Nogo-A-specific antibody treatment enhances sprouting and functional recovery after cervical lesion in adult primates
Abstract
In rodents, after spinal lesion, neutralizing the neurite growth inhibitor Nogo-A promotes axonal sprouting and functional recovery. To evaluate this treatment in primates, 12 monkeys were subjected to cervical lesion. Recovery of manual dexterity and sprouting of corticospinal axons were enhanced in monkeys treated with Nogo-A-specific antibody as compared to monkeys treated with control antibody.
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Contralesional plasticity as a basis for neurological recovery occurs in several species, including rats, mice, and macaques.
“Contralesional plasticity as a basis for neurological recovery occurs in several species (eg, in rats,11,15,17 mice,12,19,24 and macaques32).”
From Promoting brain remodelling and plasticity for stroke recovery: therapeutic promise and potential pitfalls of clinical translation (2012) · cites this paper as [32]
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References 15 · Cited by 335
- Authors
- Freund, P., Schmidlin, E., Wannier, T., Bloch, J., Mir, A., Schwab, M. E., & Rouiller, E. M.
- Affiliations
- University of Fribourg (CH)
- Centre Hospitalier Universitaire Vaudois (CH)
- Novartis (Switzerland) (CH)
- University of Zurich (CH)
- Corresponding author
- Rouiller, Eric M
- Venue
- Nature Medicine
- Published
- 2006-07-01
- Volume
- 12
- Issue
- 7
- Pages
- 790-792
- ISSN
- 1078-8956 (ISSN-L)
- 1546-170X
- OpenAlex
- W2090518955
- Cited by
- 335
- References
- 15
- Citations by year
- 2026: 4 · 2025: 10 · 2024: 10 · 2023: 8 · 2022: 13 · 2021: 7 · 2020: 11 · 2019: 13 · 2018: 13 · 2017: 17 · 2016: 16 · 2015: 12 · 2014: 24 · 2013: 19 · 2012: 32
- FWCI
- 9.54
- Type
- journal article
- Language
- en
- Update notices
- erratum (2006-10-01)
- Open access
- closed
- Locations
- Nature Medicine (publishedVersion)
- PubMed (publishedVersion)
- reroDoc Digital Library (submittedVersion)
- UCL Discovery (University College London) (submittedVersion)
- IRIS (submittedVersion)
- SERVAL (Université de Lausanne) (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
- Health Sciences › Medicine › Pathology and Forensic Medicine › Spinal Cord Injury Research
- Health Sciences › Medicine › Rehabilitation › Stroke Rehabilitation and Recovery
- Keywords
- Nogo-A, anti-Nogo-A antibody, axonal sprouting, corticospinal tract, spinal cord injury, cervical spinal cord injury, functional recovery, manual dexterity, axon regeneration, primates, monkeys, neuroprotection
- MeSH terms
- Nogo Proteins, Animals, Antibodies, Uterine Cervical Diseases, Cervix Uteri, Disease Models, Animal, Female, Macaca, Motor Activity, Myelin Proteins
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