Cooperative targeting of melanoma heterogeneity with an AXL antibody-drug conjugate and BRAF/MEK inhibitors

Boshuizen, Julia, Koopman, Louise A, Krijgsman, Oscar, Shahrabi, Aida, van den Heuvel, Elke Gresnigt–, Ligtenberg, Maarten A, Vredevoogd, David W, Kemper, Kristel +12 more·2018·Nature Medicine

Cited by (230)

Items 101–200 of 230

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  2. Statistical analysis of longitudinal data on tumour growth in mice experiments
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  3. Expert consensus on the clinical application of antibody‐drug conjugates in the treatment of malignant tumors (2021 edition)
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  4. Hybrid Extracellular Vesicles‐Liposomes Camouflaged Magnetic Vesicles Cooperating with Bioorthogonal Click Chemistry for High‐Efficient Melanoma Circulating Tumor Cells Enrichment
    Ke Kang, Yujia Zhang, Xiaoxi Zhou, Yue Yu, Nanhang Zhu, Jia Cheng, Qiangying Yi, Yao Wu · 2023 · Advanced Healthcare Materials
  5. In Situ Nanofiber Formation Blocks AXL and GAS6 Binding to Suppress Ovarian Cancer Development
    Han Yin, Yue Hua, Songwei Feng, Yi Xu, Yue Ding, Sicong Liu, Dongsheng Chen, Furong Du, Gaolin Liang, Wenjun Zhan et al. · 2024 · Advanced Materials
  6. Targeting AXL in NSCLC
    Aubhishek Zaman, Trever Grant Bivona · 2021 · Lung Cancer Targets and Therapy
  7. Mechanisms of Resistance to BRAF-Targeted Melanoma Therapies
    Özgecan Dülgar, Tuğçe Kütük, Zeynep Eroglu · 2020 · American Journal of Clinical Dermatology
  8. Cross-Linking Ligation and Sequencing of Hybrids (qCLASH) Reveals an Unpredicted miRNA Targetome in Melanoma Cells
    Ines Kozar, Demetra Philippidou, Christiane Margue, Lauren A. Gay, Rolf Renne, Stephanie Kreis · 2021 · Cancers
  9. The pleiotropic roles of circular and long noncoding RNAs in cutaneous melanoma
    Barbara Montico, Giorgio Giurato, Giovanni Pecoraro, Annamaria Salvati, Alessia Covre, Francesca Colizzi, Agostino Steffan, Alessandro Weisz, Michele Maio, Luca Sigalotti et al. · 2021 · Molecular Oncology
  10. Balancing activation and co-stimulation of CAR tunes signaling dynamics and enhances therapeutic potency
    Yanting Duan, Jiangqing Chen, Xianhui Meng, Longwei Liu, Kai Shang, Xiaoyan Wu, Yajie Wang, Zihan Huang, Houyu Liu, Yanjie Huang et al. · 2022 · Molecular Therapy
  11. AXL signal mediates adaptive resistance to KRAS G12C inhibitors in KRAS G12C-mutant tumor cells
    Morimoto, Kenji, Yamada, Tadaaki, Hirai, Soichi, Katayama, Yuki, Fukui, Sarina, Sawada, Ryo, Tachibana, Yusuke, Matsui, Yohei, Nakamura, Ryota, Ishida, Masaki et al. · 2024 · Cancer Letters
  12. Elucidation of Abnormal Extracellular Regulated Kinase (ERK) Signaling and Associations with Syndromic and Non-syndromic Autism
    Aarti Tiwari, Saloni Rahi, Sidharth Mehan · 2020 · Current Drug Targets
  13. Antibody-drug conjugates: beyond current approvals and potential future strategies
    Siddharth Menon, Sagun Parakh, Andrew Mark Scott, Hui Kong Gan · 2022 · Exploration of Targeted Anti-tumor Therapy
  14. The role of yes activated protein (YAP) in melanoma metastasis
    Andrew Leask, John Nguyen, Angha Naik, Pratyusha Chitturi, Bruce L. Riser · 2024 · iScience
  15. Advanced Melanoma
    Alexandra M. Haugh, April K.S. Salama, Douglas Buckner Johnson · 2020 · Hematology/Oncology Clinics of North America
  16. Enapotamab Vedotin, an AXL-Specific Antibody-Drug Conjugate, Demonstrates Antitumor Efficacy in Patient-Derived Xenograft Models of Soft Tissue Sarcoma
    Britt Van Renterghem, Agnieszka Woźniak, Patricia Garrido Castro, Patrick Franken, Nora Pencheva, Raf Sciot, Patrick Schöffski · 2022 · International Journal of Molecular Sciences
  17. Detection of AXL expression in circulating tumor cells of lung cancer patients using an automated microcavity array system
    Mio Ikeda, Yasuhiro Koh, Shunsuke Teraoka, Koichi Sato, Kuninobu Kanai, Atsushi Hayata, Nahomi Tokudome, Hiroaki Akamatsu, Yuichi Ozawa, Keiichiro Akamatsu et al. · 2020 · Cancer Medicine
  18. Antibody Drug Conjugates in Lung Cancer: State of the Current Therapeutic Landscape and Future Developments
    Joshua E. Reuss, Laura Gosa, Stephen V. Liu · 2021 · Clinical Lung Cancer
  19. Exposure‐safety and exposure‐efficacy analyses for tisotumab vedotin for patients with locally advanced or metastatic solid tumors
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  20. A Cell Surface-Binding Antibody Atlas Nominates a MUC18-Directed Antibody–Drug Conjugate for Targeting Melanoma
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  21. CAR NK Cell Therapy for the Treatment of Metastatic Melanoma: Potential & Prospects
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  22. The Challenge of Classifying Metastatic Cell Properties by Molecular Profiling Exemplified with Cutaneous Melanoma Cells and Their Cerebral Metastasis from Patient Derived Mouse Xenografts
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  23. Deciphering Melanoma Cell States and Plasticity with Zebrafish Models
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  24. Synergistic effect of the inhibitors of RAF/MEK and AXL on KRAS‐mutated ovarian cancer cells with high AXL expression
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  25. Novel AXL‑targeted agents overcome FLT3 inhibitor resistance in FLT3‑ITD+ acute myeloid leukemia cells
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  27. Development of Personalized Strategies for Precisely Battling Malignant Melanoma
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  28. Single-Cell-Derived Tumor Organoid (STO) arrays on a microfluidic chip for personalized drug screening to address heterogeneity-induced drug resistance in colorectal cancer
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  29. Programmed cell death‐1 blockade therapy in melanoma: Resistance mechanisms and combination strategies
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  30. Genomic and Transcriptomic Underpinnings of Melanoma Genesis, Progression, and Metastasis
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  31. The Potential of Antibody Technology and Silver Nanoparticles for Enhancing Photodynamic Therapy for Melanoma
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  39. Tyrosine-Dependent Phenotype Switching Occurs Early in Many Primary Melanoma Cultures Limiting Their Translational Value
    Ahmad Najem, Jasper Wouters, Mohammad Krayem, Florian Rambow, Malak Sabbah, François Salès, Ahmad Hussein Awada, Stein Aerts, Fabrice Journé, Jean‐Christophe Marine et al. · 2021 · Frontiers in Oncology
  40. Bioluminescent RAPPID Sensors for the Single-Step Detection of Soluble Axl and Multiplex Analysis of Cell Surface Cancer Biomarkers
    Eva A. van Aalen, Simone F. A. Wouters, Dennis Verzijl, Maarten Merkx · 2022 · Analytical Chemistry
  41. Mechanisms of resistance and predictive biomarkers of response to targeted therapies and immunotherapies in metastatic melanoma
    Samia Mourah, Baptiste Louveau, Nicolas Dumaz · 2019 · Current Opinion in Oncology
  42. Monitoring melanoma patients on treatment reveals a distinct macrophage population driving targeted therapy resistance
    Jeļena Vasiļevska, Phil Fang Cheng, Julia Lehmann, Egle Ramelyte, Julia M. Martínez Gómez, Florentia Dimitriou, Federica Sella, Daria Ferretti, Adrián Salas-Bastos, Whitney Jordaan et al. · 2024 · Cell Reports Medicine
  43. Bevacizumab and anexelekto inhibitor, TP-0903 inhibits TGF-β1-induced epithelial–mesenchymal transition of colon cancer cells
    Se-Hee Kim, Sangtae Choi, Won-Suk Lee · 2021 · Anti-Cancer Drugs
  44. Lineage dependence of the neuroblastoma surfaceome defines tumor cell state-dependent and -independent immunotherapeutic targets
    Nathan M. Kendsersky, Michal Odrobina, Nathaniel W. Mabe, Alvin Farrel, Liron D. Grossmann, Matthew Tsang, David Groff, Adam J. Wolpaw, Alaa Narch, Francesca Zammarchi et al. · 2025 · Neuro-Oncology
  45. The genetic and epigenetic basis of distinct melanoma types
    Junna Oba, Scott Eric Woodman · 2021 · The Journal of Dermatology
  46. Cytoskeletal Remodelling as an Achilles’ Heel for Therapy Resistance in Melanoma
    Adrian Barreno, José Luis Orgaz · 2022 · Cells
  47. Antibody-Drug Conjugates for Melanoma and Other Skin Malignancies
    Rachel S. Goodman, Douglas Buckner Johnson · 2022 · Current Treatment Options in Oncology
  48. Pharmacokinetics and Toxicity Considerations for Antibody–drug Conjugates: An Overview
    Siddhanth Hejmady, Rajesh Pradhan, Shobha Kumari, Meghna Pandey, Sunil Kumar Dubey, Rajeev Taliyan · 2023 · Bioanalysis
  49. Engineered AXL‑ECD‑Fc variants that abolish the AXL/Gas6 interaction suppress tumor cell migration
    Yanting Duan, Bo Hu, Chunxia Qiao, Longlong Luo, Xinying Li, Jing Wang, Hao Liu, Tingting Zhou, Beifen Shen, Ming Lv et al. · 2019 · Oncology Letters
  50. The Elongin BC Complex Negatively Regulates AXL and Marks a Differentiated Phenotype in Melanoma
    Sebastiaan M. Schieven, Joleen J.H. Traets, Alex v. Vliet, Martijn v. Baalen, Ji‐Ying Song, Marcos Da Silva Guimaraes, Thomas Kuilman, Daniel S. Peeper · 2023 · Molecular Cancer Research
  51. Fatty acid uptake activates an AXL–CAV1–β-catenin axis to drive melanoma progression
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  52. Antibody-drug conjugates: an evolving approach for melanoma treatment
    Trevor S. Anderson, Amanda L. McCormick, Ninh My La-Beck, Dipongkor Saha, Devin B. Lowe · 2020 · Melanoma Research
  53. An immature subset of neuroblastoma cells synthesizes retinoic acid and depends on this metabolite
    Tim van Groningen, Camilla U. Niklasson, Alvin Chan, Nurdan Akogul, Ellen M. Westerhout, Kristoffer von Stedingk, Mohamed Hamdi, Linda J. Valentijn, Sofie Mohlin, Peter J.M. Stroeken et al. · 2021 · bioRxiv (Cold Spring Harbor Laboratory)
  54. Modeling stress-induced responses: plasticity in continuous state space and gradual clonal evolution
    Anuraag Bukkuri · 2024 · Theory in Biosciences
  55. Phase I/II Study of AXL-Specific Antibody–Drug Conjugate Enapotamab Vedotin in Patients with Advanced Solid Tumors
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  56. AXL Inhibition Represents a Novel Therapeutic Approach in BCR-ABL Negative Myeloproliferative Neoplasms
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  57. Tumor evolution-targeted nanomedicineEVT
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  58. iVS analysis to evaluate the impact of scaffold diversity in the binding to cellular targets relevant in cancer
    Agostino Cilibrizzi, Giuseppe Floresta, Vincenzo Abbate, Maria Paola Giovannoni · 2018 · Journal of Enzyme Inhibition and Medicinal Chemistry
  59. Discovery and development of ADCs: obstacles and opportunities
    Hsuan‐Ping Chang, Yuen Kiu Cheung, Dhaval K. Shah · 2023 · Elsevier eBooks
  60. Insights into RAS-driven melanoma and its therapeutic implications
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  61. Antibody–Drug Conjugates in the Pipeline for Treatment of Melanoma: Target and Pharmacokinetic Considerations
    Ina Lami, Andrew J. Wiemer · 2024 · Drugs in R&D
  62. Axl inhibitor-mediated reprogramming of the myeloid compartment of the in vitro tumor microenvironment is influenced by prior targeted therapy treatment
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  63. Analysis of Tumor Heterogeneity Through AXL Activation in Primary Resistance to EGFR Tyrosine Kinase Inhibitors
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