Finding the tumor copycat: Approximating a human cancer
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Less than 10% of anticancer drugs that enter clinical trials ever reach the market.
“Today, less than 10% of the anticancer drugs that enter clinical trials ever reach the market [7,8].”
From The Tumor-on-Chip: Recent Advances in the Development of Microfluidic Systems to Recapitulate the Physiology of Solid Tumors (2019) · cites this paper as [7]
In “Approximating a human cancer” (page unavailable), the paper says that only 5% of cancer therapies targeted to specific molecular drivers and tested in the clinic prove efficacious. That supports a low clinical success rate, but it does not establish the proportion of all anticancer drugs entering trials that reach the market; efficacy and market entry are different endpoints. (LLM, conf=0.86)
Experimental — accuracy not yet measuredAnimal models are time-, resource-, and expertise-intensive.
“However, animal models have their own complications [7,17,96] because they are time-, resource-, and expertise-intensive, and animal use is increasingly being questioned by different public entities for ethical/humanitarian concerns [97,98,99].”
From The Tumor-on-Chip: Recent Advances in the Development of Microfluidic Systems to Recapitulate the Physiology of Solid Tumors (2019) · cites this paper as [7]
The ‘Approximating a human cancer’ section discusses accurately engineering mouse cancer models and their value for preclinical research, but does not address the time, resources, or expertise they require. Searches for those demands found no supporting passage in our copy; no page number was provided. (LLM, conf=0.75)
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References 8 · Cited by 19
- Authors
- Van Dyke, T.
- Venue
- Nature Medicine
- Published
- 2010-09
- Volume
- 16
- Issue
- 9
- Pages
- 976-977
- ISSN
- 1078-8956 (ISSN-L)
- 1546-170X
- PMC
- PMC3533444
- OpenAlex
- W2005946855
- Cited by
- 19
- References
- 8
- Citations by year
- 2023: 1 · 2019: 2 · 2017: 1 · 2016: 2 · 2014: 2 · 2013: 2 · 2012: 4
- FWCI
- 1.11
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Medicine (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (Z99 CA999999)
- National Cancer Institute (Y99 CA999999)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer Genomics and Diagnostics
- Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
- Health Sciences › Medicine › Oncology › Pancreatic and Hepatic Oncology Research
- Keywords
- mouse tumor model, animal models of cancer, translational research, pancreatic cancer, spheroids, chemoresistance, research ethics committees
- MeSH terms
- Gemcitabine, Adenocarcinoma, Animals, Antineoplastic Agents, Cell Division, Deoxycytidine, Disease Models, Animal, Neoplasms, Carcinoma, Pancreatic Ductal, Animals, Genetically Modified, Mice
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