The DOI matches its Crossref record; 15 of the 15 references it cites were found in a registry or an index.
Synaptic release of GABA by AgRP neurons is required for normal regulation of energy balance
Open accessAbstract
The physiologic importance of GABAergic neurotransmission in hypothalamic neurocircuits is unknown. To examine the importance of GABA release from agouti-related protein (AgRP) neurons (which also release AgRP and neuropeptide Y), we generated mice with an AgRP neuron–specific deletion of vesicular GABA transporter. These mice are lean, resistant to obesity and have an attenuated hyperphagic response to ghrelin. Thus, GABA release from AgRP neurons is important in regulating energy balance.
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Cites
Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus
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NPY/AgRP Neurons Are Essential for Feeding in Adult Mice but Can Be Ablated in Neonates
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Glucose sensing by POMC neurons regulates glucose homeostasis and is impaired in obesity
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Self-citationOrexigenic Action of Peripheral Ghrelin Is Mediated by Neuropeptide Y and Agouti-Related Protein
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Rapid, reversible activation of AgRP neurons drives feeding behavior in mice
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Self-citationDeconstruction of a neural circuit for hunger
Atasoy, D., Betley, J. N., Su, H. H., & Sternson, S. M. (2012) · Nature · doi:10.1038/nature11270 · Cited by 969
Autophagy—a key player in cellular and body metabolism
Kim, K. H., & Lee, M.-S. (2014) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2014.35 · Cited by 963
A molecular census of arcuate hypothalamus and median eminence cell types
Campbell, J. N., Macosko, E. Z., Fenselau, H., Pers, T. H., Lyubetskaya, A., Tenen, D., Goldman, M., Verstegen, A. M. J., Resch, J. M., McCarroll, S. A., et al. (2017) · Nature Neuroscience · doi:10.1038/nn.4495 · Cited by 817
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Metadata
- Authors
- Tong, Q., Ye, C.-P., Jones, J. E., Elmquist, J. K., & Lowell, B. B.
- Venue
- Nature Neuroscience
- Published
- 2008-08-10
- Volume
- 11
- Issue
- 9
- Pages
- 998-1000
- ISSN
- 1097-6256 (ISSN-L)
- 1546-1726
- OpenAlex
- W2032668395
- Cited by
- 687
- References
- 15
- FWCI
- 7.22
- Type
- journal article
- Language
- en
- Open access
- green
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- Tong, Q., Ye, C.-P., Jones, J. E., Elmquist, J. K., & Lowell, B. B. (2008). Synaptic release of GABA by AgRP neurons is required for normal regulation of energy balance. Nature Neuroscience. https://doi.org/10.1038/nn.2167
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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