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Cited by 332

The DOI matches its Crossref record; 27 of the 27 references it cites were found in a registry or an index.

Nanofibrous biologic laminates replicate the form and function of the annulus fibrosus

Open access
Nerurkar, Nandan L., Baker, Brendon M., Sen, Sounok, Wible, Emily E., Elliott, Dawn M., Mauck, Robert L.·2009·Nature Materials
DOI 10.1038/nmat2558
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Abstract

Successful engineering of load-bearing tissues requires recapitulation of their complex mechanical functions. Given the intimate relationship between function and form, biomimetic materials that replicate anatomic form are of great interest for tissue engineering applications. However, for complex tissues such as the annulus fibrosus, scaffolds have failed to capture their multi-scale structural hierarchy. Consequently, engineered tissues have yet to reach functional equivalence with their native counterparts. Here we present a novel strategy for annulus fibrosus tissue engineering that replicates this hierarchy with anisotropic nanofibrous laminates seeded with mesenchymal stem cells. These scaffolds directed the deposition of organized, collagen-rich extracellular matrix that mimicked the angle-ply, multi-lamellar architecture and achieved mechanical parity with native tissue after 10 weeks of in vitro culture. Further, we identified a novel role for inter-lamellar shearing in reinforcing the tensile response of biologic laminates, a mechanism that has not previously been considered for these tissues.

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Metadata

Authors
Nerurkar, N. L., Baker, B. M., Sen, S., Wible, E. E., Elliott, D. M., & Mauck, R. L.
Venue
Nature Materials
Publisher
Springer Science and Business Media LLC
Published
2009-10-25
Volume
8
Issue
12
Pages
986-992
ISSN
  • 1476-1122 (ISSN-L)
  • 1476-4660
DOI
10.1038/nmat2558
OpenAlex
W2004991594
Cited by
332
References
27
FWCI
11.21
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: Nanofibrous biologic laminates replicate the form and function of the annulus fibrosus. https://app.cochat.ai/papers/10.1038/nmat2558
The paper
Nerurkar, N. L., Baker, B. M., Sen, S., Wible, E. E., Elliott, D. M., & Mauck, R. L. (2009). Nanofibrous biologic laminates replicate the form and function of the annulus fibrosus. Nature Materials. https://doi.org/10.1038/nmat2558

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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