Fused cerebral organoids model interactions between brain regions

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1. Seeing clearly with CLARI-O: a window into cellular architecture, interactions, and morphology of organoid models
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2. A Little Bit of Guidance: Mini Brains on Their Route to Adolescence
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3. Establishment of the microscope incubation system and its application in evaluating tumor treatment effects through real-time live cellular imaging
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4. The Assembly of Miniaturized Droplets toward Functional Architectures
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5. Prediction and Identification of Signature Genes Expressed in Different Brain Regions through RNA-Seq Data Analysis
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6. Morphogenetic Designs, and Disease Models in Central Nervous System Organoids
   Minsung Bock, Sung Jun Hong, Songzi Zhang, Yerin Yu, Somin Lee, Hae-Eun Shin, Byung Hyune Choi, Inbo Han · 2024 · International Journal of Molecular Sciences
7. Microgels Enable iPSCs to Assemble, Expand, and Differentiate Into Organoids—From Sizable to High‐Throughput
   Laura Klasen, Matthias Mork, Ramin Nasehi, Vasudha Turuvekere Krishnamurthy, Kira Zeevaert, Aaron Babendreyer, Jacopo Di Russo, Wolfgang Wagner, Laura De Laporte · 2026 · Advanced Materials
8. Building a Better Beast: Enhancing the Minds of Animals
   Eric Schneider, Veljko Dubljević · 2022 · Advances in neuroethics
9. Cellular and molecular neurobiology of autism spectrum disorder
   Gareth Chapman, Irene Antony, Mishka Narasimhan, Renata Shen, Rachel Elman, Kristen L. Kroll · 2022 · Elsevier eBooks
10. How might we build limbs in vitro informed by the modular aspects and tissue-dependency in limb development?
    Rio Tsutsumi, Mototsugu Eiraku · 2023 · Frontiers in Cell and Developmental Biology
11. Mechanisms of tangential migration of interneurons in the developing forebrain
    Fanny Lepiemme, Carla G. Silva, Laurent Nguyen · 2020 · Elsevier eBooks
12. Spatially defined axonal guidance in neural organoids with micropatterned microfluidic channels
    Ariana C Cisneros, Maryam Moarefian, Jens Duru, Katherine Karinicolas, Talia Goodman, Zaira Gonzalez, Anton Zatserklyaniy, Sawyer McKenna, Asia Anderson, Noah Williams et al. · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
13. ZIKV Teratogenesis: Clinical Findings in Humans, Mechanisms and Experimental Models
    Fabiele Baldino Russo, Carmen Melo Toledo, Fernando Ribeiro Tocantins, Giovanna V. Souza, Patrícia Cristina Baleeiro Beltrão-Braga · 2022 · Frontiers in Virology
14. Physiological oxygen measurements in vitro-Schrödinger’s cat in 3D cell biology
    Eric Gottwald, Christoph Grün, Cordula Nies, Gregor Liebsch · 2023 · Frontiers in Bioengineering and Biotechnology
15. Approaches in vivo and in vitro for solving the vascularization issue of brain organoids
    Tianyi Li · 2025 · Highlights in Science Engineering and Technology
16. Advances of organoids in the study of nervous system diseases: A narrative review
    Zhenyu Zhou, Zhen Qi, Chengxu Lei, Yi Dong, Junze Zhang, Yutong Liu, Yuanli Zhao, Shihao He · 2025 · Advanced technology in neuroscience .
17. Exploring roles of neuroglobin in oxygen homeostasis and neurodevelopment based on human cerebral organoid models
    Yuan‐Hsuan Liu, Meng-Ting Chung, Hsi-Chieh Lin, Hsin-Lei Lin, Hsuan Lin, Ya-Jen Cheng, Hsiao-Mei Wu, Tzyy‐Wen Chiou, Yi‐Chung Tung · 2026 · iScience
18. Modeling the lung‒brain axis in critical illness: Multifactorial crosstalk through organoids and organ‐on‐a‐chip system
    Wanyi Zhang, Ting Wei Wang, Mengying Yao, Longxiang Su, Lixin Xie, Pan Pan · 2026 · Open Research (University of Surrey)
19. Disease modelling with in vitro vascularised organoids
    Chloe Kan, Lin Liu, Ryohichi Sugimura · 2026 · Disease Models & Mechanisms
20. Cerebral organoids: a promising model in cellular technologies
    Т. А. Шнайдер · 2018 · Vavilov Journal of Genetics and Breeding
21. Recent advances in brain organoids: a comprehensive review of the last eight years
    You-Ran Xiong, Ting‐Hua Wang · 2024 · New discovery.
22. A new protocol for the development of organoids based on molecular mechanisms in the developing newborn rat brain: Prospective applications in the study of Alzheimer’s disease
    Eleni Tzekaki, Chryssa Bekiari, Αnastasia A. Pantazaki, Maria P. Tsantarliotou, Magda Tsolaki, Sophia N. Lavrentiadou · 2025 · Journal of Neuroscience Methods
23. Human neurogenesis
    Aparna Bhaduri, Madeline G. Andrews, Arnold R. Kriegstein · 2020 · Elsevier eBooks
24. Light-Induced Differentiation of Forebrain Organoids by NVOC-SAG
    Ryuji Misawa, Yoshiho Ikeuchi · 2021 · Methods in molecular biology
25. Harnessing the Power of Stem Cell Models to Study Shared Genetic Variants in Congenital Heart Diseases and Neurodevelopmental Disorders
    Xuyao Chang, Mingxia Gu, Jason H. Tchieu · 2022 · Cells
26. iPS cell technologies toward overcoming neurological diseases
    Toshiya Kimura, Keiko Muguruma · 2022 · Folia Pharmacologica Japonica
27. Generating Human Pluripotent Stem Cell-Derived Neural AssemBloids™ to Model Interneuron Migration and Immune Cell Interactions
    Negin Imani Farahani, Jeanne Chan, Adam Añonuevo, Leon H. Chew, Erin Knock · 2023 · Neuromethods
28. Telencephalic organoids as model systems to study cortical development and diseases
    Woo Sub Yang, Ferdi Rıdvan Kiral, In‐Hyun Park · 2024 · Organoid
29. Functional Exploration of Epilepsy Genes in Patient-Derived Cells
    Maria Celeste Varela, Ranmal Aloka Samarasinghe, Jack M. Parent · 2024 · Oxford University Press eBooks
30. Research progress of brain organoids in the field of diabetes
    Ying Su, Aimei Liu, Hongguang Chen, Qingjie Chen, Bo Zhao, Runze Gao, Kangwei Zhang, Tie Peng, Zhenwang Zhang, Changhan Ouyang et al. · 2024 · Molecular Brain
31. Des organoïdes cérébraux pour la compréhension et la thérapie des maladies génétiques rares avec troubles neurodéveloppementaux
    Fatima El It, Laurence Olivier Faivre, Christel Thauvin‐Robinet, Antonio Vitobello, Laurence Duplomb · 2024 · médecine/sciences
32. Tourette syndrome
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33. Generating Inhibitory Neuron Diversity through Morphogenic Patterning: From in vivo Studies to New in vitro Models
    Tanya Deutsch Guerrero, Chloé Borowski, Julien Ferent · 2025 · Developmental Neuroscience
34. Pluripotent Stem Cell Based Cultures to Study Key Aspects of Human Cerebral Cortex Development
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35. Modeling Down Syndrome Neurodevelopment with Dosage Compensation
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36. Induced pluripotent stem cells as models of human neurodevelopmental disorders
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37. Cerebral Organoids: A Model of Brain Development
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38. Use of iPSC-derived brain organoids to study human brain evolution
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39. 15. Humane Hirnorganoide: Die deutsche Rechtslage
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40. Current progress in brain organoid technology
    Wei PANG, YanTong LIU, Yangfei Xiang · 2022 · Scientia Sinica Vitae
41. Brain Organoids as a Model to Study Zika Virus and SARS-CoV-2 Infections
    Veronica Krenn, Luiza M. Higa, Patricia Pestana Garcez · 2022 · Neuromethods
42. Organoids-on-a-chip
    Yaqing WANG, Tingting Tao, Jianhua Qin · 2022 · Scientia Sinica Vitae
43. Potentiel des organoïdes cérébraux comme modèles d’étude des neuropathologies chez les animaux domestiques
    Bertrand Pain, Noémie Aurine, Théo La Rosa, Camille Baquerre, Muriel Coulpier · 2023 · INRAE Productions Animales
44. Self-organized anteroposterior regionalization of early midbrain and hindbrain/spinal cords using micropatterned human pluripotent stem cells
    Tianfa Xie, Han Jiang, Lauren E. Brown, ChangHui Pak, Yubing Sun · 2026 · SLAS TECHNOLOGY
45. Early Neuronal Differentiation/patterning of the Human Pallium, Modeling by in Vitro Systems, and Disruption in Developmental Disorders
    Soraya Scuderi, Alexandre Jourdon, Flora Maria Vaccarino · 2023 · Wiley eBooks
46. An interface of genetically engineered human forebrain assembloids and polymeric nanofiber scaffolds for multiscale profiling of interneuron migration disorders
    Riya Rauthan, Vishal Bharti, Atharva Agashe, Praveen Singh, Harrison M. York, Amrinder S. Nain, Senthil Arumugam, Debojyoti Chakraborty · 2024 · Research Square
47. Early Neurodevelopmental Defects in Huntington’s Disease are Driven by Choroid Plexus Overgrowth and Altered Paracrine Signaling
    Karolina Świtońska-Kurkowska, Jakub Kubiś, Joanna Delimata-Raczek, Bart Krist, Magda Surdyka, Żaneta Kalinowska-Pośka, Piotr Piasecki, Luiza Handschuh, Jan Podkowiński, Magdalena Rakoczy et al. · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
48. Building Neurovascular tissue from autologous blood for modeling brain activity
    Rhythm Arora, Alka Bhardwaj, Naresh Kumar Panda, Sanhita Sinharay, Jaimanti Bandhu Bakshi, Ramandeep Singh Virk, Sanjay Kumar Munjal, N. Banumathy, Gyanaranjan Nayak, Sourabha Kumar Patro et al. · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
49. Mapping the temporal and functional landscape of Sonic Hedgehog signaling reveals new insights into early human forebrain development
    Veranika Panasenkava, Jules Garreau, Hélène Guyodo, Farah Diab, Ariane Mahieux, Wilfrid Carré, Yann Verrès, Emmanuelle Jullion, Sylvie Odent, Christèle Dubourg et al. · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
50. High-density extracellular recordings from the interior of intact brain organoids enable automated high-throughput functional assay
    Fan Wu, Cuthbert Steadman, Liam P. Argent, Brian G. Jamieson, Shamsudheen Karuthedath Vellarikkal, Alex M. Tamburino, Iya G. Khalil, Vanessa M. Peterson, Matthew E Kennedy, Rebecca S. Mathew et al. · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
51. Microfluidic gradients create a stem cell model of the human central nervous system
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52. Transporter×Circuit Specificity Paradigm: Integration Pathway of Cross-BBB Transporter Heterogeneity and Neural Circuit Precision Delivery
    Weixiang Zhou, Zhichao Wang, Weihao Wang, Jingyi Yang, Weiyan Qi, Hanmei Xu, Jianpeng Xue · 2026 · SSRN Electronic Journal
53. Systems Biology Perspectives for Studying Neurodevelopmental Events
    Elodie Mathieux, Marco Antonio Mendoza-Parra · 2019 · IntechOpen eBooks
54. From Zero to Neuro-Reprogramming: Innovations in Translational Neuroregenerative Medicine
    Ahmad Galuta, Eve Chung Tsai · 2019 · University of Ottawa Journal of Medicine
55. Brain organoids as a model system for human neurodevelopment in health and disease
    Orly Reiner, Eyal Karzbrun · 2020 · Elsevier eBooks
56. Molecular mechanisms underlying malformations of cortical development
    Sabrina Oishi · 2020 · The University of Queensland
57. TLR4-Mediated Neuroinflammation in Human Induced Pluripotent Stem Cells and Cerebral Organoids
    Massimiliano De Paola · 2020 · Progress in inflammation research
58. Complementing Subarachnoid Hemorrhage
    Bart J. van Dijk · 2020
59. Engineering micro-perfusable scaffolds for MesoPhysiological Systems using projection Micro-StereoLithography
    Pierre Sphabmixay · 2020 · DSpace@MIT (Massachusetts Institute of Technology)
60. 3D organotypic cell structures for drug development and Microorganism-Host interaction research
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61. Multi‐Tissue Organoid Engineering: Bio‐assembling Macro‐Scale, Lumenized Airway Tubes of Defined Shape via Multi‐Organoid Patterning and Fusion (Adv. Sci. 9/2021)
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62. Human induced pluripotent stem cell-based studies; a new route toward modeling autism spectrum disorders
    Gilles Maussion, Cecilia Rocha, Luisa S.B. Pimentel, Lenore K. Beitel, Thomas M. Durcan · 2021 · Elsevier eBooks
63. Investigating the pathophysiology of anorexia nervosa using induced pluripotent stem cells
    Gilles Maussion, Iveta Demirova, Philip A. P. M. Gorwood, Nicolás Ramoz · 2021 · Elsevier eBooks
64. Pluripotent stem cell–derived brain-region-specific organoids
    Phuong Trang Nguyen, Hongjun Song, Guo‐li Ming · 2021 · Elsevier eBooks
65. The construction of 3D cognitive networks from iPSCs through precise spatiotemporal specification
    Kai-Kei Miu, Dandan Cao, Zhangting Wang, Suyu Hao, Wai‐Yee Chan · 2021 · Elsevier eBooks
66. BRAIN ORGANOIDS - A REVIEW
    2021 · International Journal of Biology Pharmacy and Allied Sciences
67. Classics never get old: neurotransmitters shape human cortical interneuron migration
    Antonela Bonafina, Míriam Javier‐Torrent, Laurent Nguyen · 2021 · The EMBO Journal
68. Human induced pluripotent stem cell modeling of neurofibromatosis type 1
    Sarah V. Schurr, Kelly A. Hartigan, David H. Gutmann · 2021 · Elsevier eBooks
69. Induced pluripotent stem cell–derived neural stem cells
    Lars Roll, Andréas Faissner · 2021 · Elsevier eBooks
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71. Toward Construction of a Brain in a Dish: Cultured Neurons, Brain Organoids, and Beyond
    Yoshiho Ikeuchi · 2021 · The Brain & Neural Networks
72. Tourette syndrome
    Liana Fasching, Melanie V. Brady, Michael H. Bloch, Paul J. Lombroso, Flora Maria Vaccarino · 2020 · Elsevier eBooks
73. Toward Understanding Neurodegeneration Using Brain Organoids
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74. Applications of Neural Organoids in Neurodevelopment and Regenerative Medicine
    Jing Gong, Jiahui Kang, Minghui Li, Xiao Liu, Jun Yang, Haiwei Xu · 2022 · Biomedical engineering
75. Faculty Opinions recommendation of Generation and assembly of human brain region-specific three-dimensional cultures.
    Alysson Renato Muotri · 2019 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
76. Faculty Opinions recommendation of Individual brain organoids reproducibly form cell diversity of the human cerebral cortex.
    Vijay Kumar Tiwari, Jonathan McComb, Deborah P. Lavin · 2019 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
77. Faculty Opinions recommendation of Translational potential of human brain organoids.
    Alysson Renato Muotri · 2019 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
78. Faculty Opinions recommendation of Specification of positional identity in forebrain organoids.
    Arnold R. Kriegstein · 2019 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
79. Faculty Opinions recommendation of hESC-Derived Thalamic Organoids Form Reciprocal Projections When Fused with Cortical Organoids.
    Alysson Renato Muotri · 2019 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
80. Faculty Opinions recommendation of Applications of human brain organoids to clinical problems.
    Alysson Renato Muotri · 2019 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
81. Faculty Opinions recommendation of Individual brain organoids reproducibly form cell diversity of the human cerebral cortex.
    Vı́ctor Borrell · 2019 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
82. Gene edited fluorescent cerebral organoids to study human brain function and disease
    Lisa Bachmann, Lucia Gallego Villarejo, Natalie Heinen, David Marks, Thorsten Müller · 2020 · bioRxiv (Cold Spring Harbor Laboratory)
83. Generación de nuevos modelos y búsqueda de modificadores para el Síndrome de Dravet en Drosophila Melanogaster
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84. iPSC-derived models of autism
    Gilles Maussion, Cecilia Rocha, Luisa S.B. Pimentel, Thomas M. Durcan · 2022 · Elsevier eBooks
85. Effective and sustainable patient participation
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86. Interdisciplinary approaches to brain organoid biology
    Tomoki Kodera, Fumitaka Osakada · 2022 · Folia Pharmacologica Japonica
87. Generation of Projection Neuron Diversity in the Neocortex
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88. Cortical Neuron Migration in Health and Disease
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89. Understanding Human Forebrain Morphogenesis and Early Expansion Using Organoids
    Magdalena A. Sutcliffe, Madeline A. Lancaster · 2023 · Wiley eBooks
90. Applications and prospect of human brain organoids in neurodegenerative diseases
    Hongye Yan, Huimin Wang, Wendiao Zhang, Jiamei Jiang, Juan Wan, Zhenhong Xu, Zhenyu Yang, Beisha Tang, Qingtuan Meng · 2023 · Scientia Sinica Vitae
91. Natur und Immunmechanismen psychischer Erkrankungen
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92. Additional file 1 of Brain organoid: a 3D technology for investigating cellular composition and interactions in human neurological development and disease models in vitro
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93. Association between human blood metabolites and cerebral cortex architecture: evidence from a Mendelian randomization study
    Zongzhi Jiang, Yining Sun, Songyan Liu · 2024 · Frontiers in Neurology
94. Engineering Nanocellulose-based Matrices for 3D Cell Cultures
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95. Detailed protocol for the generation of polarized cortical assembloids (polCA)
    Camilla Bosone, Sara E. Barilà, Veronica Krenn, Juergen A. Knoblich · 2024 · Research Square
96. Human Cerebral Organoids in Pillar/Perfusion Plates for Modeling Neurodevelopmental Disorders
    Prabha Acharya · 2024
97. Advancements and prospects in human organoid phenomics: a comprehensive review
    Wendiao Zhang, XingYu YIN, HaiXia GU, ShuQi HUANG, Chao Chen · 2024 · Scientia Sinica Vitae
98. Current Trends in Brain Organoid Research: Scientific Opportunities and Challenges
    Michael J. Borrett, Rahel Kästli · 2024 · Collaborative bioethics
99. Identification of neuron-glia signaling feedback in human schizophrenia using patient-derived, mix-and-match forebrain assembloids
    Eunjee Kim, Yunhee Kim, Soojung Hong, Inha Kim, Juhee Lee, Kwanghwan Lee, Myungmo An, Sung‐Yon Kim, Sanguk Kim, Kunyoo Shin · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
100. Identification of neurodevelopmental organization of the cell populations of juvenile Huntington’s disease using dorso-ventral HD organoids and HD mouse embryos
     Karolina Świtońska-Kurkowska, Jakub Kubiś, Joanna Delimata-Raczek, Bart Krist, Magda Surdyka, Żaneta Kalinowska-Pośka, Piotr Piasecki, Luiza Handschuh, Jan Podkowiński, Magdalena Rakoczy et al. · 2025 · eLife