Manipulating critical period closure across different sectors of the primary auditory cortex
Open accessAbstract
During early brain development and through 'adult' experience-dependent plasticity, neural circuits are shaped to represent the external world with high fidelity. When raised in a quiet environment, the rat primary auditory cortex (A1) has a well-defined 'critical period', lasting several days, for its representation of sound frequency. The addition of environmental noise extends the critical period duration as a variable function of noise level. It remains unclear whether critical period closure should be regarded as a unified, externally gated event that applies for all of A1 or if it is controlled by progressive, local, activity-driven changes in this cortical area. We found that rearing rats in the presence of a spectrally limited noise band resulted in the closure of the critical period for A1 sectors representing the noise-free spectral bands, whereas the critical period appeared to remain open in noise-exposed sectors, where the cortex was still functionally and physically immature.
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The shift in inhibition is likely mediated by PV+ interneurons, which are also thought to regulate sensitive period plasticity in sensory cortex, making them attractive candidates for pubertal regulation of association cortex plasticity.
“This shift in inhibition is likely mediated by PV+ interneurons, which are also thought to regulate sensitive period plasticity in sensory cortex (Davis et al., 2015; de Villers-Sidani et al., 2008; Hensch, 2005; Le Magueresse and Monyer, 2013; Werker and Hensch, 2015), and therefore are attractive candidates for pubertal regulation of association cortex plasticity.”
From Does puberty mark a transition in sensitive periods for plasticity in the associative neocortex? (2017) · cites this paper as de Villers-Sidani et al., 2008
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References 49 · Cited by 137
- Authors
- de Villers-Sidani, E., Simpson, K. L., Lu, Y.-F., Lin, R. C. S., & Merzenich, M. M.
- Affiliations
- University of Mississippi Medical Center (US)
- University of California, San Francisco (US)
- ORCID
- Merzenich, Michael M
- Venue
- Nature Neuroscience
- Published
- 2008-07-06
- Volume
- 11
- Issue
- 8
- Pages
- 957-965
- ISSN
- 1097-6256 (ISSN-L)
- 1546-1726
- PMC
- PMC2755097
- OpenAlex
- W2053516515
- Cited by
- 137
- References
- 49
- Citations by year
- 2025: 5 · 2024: 4 · 2023: 4 · 2022: 5 · 2021: 8 · 2020: 11 · 2019: 6 · 2018: 7 · 2017: 8 · 2016: 6 · 2015: 9 · 2014: 8 · 2013: 14 · 2012: 8
- FWCI
- 5.86
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- National Institute of Mental Health (P50MH077970)
- National Institute of Neurological Disorders and Stroke (NS10414, P01NS034835, R01NS010414, F32NS010414, P02 NS34835-09)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neuroscience and Music Perception
- Life Sciences › Neuroscience › Sensory Systems › Hearing, Cochlea, Tinnitus, Genetics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Tactile and Sensory Interactions
- Keywords
- critical period, primary auditory cortex, experience-dependent plasticity, environmental noise, rearing conditions, cortical development, rat auditory cortex
- MeSH terms
- Acoustic Stimulation, Animals, Animals, Newborn, Auditory Cortex, Brain Mapping, Critical Period, Psychological, Electrodes, Implanted, Female, Hearing Tests, Neurons, Noise, Parvalbumins, Reaction Time, Spectrum Analysis, Time Factors, Rats, Sprague-Dawley, Recovery of Function, Rats
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