Integrin αvβ3 is a coreceptor for human cytomegalovirus
Open accessAbstract
Human cytomegalovirus (HCMV) is a widespread opportunistic pathogen that causes birth defects in newborns and severe disease in immunocompromised individuals. The broad tropism of HCMV infection suggests that it uses multiple receptors. We recently showed that the epidermal growth factor receptor (EGFR) serves as a receptor for HCMV. Here we show that HCMV also uses integrin alphavbeta3 as a coreceptor. Upon infection, HCMV glycoproteins gB and gH independently bind to EGFR and alphavbeta3, respectively, to initiate viral entry and signaling. Alphavbeta3 then translocates to lipid rafts where it interacts with EGFR to induce coordinated signaling. The coordination between EGFR and alphavbeta3 is essential for the early events of HCMV infection, including viral entry, RhoA downregulation, stress-fiber disassembly and viral nuclear trafficking. Our findings support a model in which EGFR and alphavbeta3 work together as coreceptors for HCMV entry and signaling. This discovery is fundamental to understanding HCMV pathogenesis and developing treatment strategies targeted to viral receptors.
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αvβ3 integrin acts as a co-receptor for HSV1 and HCMV.
“αvβ3 integrin acts as a co-receptor for HSV1 and HCMV (Wang et al., 2005; Gianni and Campadelli-Fiume, 2012).”
From The Pathogenesis and Immune Evasive Mechanisms of Equine Herpesvirus Type 1 (2021) · cites this paper as Wang et al., 2005
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References 53 · Cited by 268
Research works printed but not linked: 1
- [3]Mocarski, E.S., and Courcelle C. T. Cytomegaloviruses and Their Replication, in Fields Virology, Vol. 2 (ed. Knipe, D.M., and Howley, P. M.) 2629–2673 (Lippincott William & Wilkins, Philadelphia, 2001).
- Authors
- Wang, X., Huang, D. Y., Huong, S.-M., & Huang, E.-S.
- Affiliations
- University of North Carolina at Chapel Hill (US)
- Corresponding author
- Huang, Eng-Shang
- Venue
- Nature Medicine
- Published
- 2005-04-17
- Volume
- 11
- Issue
- 5
- Pages
- 515-521
- ISSN
- 1078-8956 (ISSN-L)
- 1546-170X
- PMC
- PMC1904494
- OpenAlex
- W1996688582
- Cited by
- 268
- References
- 53
- Citations by year
- 2026: 5 · 2025: 8 · 2024: 8 · 2023: 5 · 2022: 5 · 2021: 17 · 2020: 10 · 2019: 7 · 2018: 9 · 2017: 13 · 2016: 13 · 2015: 16 · 2014: 16 · 2013: 9 · 2012: 13
- FWCI
- 15.13
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Medicine (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Carolina Digital Repository (University of North Carolina at Chapel Hill) (submittedVersion)
- UNC Libraries
- Funders
- National Cancer Institute (CA 19014, P01CA019014)
- National Institute of Allergy and Infectious Diseases (AI47468, R01AI047678)
- Topics
- Health Sciences › Medicine › Epidemiology › Cytomegalovirus and herpesvirus research
- Health Sciences › Medicine › Immunology and Allergy › Cell Adhesion Molecules Research
- Health Sciences › Medicine › Epidemiology › Herpesvirus Infections and Treatments
- Keywords
- human cytomegalovirus, integrin αvβ3, epidermal growth factor receptor, viral coreceptor, viral entry, lipid rafts, receptor signaling, viral tropism
- MeSH terms
- Cell Line, Cytomegalovirus Infections, Cytomegalovirus, Humans, Microscopy, Fluorescence, Viral Envelope Proteins, Signal Transduction, DNA Primers, Phosphatidylinositol 3-Kinases, Reverse Transcriptase Polymerase Chain Reaction, rhoA GTP-Binding Protein, Membrane Microdomains, Integrin alphaVbeta3, ErbB Receptors
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