Probing cellular events, one quantum dot at a time
Abstract
Monitoring the behavior of single molecules in living cells is a powerful approach to investigate the details of cellular processes. Owing to their optical, chemical and biofunctional properties, semiconductor quantum dot (QD) probes promise to be tools of choice in this endeavor. Here we review recent advances that allow ever more controlled experiments at the single-nanoparticle level in live cells. Several examples, related to membrane dynamics, cell signaling or intracellular transport, illustrate how single QD tracking can be readily used to decipher complex biological processes and address key concepts that underlie cellular organization and dynamics.
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The surface mobility of neurotransmitter receptors is dynamically regulated to control synaptic activity and is a key component underlying plasticity at nerve terminals.
“The surface mobility of neurotransmitter receptors is dynamically regulated to control synaptic activity and is emerging as another key component underlying plasticity at nerve terminals.40,53,54”
From The autism and schizophrenia associated gene CYFIP1 is critical for the maintenance of dendritic complexity and the stabilization of mature spines (2014) · cites this paper as [54]
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An overview of nanoparticles commonly used in fluorescent bioimaging
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“Hyper‐bright” Near‐Infrared Emitting Fluorescent Organic Nanoparticles for Single Particle Tracking
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- Authors
- Pinaud, F., Clarke, S., Sittner, A., & Dahan, M.
- Affiliations
- Centre National de la Recherche Scientifique (FR)
- Corresponding author
- Dahan, Maxime
- Venue
- Nature Methods
- Published
- 2010-03-30
- Volume
- 7
- Issue
- 4
- Pages
- 275-285
- ISSN
- 1548-7091 (ISSN-L)
- 1548-7105
- OpenAlex
- W2028890857
- Cited by
- 401
- References
- 1
- Citations by year
- 2026: 2 · 2025: 7 · 2024: 8 · 2023: 8 · 2022: 11 · 2021: 17 · 2020: 25 · 2019: 25 · 2018: 31 · 2017: 19 · 2016: 25 · 2015: 38 · 2014: 48 · 2013: 41 · 2012: 40
- FWCI
- 2.12
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Methods (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Materials Science › Materials Chemistry › Quantum Dots Synthesis And Properties
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biophysics › Advanced Fluorescence Microscopy Techniques
- Physical Sciences › Physics and Astronomy › Atomic and Molecular Physics, and Optics › Semiconductor Quantum Structures and Devices
- Keywords
- semiconductor quantum dots, single-particle tracking, live-cell imaging, single-molecule tracking, membrane dynamics, signal transduction, intracellular transport, cell organization, fluorescent probes
- MeSH terms
- Cell Physiological Phenomena, Cytological Techniques, Quantum Dots
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