The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Catching bird flu in a droplet
Open accessAbstract
It is assumed that a timely mass administration of antiviral drugs, backed by quarantines and social distancing, could contain a nascent influenza epidemic at its source, provided that the first clusters of cases were localized within a short time. However, effective routine surveillance may be impossible in countries lacking basic public health resources. For a global containment strategy to be successful, low-cost, easy-to-use handheld units that permit decentralized testing would be vital. Here we present a microfluidic platform that can detect the highly pathogenic avian influenza virus H5N1 in a throat swab sample by using magnetic forces to manipulate a free droplet containing superparamagnetic particles. In a sequential process, the viral RNA is isolated, purified, preconcentrated by 50,000% and subjected to ultrafast real-time RT-PCR. Compared to commercially available tests, the bioassay is equally sensitive and is 440% faster and 2,000–5,000% cheaper.
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Citations
Cites
The origins and the future of microfluidics
Whitesides, G. M. (2006) · Nature · doi:10.1038/nature05058 · Cited by 9,687
Cited by
Microfluidics for medical diagnostics and biosensors
Rivet, C., Lee, H., Hirsch, A., Hamilton, S., & Lu, H. (2011) · Chemical Engineering Science · doi:10.1016/j.ces.2010.08.015 · Cited by 356
Recent Developments in Magnetic Diagnostic Systems
Lee, H., Shin, T.-H., Cheon, J., & Weissleder, R. (2015) · Chemical Reviews · doi:10.1021/cr500698d · Cited by 292
Towards non- and minimally instrumented, microfluidics-based diagnostic devices
Weigl, B., Domingo, G., LaBarre, P., & Gerlach, J. (2008) · Lab on a Chip · doi:10.1039/b811314a · Cited by 259
Metadata
- Authors
- Pipper, J., Inoue, M., Ng, L. F.-P., Neuzil, P., Zhang, Y., & Novak, L.
- Venue
- Nature Medicine
- Published
- 2007-09-23
- Volume
- 13
- Issue
- 10
- Pages
- 1259-1263
- ISSN
- 1078-8956 (ISSN-L)
- 1546-170X
- OpenAlex
- W2063417772
- Cited by
- 218
- References
- 1
- FWCI
- 11.20
- Type
- journal article
- Language
- en
- Open access
- bronze
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