Expression of specific inflammasome gene modules stratifies older individuals into two extreme clinical and immunological states
Furman, David, Chang, Junlei, Lartigue, Lydia, Bolen, Christopher R, Haddad, François, Gaudilliere, Brice, Ganio, Edward A, Fragiadakis, Gabriela K +12 more·2017·Nature Medicine
DOI 10.1038/nm.4267
Cited by (399)
Items 301–399 of 399
- Role of N4-acetylcytidine for continuously activating NLRP3 inflammosome by HMGB1 pathway in microgliaHua Bai, Qifang Zhang · 2020 · Neural Regeneration Research
- New insights and advances of sodium-glucose cotransporter 2 inhibitors in heart failureJuexing Li, Lei Zhou, Hui Gong · 2022 · Frontiers in Cardiovascular Medicine
- Inflammatory Diseases and Risk of Atherosclerotic Cardiovascular Disease: A New Focus on PreventionRenato Quispe, Bibin T. Varghese, Erin D. Michos · 2022 · Contemporary cardiology
- Exploring the impact of N4-acetylcytidine modification in RNA on non-neoplastic disease: unveiling its role in pathogenesis and therapeutic opportunitiesKeyu Wan, Tiantian Nie, Wenhao Ouyang, Yunjing Xiong, Jing Bian, Ying Huang, Ling Li, Zhenjun Huang, Xianhua Zhu · 2024 · Briefings in Functional Genomics
- Systems Immunology: OriginsMark M. Davis · 2023 · The Journal of Immunology
- Enhancing vaccine effectiveness in the elderly to counter antibiotic resistance: The potential of adjuvants via pattern recognition receptorsMyunghwan Jung, Hongmin Kim, Eunsol Choi, Min‐Kyoung Shin, Sung Jae Shin · 2024 · Human Vaccines & Immunotherapeutics
- Association between C-reactive protein, Life's Essential 8, and mortality in American adults: Insights from NHANES 2005–2010 data analysisXin Li, Yongxin Zhu, Tingting Yan, Jie Fang, Xin Xu, Xiaodong Xu · 2024 · Experimental Gerontology
- Anti-inflammatory and antinociceptive effects of LQFM275 − A new multi-target drugLarissa Córdova Turones, Daiany Priscilla Bueno da Silva, Iziara Ferreira Florentino, Aline Nazareth Martins, Dionys de Souza Almeida, Lorrane Kelle da Silva Moreira, Milena M Oliveira Silva, Lucas Santos Machado, Gerlon de Almeida Ribeiro Oliveira, Luciano Morais Lião et al. · 2024 · International Immunopharmacology
- Introductory Chapter: Caffeine, a Major Component of Nectar of the Gods and Favourite Beverage of Kings, Popes, Artists and Revolutionists, a Drug or a Poison?Magdalena Latosińska, Jolanta Natalia Latosińska · 2017 · InTech eBooks
- Immunosenescence, Oxidative Stress, and CancersTamàs Fülöp, Graham Pawelec, Gilles Dupuis, Rami R. Kotb, Bertrand Friguet, Jacek Maciej Witkowski, Anis Larbi · 2020 · Springer eBooks
- Effects of lysophosphatidic acid receptor 5 on NLRC4 inflammasome in brain tissues of transient cerebral ischemia/reperfusion ratXuling Zhang, Tao Huang, Lubo Lang, Ling Yu · 2022 · Human & Experimental Toxicology
- Porcine β-Defensin 114: Creating a Dichotomous Response to InflammationGuoqi Su, Sheng Huang, Shan Jiang, Li Chen, Feiyun Yang, Zuohua Liu, Guixue Wang, Jinxiu Huang · 2024 · International Journal of Molecular Sciences
- Clinical Development and Commercialization of Placenta-Derived Cell TherapyNoa Sher, Racheli Ofir · 2018 · Elsevier eBooks
- Integrative adaptive indexes from noisy routine haematological markers can predict and discriminate health status and biological ageSantiago Hernández-Orozco, Abicumaran Uthamacumaran, Francisco Hernández-Quiroz, Kourosh Saeb‐Parsy, Héctor Zenil · 2026 · Computers in Biology and Medicine
- Effect of different sources of saturated and polyunsaturated fatty acids on postprandial inflammation: A double-blind randomized crossover trialNaman Limani, Hege Berg Henriksen, Mina Marie Minge, Viviana Sandoval, Rikard Landberg, Helen M. Lindqvist, Kirsten Bjørklund Holven, Stine Marie Ulven, Linnea Bärebring · 2026 · Clinical Nutrition ESPEN
- Clinical characteristics and survival analysis of patients with hepatocellular carcinoma after hepatitis B virus turning negativeHong Li, Wenmin Guo, Xie Qian, Xiu Li Sun, Qiong A Wang · 2022 · Advances in Clinical and Experimental Medicine
- Investigation of epigenetics insights of hypertension: A bibliometric analysisNannan Liu, Lina Xia · 2023 · Medicine
- Amiloride lowers plasma TNF and interleukin-6 but not interleukin-17A in patients with hypertension and type 2 diabetesSai Sindhu Thangaraj, Christina Stolzenburg Oxlund, Henrik Ørbæk Andersen, Per Svenningsen, Jane Stubbe, Yaseelan Palarasah, Micaella Pereira da Fonseca, Daniel F.J. Ketelhuth, Camilla Enggaard, Maria Høj Hansen et al. · 2024 · American Journal of Physiology-Renal Physiology
- Stress Response to Surgery in the ElderlyNazish Khalid Hashmi, Mihai V. Podgoreanu · 2018 · Cambridge University Press eBooks
- Stromal inflammation is a targetable driver of hematopoietic agingEvgenia V. Verovskaya, Carl A. Mitchell, Fernando J. Calero‐Nieto, Aurélie Hérault, Paul V. Dellorusso, Xiaonan Wang, Si Yi Zhang, Arthur Flohr Svendsen, Eric Martin Pietras, Sietske T. Bakker et al. · 2021 · bioRxiv (Cold Spring Harbor Laboratory)
- CITMIC: Comprehensive Estimation of Cell Infiltration in Tumor Microenvironment based on Individualized Intercellular CrosstalkXilong Zhao, Jiashuo Wu, Jiyin Lai, Bingyue Pan, Miao Ji, Xiangmei Li, Yalan He, Junwei Han · 2024 · Advanced Science
- Inflammatory memory in interleukin-1β promoter methylation of bone marrow-derived stromal cells from healthy humansDmitriy Vladimirovich Karpenko · 2024 · Human Gene
- The roles of tertiary lymphoid structures in orchestrating immune responses in peripheral organsKeisuke Taniguchi, Takahisa Yoshikawa, Motoko Yanagita · 2025 · Inflammation and Regeneration
- The cell’s autonomous response window for advanced healingEnrique Feoli-Tufi, G. M. Redondo, J. Flores, D. Jara · 2025 · Discover medicine
- Genome‐wide postnatal changes in immunity following fetal inflammatory responseDaniel Costa, Núria Bonet, Amanda Solé, José Manuel González de Aledo‐Castillo, Eduard Sabidó, Ferrán Casals, Carlota Rovira, Alfons Nadal, José Luis Marı́n, Teresa Cobo et al. · 2020 · FEBS Journal
- Monitoring Social Determinants of Health Assessing Patients and CommunitiesVincent Morelli, Robert Heizelman · 2023 · Primary Care Clinics in Office Practice
- Evaluating Monocyte-to-high-density Lipoprotein Ratio Across Age and Gender in Healthy IndividualsHatice Aslan Sırakaya · 2023 · Bagcilar Medical Bulletin
- Neuroinflammation and oxidative stress in the aging brain: Linking in metabolism, stem cells, proteostasis, and stress adaptationJoana C. d’Avila · 2020 · Elsevier eBooks
- An inflammatory ageing clock to detect cardiovascular and other age-related diseases: a new approach to preventive medicineGiovanna Liuzzo, Massimo Volpe · 2021 · European Heart Journal
- Action Mechanisms of Small Extracellular Vesicles in InflammagingRocío Mato-Basalo, Sergio Lucio-Gallego, Carmen Alarcón-Veleiro, Marta Sacristán-Santos, María del Pilar Miranda Quintana, Miriam Morente-López, Francisco Javier de Toro Santos, Lucía Silva-Fernández, Alba González Rodríguez, María C. Arufe et al. · 2022 · Life
- The Effect of 12 Weeks Combined Training and Caffeine on Plasma Levels of Interleukin-1β and Interleukin 10 in Obese MenShirin Ghaderi Goodarzi, Asieh Abbassi Daloii, Ahmad Abdi, Ayoub Saeidi · 2021 · Quarterly of Horizon of Medical Sciences
- Elevated circulating procathepsin L as a potential biomarker of inflamm-agingShu Zhu, Weiqiang Chen, Xiaoling Qiang, Li Lou, Jianhua Li, Haichao Wang · 2024 · Medical Hypotheses
- Could a coffee a day keep the inflammasome away?Mallar Bhattacharya · 2017 · Science Translational Medicine
- The FluPRINT dataset: A multidimensional analysis of the influenza vaccine imprint on the immune systemAdriana Tomić, Ivan Tomic, Cornelia L. Dekker, Holden Terry Maecker, Mark M. Davis · 2019 · bioRxiv (Cold Spring Harbor Laboratory)
- Molecular regulation of NAIP/NLRC4 inflammasomesMarcelo Pires Amaral, Laura Migliari Branco, Silvia Lucena Lage, Karina Ramalho Bortoluci · 2022 · Elsevier eBooks
- Exploration of Biomarkers of Food Intake in a Caribbean Hispanic PopulationLaurence D. Parnell, Liam E. Fouhy, Oladimeji J Akinlawon, Chao‐Qiang Lai, Frederick Nusetor, José María Ordovás, Kelsey McKee Mangano, Katherine L. Tucker, Sabrina E. Noel · 2025 · Molecular Nutrition & Food Research
- RNA N4-acetylcytidine modification in gastrointestinal cancer: Novel functions, mechanisms, and therapeutic implicationsJialin Lu, Ye Gao, Qiuxin Li, Yunfei Jiao, Yan Bian, Han Lin, Xin Lei, Wei Wang, Zhaoshen Li, Luo‐Wei Wang · 2025 · Critical Reviews in Oncology/Hematology
- Causal Association Between Immune Cell Traits and Risk of Multiple Malignant and Nonmalignant CNS Diseases: A Mendelian Randomization and Single‐Cell Transcriptomic AnalysisShanbao Ke, Junya Yan, Baiyu Li, Xiao Feng · 2025 · Brain and Behavior
- Regional variations in seeding activity, phosphorylation, and protein levels of tau in Alzheimer’s disease brainYirong Yang, Huiying Guan, Zihao Zhang, Hailun Wu, Ying Xiong, Can Xu, Hengxu Mao, Wuxin You, Yaoyun Kuang, Qi‐Lei Zhang et al. · 2025 · npj Biosensing
- Sjögren’s disease metabolome reveals biomarker signatures to characterise patients and assess disease activityMadeleine Suffiotti, Lukas Tanner, Łukasz Kozera, Agata Sebastian, André van Maurik, Daniel S. Strasser · 2026 · RMD Open
- Meta-Analysis on the Impact of Inflammatory Rheumatological Conditions on Outcomes Following Acute Coronary SyndromeMarah M Omer, Morshed Alam, Anurag Rawat, Fahad Lakhdhir, Mohammad Alhneif, Dhaval Rabadia, Calvin Ronchen Wei, Shamsha Hirani · 2023 · Cureus
- Bayesian Sequential Pragmatic Cluster Randomized Clinical Trial Design for PrEventive Effect of MEditerranean Diet in Children: PEMED Trial Research ProtocolDanila Azzolina, Salvatore Auricchio, Luigi Greco, Renata Auricchio · 2025 · Journal of Clinical Medicine
- Modulation of Primary Amine Oxidase by PhytochemicalsPadraig Shanahan · 2019 · Arrow - TU Dublin (Technological University Dublin)
- Role of Inflammation and Inflammasomes in Bone PathophysiologyGabriel Mbalaviele, Yousef Abu‐Amer · 2019 · Elsevier eBooks
- "Smurf Mice": revolutionising our understanding of age-related and end-of-life animal physiologyCéline Cansell, Vivien Goepp, Fanny Bain, Nicolas Todd, Véronique Douard, Magali Monnoye, Flaminia Zane, Clara Sanchez, Nicolas Pietrancosta, Carole Rovère et al. · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
- Immunosenescence and Ageing in HIVChristos Micheal Tsoukas · 2019 · Springer eBooks
- Integrating Modern Immunology into MedicineMark M. Davis, Robert M. DiFazio · 2019 · Springer eBooks
- The Effects of Early-Life Drug and Dietary Interventions on Late-Life Disease DevelopmentTheresa Mau · 2019 · Deep Blue (University of Michigan)
- Age-related Disease: A Revolution Is Coming.Jeffrey S. Bland · 2018 · Europe PMC (PubMed Central)
- Myeloid cells, tissue homeostasis, and anatomical barriers as innate immune effectors in arterial hypertensionJohannes Wild, Philip Wenzel · 2021 · Journal of Molecular Medicine
- Towards New Promising Discoveries for Lung Cancer Patients: A Selection of Papers from the First Joint Meeting on Lung Cancer of the FHU OncoAge (Nice, France) and the MD Anderson Cancer Center (Houston, TX, USA)Calin, George, Paul M Hofman, Sendurai A. Mani · 2019 · MDPI eBooks
- Estudio celular de la inmunosenescencia en adultos mayores vacunados y en pacientes con cáncer de mamaRodríguez Rodríguez, Ivon Johanna · 2021
- Chromogranin A plays a crucial role in the age-related development of insulin resistance and hypertensionMatthew A. Liu, Suborno Jati, Kechun Tang, Geert van den Bogaart, Gourisankar Ghosh, Sushil K. Mahata · 2021 · bioRxiv (Cold Spring Harbor Laboratory)
- ENERGY DISTRIBUTION OF SHOCKS CREATED BY PARTICLES DISPLACED BY IRRADIATION INSIDE AN ALLOY.Pierre Joyes · 1967 · OSTI OAI (U.S. Department of Energy Office of Scientific and Technical Information)
- Acylated Ghrelin Directly Modulates In Vitro Cytokine Secretion in Lipopolysaccharide-Stimulated Bone Marrow-Derived Macrophages from Male C57BL/6J MiceAlexander Wiseman · 2021
- Immunosenescence and Ageing in HIVChristos Micheal Tsoukas · 2017 · Springer eBooks
- Analysis of Genetically Determined Gene Expression Suggests Role of Inflammatory Processes in Etiology of Exfoliation SyndromeJibril B Hirbo, Francesca Pasutto, Eric R. Gamazon, Patrick D. Evans, Priyanka Prabhakar Pawar, Daniel Berner, Julia Sealock, Ran Tao, Péter Straub, Anuar I. Konkashbaev et al. · 2020
- Faculty Opinions recommendation of Epigenetics meets proteomics in an epigenome-wide association study with circulating blood plasma protein traits.Isabelle M. Mansuy · 2020 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
- Expression of NLRC4 Inflammasome and Its Correlation with Treponema denticola in Stage III/IV Periodontitis with Type II Diabetes MellitusSumi Priyadarshini, Devapriya Appukuttan, Dhayanand John Victor, Santhosh Venkadassalapathy, Vanaja Krishna Naik · 2022 · Turkish Journal of Immunology
- Skrining Status Kadar Gula Darah dan Kolestrol Total Sebagai Upaya Untuk Mencegah Penyakit Meta-InflamasiAnas Fadli Wijaya, Rian Anggia Destiawan, Ahdiah Imroatul Muflihah · 2023 · Faedah Jurnal Hasil Kegiatan Pengabdian Masyarakat Indonesia
- Predicting Fracture Risk for Chinese Elderly Osteoporosis Patients by Hybrid ModelMenghan Liu, Xin Wei, Xiaodong Xing, Zicheng Ma, Jiwu Ren, Xiaofeng Gao, Ajing Xu · 2023 · Research Square
- PVN microglia via P2Y 12 transmit hemodynamic signal to promote sympathetic excitation in hypertensionWei Bo, Guo Cheng, Li Li, Qihang Sun, Qianqian Bi, Cheng Chang Lu, Chunyou Yin, Ningting Chen, Miner Hu, Haoran Lu et al. · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
- The kynurenine pathway and cognitive functioningLieke Bakker · 2023
- Synthesis and Evaluation of Novel Quinazolin-4-(3h)-one Analogues for their Anti-Inflammatory ActivityRS Kulkarni, NK Sathish, AA Kempwade, Satish Annayya Kavatagimath · 2023 · International Journal of Pharmaceutical Quality Assurance
- Methylation of the CpG at -299 bp from transcription start site of interleukin-1β is a sustained marker of inflammation exerted by TNFa on bone marrow-derived mesenchymal cells of healthy humansDmitriy Vladimirovich Karpenko · 2024 · Research Square
- Additional file 1 of Plasma metabolomics provides new insights into the relationship between metabolites and outcomes and left ventricular remodeling of coronary artery diseaseZhu, Qian, Min Qin, Zixian Wang, Yonglin Wu, Xiaoping Chen, Chen Liu, Qilin Ma, Yibin Liu, Weihua Lai, Hui Chen et al. · 2022 · Figshare
- The Goldilocks Zone of Healing An unexploited resource for advanced healingEnrique Feoli, German Madrigal Redondo, Jeniffer Sandí Flores, Daniela Porras Jara · 2024
- Impact of Pretransplant C-Reactive Protein, Neutrophiles, Platelets, and Albumin Levels on Recipient Survival After Simultaneous Pancreas and Kidney TransplantationMichał Macech, Tadeusz Grochowiecki, Magdalena Durlik, Leszek Pączek, Sławomir Nazarewski · 2024 · Transplantation Proceedings
- The influence of the microtubule-targeting agent pretubulysin on inflammatory processes of the vascular endotheliumTobias Primke · 2024
- Interação dos receptores P2X7 e TRPV1 na ativação do inflamassoma NLRP3 e na liberação de vesículas extracelulares na linhagem murina de micróglia BV2Sávio Bastos · 2024
- Biomedical Research in AgingJosé Mario González-Meljem, Scott Haston, Suchira Gallage, Andrew J. Innes, Christian Quintus Scheckhuber · 2024 · Springer eBooks
- Deciphering the Instruction of Low‐Grade Inflammation in the Trajectory of Hyperuricemia and Gout: Perspectives From Healthcare PractitionersYawen Hu, Xu Li, Cheng Chen, Di Wu · 2025 · International Journal of Rheumatic Diseases
- PseudoCell : A Multivalued Logical Regulatory Network to Investigate Premature Senescence Dynamics and HeterogeneityVinícius Pierdoná, Patrícia Lavandoski, Rafael Moura Maurmann, Guilherme Antonio Borges, José C. M. Mombach, Fátima Theresinha Costa Rodrigues Guma, Florencia María Barbé‐Tuana · 2025 · Aging Medicine
- Unravelling the impact of NLRP3 inflammasome in fibrosis: Molecular insights into the fibrosis of diverse tissues and potential therapeutic optionsMihir Parikh, Arun Soni, Tejal Ricky Gandhi · 2025 · Elsevier eBooks
- Inflammation-modulating agents in chronic limb-threatening ischemia: a narrative review of therapeutic potential and future directionsAditya Gaur, Precious Elechi Dike, Timilehin Mayowa, Favour C Mekowulu, Anas Abdulkader, Medha Sridhar Rao, Awogboro Shola, Promise Ajala, O. Adeyemi Oluwatobi, Israel Charles Abraham et al. · 2025 · Annals of Medicine and Surgery
- Additional file 2 of Plasma metabolomics provides new insights into the relationship between metabolites and outcomes and left ventricular remodeling of coronary artery diseaseQian Zhu, Qin, Min, Wang, Zixian, Wu, Yonglin, Chen, Xiaoping, Liu, Chen, Qilin Ma, Liu, Yibin, Lai, Weihua, Chen, Hui et al. · 2022 · Figshare
- ASCH Domain-Containing Proteins Act as tRNA N 4 -acetylcytidine ErasersRoberta Statkevičiūtė, Mikas Sadauskas, Agota Aučynaitė, Audrius Laurynėnas, Greta Gakaite, Rolandas Meškys · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
- Age-related increase of NLRC4 inflammasome and TGF-β1 signaling exacerbates airway inflammation and remodeling in asthmaJe-Won Ko, J. Kim, Jeong-Won Kim, Ji-Soo Jeong, Su-Ha Lee, Kwan-Hoo Kim, Na Young Kim, Tae-Won Kim, Je‐Won Ko, Tae-Won Kim · 2026 · GeroScience
- Molecular and cellular bases of systemic autoinflammatory disorders including Adult-onset Still’s diseaseEman Assrawi · 2019
- IRM multi-paramétrique du muscle squelettique dans le contexte de la sarcopénie et de la fragilitéStéphane Loubrie · 2020
- Les lymphocytes T CD8 innés, une nouvelle population T non conventionnelle (re)programmée en transplantation rénaleLauren Daniel · 2021
- Inflammation, aging and chronic diseases : implication of inflammasomesFlorent Guerville · 2023 · theses.fr (ABES)
- Associations of systemic inflammatory indices and metabolically healthy vs. unhealthy obesity in childrenMeliha Esra Bilici · 2026 · The Italian Journal of Pediatrics/Italian journal of pediatrics
- Calcium Carbonate-Stabilized Nano-Caffeine Emulsion Attenuates Diabetic Cardiomyopathy via Antioxidant, Anti-Inflammatory, and Anti-Fibrotic Pathways in Type 2 Diabetic Rats with HPLC-Quantified Cardiac Caffeine LevelsRasha Abdulrashed Mansouri, Esam Mohamed Aboubakr, Huda F. Alshaibi, Wafaa Mohammed Fouda, Abeer A. Banjabi, Maha Mohammed Al-Bazi, Hamdoon Abdelhamid Mohammed, Adel Ahmed · 2026 · International Journal of Nanomedicine
- Comparative study on the predictive value of PNI and GNRI for all-cause mortality rates of elderly patients in cardiac care unit and cardiovascular intensive care unitWanlu Zhou, Jingjia Yu, Min Zheng, Ruizheng Shi · 2026 · European Journal of Clinical Nutrition
- Association between coffee consumption and cardiovascular disease in individuals with thyroid dysfunction: a cross-sectional studyYan Xu, Yuexin Huang, Ning Wang, En Chen, Xiguo Zhou, Bo Yuan, Zhiwei Xia · 2026 · Cogent Food & Agriculture
- The role of Dymeclin in chronic unpredictable mild stress-induced depression: maintaining the Golgi apparatus structure and regulating NLRP3 inflammasome activationLongfei Du, Zifan Ding, Lei Sun, Ye Qin, Huiling Sun, Yuqin Pan, S Wang · 2026 · Molecular Medicine
- Remodeling of innate antiviral immunity in agingXu Zhang, Qing Yang · 2026 · Cell Insight
- B-cell Immunity to Influenza (SLVP017) 2013Mark M. Davis · 2020 · ImmPort
- B-cell Immunity to Influenza (SLVP017) 2011Mark M. Davis · 2020 · ImmPort
- The central dogma of agingJie Zhang, Wen Su, Juanli Duan, Ying Sun, Baohua Liu · 2026 · The Innovation Life
- Cardiovascular health and longevity: where are we?Amith Seri, Bing Yue, Muzamil Khawaja, W. H. Wilson Tang, Yochai Birnbaum, Carl J. Lavie, Salim S. Virani, Markus Strauß, Chayakrit Krittanawong · 2026 · Frontiers in Cardiovascular Medicine
- B-cell Immunity to Influenza (SLVP017) 2010Mark Davis · 2020 · ImmPort
- Role of CD4+ Memory Phenotype, Memory, and Effector T Cells in Vaccination and Infection (SLVP030)Cornelia Dekker · 2024 · ImmPort
- T cell responses to H1N1v and a longitudinal study of seasonal influenza vaccination SLVP015 2014Mark Davis · 2019 · ImmPort
- Immune Senescence: Comparison of Immune Response to Influenza Vaccine 2007 in Adults of Different AgesMark Davis · 2024 · ImmPort
- Innate and Acquired Immunity to Influenza Infection and Immunization (SLVP029)Cornelia Dekker · 2024 · ImmPort
- Genetic and Environmental Factors in the Response to Influenza Vaccination 2014Cornelia Dekker · 2024 · ImmPort
- Plasmablast response to inactivated and live attenuated influenza vaccines (TIV3/TIV3 ID) in 2014Harry Greeb=nberg · 2024 · ImmPort