Cell type–specific regulation of DARPP-32 phosphorylation by psychostimulant and antipsychotic drugs

Bateup, Helen S; Svenningsson, Per; Kuroiwa, Mahomi; Gong, Shiaoching; Nishi, Akinori; Heintz, Nathaniel; Greengard, Paul

doi:10.1038/nn.2153

Cell type–specific regulation of DARPP-32 phosphorylation by psychostimulant and antipsychotic drugs

DARPP-32 is a dual-function protein kinase/phosphatase inhibitor that is involved in striatal signaling. The phosphorylation of DARPP-32 at threonine 34 is essential for mediating the effects of both psychostimulant and antipsychotic drugs; however, these drugs are known to have opposing behavior…