SpatialDE: identification of spatially variable genes

Svensson, Valentine, Teichmann, Sarah A, Stegle, Oliver·2018·Nature Methods

Cited by (710)

Items 501–600 of 710

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  3. Spatial dissimilarity analysis in single-cell transcriptomics
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  4. VISTA uncovers missing gene expression and spatial-induced information for spatial transcriptomic data analysis
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  5. Next generation statistical framework for next generation spatial transcriptomics data
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  6. Modelling Diffuse Subcellular Protein Structures as Dynamic Social Networks
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  7. Omics Technologies in Spaceflight: Challenges and Considerations for Applying Single-Cell and Spatially Resolved Gene Expression Technologies to Samples Collected In-Flight
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  8. BayesTME: A unified statistical framework for spatial transcriptomics
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  9. Spatial embryo profiling (STEP) of primate implantation stages
    Sophie Bergmann, Christopher A. Penfold, Erin M. Slatery, Thorsten Boroviak · 2022 · Research Square
  10. Spanve: A Statistical Method for Detecting Downstream-Friendly Spatially Variable Genes in Large-Scale Spatial Transcriptomic Data
    Guoxin Cai, Yichang Chen, Shuqing Chen, Xun Gu, Zhan Mei Zhou · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
  11. The Overlooked Role of Specimen Preparation in Bolstering Deep Learning-Enhanced Spatial Transcriptomics Workflows
    Michael Fatemi, Yunrui Lu, Alos Diallo, Gokul Srinivasan, Zarif Azher, Brock C. Christensen, Lucas A. Salas, Gregory J. Tsongalis, Scott M. Palisoul, Laurent Perreard et al. · 2023 · medRxiv
  12. ATAT: Automated Tissue Alignment and Traversal in Spatial Transcriptomics with Self-Supervised Learning
    Steven Song, Emaan Mohsin, Renyu Zhang, Andrey Kuznetsov, Le Shen, Robert L. Grossman, Christopher R. Weber, Aly Azeem Khan · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
  13. Detection of spatial chromatin accessibility patterns with inter-cellular correlations
    Xiaoyang Chen, Keyi Li, Xiaoqing Wu, Zhen Li, Qun Jiang, Yanhong Wu, Rui Jiang · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
  14. A Universal Framework for Spatial Transcriptomics Data Mining with Interpretable Unsupervised Graph Representation Learning
    Long Liu, Shuyuan Bi, Ning Wang, Minghui Wang · 2024 · SSRN Electronic Journal
  15. Spatial motifs reveal patterns in cellular architecture of complex tissues
    Zainalabedin Samadi, Amjad Askary · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
  16. scBSP: A fast and accurate tool for identifying spatially variable genes from spatial transcriptomic data
    Jinpu Li, Yiqing Wang, Mauminah Raina, Chunhui Xu, Li Su, Qi Guo, Qin Ma, Juexin Wang, Dong He Xu · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
  17. A DIY guide for image-based spatial transcriptomic: TLS as a case example
    Thomas Defard, Auxence Desrentes, Charles Fouillade, Florian Mueller · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
  18. SpaceExpress enables differential spatial transcriptomics with natural coordinate systems
    Yeojin Kim, Abhishek Ojha, Alex W. Schrader, Juyeon Lee, Zijun Wu, Ian M. Traniello, Saumya Jain, Gene E. Robinson, Hee Sun Han, Sihai Dave Zhao et al. · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
  19. Guidestar: a spike-in approach to improve RNA detection accuracy in imaging-based spatial transcriptomics
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  20. Powerful and accurate case-control analysis of spatial molecular data
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  21. Nearest-neighbor nonnegative spatial factorization to study spatial and temporal transcriptomics
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  22. Spatial Metagene Discovery and Associated Molecular Pattern Characterization in Spatial Transcriptomics and Multi-Omics using SEPAR
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  23. A Gentle Introduction to Spatial Transcriptomic Analysis with 10X Visium Data
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  24. A computational framework for mapping isoform landscape and regulatory mechanisms from spatial transcriptomics data
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  25. SimSpace: a comprehensive in-silico spatial omics data simulation and modeling framework
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  26. Population-Scale Integration of Spatial Omics Networks for Clinical Prediction and Biological Discovery by SPIN
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  27. Uncovering directionally and temporally variable genes with STAVAG
    Qunlun Shen, Kuo Gai, Shang Li, Fangkun Yang, Hanbin Cui, Shuqin Zhang, Shihua Zhang · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
  28. S3R: Modeling spatially varying associations with Spatially Smooth Sparse Regression
    Xinyu Zhou, Pengtao Dang, Xiao Wang, Laura Xianlu Peng, Jen Jen Yeh, Nan Zhang, Brian Neelon, Rosalie C. Sears, Teresa A. Zimmers, Chi Zhang et al. · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
  29. Mapping disease critical spatially variable gene programs by integrating spatial transcriptomics with human genetics
    Hanbyul Lee, Haochen Sun, Xuewei Cao, Berke Karaahmet, Zhijian Li, Hans Ulrich-Klein, Mariko F. Taga, Gao T. Wang, Philip L. De Jager, David Alan Bennett et al. · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
  30. SpacGPA: annotating spatial transcriptomes through de novo interpretable gene programs
    Yupu Xu, Lirui Chen, Shisong Ma · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
  31. Spatial Dependence and Heterogeneity in Molecular Imaging: Moran Quadrant Maps Enable Advanced Spatial-Statistical Analysis
    Léonore E. M. Tideman, Felipe A. Moser, Lukasz G. Migas, Jacquelyn Spathies, Katerina V. Djambazova, Cody R. Marshall, Matthew Schrag, Eric Patrick Skaar, Jeffrey M. Spraggins, Raf Van de Plas · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
  32. NicheAgent: LLM-Guided Zero-Shot Niche Identification for Spatial Transcriptomics
    Sajib Acharjee Dip, Liqing Zhang · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
  33. SparseAEH: Scalable autoregressive expression histology discovery in spatial transcriptomics via sparse Gaussian kernels
    Tianjie Wang, Lingyu Li, Yuanhua Huang · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
  34. Unlocking Multi-Sample Differential Expression for Spatial Transcriptomics Data with TESSERA
    Florica Constantine, Zoltan G. Laszik, Sandrine Dudoit, Elizabeth A. Purdom · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
  35. Polar Gini Curve: a Technique to Discover Single-cell Biomarker Using 2D Visual Information
    Thanh Minh Nguyen, Jacob John Jeevan, Nuo Xu, Jake Y. Chen · 2020 · bioRxiv (Cold Spring Harbor Laboratory)
  36. Next Generation Sequencing Methods: Pushing the Boundaries
    Laura A Finnegan, Fiona Crispie, Marcus Joakim Claesson, Paul D. Cotter, John G. Kenny · 2020 · Elsevier eBooks
  37. Model of counsellors leadership and emotional intelligence as predictors of students' social and emotional learning outcomes
    Juliet Yayra Tengey · 2021 · Unisa Institutional Repository (University of South Africa)
  38. Detecting Hot Spots Using GIS Analysis: Case Study of Indonesia's Political Opposition Hashtag
    Bambang Ruswandi, Zulkifli Zulkifli, Raspiani Raspiani, Taufik Edy Sutanto · 2021 · International Conference on Cyber and IT Service Management (CITSM)
  39. SPRI: Spatial Pattern Recognition using Information based method for spatial gene expression data
    Jinxian Hu, Zhi-Rui Hu, Ye Yuan, Hong‐Bin Shen · 2022 · bioRxiv (Cold Spring Harbor Laboratory)
  40. SPIRAL: Significant Process InfeRence ALgorithm for single cell RNA-sequencing and spatial transcriptomics
    Hadas Biran, Tamar Hashimshony, Yael Mandel‐Gutfreund, Zohar Yakhini B · 2022 · bioRxiv (Cold Spring Harbor Laboratory)
  41. Identification of spatially variable genes with graph cuts
    Ke Zhang, Wanwan Feng, Peng Wang · 2022 · Research Square
  42. Identifying Genes with Location Dependent Noise Variance in Spatial Transcriptomics Data
    Mohammed Abid Abrar, Mohammad Kaykobad, Mohammad Saifur Rahman, Md. Abul Hassan Samee · 2022 · bioRxiv (Cold Spring Harbor Laboratory)
  43. Inferring Spatially Resolved Transcriptomics Data from Whole Slide Images for the Assessment of Colorectal Tumor Metastasis: A Feasibility Study
    Michael Fatemi, Eric Feng, Cyril Sharma, Zarif Azher, Tarushii Goel, Ojas A. Ramwala, Scott M. Palisoul, Rachael E. Barney, Laurent Perreard, Fred Kolling et al. · 2022 · bioRxiv (Cold Spring Harbor Laboratory)
  44. Cell composition inference and identification of layer-specific transcriptional profiles with POLARIS
    Jiawen Carmen Chen, Tianyou Luo, Min-Zhi Jiang, Jiandong Liu, Gaorav P. Gupta, Yun Li · 2022 · bioRxiv (Cold Spring Harbor Laboratory)
  45. Unraveling Spatial Gene Associations with SEAGAL: a Python Package for Spatial Transcriptomics Data Analysis and Visualization
    Linhua Wang, Chaozhong Liu, Zhandong Liu · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
  46. Spatial transcriptomics dimensionality reduction using wavelet bases
    Zhuoyan Xu, Kris Sankaran · 2022 · F1000Research
  47. Finding spatially variable ligand-receptor interactions from spatial transcriptomes
    Shiying Li, Ruohan Wang, Sitong LIU, Shuai Cheng Li · 2023 · Research Square
  48. InGene: Finding influential genes from embeddings of nonlinear dimension reduction techniques
    Chitrita Goswami, N Bhattacharya, Debarka Sengupta · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
  49. Identification of treatment-responsive genes in spatial transcriptomics data by leveraging injection site information
    Felicita Pia Masone, Francesco Napolitano · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
  50. Finding spatially variable ligand-receptor interactions from spatial transcriptomes
    Shiying Li, Ruohan Wang, Sitong LIU, Shuai Cheng Li · 2023 · Research Square
  51. Exploring the Mosaic-like Tissue Architecture of Kidney Diseases Using Relation Equivariant Graph Neural Networks on Spatially Resolved Transcriptomics
    Mauminah Raina, Hao Cheng, Hari Naga Sai Kiran Suryadevara, Treyden Stransfield, Dong He Xu, Qin Ma, Michael T. Eadon, Juexin Wang · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
  52. Additional file 17 of CoSTA: unsupervised convolutional neural network learning for spatial transcriptomics analysis
    Yang Xu, Rachel Patton McCord · 2021 · Figshare
  53. Additional file 4 of Modeling zero inflation is not necessary for spatial transcriptomics
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  54. Additional file 6 of Modeling zero inflation is not necessary for spatial transcriptomics
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  55. Additional file 1 of Feature selection revisited in the single-cell era
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  56. Additional file 16 of CoSTA: unsupervised convolutional neural network learning for spatial transcriptomics analysis
    Yang Xu, Rachel Patton McCord · 2021 · Figshare
  57. Additional file 1 of Modeling zero inflation is not necessary for spatial transcriptomics
    Peiyao Zhao, Jiaqiang Zhu, Ma, Ying, Xiang Qin Zhou · 2022 · Figshare
  58. Additional file 5 of Modeling zero inflation is not necessary for spatial transcriptomics
    Peiyao Zhao, Jiaqiang Zhu, Ying Ma, Xiang Zhou · 2022 · Figshare
  59. Additional file 2 of Modeling zero inflation is not necessary for spatial transcriptomics
    Peiyao Zhao, Jiaqiang Zhu, Ying Ma, Xiang Zhou · 2022 · Figshare
  60. Additional file 3 of Modeling zero inflation is not necessary for spatial transcriptomics
    Peiyao Zhao, Jiaqiang Zhu, Ying Ma, Xiang Zhou · 2022 · Figshare
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  62. Lessons from spatial transcriptomics and computational geography in mapping the transcriptome
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  63. Inferring metabolite states from spatial transcriptomes using multiple graph neural network
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  64. A zero-inflated hierarchical generalized transformation model to address non-normality in spatially-informed cell-type deconvolution
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  65. Identifying Differential Spatial Expression Patterns across Different Slices, Conditions and Developmental Stages with Interpretable Deep Learning
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  66. Cell-specific priors rescue differential gene expression in spatial spot-based technologies
    Ornit Nahman, Timothy J Few-Cooper, Shai S. Shen-Orr · 2024 · Briefings in Bioinformatics
  67. Evaluation of Spatially Variable Genes as Biomarkers in Tumor Initiation and Progression
    Aylin Seher Uzunoğlu, Merve Saide Uzunoğlu, Sümeyya Çapuk, Sevgi Kalkanlı Taş · 2024 · Advances in medical diagnosis, treatment, and care (AMDTC) book series
  68. MuST: Maximizing the Latent Capacity of Spatial Transcriptomics Data with Multi-modality Structure Transformation
    Zelin Zang, Liangyu Li, Yongjie Xu, Jiahao Li, Chenrui Duan, Yi Sun, Zhen Lei, Stan Ziqing Li · 2024 · IEEE International Conference on Bioinformatics and Biomedicine (BIBM)
  69. SpaFun: discovering domain-specific spatial expression patterns and new disease-relevant genes using functional principal component analysis
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  70. Mapping shared and unique features in spatial transcriptomics through multivariate curve resolution
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  71. From Data-Driven to Expert-Guided: Combining Unsupervised and Semi-supervised Clustering in Spatial Transcriptomics
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  72. Precise Characterization of Cellular States and Spatial Variable Patterns within Spatial Transcriptomics
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  73. Single Cell and Spatial Omics and Applications in Toxicology
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  74. CSFeatures improves the identification of cell-type-specific differential features in single-cell and spatial omics data
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  75. Spatial Transcriptomics Domain Identification Algorithm Based on Multi-scale Contrastive Learning
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  76. Semantic consistency-guided patch-wise relation graph reasoning scheme for lung cancer organoid segmentation in brightfield microscopy
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  77. spOT-NMF: Optimal Transport-Based Matrix Factorization for Accurate Deconvolution of Spatial Transcriptomics
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  78. Deciphering context-specific gene programs from single-cell and spatial transcriptomics data with DeCEP
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  79. gnSPADE: a reference-free deconvolution method incorporating gene network structures in spatial transcriptomics
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  80. BISON: bi-clustering of spatial omics data with feature selection
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  81. Reference-informed spatial domain detection using weak supervision for spatial transcriptomics
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  82. DiSTect: a Bayesian model for disease-associated gene discovery and prediction in spatial transcriptomics
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  83. How to get the most out of your cancer spatial transcriptomics data
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  86. Can Lightweight LLM Agents Improve Spatial Transcriptomics Annotation?
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  87. scBrainScope: cross-species multidimensional brain atlas
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  88. Adding highly variable genes to spatially variable genes can improve cell type clustering performance in spatial transcriptomics data
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  90. Spatially Regularized Gaussian Mixtures for Clustering Spatial Transcriptomic Data
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  92. Variational sparse Gaussian-process method for detecting spatially variable genes and cellular interactions in spatial transcriptomics
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  93. Additional file 6 of CoSTA: unsupervised convolutional neural network learning for spatial transcriptomics analysis
    Xu, Yang, Rachel Patton McCord · 2021 · Figshare
  94. Additional file 11 of CoSTA: unsupervised convolutional neural network learning for spatial transcriptomics analysis
    Xu, Yang, Rachel Patton McCord · 2021 · Figshare
  95. Additional file 2 of Feature selection revisited in the single-cell era
    Pengyi Yang, Huang, Hao, Liu, Chunlei · 2021 · Figshare
  96. Additional file 1 of SPARK-X: non-parametric modeling enables scalable and robust detection of spatial expression patterns for large spatial transcriptomic studies
    Zhu, Jiaqiang, Sun, Shiquan, Zhou, Xiang · 2021 · Figshare
  97. Additional file 5 of CoSTA: unsupervised convolutional neural network learning for spatial transcriptomics analysis
    Xu, Yang, Rachel Patton McCord · 2021 · Figshare
  98. Additional file 10 of CoSTA: unsupervised convolutional neural network learning for spatial transcriptomics analysis
    Xu, Yang, Rachel Patton McCord · 2021 · Figshare
  99. Additional file 2 of SRTsim: spatial pattern preserving simulations for spatially resolved transcriptomics
    Zhu, Jiaqiang, Lulu Shang, Zhou, Xiang · 2024 · Figshare
  100. Additional file 3 of SRT-Server: powering the analysis of spatial transcriptomic data
    Yang, Sheng, Zhou, Xiang · 2024 · Figshare