Representation and transformation of sensory information in the mouse accessory olfactory system
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In mice, nonvolatile social cues are detected and analyzed by the accessory olfactory system (AOS). Here we provide a first view of information processing in the AOS with respect to individual chemical cues. 12 sulfated steroids, recently discovered mouse AOS ligands, caused widespread activity among vomeronasal sensory neurons (VSNs), yet VSN responses clustered into a small number of repeated functional patterns or processing streams. Downstream neurons in the accessory olfactory bulb (AOB) responded to these ligands with enhanced signal/noise compared to VSNs. Although the dendritic connectivity of AOB mitral cells suggests the capacity for broad integration, most sulfated steroid responses were well-modeled by linear excitatory drive from just one VSN processing stream. However, a substantial minority demonstrated multi-stream integration. Most VSN excitation patterns were also observed in the AOB, but excitation by estradiol sulfate processing streams was rare, suggesting AOB circuit organization is specific to the biological relevance of sensed cues.
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An important transformation of sensory information occurs in the AOB, from a segregated sampling system in the VNO to more integrated codes in the AOB.
“This organization suggests that an important transformation of sensory information occurs in the AOB, from a segregated sampling system in the VNO to more integrated codes in the AOB (Luo et al., 2003; Meeks et al., 2010).”
From Neuronal Representation of Social Information in the Medial Amygdala of Awake Behaving Mice (2017) · cites this paper as Meeks et al., 2010
Selective inhibition also shapes social discrimination in the AOB.
“Intriguingly, selective inhibition also shapes social discrimination in the AOB (Luo et al., 2003; Meeks et al., 2010).”
From Neuronal Representation of Social Information in the Medial Amygdala of Awake Behaving Mice (2017) · cites this paper as Meeks et al., 2010
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References 41 · Cited by 85
- Authors
- Meeks, J. P., Arnson, H. A., & Holy, T. E.
- Affiliations
- Washington University in St. Louis (US)
- Corresponding author
- Holy, Timothy E
- Venue
- Nature Neuroscience
- Published
- 2010-05-09
- Volume
- 13
- Issue
- 6
- Pages
- 723-730
- ISSN
- 1097-6256 (ISSN-L)
- 1546-1726
- PMC
- PMC2930753
- OpenAlex
- W1974326103
- Cited by
- 85
- References
- 41
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 7 · 2023: 1 · 2021: 2 · 2020: 7 · 2019: 3 · 2018: 10 · 2017: 5 · 2016: 7 · 2015: 10 · 2014: 12 · 2013: 9 · 2012: 3
- FWCI
- 3.26
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Deafness and Other Communication Disorders (R01DC005964, F32DC009352, R01DC010381)
- Topics
- Life Sciences › Neuroscience › Sensory Systems › Olfactory and Sensory Function Studies
- Life Sciences › Neuroscience › Sensory Systems › Ion Channels and Receptors
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Keywords
- accessory olfactory system, vomeronasal sensory neurons, steroid sulfates, accessory olfactory bulb, mitral cells, social odors, estradiol sulfate, signal-to-noise ratio
- MeSH terms
- Action Potentials, Animals, Cues, Dendrites, Estradiol, Male, Microelectrodes, Models, Neurological, Olfactory Bulb, Physical Stimulation, Sensory Receptor Cells, Social Perception, Steroids, Sulfates, Urine, Cluster Analysis, Linear Models, Vomeronasal Organ, Mice, Olfactory Perception, In Vitro Techniques
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