L-type Ca2+ channels provide a major pathway for iron entry into cardiomyocytes in iron-overload cardiomyopathy

Oudit, Gavin Y, Sun, Hui, Trivieri, Maria G, Koch, Sheryl E, Dawood, Fayez, Ackerley, Cameron, Yazdanpanah, Mehrdad, Wilson, Greg J +3 more·2003·Nature Medicine
DOI 10.1038/nm920

Cited by (480)

Items 401–480 of 480

  1. Disorders of Red Cell Production and the Iron-Loading Anemias
    Stefano Rivella · 2011 · Humana Press eBooks
  2. Effect of 3-keto-1,5-bisphosphonates on obese-liver’s rats
    Karima Lahbib, Soufiane Touil · 2016 · Biomedicine & Pharmacotherapy
  3. Unchanneling cardiac iron in humans
    Thomas D. Coates · 2016 · Blood
  4. Hubungan Kadar Feritin dan Ion Kalsium Serum pada Penyandang Thalassemia Mayor Anak yang Mendapat Transfusi Berulang
    Mercy Amelia, Dida Akhmad Gurnida, Lelani Reniarti · 2016 · Sari Pediatri
  5. EFFECT OF CHRONIC IRON OVERLOADING ON CARDIOVASCULAR SYSTEM IN ADULT MALE ALBINO RATS
    Ali Khalil Asalah, Nabil Abass Soliman, Suzan M. M. Moursi, Wessam Taiser · 2017 · Al-Azhar Medical Journal
  6. The effect of different digoxin concentrations on heart tissue and antioxidant status in iron-overloaded rats.
    Beydolah Shahouzehi, Hamidreza Nasri, Yaser Masoumi‐Ardakani · 2018 · Europe PMC (PubMed Central)
  7. Hepcidin Peptide Inhibitor as Cardioprotection by Targeting Oxidative Stress and Inflammation in Type 1 Diabetic
    Motahareh Zeinivand, Arezo Nahavandi, Tourandokht Baluchnejadmojarad, Mehrdad Roghani, Fereshteh Golab · 2019 · International Journal of Peptide Research and Therapeutics
  8. Deposition diseases cardiomyopathy: A review and pooled analysis of pathophysiology, diagnosis and clinical management
    Aref Albakri · 2019 · Trends in Research
  9. Cellular Iron Uptake and Export in Mammals
    Robert R. Crichton · 2009 · Wiley eBooks
  10. Long-Term and Transient Calcium Channel Blockers; A Systematic Review of Their Role in the Management of Cardiomyopathy in Transfusion-Dependent Thalassemia
    Ali Bazı, Alireza Khanahmad, Mohammad Hossein Khazaee‐Nasirabadi, Mohammad Pirouzbakht, Kobra Ghorbani Biregani, Fatemeh Peymaninezhad, Roohollah Mirzaee Khalilabadi · 2025 · Hemoglobin
  11. Correlation between vitamin D level and left ventricular myocardial function demonstrated by speckle tracking echocardiography among β-thalassemia major children
    Eman Abdelrahman, Ahmed Mahmoud Ezzat, Lina Abdelhady Mohammed, Reem Fakher, Samar Mahmoud Elbahy · 2025 · European Journal of Pediatrics
  12. A NIR fluorescence probe for dynamic profiling of lipid droplets in iron overload cardiomyopathy
    Yuzhe Zhao, Dan Zheng, Jiaping Wu, Yong Ye, Xiaolan Meng, Liping Xu, Lintao Zeng, Xiaojun Qin, Xingye Yang · 2026 · Sensors and Actuators B Chemical
  13. Non-transferrin-bound iron uptake by cardiomyocytes
    Qian Guo, LI Yao-zhao, Zhong‐Ming Qian, Christopher Qian · 2026 · Journal of Molecular Medicine
  14. Cardiovascular Function and Treatment in β-Thalassemia Major A Consensus Statement From the American Heart Association Endorsed by the Thalassaemia International Federation, European Society of Cardiology Working Group on Cardiovascular Magnetic Resonance, and Society for Cardiovascular Magnetic Resonance
    Dudley John Pennell, James E. Udelson, Andrew E. Arai, Biykem Bozkurt, Alan R. Cohen, Renzo Galanello, Timothy M. Hoffman, Matthew C. Kiernan, Stamatios Lerakis, Antonio Giulio Piga et al. · 2013
  15. Treatment of Systemic Iron Overload
    John B. Porter · 2016 · Royal Society of Chemistry eBooks
  16. Iron Overload Reduces Cholestrol and Triglyceride Serum of Mice
    Devi Agustin Setiawati, Mas Rizky A. A. Syamsunarno, Pandji Irani Fianza, Nur Atik, Neni Anggraeini, Mohammad Ghozali, Ratu Safitri, Ramdan Panigoro · 2017 · KnE Life Sciences
  17. Iron Absorption
    Nancy C. Andrews · 2006 · Elsevier eBooks
  18. Estimation of Heavy Metal Accumulation in Cardiac Tissue of Gallus gallus Within Polluted Areas
    Bashar Shaker Mahmood · 2023 · E3S Web of Conferences
  19. Nonmitochondrial Metabolic Cardioskeletal Myopathies
    Areeg El‐Gharbawy, Jerry E. Vockley · 2016 · Elsevier eBooks
  20. Management of Comorbidities in Heart Failure
    Justin Adrian Ezekowitz · 2020 · Elsevier eBooks
  21. Post-transcriptional regulation of HFE gene expression
    Rute Martins · 2011 · Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT)
  22. Flavonoid galangin prevents smooth muscle fatigue of pig urinary bladder
    Míriam Dambros, Rik de Jongh, Gommert Anton van Koeveringe, Aalt Bast, Chantal G.M Heijnen, Philip Van Kerrebroeck · 2005 · Journal of Pharmacy and Pharmacology
  23. Thalassaemia Major and the Heart
    John Malcolm Walker · 2013 · Thalassemia Reports
  24. Cellular Iron Uptake and Export in Mammals
    2016 · Wiley eBooks
  25. Ferric carboxymaltose has a higher distribution into myocardium than gadobutrol – a quantitative T1 mapping study in healthy volunteers
    Goran Abdula, Magnus Lundin, Jannike Nickander, Peder Sörensson, Andreas Sigfridsson, Raquel Espregueira Themudo, Martin Ugander · 2023 · medRxiv
  26. Intravenous iron therapy with ferric carboxymaltose results in a rapid and sustained rise in myocardial iron content through a non-canonical pathway: a translational study
    Mayra Vera‐Aviles, S Kabir, Akshay Shah, Paolo Polzella, Y Lim, P Buckley, C Ball, Dorine W. Swinkels, Hanke L. Matlung, Colin Blans et al. · 2024 · medRxiv
  27. Efficacy of Deferasirox in Preventing Complications of Iron Overload in the Iron Overloaded Gerbil
    Rabaa M. Al‐Rousan · 2009
  28. Lack of Transferrin Receptor 1 in the Heart Causes Lethal Cardiomyopathy and Disruption of Mitophagy in Mice
    Wenjing Xu · 2015 · DukeSpace (Duke University)
  29. Mammalian Models of Iron Homeostasis
    Robert S. Britton, Bruce R. Bacon, Robert E. Fleming · 2011 · Humana Press eBooks
  30. Regulation of hepcidin and hemojuvelin expression and their role in iron homeostasis
    Mohamed Salama · 2010 · UCL Discovery (University College London)
  31. Mutations du gène HFE dans le cancer épithélial de l'ovaire
    Sanae Medelci · 2008
  32. From the American Heart Association -Thalassemia Major: A Consensus Statement β Cardiovascular Function and Treatment in
    Timothy M. Hoffman, Matthew C. Kiernan, Antonio Giulio Piga, J. Phillip Pennell, James E. Udelson, Andrew E. Arai, Biykem Bozkurt, Alan R. Cohen · 2014
  33. Iron transport and liver injury in mouse models of hereditary haemochromatosis
    De Lima, Roheeth · 2013 · UWA Profiles and Research Repository (University of Western Australia)
  34. NEW APPROACHES TO THE TREATMENT OF HEMOGLOBINOPATHIES AND THALASSEMIA
    Martin H. Steinberg, Bernard G. Forget, Douglas R. Higgs, David John Weatherall · 2009 · Cambridge University Press eBooks
  35. 2. Iron Metabolism and Iron Overload.
    Yutaka Kohgo · 2011 · Nihon Naika Gakkai Zasshi
  36. 2. Cardiomyopathy and Iron Overload.
    Yoshitaka Iwanaga · 2010 · Nihon Naika Gakkai Zasshi
  37. OXIDATIVE STRESS-INDUCED VASCULAR DYSFUNCTION: MECHANISTIC PERSPECTIVES AND PREVENTIVE STRATEGIES
    Sathish Babu Vasamsetti, Srigiridhar Kotamraju · 2011
  38. cardiomyocyte necrosis as a primary mediator of heart failure
    Hiroyuki Nakayama, Xiongwen Chen, Christopher P. Baines, Raisa Klevitsky, Xiaoying Zhang, Hongyu Zhang, Naser Jaleel, Timothy Edwin Hewett, Jeffrey M. Robbins, Steven R. Houser et al. · 2007
  39. Sobrecarga de ferro em pacientes talassêmicos brasileiros Iron overload in Brazilian thalassemic patients
    Reijâne Alves de Assis, Fernando Uliana Kay, Laércio Alberto Rosemberg, Alexandre Henrique, C Parma, Sandra Regina Loggetto, Aderson da Silva Araújo, Antônio Fabron, Giorgio Roberto Baldanzi, Merula Steagall et al. · 2011
  40. Calcium channels and heavy metals involved in autism
    Tahar Hazzaz Abouamal, Taoufiq Fechtali · 2016
  41. Investigations on potential digenic HAMP (hepcidin) and HFE haemochromatosis gene mutations in the development of iron overload in Irish patients with dilated cardiomyopathy
    Noel Abique Jereza · 2016 · UWE Research Repository (UWE Bristol)
  42. Iron metabolism and laboratory testing for iron status
    Vesna M. Coric · 2016 · Medicinski podmladak
  43. Korelasi Kadar Ion Kalsium Serum dengan Dimensi, Fungsi Sistol dan Diastol Ventrikel Kiri pada Thalassemia Mayor dengan Hemosiderosis
    Ira Furnia, Dwi Prasetyo, Lelani Reniarti · 2016 · Sari Pediatri
  44. Hypertrophic cardiomyopathy or hereditary hemochromatosis? (RCD code: III-2B.3.o)
    Katarzyna Holcman, Paweł Rubiś, Sylwia Wiśniowska‐Śmiałek, Agata Leśniak‐Sobelga, Marta Hlawaty, Magdalena Kostkiewicz, Piotr Stanisław Podolec · 2016 · Journal of Rare Cardiovascular Diseases
  45. Síntese de conjugados desferrioxamina-peptídeo para quelação de ferro lábil mitocondrial
    Elizabeth C. Pastrana · 2016
  46. Iron overload in Brazilian thalassemic patients Sobrecarga de ferro em pacientes talassêmicos brasileiros
    Reijâne Alves de Assis, Fernando Uliana Kay, Laércio Alberto Rosemberg, Alexandre Henrique, C Parma, Sandra Regina Loggetto, Aderson da Silva Araújo, Antônio Fabron, Giorgio Roberto Baldanzi, Merula Steagall et al. · 2011
  47. Impact of the UPR on the expression of relevant genes for cellular iron metabolism
    Susana João Oliveira · 2011
  48. TO STUDY RIGHT VENTRICLE (RV) AND LEFT VENTRICLE ( LV) DYSFUNCTION IN TRANSFUSION DEPENDENT BETA THALASSEMIA CHILDREN AT TERTIARY CARE HOSPITAL IN NORTH WEST RAJASTHAN
    Sandeep Kulhari, Deepak K. Choudhary, Dinesh Choudhary, Himanshu Gupta, Rajneesh Patel, Jaipal Bugalia, Sunil Budania, Pramod Kumar Berwal · 2021 · International Journal of Medical and Biomedical Studies
  49. THE CORRELATION OF RELATIVE WALL THICKNESS, LV MASS/LV MASS INDEX, CARDIAC INDEX AND PCWP IN RELATION TO SERUM FERRITIN IN TRANSFUSION DEPENDENT BETA THALASSMEIC CHILDREN IN NORTH WEST RAJASTHAN
    Sandeep Kulhari, Dinesh Choudhary, Deepak K. Choudhary, Rajneesh Patel, Jaipal Bugalia, Sunil Budania, Pramod Kumar Berwal · 2021 · International Journal of Medical and Biomedical Studies
  50. Blocking effect of ferritin on the ryanodine receptor-isoform 2
    Marta Gaburjáková, Jana Gaburjáková, Eva Krejčíová, Daniel Kosnáč, Helena Kosnáčová, Štefan Nagy, Štefan Polák, Michal Šabo, Michal Trnka, Martin Kopáni · 2021 · Archives of Biochemistry and Biophysics
  51. Iron
    Santosh L. Saraf, Victor R. Gordeuk · 2020 · Elsevier eBooks
  52. JournalScan
    Iqbal Saeed Malik · 2003 · Heart
  53. Molecular dynamics of iron transport in iron disorders
    JuOae Chang · 2019
  54. Speichererkrankungen mit kardialer Manifestation
    Katharina Knoll, Wibke Hengstenberg, Teresa Trenkwalder · 2022 · Kardiologie up2date
  55. Molecular testing in hemochromatosis
    Alberto Piperno, Sara Pelucchi, Raffaella Mariani · 2023 · Elsevier eBooks
  56. Ferroptosis in Cardiovascular Disease
    Jason K. Higa, Nicholas K. Kawasaki, Takashi Matsui · 2023 · Springer eBooks
  57. Amlodipine Therapy in β-Thalassemia Patients: A Systematic Review and Meta-Analysis on Ferritin Levels and Liver MRI T2*
    Aily Aliasgharian, Hossein Karami, Mohammad Zahedi, Reza Jahanshahi, Hossein Bakhtiari-Dovvombaygi, Amirreza Nasirzadeh, Mohammad Naderisorki, Mehrnoush Kosaryan, Ebrahim Salehifar, Mobin Ghazaiean et al. · 2023 · Thalassemia Reports
  58. ภาวะแทรกซอนทางระบบหวใจและหลอดเลอดในผปวยโรคบตาธาลสซเมย
    สุดารัตน์ สถิตธรรมนิตย์ · 2014 · Chulalongkorn Medical Journal
  59. Causality between iron overload and osteoarthritis a Mendelian randomization study
    Liang Yin, Fan Zhang, Rongxiu Bi, Honghao Xu, Shilu Wang · 2024 · Research Square
  60. Pesquisa Multidisciplinar em Saúde - Edição XIII
    Guilherme Barroso L. De Freitas, Hanan Khaled Sleiman · 2024
  61. Geosciences Fina Public Health: Geochemical Variables as Causal Co-Factor Diseases of Unknown Aetiology in the Dynamic and Highly Evolving Environment
    Ibrahim OI, Adams SB, Ibrahim BD, Adebowale SB · 2025 · International Journal of Scientific Research in Science and Technology
  62. Male reproductive phenotype alterations in heterozygous β-globin gene knockout thalassemia (BKO) mice as a model for β-thalassemia patients
    S Aiemongkot, Sukanya Ruschadaariyachat, Chinarat Changsangfa, Khanita Nuamsee, Kittikun Viwatpinyo, Pornthip Chaichompoo, Saovaros Svasti, Kakanang Buranaamnuay · 2025 · Scientific Reports
  63. Advances in Mechanisms of Ferroptosis in Cardiovascular Disease
    婷 李 · 2025 · Advances in Clinical Medicine
  64. Reversion of a RND transporter pseudogene uncovers latent stress resistance in Brucella ovis
    Thomas Kim, Bongjin Hong, Thomas V. O’Halloran, Erika Mathes Lisabeth, Richard R. Neubig, Aretha Fiebig, Sean Crosson · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
  65. Amlodipine as an Adjunct Bacterial Growth Inhibitor in Iron-Overloaded Conditions: In Vitro Effects Against E. Coli
    Selim Mehmet Eke, Arnold Paul C. Cua · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
  66. Metabolic-Electrophysiological Coupling in Heart Failure: from Bidirectional Decoupling to Therapeutic Recoupling
    Hong Yu, Shi-Yao Chang, Xin Tian, Hui Rong Xiao, Jiajia Xu, Cai-li Zhu, Dan Li, Lili Xu · 2025 · Current Heart Failure Reports
  67. The role of brain natriuretic peptide and tissue doppler echocardiography in the management of transfusion dependent thalassaemia patients
    Sunil V. Nair · 2012 · UCL Discovery (University College London)
  68. Régulation de l'hepcidine et le rôle de la lipocaline 2 dans l'homéostasie du fer / Novel insights into the regulation of hepcidin and the role of lipocalin 2 in iron homeostasis
    Hua Huang · 2013
  69. RECENT ADVANCES IN POST-TRANSFUSION IRON OVERLOAD: PATHOPHYSIOLOGY, DIAGNOSIS, AND CURRENT MANAGEMENT PERSPECTIVES
    Masayoshi Kobune, Hiroto Horiguchi, Satoshi Iyama, Akari Goto, M. Yoshida · 2025 · Japanese Journal of Transfusion and Cell Therapy
  70. Acid-sensing ion channel 1a contributes to the calcium/calmodulin-dependent ferroptosis and aggravates intervertebral disc degeneration
    Lu-Ping Zhou, Jia-Qi Wang, Liang Kang, Yan-Xiang Hou, Xu Yan, Chen-Hao Zhao, Chong-Yu Jia, Huaqing Zhang, Renjie Zhang, Cai-Liang Shen · 2026 · Redox Report
  71. A Switch in Iron Delivery Is Critical for Postnatal Kidney Development
    Andong Qiu, Mélanie Viltard, Rong Deng, Jacob Stauber, Aryan Ghotra, Max Werth, Christian Hinze, Andrew Beenken, Tian Huai Shen, Atlas Khan et al. · 2026 · Kidney360
  72. Role of iron regulatory proteins in the regulation of iron metabolism by nitric oxide
    Agnieska Stys · 2011
  73. Mutation HFE et performance physique
    Haidar Djemai · 2018 · theses.fr (ABES)
  74. Effects of vitamin D deficiency and supplementation on myocardial and hepatic iron status and function in children with beta-thalassemia
    Hüseyin Avni Solğun, Mustafa Özay · 2026 · Annals of Hematology
  75. Molecular and cellular determinants of human iron overload cardiomyopathy
    Sayli S. Modak, Lina Greenberg, W. Tom Stump, Akiva E. Greenberg, Nathaniel Huebsch, Michael J. Greenberg · 2026 · Molecular Biology of the Cell
  76. Atrial Fibrillation in Infiltrative Cardiomyopathies: From Atrial Cardiomyopathy Imaging to Targeted Management—A Narrative Review
    Matteo Brusamolino, Francesco Catagnano, M. Lo Monaco, Silvia Malara, Matteo De Carli, Margherita Celeste Licastro, Valentina Rossi, Gaspare Maranzano, Federica Frascaro, Stefano Frittella et al. · 2026 · Medicina
  77. Iron overload cardiomyopathy
    Georgios Papingiotis, Marina Mantzourani, Helen Gogas, Gerasimos S Filippatos, Dimitrios T. Farmakis · 2026 · Heart Failure Reviews
  78. Ferroptosis and NMDA Receptor Activity in Alzheimer's Disease: Implications for Amyloid Pathology and P‐Glycoprotein Regulation
    Jotiram Salunkhe, Vinod G. Ugale · 2026 · Drug Development Research
  79. Pancreatic iron overload as a marker of endocrine complications in transfusion‐dependent thalassaemia: A multicentre study
    Antonella Meloni, Laura Pistoia, Filomena Longo, Paolo Ricchi, Valerio Cecinati, Giuseppe Messina, Lorenza Torti, Elisabetta Corigliano, Michela Zerbini, Stefania Renne et al. · 2026 · British Journal of Haematology
  80. La régulation de l’hepcidine à travers les récepteurs Toll-like dans les macrophages
    Antonio Layoun · 2009