Local gene knockdown in the brain using viral-mediated RNA interference

Hommel, Jonathan D, Sears, Robert M, Georgescu, Dan, Simmons, Diana L, DiLeone, Ralph J·2003·Nature Medicine
DOI 10.1038/nm964

Cited by (334)

Items 201–300 of 334

  1. Promises and Challenges in Developing RNAi as a Research Tool and Therapy for Neurodegenerative Diseases
    Xu‐Gang Xia, Hongxia Zhou, Zuoshang Xu · 2005 · Neurodegenerative Diseases
  2. The protein kinase Mζ network as a bistable switch to store neuronal memory
    Hideaki Ogasawara, Mitsuo Kawato · 2010 · BMC Systems Biology
  3. Striatin-1 is a B subunit of protein phosphatase PP2A that regulates dendritic arborization and spine development in striatal neurons
    Daniel Li, Veronica Musante, Wen‐Liang Zhou, Marina R. Picciotto, Angus Clark Nairn · 2018 · Journal of Biological Chemistry
  4. Pitfalls And Hopes in Down Syndrome Therapeutic Approaches: In the Search for Evidence-Based Treatments
    Mara Dierssen, Jon Ortiz-Abalia, Glòria Arqué, María Martínez de Lagrán, Cristina Fillat · 2006 · Behavior Genetics
  5. Rat genetics: the next episode
    Bart M. G. Smits, Edwin P. J. G. Cuppen · 2006 · Trends in Genetics
  6. Lobotomy of genes: use of RNA interference in Neuroscience
    Torgeir Holen, Charles V. Mobbs · 2004 · Neuroscience
  7. RNAi and microRNAs: From animal models to disease therapy
    Anders Fjose, Øyvind Drivenes · 2006 · Birth Defects Research Part C Embryo Today Reviews
  8. Neuronal firing activity and gene expression changes in the subthalamic nucleus after transplantation of dopamine neurons in hemiparkinsonian rats
    Regina Rumpel, Mesbah Alam, Alexander Klein, Meltem Hohmann, Maike Wesemann, Xingxing Jin, Joachim Kurt Krauss, Kerstin Schwabe, Andreas Ratzka, Claudia Grothe · 2013 · Neurobiology of Disease
  9. The Role of SUMO-Conjugating Enzyme Ubc9 in the Neuroprotection of Isoflurane Preconditioning Against Ischemic Neuronal Injury
    Tong Li, Zhixin Wu, Mingzi Ran, Yu Chen, Lujia Yang, Haopeng Zhang, Lina Zhang, Hailong Dong, Lize Xiong · 2014 · Molecular Neurobiology
  10. Adenovirus-Mediated Silencing of Huntingtin Expression by shRNA
    Bin Huang, Stefan Kochanek · 2005 · Human Gene Therapy
  11. RNA Interference in Neuroscience: Progress and Challenges
    Victor M. Miller, Henry Lauris Paulson, Pedro Gonzalez‐Alegre · 2005 · Cellular and Molecular Neurobiology
  12. RNAi-mediated silencing of leptin gene expression increases cell death in C6 glioblastoma cells
    Russell Brown, Barbara A. Morash, Ehud Ur, Michael Wilkinson · 2005 · Molecular Brain Research
  13. Antisense and RNA interference approaches to target validation in pain research.
    Jens Kurreck · 2004 · PubMed
  14. Specific knock-down of GAD67 in the striatum using naked small interfering RNAs
    Christine Manrique, Valérie Compan, Céline Rosselet, Sylvie D.D. Gustave · 2009 · Journal of Biotechnology
  15. Targeting neurological disease with RNAi
    Paul Lingor, Mathias Bähr · 2007 · Molecular BioSystems
  16. Mineralocorticoid receptor in the NTS stimulates saline intake during fourth ventricular infusions of aldosterone
    Bhuvaneswari Koneru, Chandra Sekhar Bathina, Brandon Cherry, Steve Mifflin · 2013 · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology
  17. Brain distribution of genes related to changes in locomotor activity
    Pasquale Mignogna, Davide Viggiano · 2010 · Physiology & Behavior
  18. Overexpression of hippocampal Ca2+/calmodulin‐dependent protein kinase II improves spatial memory
    David J. Poulsen, D. Standing, K. Bullshields, Kathryn B. Spencer, Paul E. Micevych, Alex M. Babcock · 2006 · Journal of Neuroscience Research
  19. In vivo targeting of subventricular zone astrocytes
    Carlyn Mamber, Joost Verhaagen, Elly M. Hol · 2010 · Progress in Neurobiology
  20. Histone Lysine Demethylase JMJD2D/KDM4D and Family Members Mediate Effects of Chronic Social Defeat Stress on Mouse Hippocampal Neurogenesis and Mood Disorders
    Swati Maitra, Nitin Khandelwal, Scherazad Kootar, Pooja Sant, Salil Saurav Pathak, Sujatha Reddy, P. K. Annapoorna, Upadhyayula Suryanarayana Murty, Sumana Chakravarty, Arvind Kumar · 2020 · Brain Sciences
  21. Silence of the genes
    Oded Singer, Amiel Yanai, Inder M. Verma · 2004 · Proceedings of the National Academy of Sciences
  22. A Functional Role for the Epigenetic Regulator ING1 in Activity-induced Gene Expression in Primary Cortical Neurons
    Laura Jane Leighton, Qiongyi Zhao, Xiang Li, Chuan-Yang Dai, Paul Robert Marshall, Sha Liu, Yi Wang, Esmi Lau Zajaczkowski, Nitin Khandelwal, Arvind Kumar et al. · 2017 · Neuroscience
  23. Microelectrode Array (MEA) Platform for Targeted Neuronal Transfection and Recording
    T. Jain, Jit Muthuswamy · 2008 · IEEE Transactions on Biomedical Engineering
  24. Hippocampal knockdown of α2 nicotinic or M1 muscarinic acetylcholine receptors in C57BL/6J male mice impairs cued fear conditioning
    Yann S. Mineur, Charlotte Ernstsen, Ashraful Islam, Kathrine Lefoli Maibom, Marina R. Picciotto · 2020 · Genes Brain & Behavior
  25. RNA interference as a tool for target validation
    Eduardo Pauls, José A. Esté · 2004 · Drug Discovery Today Technologies
  26. Applying Stereotactic Injection Technique to Study Genetic Effects on Animal Behaviors
    Colleen McSweeney, Yingwei Mao · 2015 · Journal of Visualized Experiments
  27. TREK-2 Mediates the Neuroprotective Effect of Isoflurane Preconditioning Against Acute Cerebral Ischemia in the Rat
    Guangchao Zhao, Lujia Yang, Shiquan Wang, Min Cai, Sisi Sun, Hailong Dong, Lize Xiong · 2018 · Rejuvenation Research
  28. Investigating gene function using mouse models
    Daekee Lee, David W. Threadgill · 2004 · Current Opinion in Genetics & Development
  29. Virus-Delivered RNA Interference in Mouse Brain to Study Addiction-Related Behaviors
    Amy W. Lasek, Nourredine Azouaou · 2009 · Methods in molecular biology
  30. Effects of AAV-mediated knockdown of nNOS and GPx-1 gene expression in rat hippocampus after traumatic brain injury
    Deborah R. Boone, Jeanna M. Leek, Michael T. Falduto, Karen E. O. Torres, Stacy L. Sell, Margaret A. Parsley, Jeremy C. Cowart, Tatsuo Uchida, Maria‐Adelaide Micci, Douglas S. DeWitt et al. · 2017 · PLoS ONE
  31. Decreased HCN2 expression in STN contributes to abnormal high-voltage spindles in the cortex and globus pallidus of freely moving rats
    Yang Chen, Jiarui Zhang, Lei Chen, Shunnan Ge, Ju-Lei Wang, Zhi-Qiang Yan, Dong Jia, Jun-Ling Zhu, Guodong Gao · 2015 · Brain Research
  32. AAV vectors for RNA-based modulation of gene expression
    Olivier Danos · 2008 · Gene Therapy
  33. Gene therapy in rodent amygdala against fear disorders
    Rupshi Mitra, Robert Morris Sapolsky · 2010 · Expert Opinion on Biological Therapy
  34. First Knockdown Gene Expression in Bat (Hipposideros armiger) Brain Mediated by Lentivirus
    Qi Chen, Tengteng Zhu, Gareth Jones, Junpeng Zhang, Yi Sun · 2012 · Molecular Biotechnology
  35. Primate models of schizophrenia: future possibilities
    Arthur A. Simen, Ralph Dileone, Amy F.T. Arnsten · 2009 · Progress in brain research
  36. ΔFosB in the supraoptic nucleus contributes to hyponatremia in rats with cirrhosis
    Joseph Thomas Cunningham, Thekkethil Prashant Nedungadi, Joseph D. Walch, Eric J. Nestler, Helmut B. Gottlieb · 2012 · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology
  37. A novel strategy for cancer gene therapy: RNAi
    Qiuwei Pan, Rong Cai, Xinyuan Liu, Cheng Qian · 2006 · Chinese Science Bulletin
  38. Behavioral pattern separation and cognitive flexibility are enhanced in a mouse model of increased lateral entorhinal cortex-dentate gyrus circuit activity
    S. Yun, I. Soler, Fionya H. Tran, Harley A. Haas, R. Shi, Grace L. Bancroft, Maiko Suarez, Christopher R. de Santis, Ryan P. Reynolds, A. Eisch · 2023 · Frontiers in Behavioral Neuroscience
  39. Therapeutic opportunities of small interfering RNA
    Bhoomika R. Goyal, Bhoomika M. Patel, Mithil K. Soni, Shraddha V. Bhadada · 2009 · Fundamental and Clinical Pharmacology
  40. Regulation of Cell Death and Survival by RNA Interference – The Roles of miRNA and siRNA
    Paul Lingor · 2009 · Springer eBooks
  41. Recent advances in the manipulation of murine gene expression and its utility for the study of human neurological disease
    Chiara Cazzin, C. Ring · 2009 · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
  42. Fibroblast growth factor 13-mediated regulation of medium spiny neuron excitability and cocaine self-administration
    Nolan Michael Dvorak, Jessica Di Re, Tileena E. S. Vasquez, Máté Marosi, Poonam Shah, Yorkiris M. Mármol Contreras, Matteo Bernabucci, Aditya Kumar Singh, Jariatu Stallone, Thomas A. Green et al. · 2023 · Frontiers in Neuroscience
  43. LRG‐1 promotes fat graft survival through the RAB31‐mediated inhibition of hypoxia‐induced apoptosis
    Chiakang Ho, Danning Zheng, Jiaming Sun, Dongsheng Wen, Shan Wu, Yu Li, Ya Gao, Yifan Zhang, Qingfeng Li · 2022 · Journal of Cellular and Molecular Medicine
  44. Modeling Human Anxiety and Depression in Mutant Mice
    Andrew Holmes, John F. Cryan · 2006 · Contemporary clinical neuroscience
  45. Targeted silencing of TrkA expression in rat forebrain neurons via the p75 receptor
    Degu A. Berhanu, Robert Archer Rush · 2008 · Neuroscience
  46. Adeno-associated viral serotypes differentially transduce inhibitory neurons within the rat amygdala
    Christopher A. de Solis, Matthew P. Hosek, Roopashri Holehonnur, A. Ho, Anwesha Banerjee, Jonathan A. Luong, Lauren E. Jones, Dushyant Chaturvedi, Jonathan E. Ploski · 2017 · Brain Research
  47. Viral delivery of shRNA to amygdala neurons leads to neurotoxicity and deficits in Pavlovian fear conditioning
    Christopher A. de Solis, Roopashri Holehonnur, Anwesha Banerjee, Jonathan A. Luong, Srihari K. Lella, Anthony Ho, Bahram Pahlavan, Jonathan E. Ploski · 2015 · Neurobiology of Learning and Memory
  48. Incubation of feeding behavior is regulated by neuromedin U receptor 2 in the paraventricular nucleus of the hypothalamus
    David L. McCue, James M. Kasper, Ara, Jonathan D. Hommel · 2018 · Behavioural Brain Research
  49. Potential application of RNAi for understanding and therapy of neurodegenerative diseases
    I. Schwartz Elena · 2009 · Frontiers in bioscience
  50. RNA de interferencia: biogénesis, mecanismos moleculares y sus aplicaciones en cáncer cervical
    Óscar Peralta-Zaragoza, Víctor Hugo Bermúdez-Morales, Vicente Madrid‐Marina · 2010 · Revista de investigaci�n Cl�nica
  51. Systemic Blockade of Dopamine D2-Like Receptors Increases High-Voltage Spindles in the Globus Pallidus and Motor Cortex of Freely Moving Rats
    Yang Chen, Shunnan Ge, Jiarui Zhang, Lei Chen, Zhi-Qiang Yan, Lijun Heng, Tianzhi Zhao, Weixin Li, Dong Jia, Jun-Ling Zhu et al. · 2013 · PLoS ONE
  52. Intracerebroventricular losartan infusion modulates angiotensin II type 1 receptor expression in the subfornical organ and drinking behaviour in bile‐duct‐ligated rats
    Joseph D. Walch, Flavia Regina Carreno, Joseph Thomas Cunningham · 2012 · Experimental Physiology
  53. C1 Silencing Attenuates Inflammation and Alveolar Bone Resorption in Endodontic Disease
    Yuhui Wang, Wei Chen, Liang Hao, Abigail McVicar, Jinjin Wu, Ning Gao, Yuehua Liu, Yiping Li · 2019 · Journal of Endodontics
  54. GluN2B-mediated regulation of silent synapses for receptor specification and addiction memory
    Hyun Jin Kim, Sangjun Lee, Gyu Hyun Kim, Kibong Sung, Taesik Yoo, Jung Hyun Pyo, Hee-Jung Jo, Sanghyeon Lee, Hyun Young Lee, Jung Hoon Jung et al. · 2025 · Experimental & Molecular Medicine
  55. Reversal of Mdr1b-dependent Multidrug Resistance in a Rat Astrocyte Model by Adenoviral-delivered Short Hairpin RNA
    Lei Chen, Linyu Tian, Tianhua Yang, Xin-Wang Cheng, Hermann Stefan, Dong Zhou · 2008 · Cellular and Molecular Neurobiology
  56. Role of neuropeptide neuromedin U in the nucleus accumbens shell in cocaine self-administration in male rats
    James M. Kasper, Ashley E. Smith, Sierra N. Miller, Ara, William K. Russell, Kathryn A. Cunningham, Jonathan D. Hommel · 2021 · Neuropsychopharmacology
  57. Development of an in vivo adeno-associated virus-mediated siRNA approach to knockdown tyrosine hydroxylase in the lateral retrochiasmatic area of the ovine brain
    Laurence Dufourny, Martine Migaud, Jean‐Claude Thiéry, Benoît Malpaux · 2008 · Journal of Neuroscience Methods
  58. shRNA-Induced Interferon-Stimulated Gene Analysis
    Núria Morral, Scott R. Witting · 2011 · Methods in molecular biology
  59. Molecular and Genetic Approaches for Behavioral Analysis of Protein Function
    David W. Self · 2005 · Biological Psychiatry
  60. New tool for an old problem: can RNAi efficiently resolve the issue of genetic redundancy?
    Lixin Kan, John A. Kessler · 2004 · BioEssays
  61. Peptide-Mediated Delivery of Nucleic Acids into Mammalian Cells
    Sébastien Deshayes, Federica Simeoni, May Catherine Morris, Gilles Divita, F. Heitz · 2007 · Methods in molecular biology
  62. Innate cocaine-seeking vulnerability arising from loss of serotonin-mediated aversive effects of cocaine in rats
    Ying S. Chao, Jeffrey Parrilla-Carrero, Maya Eid, Oliver Paul Culver, Tyler B. Jackson, Rachel Lipat, Makoto Taniguchi, Thomas C. Jhou · 2023 · Cell Reports
  63. Illuminating the Gateway of Gene Silencing: Perspective of RNA Interference Technology in Clinical Therapeutics
    Annu Sindhu, Pooja Arora, Ashok Chaudhury · 2011 · Molecular Biotechnology
  64. Mice in Ecstasy: Advanced Animal Models in the Study of MDMA
    Christophe Pol Stove, Els A. De Letter, Michel H A Piette, Willy E. Lambert · 2010 · Current Pharmaceutical Biotechnology
  65. Inhibition of P-glycoprotein Over-expression by shRNA-mdr1b in Rat Astrocytes
    Lei Chen, Xin-Wang Cheng, Linyu Tian, Tianhua Yang, Stefan Hermann, Dong Zhou · 2008 · Neurochemical Research
  66. A New Approach for Therapeutic Use by RNA Interference in the Brain
    Yukio Akaneya · 2010 · Methods in molecular biology
  67. RIBONUCLEIC ACID INTERFERENCE FOR NEUROLOGICAL DISORDERS
    Thais Federici, Nicholas M. Boulis · 2007 · Neurosurgery
  68. Tyrosine Hydroxylase Knockdown at the Hypothalamic Supramammillary Nucleus Area Induces Obesity and Glucose Intolerance
    Yahong Zhang, Tsung‐Huang Tsai, Michael Ezrokhi, Carl R. Stoelzel, Anthony H. Cincotta · 2023 · Neuroendocrinology
  69. Signaling Pathways in Biliary Epithelial Cells
    M. Fátima Leite, Viviane Aguiar Andrade, Michael H. Nathanson · 2009 · Springer eBooks
  70. Improved Models for Animal Research
    Rolf Sprengel, Leonid G. Eshkind, Jan Georg Hengstler, Ernesto Bockamp · 2008 · Humana Press eBooks
  71. Variability in RNA interference in neuroendocrine PC12 cell lines stably transfected with an shRNA plasmid
    Anne L. Cahill, Johnnie M. Moore, Fatima I. Sabar, Amy B. Harkins · 2007 · Journal of Neuroscience Methods
  72. Exploring the genetic basis of disease using RNA interference
    Stephan Kissler, Luk Van Parijs · 2004 · Expert Review of Molecular Diagnostics
  73. Psychiatric Applications of Viral Vectors
    Thomas A. Green, Eric J. Nestler · 2006 · Elsevier eBooks
  74. Examining the Role of Hypothalamus-Derived Neuromedin-U (NMU) in Bone Remodeling of Rats
    Gabriella Born-Evers, Ashley L. Orr, Elizabeth Q. Hulsey, Maria E. Squire, Julia M. Hum, Lilian Irene Plotkin, Catherine M. Sampson, Jonathan D. Hommel, Jonathan Wayne Lowery · 2023 · Life
  75. Specific knockdown of δ-sarcoglycan gene in C2C12 in vitro causes post-translational loss of other sarcoglycans without mechanical stress
    Michiyo Honda, Mari Hosoda, Nobuyuki Kanzawa, Takahide Tsuchiya, Teruhiko Toyo‐oka · 2008 · Molecular and Cellular Biochemistry
  76. RNAi as a novel therapeutic platform technology for oncological solutions
    Gowhar Shafi, Kaiser Jamil, Atya Kapley, Hemant J. Purohit, Mohana Vamsy · 2009 · Biotechnology and Molecular Biology Reviews
  77. Optogenetic manipulation of Ventral Tegmental Area (VTA) Neurons that project to the Nucleus Accumbens (NAc) and medial Prefrontal Cortex (mPFC)
    Jessica J. Walsh, Jessica J. Walsh, Dipesh Chaudhury, Allyson K. Friedman, Barbara Juarez, Stacy M. Ku, Mary Kay Lobo, Ming‐Hu Han · 2012 · Protocol Exchange
  78. Transgenic RNA Interference to Investigate Gene Function in the Mouse
    Tilo Kunath · 2008 · Methods in molecular biology
  79. Genetics as a Tool in Neurology
    Dennis R. Johnson, Fuki Marie Hisama · 2007 · Elsevier eBooks
  80. Presynaptic Mechanisms in Plasticity and Memory
    Craig M. Powell, Pablo E. Castillo · 2008 · Elsevier eBooks
  81. Vector-Mediated and Viral Delivery of Short Hairpin RNAs
    Henry Fechner, Jens Kurreck · 2008 · Royal Society of Chemistry eBooks
  82. In Vivo Gene Silencing by Virally Delivered MicroRNA
    Eugenia V. Gurevich, Mohamed Rafiuddin Ahmed, Yonatan T. Carl · 2013 · Neuromethods
  83. RNAi Therapeutic Potentials and Prospects in CNS Disease
    Kyoungjoo Cho, Gyung Whan Kim · 2016 · InTech eBooks
  84. RNAi and Applications in Neurobiology
    Josef T. Kittler, Stephen J. Moss · 2006 · CRC Press eBooks
  85. Use of Viral Vectors to Influence Behavior
    Sergei A. Musatov, Michael G. Kaplitt, Donald W. Pfaff, Sonoko Ogawa · 2006 · Elsevier eBooks
  86. Murine Models of Alcoholism
    Chris Downing, Beth Bennett, Thomas E. Johnson · 2007 · Humana Press eBooks
  87. Signaling pathways in biliary epithelial cells
    M. Fátima Leite, Mateus T. Guerra, Viviane Aguiar Andrade, Michael H. Nathanson · 2015
  88. To investigate the association of serum osteocalcin with cognitive functional status in patients with type 2 diabetes: A systematic review with meta-analysis
    Hao Liu, Xia He, Li Tang, Yan Deng, Lu Jing Yan · 2023 · Medicine
  89. Gene therapy of virus replication with RNAi
    Takanori Yokota · 2005 · Uirusu
  90. Targeting Neurological Disease with siRNA
    Jan Christoph Koch, Mathias Bähr, Paul Lingor · 2011 · Neuromethods
  91. Huntingtin lowering therapeutics
    Neil Aronin M. D, Miguel Sena‐Esteves, Anastasia Khvorova, Marian DiFiglia, Michael Brodsky · 2024 · Elsevier eBooks
  92. Genome-Wide RNA Interference Screening
    Megan L. Goodall, Jeffrey P. MacKeigan · 2012 · Elsevier eBooks
  93. RNA Interference: The Next Gene‐Targeted Medicine
    Andrew V. Oleinikov, Matthew D. Gray · 2010 · Pharmaceutical Sciences Encyclopedia
  94. The Role of Lateral Hypothalamic Neuropeptides in Drug Addiction and Feeding Behavior
    Dan Georgescu · 2004
  95. Small Interfering Ribonucleic Acids
    Laura M. Gianellini, Juergen Moll · 2007 · Elsevier eBooks
  96. Signaling Pathways in Biliary Epithelial Cells
    M. Fátima Leite, Michael H. Nathanson · 2005 · Springer eBooks
  97. Behavioral consequences of calcium/calmodulin kinase II inhibition in rats
    Elizabeth Ann. Schwartz · 2005 · Montana State University ScholarWorks (Montana State University)
  98. RNA Interference Mechanisms and Therapeutic Applications
    Anne E. Lamers, Dominique P.V. de Kleijn · 2006 · Springer eBooks
  99. Molecular mechanisms in low-serotonin induced mood and anxiety disorders.
    Lee Tran · 2010
  100. Efecto de dosis génica de DYRK1A (minibrain) en el proceso neurodegenerativo asociado al envejecimiento: Un estudio con ratones genéticamente modificados
    María Martínez de Lagrán Cabredo · 2006 · LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas)