Interleukin-6-deficient mice develop mature-onset obesity
Abstract
The immune-modulating cytokine interleukin-6 (IL-6) is expressed both in adipose tissue and centrally in hypothalamic nuclei that regulate body composition. We investigated the impact of loss of IL-6 on body composition in mice lacking the gene encoding IL-6 (Il6-/- mice) and found that they developed mature-onset obesity that was partly reversed by IL-6 replacement. The obese Il6-/- mice had disturbed carbohydrate and lipid metabolism, increased leptin levels and decreased responsiveness to leptin treatment. To investigate the possible mechanism and site of action of the anti-obesity effect of IL-6, we injected rats centrally and peripherally with IL-6 at low doses. Intracerebroventricular, but not intraperitoneal IL-6 treatment increased energy expenditure. In conclusion, centrally acting IL-6 exerts anti-obesity effects in rodents.
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Accumulating data suggest that IL-6 enhances glucose uptake in myocytes.
“Thus, accumulating data suggest that IL-6 enhances glucose uptake in myocytes [54–57].”
From Exercise as a Mean to Control Low‐Grade Systemic Inflammation (2008) · cites this paper as [54]
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References 36 · Cited by 1,213
- Authors
- Wallenius, V., Wallenius, K., Ahrén, B., Rudling, M., Carlsten, H., Dickson, S. L., Ohlsson, C., & Jansson, J.-O.
- Affiliations
- University of Gothenburg (SE)
- Karolinska Institutet (SE)
- University of Cambridge (GB)
- Corresponding author
- Jansson, John-Olov
- ORCID
- Venue
- Nature Medicine
- Published
- 2002-01
- Volume
- 8
- Issue
- 1
- Pages
- 75-79
- ISSN
- 1078-8956 (ISSN-L)
- 1546-170X
- OpenAlex
- W2040901874
- Cited by
- 1,213
- References
- 36
- Citations by year
- 2026: 10 · 2025: 27 · 2024: 43 · 2023: 38 · 2022: 42 · 2021: 47 · 2020: 40 · 2019: 52 · 2018: 43 · 2017: 48 · 2016: 42 · 2015: 58 · 2014: 61 · 2013: 72 · 2012: 58
- FWCI
- 18.50
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Medicine (publishedVersion)
- PubMed (publishedVersion)
- Lund University Publications (Lund University) (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Oncology › Cytokine Signaling Pathways and Interactions
- Keywords
- interleukin-6, IL-6 deficiency, body composition, leptin resistance, carbohydrate metabolism, lipid metabolism, energy expenditure, hypothalamus, intracerebroventricular administration, anti-obesity, adipose tissue, cytokines
- MeSH terms
- Age Factors, Animals, Blood Glucose, Body Composition, Corticosterone, Eating, Energy Metabolism, Female, Glucose Tolerance Test, Injections, Intraventricular, Lipids, Male, Mice, Mutant Strains, Obesity, Sex Factors, Interleukin-6, Leptin, Mice
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