Alzheimer's APP mangles mitochondria
Lin, Michael T, Beal, M Flint·2006·Nature Medicine
Cited by (146)
Items 101–146 of 146
- What Role Does Mitochondrial Stress Play in Neurodegenerative Diseases?Alicia M. Pickrell, Carlos Torres Moraes · 2010 · Methods in molecular biology
- Mitophagy pathways and Alzheimer's disease: From pathogenesis to treatmentXian-Ji Pan, Afzal Misrani, Sidra Tabassum, Li Yang · 2021 · Mitochondrion
- Effects of Ultramicronized Palmitoylethanolamide on Mitochondrial Bioenergetics, Cerebral Metabolism, and Glutamatergic Transmission: An Integrated Approach in a Triple Transgenic Mouse Model of Alzheimer's DiseaseFrancesco Bellanti, Vidyasagar Naik Bukke, Archana Moola, Rosanna Villani, Caterina Scuderi, Luca Steardo, Gianmauro Palombelli, Rossella Canese, Sarah Beggiato, Mario Altamura et al. · 2022 · Frontiers in Aging Neuroscience
- Spatial, Temporal, and Quantitative Manipulation of Intracellular Hydrogen Peroxide in Cultured CellsIshraq Alim, R. Haskew-Layton, H. Aleyasin, Heng-chang Guo, R. Ratan · 2014 · Methods in Enzymology
- The Genetics of Alzheimer’s Disease and Parkinson’s DiseaseL. Bekris, Chang-En Yu, T. Bird, D. Tsuang · 2011 · Advances in neurobiology
- Decreased Numeric Density of Succinic Dehydrogenase-Positive Mitochondria in CA1 Pyramidal Neurons of 3xTg-AD MicePatrizia Fattoretti, Marta Balietti, Tiziana Casoli, Belinda Giorgetti, Giuseppina Di Stefano, Carlo Bertoni–Freddari, Fabrizia Lattanzio, Stefano Luca Sensi · 2009 · Rejuvenation Research
- A CHCHD6–APP axis connects amyloid and mitochondrial pathology in Alzheimer’s diseaseYutong Shang, Xiaoyan Sun, Xiaoqin Chen, QuanQiu Wang, Evan J. Wang, Emiko Miller, Rong Xu, Andrew A. Pieper, Xin Qi · 2022 · Acta Neuropathologica
- The mitochondrial function was impaired in APP knockout mouse embryo fibroblast cellsBaiyang Sheng, Ying Niu, Hui Ren Zhou, Jiaxin Yan, Nanming Zhao, Xiufang Zhang, Yandao Gong · 2009 · 中国科学通报:英文版
- Alzheimer disease-related presenilin-1 variants exert distinct effects on monoamine oxidase-A activity in vitroPaul R. Pennington, Ze-Lan Wei, Lewei Rui, Jennifer Doig, B. Graham, Kelly Kuski, Geraldine G. Gabriel, D. Mousseau · 2011 · Journal of neural transmission
- Identification and Characterization of Amyloid-β Accumulation in Synaptic MitochondriaYan, Shi Fang, Akhter, Firoz, Sosunov, Alexander A., Yan, Shirley ShiDu · 2018 · Methods in Molecular Biology
- Gene expression profile in β-amyloid-treated SH-SY5Y neuroblastoma cellsTamara Martínez, Angel Pascual · 2007 · Brain Research Bulletin
- The p38 mitogen-activated protein kinase signaling pathway is involved in regulating low-density lipoprotein receptor-related protein 1-mediated β-amyloid protein internalization in mouse brainKaige Ma, Jia Lv, Xiao- Dan Hu, Lili Shi, Ke-Wei Chang, Xinlin Chen, Yi‐Hua Qian, Weina Yang, Qiumin Qu · 2016 · The International Journal of Biochemistry & Cell Biology
- PINK1-dependent NFKB signaling contributes to amyloid pathology in Alzheimer diseaseFang Du, Qing Yu, Gang Hu, Chyuan‐Sheng Lin, Shirley ShiDu Yan · 2025 · Autophagy
- Novel Antioxidants Protect Mitochondria from the Effects of Oligomeric Amyloid Beta and Contribute to the Maintenance of Epigenome FunctionDiego Mastroeni, Omar M. Khdour, Pablo M. Arce, Sidney M. Hecht, Paul D. Coleman · 2015 · ACS Chemical Neuroscience
- Hydrogen Sulfide Selectively Inhibits γ-Secretase Activity and Decreases Mitochondrial Aβ Production in Neurons from APP/PS1 Transgenic MiceFengli Zhao, Peifeng Qiao, Ning Yan, Dan Gao, Mengjie Liu, Yong Ping Yan · 2015 · Neurochemical Research
- Effects of amyloid-β on protein SUMOylation and levels of mitochondrial proteins in primary cortical neuronsEricks Sousa Soares, Ana Cristina Guerra Souza, Camila A. Zanella, Ruth E. Carmichael, Jeremy Martin Henley, Kevin A. Wilkinson, Helena Cimarosti · 2022 · IBRO Neuroscience Reports
- Exploring the efficient natural products for Alzheimer’s disease therapy via Drosophila melanogaster (fruit fly) modelsMengdi Wu, Ying Li, Yaodong Miao, Huanhuan Qiao, Yiwen Wang · 2023 · Journal of drug targeting
- Alterations of Mitochondria and Golgi Apparatus Are Related to Synaptic Pathology in Alzheimer's DiseaseJ. Stavros · 2013 · InTech eBooks
- GPP-TSAIII nanocomposite hydrogel-based photothermal ablation facilitates melanoma therapyXing Huang, Yihao He, Miao Zhang, Zhenhui Lu, Tong Zhang, Bing Wang · 2023 · Expert Opinion on Drug Delivery
- 2-Arachidonoylglycerol metabolism is differently modulated by oligomeric and fibrillar conformations of amyloid beta in synaptic terminalsAna C. Pascual, Virginia L. Gaveglio, Norma Maria Giusto, Susana J. Pasquaré · 2017 · Neuroscience
- Potential protection from Alzheimer’s disease by wheat germ and rice bran nano-form in rat modelAttia A. Yaseen, Sahar Y. Al‐Okbi, Ahmed Hussein, Doha Abdou Mohamed, Ayman A. Mohammad, Karem Aly Fouda, Fathy M. Mehaya · 2019 · Journal of Applied Pharmaceutical Science
- Effect of acute hyperkalemia on plasma insulin and glucagon.Fausto Santeusanio, J. P. Knochel, Edward M. Schlein, Gerald R. Faloona, R. H. Unger · 1971 · PubMed
- Genetics of Alzheimer's DiseaseLynn M. Bekris, Chang‐En Yu, Thomas D. Bird, Debby W. Tsuang · 2010 · Wiley eBooks
- Restoration of Miro1’s N-terminal GTPase function alleviates prenatal stress-induced mitochondrial fission via Drp1 modulationGee Euhn Choi, Ji Yong Park, Mo Ran Park, Chang Woo Chae, Young Hyun Jung, Jae Ryong Lim, Jee Hyeon Yoon, Ji Hyeon Cho, Ho Jae Han · 2025 · Cell Communication and Signaling
- Amyloid-β Protein Precursor Deficiency Changes Neuronal Electrical Activity and Levels of Mitochondrial Proteins in the Medial Prefrontal CortexQingwei Huo, Sidra Tabassum, Ming Chen, Mengyao Sun, Yueming Deng, Xingzhi Zheng, Yi Li, Jian Chen, Cheng Long, Li Yang · 2021 · Journal of Alzheimer s Disease
- Decoding the Therapeutic Potential of Cannabis and Cannabinoids in Neurological DisordersMayur Bhimrao Kale, Mohit D. Umare, Nitu L. Wankhede, Rohitas Deshmukh, Vikrant Abbot, Md. Khalid Anwer, Brijesh Gulabrao Taksande, Aman Babanrao Upaganlawar, Milind Janrao Umekar, Seema Ramniwas et al. · 2024 · Current Pharmaceutical Design
- Perspectivas en la prevención y tratamiento farmacológico de la enfermedad de AlzheimerS Archibaldo Donoso, Carolina Delgado D · 2009 · Revista médica de Chile
- Synthesis of a novel hydrogen peroxide-responsive cyanine-based near-infrared fluorescent probe and its applications in cellular and in vivo imagingGuobin Wang, Shu-Long He, Xueli Cheng, Linlin Han, Han-Yang Zou, Jinjin Yang, Shi‐Li Shen, Xian-Hong Pang, Yan Zhu · 2025 · Bioorganic Chemistry
- Schisandrin B Enhances Glutathione Redox Cycling and Protects Against β-amyloid-induced Apoptosis in Human Neuroblastoma SH-SY5Y Cells: A Comparative Study of Various PhytochemicalsKam Ming Ko, Pou Kuan Leong, Philip Yeung Lam, Na Chen · 2014 · The Open Nutraceuticals Journal
- Mitochondria: Strategic Point in the Field of Alzheimer’s DiseaseStavros Balogiannis · 2016 · Alzheimer’s & Neurodegenerative Diseases
- A Mechanism for the Inhibition of Tau Neurotoxicity: Studies with Artificial Membranes, Isolated Mitochondria, and Intact CellsSegev Naveh‐Tassa, Shani Ben-Zichri, Shiran Lacham‐Hartman, Ofek Oren, Zeev Slobodnik, Ekaterina Eremenko, Debra Toiber, Raz Jelinek, Niv Papo · 2021 · ACS Chemical Neuroscience
- How does “Protein Corona” Affect the In vivo Efficiency of Polymeric Nanoparticles? State of Art2017 · BENTHAM SCIENCE PUBLISHERS eBooks
- In fission yeast, 65 non-essential mitochondrial proteins related to respiration and stress become essential in low-glucose conditionsAyaka Mori, Lisa Uehara, Yusuke Toyoda, Fumie Masuda, Saeko Soejima, Shigeaki Saitoh, Mitsuhiro Yanagida · 2023 · Royal Society Open Science
- Free Cholesterol — A Double-Edge Sword in Alzheimer DiseaseJosé Carlos Fernández-Checa · 2015 · InTech eBooks
- Neuroprotection Against Oxidative Injury by a Nucleic Acid–Based Health Product (Squina DNA) Through Enhancing Mitochondrial Antioxidant Status and Functional CapacityPhillip Y. Lam, Na Chen, Po Yee Chiu, Hoi Yan Leung, Kam Ming Ko · 2012 · Journal of Medicinal Food
- Organelle targeting: Focus on the mitochondriaHarish Padh, Snehal Shenoy, Shreya Thakkar, Manju Misra · 2021 · Elsevier eBooks
- Interplay of Mitochondrial Dynamics, Nutrition, and Vitamins: Evidence From Experimental and Human Studies With Implications for Women’s HealthKarkala Sreedhara Ranganath Pai, Shambhavi Shetye, Rakshith V. Patil, Shravya Acharya, Kishan S. Kulal, Ajeetkumar Patil, Saritha U Kamath · 2026 · Oxidative Medicine and Cellular Longevity
- Implication du canal potassium Kv3.1 dans la lipotoxicité du 7-cétocholestérol, 24S-hydroxycholestérol et de l’acide tétracosanoïque sur des cellules nerveuses 158N et BV-2 : Etude des relations entre Kv3.1, homéostasie potassique et métabolisme peroxysomal dans la maladie d’AlzheimerMaryem Bezine · 2017 · theses.fr (ABES)
- Mitochondrial Involvement in Neurodegeneration and AgingAlicia M. Pickrell · 2012
- Alzheimer’s Disease Genomics and Clinical ApplicationsTih-Shih W. Lee, Mei Sian · 2011 · InTech eBooks
- Maladie de Basedow et maladie de Crohn : étiopathogénie croisée ou association fortuite ? (À propos de deux cas)Ihsen Slim, Ali Sellem, Rim Hassad, Haïfa Bahri, Saoussen Zayed, Intidhar El Bez, Aida Mhiri, Mohamed Faouzi Ben Slimene · 2007 · Médecine Nucléaire
- Faculty Opinions recommendation of Cyclophilin D deficiency attenuates mitochondrial and neuronal perturbation and ameliorates learning and memory in Alzheimer's disease.Mark A. Smith, Hyun-Pil Lee · 2008 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
- Implications de la signalisation de la protéine kinase activée par l’AMP (AMPK) dans les dysfonctions mitochondriales, la pathologie amyloïde et Tau, et la neuroinflammation dans la maladie d’AlzheimerArnaud Mary · 2022 · theses.fr (ABES)
- BindingDB Entry 50047476: Identification of a Small Molecule Cyclophilin D Inhibitor for Rescuing Aß-Mediated Mitochondrial Dysfunction.BindingDB · 2017 · UC San Diego
- BindingDB Entry 50038080: Multi-target-directed ligands to combat neurodegenerative diseases.BindingDB · 2012 · UC San Diego
- BindingDB Entry 50043988: Identification of human presequence protease (hPreP) agonists for the treatment of Alzheimer's disease.BindingDB · 2014 · UC San Diego