The macrophage foam cell as a target for therapeutic intervention
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Lysosomal hydrolysis of cholesteryl ester generates unesterified cholesterol, which is re-esterified in the cytoplasm into cholesteryl ester droplets, leading to foam cell formation.
“the lysosomal hydrolysis of cholesteryl ester generates unesterified cholesterol molecules, which then exit the lysosomes and become re-esterified in the cytoplasm, with ensuing formation of cytoplasmic cholesteryl ester droplets that leads to foam cell formation, a hallmark of atherosclerosis.”
From Inflammation and its resolution in atherosclerosis: mediators and therapeutic opportunities (2019) · cites this paper as [23]
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References 94 · Cited by 700
- Authors
- Li, A. C., & Glass, C. K.
- Affiliations
- University of California San Diego (US)
- Corresponding author
- Glass, Christopher K.
- Venue
- Nature Medicine
- Published
- 2002-11
- Volume
- 8
- Issue
- 11
- Pages
- 1235-1242
- ISSN
- 1078-8956 (ISSN-L)
- 1546-170X
- OpenAlex
- W2034911894
- Cited by
- 700
- References
- 94
- Citations by year
- 2026: 9 · 2025: 12 · 2024: 15 · 2023: 18 · 2022: 22 · 2021: 28 · 2020: 25 · 2019: 37 · 2018: 30 · 2017: 29 · 2016: 25 · 2015: 42 · 2014: 34 · 2013: 37 · 2012: 37
- FWCI
- 2.41
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Atherosclerosis and Cardiovascular Diseases
- Health Sciences › Medicine › Surgery › Cholesterol and Lipid Metabolism
- Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
- Keywords
- foam cells, atherosclerosis, lipid accumulation, lipoprotein uptake, reactive oxygen species, inflammation, coronary artery disease, phagocytosis
- MeSH terms
- Animals, Arteriosclerosis, Biological Transport, Cholesterol, Foam Cells, Humans, Lipoprotein Lipase, Lymphocytes, Membrane Proteins, Oxidation-Reduction, Receptors, Immunologic, Receptors, LDL, Triglycerides, Receptors, Lipoprotein, Receptors, Scavenger, Scavenger Receptors, Class B
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
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