the CNS
    Nguyen, Linda T., Andrea Aprico, Eze C. Nwoke, Alexander D. Walsh, Farrah Blades, Raphael Avneri, Elodie Martin, Bernard Zalc, Trevor John Kilpatrick, Michele D. Binder · 2024 · Figshare
  42. Additional file 6 of Mertk-expressing microglia influence oligodendrogenesis and myelin modelling in the CNS
    Nguyen, Linda T., Andrea Aprico, Eze C. Nwoke, Alexander D. Walsh, Farrah Blades, Raphael Avneri, Elodie Martin, Bernard Zalc, Trevor John Kilpatrick, Michele D. Binder · 2024 · Figshare
  43. Additional file 5 of Mertk-expressing microglia influence oligodendrogenesis and myelin modelling in the CNS
    Nguyen, Linda T., Andrea Aprico, Eze C. Nwoke, Alexander D. Walsh, Farrah Blades, Raphael Avneri, Elodie Martin, Bernard Zalc, Trevor John Kilpatrick, Michele D. Binder · 2024 · Figshare
  44. Additional file 1 of Mertk-expressing microglia influence oligodendrogenesis and myelin modelling in the CNS
    Nguyen, Linda T., Andrea Aprico, Eze C. Nwoke, Alexander D. Walsh, Farrah Blades, Raphael Avneri, Elodie Martin, Bernard Zalc, Trevor John Kilpatrick, Michele D. Binder · 2024 · Figshare
  45. Additional file 2 of Mertk-expressing microglia influence oligodendrogenesis and myelin modelling in the CNS
    Nguyen, Linda T., Andrea Aprico, Eze C. Nwoke, Alexander D. Walsh, Farrah Blades, Raphael Avneri, Elodie Martin, Bernard Zalc, Trevor John Kilpatrick, Michele D. Binder · 2024 · Figshare
  46. Clinical and molecular characterisation of the type I interferonopathies and approaches to therapy
    Marie‐Louise Frémond · 2018 · theses.fr (ABES)
  47. Molecular and cellular basis of phosphatidylserine receptors mediated flavivirus infection
    Ophélie Dejarnac · 2017 · theses.fr (ABES)
  48. Etude du neurotropisme de deux arbovirus émergents : les virus Zika et Usutu
    Marion Clé · 2020 · theses.fr (ABES)
  49. Virus de l'hépatite E : Mécanismes d'entrée et modifications du métabolisme cellulaire
    Quentin Glaziou · 2023 · theses.fr (ABES)
  50. Étude du rôle de la protéine S et du potentiel thérapeutique d’un anticorps à domaine unique potentialisant son activité dans la drépanocytose
    Claire Auditeau · 2025 · theses.fr (ABES)
  51. Genetic mechanisms underlying host susceptibility to central nervous system viral infections
    Rohit Ninan Benjamin, Darshan Pandya, Avindra Nath · 2026 · Current Opinion in Infectious Diseases
  52. Axl Kinase in Alzheimer's Disease
    Dipanjan Karati, Shreyasi Meur · 2026 · BENTHAM SCIENCE PUBLISHERS eBooks