Sensory modality–specific homeostatic plasticity in the developing optic tectum
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We found a previously unknown form of homeostatic synaptic plasticity in multisensory neurons in the optic tectum of Xenopus laevis tadpoles. Individual tectal neurons are known to receive converging inputs from multiple sensory modalities. We observed that long-term alterations in either visual or mechanosensory activity in vivo resulted in homeostatic changes specific to each sensory modality. In contrast with typical forms of homeostatic synaptic plasticity, such as synaptic scaling, we found that this type of plasticity occurred in a pathway-specific manner that is more reminiscent of hebbian-type plasticity.
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In multisensory neurons of Xenopus tectum, sensory deprivation of one modality leads to a modality-specific enhancement in synaptic transmission.
“Interestingly, a recent study on sensory inputs to Xenopus tectum found that, in multisensory neurons, sensory deprivation of one modality led to a modality-specific enhancement in synaptic transmission, suggesting that synaptic inputs subserving different modalities can undergo independent homeostatic regulation (Deeg and Aizenman 2011).”
From Homeostatic Synaptic Plasticity: Local and Global Mechanisms for Stabilizing Neuronal Function (2012) · cites this paper as Deeg and Aizenman 2011
Synaptic inputs subserving different modalities can undergo independent homeostatic regulation.
“Interestingly, a recent study on sensory inputs to Xenopus tectum found that, in multisensory neurons, sensory deprivation of one modality led to a modality-specific enhancement in synaptic transmission, suggesting that synaptic inputs subserving different modalities can undergo independent homeostatic regulation (Deeg and Aizenman 2011).”
From Homeostatic Synaptic Plasticity: Local and Global Mechanisms for Stabilizing Neuronal Function (2012) · cites this paper as Deeg and Aizenman 2011
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Kim, J., & Tsien, R. W. (2008) · Neuron · doi:10.1016/j.neuron.2008.05.009 · Cited by 124 · see citing works
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Homeostatic Synaptic Plasticity: Local and Global Mechanisms for Stabilizing Neuronal Function
Turrigiano, G. (2012) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a005736 · Cited by 1,139 · see citing works
- Authors
- Deeg, K. E., & Aizenman, C. D.
- Affiliations
- Brown University (US)
- Corresponding author
- Aizenman, Carlos D
- ORCID
- Aizenman, Carlos D
- Venue
- Nature Neuroscience
- Published
- 2011-03-27
- Volume
- 14
- Issue
- 5
- Pages
- 548-550
- ISSN
- 1097-6256 (ISSN-L)
- 1546-1726
- PMC
- PMC3415229
- OpenAlex
- W2066687028
- Cited by
- 50
- References
- 1
- Citations by year
- 2026: 2 · 2024: 6 · 2023: 3 · 2022: 2 · 2021: 3 · 2020: 1 · 2019: 1 · 2018: 5 · 2017: 2 · 2016: 2 · 2015: 5 · 2014: 6 · 2013: 6 · 2012: 3
- FWCI
- 2.39
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Science Foundation
- Whitehall Foundation
- National Institute of Mental Health (T32MH020068)
- National Eye Institute (R01EY019578)
- Division of Integrative Organismal Systems
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Multisensory perception and integration
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Keywords
- homeostatic plasticity, optic tectum, multisensory neurons, sensory modality specificity, Hebbian plasticity, synaptic scaling, visual input, mechanosensory input, Xenopus laevis tadpoles
- MeSH terms
- Animals, Biophysics, Dark Adaptation, Electric Stimulation, Homeostasis, Functional Laterality, Neuronal Plasticity, Neurons, Physical Stimulation, Picrotoxin, Quinoxalines, Sensory Deprivation, Superior Colliculi, Xenopus laevis, Patch-Clamp Techniques, Excitatory Amino Acid Antagonists, GABA Antagonists, Excitatory Postsynaptic Potentials
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