Angiopoietin-2 sensitizes endothelial cells to TNF-α and has a crucial role in the induction of inflammation

Fiedler, Ulrike, Reiss, Yvonne, Scharpfenecker, Marion, Grunow, Verena, Koidl, Stefanie, Thurston, Gavin, Gale, Nicholas W, Witzenrath, Martin +7 more·2006·Nature Medicine
DOI 10.1038/nm1351

Cited by (930)

Items 801–900 of 930

  1. Ocular neovascularization: potential for the angiopoietin/Tie-2 pathway
    Haziq Raees Chowdhury, Nishal Patel, Sobha Sivaprasad · 2009 · Expert Review of Ophthalmology
  2. Alteration of VEGF and angiopoietins expressions in diabetic glomeruli implicated in the development of diabetic nephropathy
    Kiriko Sonezaki, Yoshiro Maezawa, Minoru Takemoto, Kaoru Kobayashi, T. Tokuyama, Aki Takada‐Watanabe, T. Simoyama, Showbu Sato, Yoshiro Saito, Koutaro Yokote · 2013 · Advanced Studies in Medical Sciences
  3. Gene Expression Profiling Associated with the Progression of Classic Kaposi's Sarcoma
    Emma Guttman‐Yassky, Andrea Chiricozzi, Jasmine Jacob‐Hirsch, Suzanne J. Tintle, Artemis Khatcherian, Ninette Amariglio, Gideon Rechavi, James G. Krueger, Steven Paul Nisticò, Richard N. Bergman et al. · 2012 · European Journal of Inflammation
  4. Direct contribution of angiogenic factors to neurodevelopment: a focus on angiopoietins
    Robert Luck, Andromachi Karakatsani, Carmen Ruiz de Almodóvar · 2020 · e-Neuroforum
  5. Angiopoietin 2
    Sascha David, Philipp Kümpers · 2009 · Der Nephrologe
  6. The role of proangiogenic cytokines in predicting sepsis in febrile neutropenic children with cancer
    Selma Çakmakçı, Neriman Sarı, Çiğdem Sönmez, İnci Ergürhan İlhan · 2024 · The Turkish Journal of Pediatrics
  7. The mortality prognostic value of plasma angiopoietin-2 levels in patients with sepsis
    Dung Thi Pham, Duong Minh Vu, Thach N Nguyen, Dung T Le, Ba Van Dang, Hung M Do, Loc T Hoang, Phong X Le, Tuan T Tran, Hung Thanh Ngo · 2025 · Disaster and Emergency Medicine Journal
  8. The endothelial growth factor angiopoietin-2 is an accurate prognostic biomarker in patients with acetaminophen-induced acute liver failure
    David S. Umbaugh, Nga T Nguyen, Steven C. Curry, Jody A. Rule, William M. Lee, Anup Ramachandran, Hartmut Jaeschke, Acute Liver Failure Study Group, Shannan Tujios, David Koch et al. · 2025 · Toxicological Sciences
  9. Sites of Injury: The Endothelium
    Johann Wojta · 2010 · Springer eBooks
  10. KSHV Paracrine Effects on Tumorigenesis
    Ramona Jochmann, Peter Lorenz, Priya Chudasama, Christian Zietz, Michael Strzl, Andreas Konr · 2012 · InTech eBooks
  11. Angiopoietin-2 (ANGPT2) as a candidate gene for somatic cell score in German Holstein cattle
    Jens Tetens, Christine F. Baes, C. Kühn, Norbert Reinsch, Georg Erwin Thaller · 2013 · Journal of Dairy Science
  12. The Lung Endothelial Barrier in Acute Inflammation
    Holger Müller-Redetzky, Jasmin Lienau, Martin Witzenrath · 2015 · Springer eBooks
  13. Higher Plasma Endothelial Markers in Adults with Cystic Fibrosis Compared with Healthy Age-matched Control Subjects
    Pavan K. Bhatraju, K. Hisert, Moira L. Aitken, Christopher Hooper Goss, Wayne Conrad Liles, William A. Altemeier · 2019 · Annals of the American Thoracic Society
  14. Diagnostic value of angiopoietin-2 in the differentiation of malignant pleural effusions
    Dilaver Taş, Alaattin Köseler · 2019 · Journal of Surgery and Medicine
  15. Angiopoietin-2 is released during anaphylactic hypotension in anesthetized and unanesthetized rats
    Tao Zhang, Toshishige Shibamoto, Mamoru Tanida, Makoto Taniguchi, Yuhichi Kuda, Wei Yang, Yasutaka Kurata · 2020 · PLoS ONE
  16. Investigational Medications
    Michael W. Stewart · 2017 · Springer eBooks
  17. Phenotypic classification and biochemical profile of obesity for cardiovascular prevention
    Marco Alfonso Perrone, Jagadish Babu Dasari, Alfredo Intorcia, Paola Gualtieri, Massimo Marche, Marco Di Luozzo, Giuseppe Merra, Sergio Bernardini, Francesco Romeo, Domenico Sergi · 2020 · Gazzetta Medica Italiana Archivio per le Scienze Mediche
  18. A better biomarker for cerebral malaria
    Hans Christian Ackerman, Ryan W. Carroll, Climent Casals‐Pascual · 2012 · Critical Care Medicine
  19. Vascular homeostasis and disease progression in chronic kidney disease
    Narisa Futrakul, Prasit Futrakul · 2009 · Asian Biomedicine
  20. Integrative Computational Identifications of the Signaling Pathway Network Related to TNF-alpha Stimulus in Vascular Endothelial Cells
    Jin Gu, Shao Li, Yang Chen, Yanda Li · 2009 · International Joint Conferences on Bioinformatics, Systems Biology and Intelligent Computing
  21. Retinal Blood Oxygen Saturation and Angiogenic and Inflammatory Biomarkers in Type 2 Diabetes
    Faryan Tayyari · 2015 · UWSpace (University of Waterloo)
  22. Host Pathogen Interactions in Malaria and Tuberculosis: Experimental Models and Translation to Novel Adjunctive Therapies
    Michael Hawkes · 2012 · TSpace (University of Toronto)
  23. Biomarkers of Severe Malaria: Complement Activation and Dysregulated Angiogenesis in Placental Malaria and Cerebral Malaria
    Andrea L. Conroy · 2012 · TSpace (University of Toronto)
  24. Molecular Regulation of Inflammation and Angiogenesis in the Tumor Microenvironment
    Lothar C. Dieterich · 2011 · KTH Publication Database DiVA (KTH Royal Institute of Technology)
  25. The brain–kidney–retinal axis in severe falciparum malaria
    Andrea L. Conroy, Dibyadyuti Datta, Angelika Hoffmann, Samuel Crocodile Wassmer · 2023 · Trends in Parasitology
  26. Directing Vascular Cells by Cyclic Tensile Strain: Contextual Role in Angiogenesis.
    Yu Ching Yung · 2008 · Deep Blue (University of Michigan)
  27. Angiopoietin-2: Prognoseparameter im kardiogenen Schock
    Andreas Link · 2013 · Medizinische Klinik - Intensivmedizin und Notfallmedizin
  28. Angiopoietin-2 in der Intensivmedizin
    Philipp Kümpers, Sascha David · 2009 · Intensivmedizin und Notfallmedizin
  29. Contributions of inflammation and angiogenesis to structural damage and pain in osteoarthritis
    Sadaf Ashraf · 2011 · Nottingham ePrints (University of Nottingham)
  30. Ação da jararagina na expressão gênica e protéica de mediadores pró-inflamatórios por células endoteliais humanas.
    Daiana Silva Lopes · 2011
  31. Fisiopatologia de la cèl·lula endotelial en la cirrosi hepàtica
    Sònia Tugues · 2008 · Dipòsit Digital de la Universitat de Barcelona (Universitat de Barcelona)
  32. Angiopoietin-1 and -2 in Infectious Diseases associated with Endothelial Cell Dysfunction
    Andrea V. Page, Wayne Conrad Liles · 2012 · TSpace (University of Toronto)
  33. ROLE OF THE ANG-TIE2 PATHWAY IN THE INVASIVE RECURRENCE OF GBM FOLLOWING ANTI-VEGF THERAPY
    Nahir Cortes‐Santiago · 2014 · Digital Commons-TMC (Texas Medical Center)
  34. From gene mutation to gene expression : studies on multiple endocrine neoplasia type 1 and vascular endothelial growth factors
    Emma Tham · 2006 · Figshare
  35. Targeting intracellular signaling pathways at the interface of T lymphocyte and innate immunity in immune-mediated inflammatory diseases
    Sarah Krausz · 2013 · UvA-DARE (University of Amsterdam)
  36. Regulation of Angiogenesis and Vascular Homeostasis Through the Angiopoietin / Tie System
    Hellmut G. Augustin, Ulrike Fiedler · 2007 · Springer eBooks
  37. La angiopoyetina-1, pero no el factor de crecimiento derivado de las plaquetas-AB, es un estimulador coadyuvante del factor de crecimiento endotelial vascular-A en el cierre de lesiones endoteliales en un modelo in vitro
    Alexander Alter, Dorothee Schmiedeck, Markus R. Fussnegger, Axel Radlach Pries, Wolfgang B. Freesmeyer, Andreas Zakrzewicz · 2009 · Anales de Cirugía Vascular
  38. Blockade von Ang-2 reduziert die Endotoxin-vermittelte mikrovaskuläre Dysfunktion der Leber
    Jan Erik Slotta, Brigitte Vollmar, Martin Karl Schilling, Michael Dieter Menger · 2007 · Springer eBooks
  39. L'Angiopoïétine-1, contrairement au Facteur de Croissance de Dérivé Plaquettaire-AB, potentialise le Facteur de Croissance Endothélial Vasculaire-A d'accélération de la cicatrisation endothéliale dans un modèle de plaie par éraflure de cellules endothéliales
    Alexandre Alter, Dorothee Schmiedeck, Markus R. Fussnegger, Axel Radlach Pries, Wolfgang B. Freesmeyer, Andreas Zakrzewicz · 2009 · Annales de Chirurgie Vasculaire
  40. Endothelial Colony Forming Cells (ECFCs): Identification, Specification and Modulation in Cardiovascular Diseases
    Lan Huang · 2010 · IUScholarWorks (Indiana University)
  41. Hypoxia in arterial and venous specification during vascular development
    Marcus Sohl · 2009 · Figshare
  42. EXPERIMENTAL STUDIES OF CORNEAL NEOVASCULARISATION
    Branka Samolov · 2009 · Figshare
  43. Pulmonary-Respiratory Medicine
    H. Tonn · 2001 · JAMA
  44. Vstat120 modulates inhibits oncolytic viral therapy induced angiogenesis and innate pro-inflamatory response, augmenting oncolytic viral thereapy of glioblastom multiforme
    Jayson J Hardcastle · 2011 · OhioLink ETD Center (Ohio Library and Information Network)
  45. Renal replacement therapy in the critically ill
    Suvi T. Vaara · 2012 · Työväentutkimus Vuosikirja
  46. AB0069 TIE2 signalling induces a pro-inflammatory and pro-angiogenic phenotype in differentiated macrophages, independently of macrophage polarization conditions
    Samuel García, Sarah Krausz, Carmen A. Ambarus, Bea Malvar Fernandez, Dominique Baeten, Paul Peter Tak, Kris A. Reedquist · 2012 · Annals of the Rheumatic Diseases
  47. Study of molecular and immunological factors that determine the sensitivity to the antitumor effect of Tumor Necrosis Factor
    Leander Huyghe · 2008 · Ghent University Academic Bibliography (Ghent University)
  48. Osteoprotegerin and Adhesion-Molecules
    Catherine Rush, Jonathan Golledge · 2016 · CRC Press eBooks
  49. The Tie2 RTK : regulation and downstream signaling.
    Celina Sturk · 2010 · TSpace (University of Toronto)
  50. Angiopoietin-2: Prognoseparameter im kardiogenen Schock
    M. Buerke · 2014
  51. High angiopoietin-2 and suppression of tumorigenicity-2 levels correlate with onset of sinusoidal obstructive syndrome—implication for the utility of serial biomarker monitoring
    Ana Tablante Nunes, Prachi Jain, David Erwin Kleiner, Nirali N. Shah, Prathima Anandi, Fariba Chinian, Pawel J. Muranski, Minoo Battiwalla, A. John Barrett, Sawa Ito · 2017 · Bone Marrow Transplantation
  52. Endothelial Biomarkers and the Pathogenesis of Cerebral Malaria
    Hassan A. Tetteh · 2014
  53. Serum angiopoietin-2
    Dina H. El Sawy, Nagwa Mohamed, Azza El Hamshary, Huda Marzouk, Sally R. Eid, Hanan A. Fathy, Amr S. Megawer, Azza K. Amer, Khadiga A. Salem, Manal M. Badawy · 2015 · Medical Research Journal
  54. The diagnosis of serious bacterial infections in the children’s emergency department
    Adam Irwin · 2016 · University of Liverpool
  55. Investigating Mediators of Endothelial Dysfunction as Potential Therapeutic Targets in Severe Malaria
    Robyn E. Elphinstone · 2016 · TSpace (University of Toronto)
  56. Pathobiology of Fatal Gastrointestinal GVHD
    Howard M. Shulman, David W. Woolston · 2019 · Springer eBooks
  57. Update in Critical Care 2006
    Eric B Milbrandt, Akitoshi Ishizaka, Derek C. Angus · 2007 · American Journal of Respiratory and Critical Care Medicine
  58. Characterization of Tie2 signalling during acute inflammation
    Tracy L. Smith · 2018 · TSpace (University of Toronto)
  59. Polarized Lung Inflammation and Tie2/Angiopoietin-Mediated Endothelial Dysfunction during Severe Orientia tsutsugamushi Infection
    Brandon Trent, Yuejin Liang, Yan Xing, Marisol Esqueda, Yang Wei, Nam-Hyuk Cho, Hong-Il Kim, Yeon-Sook Kim, Thomas R. Shelite, Jiyang Cai et al. · 2019 · bioRxiv (Cold Spring Harbor Laboratory)
  60. The effect of semaphorin 3E on angiogenesis in murine model of allergic asthma
    Nazanin Tatari · 2015 · Mspace (University of Manitoba)
  61. Psoriasis activation of cells important in cardiovascular disease
    Charlie Bridgewood · 2017 · Bradford Scholars (University of Bradford)
  62. Control of vascular integrity via endothelial growth factor and integrin cell adhesion receptor pathways
    Laura Hakanpää · 2020 · Työväentutkimus Vuosikirja
  63. Thyroid Hormone and Vascular Remodeling in Heart
    Silvana Balzan, Valter Lubrano · 2020 · Springer eBooks
  64. [Research Advances of Ang-2 in Non-small Cell Lung Cancer].
    Xin Hua, Xiaoli Zhu · 2018 · Europe PMC (PubMed Central)
  65. Endothelial Dysfunction and Microvascular Injury in Life-Threatening Diseases
    Kevin R. Barker · 2017 · TSpace (University of Toronto)
  66. Host Response to Plasmodium Infection: Implications for Pathogenesis and Management of Severe Malaria
    Sarah J. Higgins · 2014 · TSpace (University of Toronto)
  67. Functional Deficiency of Dicer in Atherosclerosis: A Role for Hemodynamic Shear Stress Regulation of the miRNA Biogenesis Pathway
    Eileen Tran · 2019 · TSpace (University of Toronto)
  68. Sensing dengue and chikungunya virus (co-) infections
    Alberto Aguilar Briseño · 2021
  69. Biomarkers of Angiogenesis in Hepatocellular Carcinoma: A Novel Sunshine Road
    Krizia Pocino, Cecilia Napodano, Gabriele Ciasca, Mariapaola Marino, Nicoletta De Matthaeis, Luca Miele, Francesca Gulli, Raffaele Saporito, Gian Ludovico Rapaccini, Umberto Basile · 2021 · Preprints.org
  70. Association of Pre-Transplant Angiopoietin-2 Index with the Risk of Acute Graft-Versus-Host Disease after Hematopoietic Stem Cell Transplantation
    Özlem Şatırer, İnci Cevher Zeytin, Berna Alkan, Jale Karakaya, Duygu Uçkan, Fatma Visal Okur · 2021 · Turkish Journal of Hematology
  71. Tie-2-expressing monocytes in hepatitis C virus-related hepatocellular carcinoma
    Afaf A. Abdel-Ghaffar, Ola M. Mahmoud, Manal Y. Zahran, Amr M. Abdelsabour, Nesma Ahmed Safwat · 2021 · The Egyptian Journal of Haematology
  72. Neovascular Glaucoma
    Malik Y. Kahook · 2009 · Elsevier eBooks
  73. Vasculature Growth
    Marc Thiriet · 2012 · Biomathematical and biomechanical modeling of the circulatory and ventilatory systems
  74. Cerebral Malaria
    Gregory S. Park, Chandy C. John · 2014 · Springer eBooks
  75. Osteoprotegerin and Adhesion Molecules
    Catherine Rush, Jonathan Golledge · 2010 · Science Publishers eBooks
  76. SUMMARY
    2016 · CRC Press eBooks
  77. Agents Targeting Angiopoietin/Tie Pathway in Diabetic Macular Edema
    Fanny Yip, Cherie YK Wong, Timothy Y. Y. Lai · 2022 · Springer eBooks
  78. Data from Host-Derived Angiopoietin-2 Affects Early Stages of Tumor Development and Vessel Maturation but Is Dispensable for Later Stages of Tumor Growth
    Patrick Nasarre, Markus Thomas, Karoline Kruse, Iris Helfrich, Vivien Wolter, Carleen Deppermann, Dirk Schadendorf, Gavin Thurston, Ulrike Fiedler, Hellmut G. Augustin · 2023
  79. Physiological Changes in the Local Onco-Sphere: Angiogenesis
    Phei Er Saw, Erwei Song · 2023 · Springer eBooks
  80. Correlation between Diabetes and Diabetic Retinopathy and Cancer Risk
    Wei‐Chuan Chang, Tsung‐Cheng Hsieh, Wen Lin Hsu, Fang-Ling Chang, Ming-Shan He · 2023 · SSRN Electronic Journal
  81. COVID-19-Induced Vascular Coagulopathy
    Sabari Nath Neerukonda · 2024 · Elsevier eBooks
  82. Mechanisms Underlying HFMD Clinical Pathology in Children
    Xingli Xu · 2024 · Springer eBooks
  83. The Role of Angiopoietins in Cardiovascular Outcomes of Kidney Transplant Recipients: An Ancillary Study from the FAVORIT
    Natalie Gendy, Liam Brown, Mary Kate Staunton, Kanika Garg, Nora H. Hernandez Garcilazo, Long Qian, Yu Yamamoto, Ugochukwu C. Ugwuowo, Wassim Obeid, Lama Al‐Qusairi et al. · 2024 · American Journal of Nephrology
  84. Sepsis-Associated Acute Kidney Injury
    Ivan Euclides Borges Saraiva, Syed A. Zaidi, Stefania Prenna, Marita Marengo, Riccardo Piscia, Andrea Colombatto, Vincenzo Cantaluppi, Hernando Gómez · 2024 · Elsevier eBooks
  85. Relationship between angiogenic growth factors and atherosclerosis in renal transplantation recipients: a cross-sectional study
    Melahat Çoban, Beyza Algül Durak, Mine Şebnem Karakan · 2024 · Sao Paulo Medical Journal
  86. The HIF-1α/miR-145b/Angpt2 axis attenuates renal fibrosis induced by unilateral renal ischemia–reperfusion
    Bingyou Cheng, Shang Huang, Lin Zhou, Pei Zhu, Zhongpu Li, Liang Hu, Jingsong Liu, Kejian Zhu · 2025 · Renal Replacement Therapy
  87. Vascular Endothelial Cells and Atherosclerosis
    Teruo Watanabe, Jianglin Fan · 2025 · Springer eBooks
  88. Evaluation of Atherosclerosis and Arterial Stiffness with Angiogenic Growth Factors in Chronic Kidney Disease Patients
    Musa İlker Durak, Melahat Çoban · 2025 · Medical Records
  89. Gastrointestinal Bleeding Following MCS
    Gal Rubinstein, Gabriel T. Sayer, Nir Y. Uriel · 2024 · Springer eBooks
  90. Retrospective study on the value of serum angiopoietin 2 and cystatin C levels in the early diagnosis of acute coronary syndrome
    Qian Zou, Yuxia Huang, Yabin Peng, Xuanhao Lu, Feilin Ye, Jie Xu, Ling Fang · 2025 · Medicine
  91. Angiopoietin-2 in sepsis: toward biomarker-guided therapy?
    Burak Katipoğlu, Andrzej Krupa, Bernard Rybczynski, Bartosz Wojciech Maj · 2025 · Disaster and Emergency Medicine Journal
  92. Associations Between Alcohol Consumption and Angiopoietin Serum Levels in Persons with HIV
    Joseph A. Belloir, Thomas Myers, Rebecca Schnall · 2025 · Biological Research For Nursing
  93. VEGFR-3 and Tie pathways in vascular network formation
    Tuomas Tammela · 2008 · Työväentutkimus Vuosikirja
  94. Additional file 1 of Randomized, double-blind, placebo-controlled, crossover trial of oral doxycycline for epistaxis in hereditary hemorrhagic telangiectasia
    K. P. Thompson, J. Sykes, Pallavi Chandakkar, Philippe Marambaud, Nicholas T. Vozoris, Douglas A. Marchuk, Faughnan, M. E. · 2022 · Figshare
  95. Research Progress on Biomarkers of Chronic Obstructive Pulmonary Disease-Associated Pulmonary Hypertension
    应婷 夏 · 2025 · Advances in Clinical Medicine
  96. Spermidine enhances metabolic flexibility and attenuates inflammation associated with ageing in farmed Atlantic salmon
    Kanchan Phadwal, Dominic Kurian, Jennifer H. Haggarty, Hervé Migaud, Victoria Nicheva, James R. Dick, Muhammad Khalid Farooq Salamat, Phillip D. Whitfield, Chessor Matthew, Nicholas M. Wade et al. · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
  97. The CXCL13 hub in obesity-related metabolic inflammation: regulation of spatiotemporal heterogeneity and targeted strategies
    Mengke Huang, Xiaolin Chen, Yongmei Jiang, Ting Liu · 2026 · Journal of Endocrinology
  98. Caractérisation de BMP9 (Bone Morphogenetic Protein 9), un nouveau biomarqueur de l'angiogenèse ?
    Marie Bidart · 2012
  99. Interactions entre les cellules satellites et les cellules vasculaires au sein du muscle strié squelettique : implications dans la myogénèse et la quiescence
    Rana Abou-Khalil · 2009 · theses.fr (ABES)
  100. Tie1 et la transition endothélio-mésenchymateuse
    Julie Garcia · 2013 · theses.fr (ABES)