D2R striatopallidal neurons inhibit both locomotor and drug reward processes
Open accessAbstract
The specific functions of dopamine D(2) receptor-positive (D(2)R) striatopallidal neurons remain poorly understood. Using a genetic mouse model, we found that ablation of D(2)R neurons in the entire striatum induced hyperlocomotion, whereas ablation in the ventral striatum increased amphetamine conditioned place preference. Thus D(2)R striatopallidal neurons limit both locomotion and, unexpectedly, drug reinforcement.
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References 15 · Cited by 297
- Authors
- Durieux, P. F., Bearzatto, B., Guiducci, S., Buch, T., Waisman, A., Zoli, M., Schiffmann, S. N., & de Kerchove d'Exaerde, A.
- Affiliations
- Université Libre de Bruxelles (BE)
- University of Modena and Reggio Emilia (IT)
- University of Zurich (CH)
- Johannes Gutenberg University Mainz (DE)
- Venue
- Nature Neuroscience
- Published
- 2009-03-08
- Volume
- 12
- Issue
- 4
- Pages
- 393-395
- ISSN
- 1097-6256 (ISSN-L)
- 1546-1726
- OpenAlex
- W2069437503
- Cited by
- 297
- References
- 15
- Citations by year
- 2026: 4 · 2025: 12 · 2024: 13 · 2023: 20 · 2022: 18 · 2021: 20 · 2020: 15 · 2019: 23 · 2018: 17 · 2017: 19 · 2016: 22 · 2015: 17 · 2014: 22 · 2013: 26 · 2012: 14
- FWCI
- 6.68
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Dépôt institutionnel de l'Université libre de Bruxelles (Université Libre de Bruxelles) (submittedVersion, other-oa)
- IRIS UNIMORE (University of Modena and Reggio Emilia) (submittedVersion)
- Zurich Open Repository and Archive (University of Zurich) (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Health Sciences › Medicine › Neurology › Neurological disorders and treatments
- Keywords
- dopamine D2 receptor, striatopallidal neurons, striatonigral neurons, GABAergic neurons, striatum, locomotion, hyperlocomotion, amphetamine, drug reward, conditioned place preference, ventral striatum, gene ablation
- MeSH terms
- Amphetamine, Animals, Autoradiography, Conditioning, Operant, Corpus Striatum, Diphtheria Toxin, Enkephalins, Gene Expression Regulation, Globus Pallidus, Glutamate Decarboxylase, Locomotion, Mice, Inbred C57BL, Mice, Transgenic, Nerve Tissue Proteins, Neurons, Protein Binding, Reinforcement Schedule, Reward, Time Factors, Tyrosine 3-Monooxygenase, Receptors, Dopamine D2, Dopamine Uptake Inhibitors, Intercellular Signaling Peptides and Proteins, Receptors, Adenosine A2, Mice, Heparin-binding EGF-like Growth Factor
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