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Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr-Abl positive cells

Druker, Brian J., Tamura, Shu, Buchdunger, Elisabeth, Ohno, Sayuri, Segal, Gerald M., Fanning, Shane, Zimmermann, Jürg, Lydon, Nicholas B.·1996·Nature Medicine
DOI 10.1038/nm0596-561
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Abstract

The bcr-abl oncogene, present in 95% of patients with chronic myelogenous leukemia (CML), has been implicated as the cause of this disease. A compound, designed to inhibit the Abl protein tyrosine kinase, was evaluated for its effects on cells containing the Bcr-Abl fusion protein. Cellular proliferation and tumor formation by Bcr-Abl-expressing cells were specifically inhibited by this compound. In colony-forming assays of peripheral blood or bone marrow from patients with CML, there was a 92-98% decrease in the number of bcr-abl colonies formed but no inhibition of normal colony formation. This compound may be useful in the treatment of bcr-abl-positive leukemias.

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Metadata

Authors
Druker, B. J., Tamura, S., Buchdunger, E., Ohno, S., Segal, G. M., Fanning, S., Zimmermann, J., & Lydon, N. B.
Venue
Nature Medicine
Publisher
Springer Science and Business Media LLC
Published
1996-05
Volume
2
Issue
5
Pages
561-566
ISSN
  • 1078-8956
  • 1546-170X
DOI
10.1038/nm0596-561
Cited by
2,967
References
1
Language
en
Licence
www.springer.com/tdm (tdm)

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