The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Energy landscapes and functions of supramolecular systems
Open accessAbstract
By means of two supramolecular systems - peptide amphiphiles engaged in hydrogen-bonded β-sheets, and chromophore amphiphiles driven to assemble by π-orbital overlaps - we show that the minima in the energy landscapes of supramolecular systems are defined by electrostatic repulsion and the ability of the dominant attractive forces to trap molecules in thermodynamically unfavourable configurations. These competing interactions can be selectively switched on and off, with the order of doing so determining the position of the final product in the energy landscape. Within the same energy landscape, the peptide-amphiphile system forms a thermodynamically favoured product characterized by long bundled fibres that promote biological cell adhesion and survival, and a metastable product characterized by short monodisperse fibres that interfere with adhesion and can lead to cell death. Our findings suggest that, in supramolecular systems, function and energy landscape are linked, superseding the more traditional connection between molecular design and function.
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Cites
Autocatalytic self-replicating micelles as models for prebiotic structures
Bachmann, P. A., Luisi, P. L., & Lang, J. (1992) · Nature · doi:10.1038/357057a0 · Cited by 494
Pathway Selection in Peptide Amphiphile Assembly
Korevaar, P. A., Newcomb, C. J., Meijer, E. W., & Stupp, S. I. (2014) · Journal of the American Chemical Society · doi:10.1021/ja503882s · Cited by 265
Self-citation
Cited by
Non-equilibrium supramolecular polymerization
Sorrenti, A., Leira-Iglesias, J., Markvoort, A. J., de Greef, T. F. A., & Hermans, T. M. (2017) · Chemical Society Reviews · doi:10.1039/c7cs00121e · Cited by 574
Dissipative out-of-equilibrium assembly of man-made supramolecular materials
van Rossum, S. A. P., Tena-Solsona, M., van Esch, J. H., Eelkema, R., & Boekhoven, J. (2017) · Chemical Society Reviews · doi:10.1039/c7cs00246g · Cited by 561
Self-citationEdelbrock, A. N., Àlvarez, Z., Simkin, D., Fyrner, T., Chin, S. M., Sato, K., Kiskinis, E., & Stupp, S. I. (2018) · Nano Letters · doi:10.1021/acs.nanolett.8b02317 · Cited by 103
Self-citationChiral Recognition of Lipid Bilayer Membranes by Supramolecular Assemblies of Peptide Amphiphiles
Sato, K., Ji, W., Álvarez, Z., Palmer, L. C., & Stupp, S. I. (2019) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.9b00553 · Cited by 35
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Metadata
- Authors
- Tantakitti, F., Boekhoven, J., Wang, X., Kazantsev, R. V., Yu, T., Li, J., Zhuang, E., Zandi, R., Ortony, J. H., Newcomb, C. J., Palmer, L. C., Shekhawat, G. S., de la Cruz, M. O., Schatz, G. C., & Stupp, S. I.
- Venue
- Nature Materials
- Published
- 2016-01-18
- Volume
- 15
- Issue
- 4
- Pages
- 469-476
- ISSN
- 1476-1122 (ISSN-L)
- 1476-4660
- OpenAlex
- W2255780632
- Cited by
- 464
- References
- 2
- FWCI
- 21.55
- Type
- journal article
- Language
- en
- Open access
- green
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- Tantakitti, F., Boekhoven, J., Wang, X., Kazantsev, R. V., Yu, T., Li, J., Zhuang, E., Zandi, R., Ortony, J. H., Newcomb, C. J., Palmer, L. C., Shekhawat, G. S., de la Cruz, M. O., Schatz, G. C., & Stupp, S. I. (2016). Energy landscapes and functions of supramolecular systems. Nature Materials. https://doi.org/10.1038/nmat4538
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