Shifting HIFs in osteoarthritis
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A stress-induced increase in HIF-2α activity overshadows HIF-1α and drives osteoarthritis changes.
“According to this paradigm, a stress-induced increase in the activity of HIF-2α will overshadow the beneficial effects of the closely related HIF-1α, then push the chondrocytes in the joint toward a more differentiated state known as hypertrophy, which then drives osteoarthritis changes [6,7].”
From Arthropod steroid hormone (20-Hydroxyecdysone) suppresses IL-1β- induced catabolic gene expression in cartilage (2015) · cites this paper as [6]
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References 24 · Cited by 101
Research works printed but not linked: 2
- [12]Wong M Bone 33 685 693 2003 14555274
- [13]Liu-Bryan R Terkeltaub R Arthritis Rheum in the press
- Authors
- Husa, M., Liu-Bryan, R., & Terkeltaub, R.
- Affiliations
- University of California San Diego (US)
- Corresponding author
- Terkeltaub, Robert
- ORCID
- Terkeltaub, Robert
- Venue
- Nature Medicine
- Published
- 2010-06
- Volume
- 16
- Issue
- 6
- Pages
- 641-644
- ISSN
- 1078-8956 (ISSN-L)
- 1546-170X
- PMC
- PMC2917906
- OpenAlex
- W1986542510
- Cited by
- 101
- References
- 24
- Citations by year
- 2026: 5 · 2025: 3 · 2024: 8 · 2023: 6 · 2022: 6 · 2021: 5 · 2020: 5 · 2019: 5 · 2018: 7 · 2017: 5 · 2016: 10 · 2015: 7 · 2014: 11 · 2013: 8 · 2012: 3
- FWCI
- 3.83
- Type
- journal article
- Language
- en
- Update notices
- erratum (2010-07-01)
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Nature Medicine (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- National Institute of Allergy and Infectious Diseases (R21AI067966)
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (AR-1067966, T32AR007608)
- Topics
- Health Sciences › Medicine › Rheumatology › Osteoarthritis Treatment and Mechanisms
- Health Sciences › Medicine › Surgery › Hip disorders and treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Proteoglycans and glycosaminoglycans research
- Keywords
- osteoarthritis, HIF-2α, disease progression, early detection, therapeutic target, joint diseases
- MeSH terms
- Endothelial PAS Domain-Containing Protein 1, Animals, Cartilage, Humans, Osteoarthritis, Transcription Factors, Chondrocytes, Basic Helix-Loop-Helix Proteins
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