The voltage-gated proton channel Hv1 enhances brain damage from ischemic stroke

Wu, Long-Jun, Wu, Gongxiong, Sharif, M Reza Akhavan, Baker, Amanda, Jia, Yonghui, Fahey, Frederic H, Luo, Hongbo R, Feener, Edward P +1 more·2012·Nature Neuroscience
DOI 10.1038/nn.3059

Cited by (252)

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  8. A NOX2-independent mechanism of Hv1 channel activation promotes inflammatory cytokine release from BV-2 microglia via intracellular Ca2+ mobilisation
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  11. Inhibition of the microglial voltage-gated proton channel 1 channel ameliorates diabetes-associated cognitive dysfunction by regulating axon demyelination
    Chunyu Li, Shujun Zhang, Jialu Xu, Yan Yang, Zhi-Xuan Zeng, Delin Ma · 2025 · World Journal of Psychiatry
  12. Interaction of divalent metal ions with the carboxyl-terminal domain of human voltage-gated proton channel Hv1
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  13. Fluctuating hydrogen-bond network of the Hv1 ion channel
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  15. Amyloid precursor protein is a subunit of microglial Hv1 channels
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  16. Voltage-gated proton channel Hv1/VSOP regulates reciprocal interactions between F-actin and endosomes in microglia
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  17. Lipid Regulation of Cardiac Ion Channels in Heart Disease
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  19. Dimerization is required for the glycosylation of S1-S2 linker of sea urchin voltage-gated proton channel Hv1
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  20. An essential role for the Hv1 voltage-gated proton channel in Pseudomonas aeruginosa corneal infections
    Priscila Rodriguez, Michaela Ellen Marshall, Jolynn Tran Chau, Jessica Abdelmeseh, Jamison L. Nourse, Francesco Tombola, Eric M. Pearlman, Serena Abbondante · 2025 · Journal of Leukocyte Biology
  21. Mechanisms of Nicotine-Induced Neuroprotection: Inhibition of NADPH Oxidase and Subsequent Proton Channel Activation by Stimulating α7 Nicotinic Acetylcholine Receptor in Activated Microglia
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  22. Functional Coupling of TRPM2 and NMDARs exacerbates excitotoxicity in ischemic brain injury
    Pengyu Zong, Jianlin Feng, Zhichao Yue, Gongxiong Wu, Baonan Sun, Yanlin He, Barbara A. Miller, Albert S. Yu, Zhongping Su, Yasuo Mori et al. · 2021 · bioRxiv (Cold Spring Harbor Laboratory)
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  24. Rol del canal de protones operado por voltaje (HVCN1) en la homeostasis ácido-base de células tumorales T humanas y su impacto en la apoptosis
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  25. A role for proton channel Hv1 in ischaemic brain damage
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  26. Alleviation of γ-enolase decrease by the chlorogenic acid administration in the stroke animal model
    Ju-Bin Kang, Murad-Ali Shah, Min-Seo Ko, Phil‐Ok Koh · 2023 · Korean Journal of Veterinary Research
  27. Voltage gated proton channel (Hv1)
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  28. WITHDRAWN: Conformational Dynamics and Ligand Binding of the Human Voltage-Gated Proton Channel
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  29. The role of microglia in ischemic stroke
    Victoria Mihailova, Stanislav Morfov, Iskren Velikov, Radoslav Spasov, Irina Ivanova Stoyanova, Anton B. Tonchev · 2023 · Varna Medical Forum
  30. Temperature Dependent Activity of the Voltage-Gated Proton Channel
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  31. Deficiency of Hv1 Proton Channel Enhances Macrophage Antigen Presentation and Anti-Tumor Responses in Glioma
    Jiaying Zheng, Lingxiao Wang, Shunyi Zhao, Katayoun Ayasoufi, Emma N. Goddery, Peter R. Strege, Yushan Wan, Wenjing Zhang, Manling Xie, Arthur Beyder et al. · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
  32. Microglial voltage-gated proton channel 1 ablation in diabetic mice mitigates diabetes-driven demyelination and cognitive decline
    Bin Li · 2025 · World Journal of Psychiatry
  33. Deficiency of the voltage‑gated proton channel Hv1 aggravates lung damage induced by exposure to carboxylated carbon black and carboxylated carbon black@lead
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  34. Proton channel Hv1 modulates microglial responses to neurological disorders
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  35. Additional file 1 of Specific depletion of resident microglia in the early stage of stroke reduces cerebral ischemic damage
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  36. Additional file 1 of Deletion of Slc9a1 in Cx3cr1+ cells stimulated microglial subcluster CREB1 signaling and microglia-oligodendrocyte crosstalk
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  37. Additional file 2 of Specific depletion of resident microglia in the early stage of stroke reduces cerebral ischemic damage
    Li, Ting, Jin Zhao, Xie, Wenguang, Wanru Yuan, Guo, Jing, Shengru Pang, Gan, Wen-Biao, Diego Gómez‐Nicola, Zhang, Shengxiang · 2021 · Figshare
  38. Additional file 1 of The voltage-gated proton channel Hv1 contributes to neuronal injury and motor deficits in a mouse model of spinal cord injury
    Madhuvika Murugan, Zheng, Jiaying, Wu, Gongxiong, Rochelle Mogilevsky, Xin Zheng, Peiwen Hu, Wu, Junfang, Wu, Long-Jun · 2020 · Figshare
  39. Additional file 2 of The voltage-gated proton channel Hv1 contributes to neuronal injury and motor deficits in a mouse model of spinal cord injury
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  40. Microglial HVCN1 Deficiency Improves Movement and Survival of SOD1 G93A ALS Mice by Enhancing Microglial Migration and Neuroprotection
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