The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Single-neuron dynamics in human focal epilepsy
Open accessAbstract
Epileptic seizures are traditionally characterized as the ultimate expression of monolithic, hypersynchronous neuronal activity arising from unbalanced runaway excitation. Here we report the first examination of spike train patterns in large ensembles of single neurons during seizures in persons with epilepsy. Contrary to the traditional view, neuronal spiking activity during seizure initiation and spread was highly heterogeneous, not hypersynchronous, suggesting complex interactions among different neuronal groups even at the spatial scale of small cortical patches. In contrast to earlier stages, seizure termination is a nearly homogenous phenomenon followed by an almost complete cessation of spiking across recorded neuronal ensembles. Notably, even neurons outside the region of seizure onset showed significant changes in activity minutes before the seizure. These findings suggest a revision of current thinking about seizure mechanisms and point to the possibility of seizure prevention based on spiking activity in neocortical neurons.
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Cites
Neuronal ensemble control of prosthetic devices by a human with tetraplegia
Hochberg, L. R., Serruya, M. D., Friehs, G. M., Mukand, J. A., Saleh, M., Caplan, A. H., Branner, A., Chen, D., Penn, R. D., & Donoghue, J. P. (2006) · Nature · doi:10.1038/nature04970 · Cited by 3,295
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Cited by
Synchronization and desynchronization in epilepsy: controversies and hypotheses.
Jiruska, P., de Curtis, M., Jefferys, J. G. R., Schevon, C. A., Schiff, S. J., & Schindler, K. (2013) · The Journal of Physiology · doi:10.1113/jphysiol.2012.239590 · Cited by 678
Failure mode analysis of silicon-based intracortical microelectrode arrays in non-human primates
Barrese, J. C., Rao, N., Paroo, K., Triebwasser, C., Vargas-Irwin, C., Franquemont, L., & Donoghue, J. P. (2013) · Journal of Neural Engineering · doi:10.1088/1741-2560/10/6/066014 · Cited by 600
Self-citationThe organization of physiological brain networks
Stam, C. J., & van Straaten, E. C. W. (2012) · Clinical Neurophysiology · doi:10.1016/j.clinph.2012.01.011 · Cited by 567
Seizure prediction – ready for a new era
Kuhlmann, L., Lehnertz, K., Richardson, M. P., Schelter, B., & Zaveri, H. P. (2018) · Nature Reviews Neurology · doi:10.1038/s41582-018-0055-2 · Cited by 450
Large-scale neural recordings with single neuron resolution using Neuropixels probes in human cortex
Paulk, A. C., Kfir, Y., Khanna, A. R., Mustroph, M. L., Trautmann, E. M., Soper, D. J., Stavisky, S. D., Welkenhuysen, M., Dutta, B., Shenoy, K. V., et al. (2022) · Nature Neuroscience · doi:10.1038/s41593-021-00997-0 · Cited by 283
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Metadata
- Authors
- Truccolo, W., Donoghue, J. A., Hochberg, L. R., Eskandar, E. N., Madsen, J. R., Anderson, W. S., Brown, E. N., Halgren, E., & Cash, S. S.
- Venue
- Nature Neuroscience
- Published
- 2011-03-27
- Volume
- 14
- Issue
- 5
- Pages
- 635-641
- ISSN
- 1097-6256 (ISSN-L)
- 1546-1726
- OpenAlex
- W1501385736
- Cited by
- 514
- References
- 1
- FWCI
- 25.02
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Truccolo, W., Donoghue, J. A., Hochberg, L. R., Eskandar, E. N., Madsen, J. R., Anderson, W. S., Brown, E. N., Halgren, E., & Cash, S. S. (2011). Single-neuron dynamics in human focal epilepsy. Nature Neuroscience. https://doi.org/10.1038/nn.2782
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