Transient stimulation of distinct subpopulations of striatal neurons mimics changes in action value
Open accessAbstract
In changing environments, animals must adaptively select actions to achieve their goals. In tasks involving goal-directed action selection, striatal neural activity has been shown to represent the value of competing actions. Striatal representations of action value could potentially bias responses toward actions of higher value. However, no study to date has demonstrated the direct effect of distinct striatal pathways in goal-directed action selection. We found that transient optogenetic stimulation of dorsal striatal dopamine D1 and D2 receptor-expressing neurons during decision-making in mice introduced opposing biases in the distribution of choices. The effect of stimulation on choice was dependent on recent reward history and mimicked an additive change in the action value. Although stimulation before and during movement initiation produced a robust bias in choice behavior, this bias was substantially diminished when stimulation was delayed after response initiation. Together, our data suggest that striatal activity is involved in goal-directed action selection.
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The insula's projection to the striatum underscores its pivotal role in motor control and action selection.
“the insula allocates over one-third of its projection to the striatum, particularly the dorsal region, underscoring its pivotal role in motor control and action selection [21][22][23][24].”
From The Insular Cortex: An Interface Between Sensation, Emotion and Cognition (2024) · cites this paper as [23]
The Discussion reports that striatal activity influences action selection and movement initiation. It does not identify an insula-to-striatum projection or establish that the insula has a pivotal role in motor control or action selection; searches for insula and insular projections found no such passage. No page number is available in our copy. (LLM, conf=0.85)
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References 53 · Cited by 399
- Authors
- Tai, L.-H., Lee, A. M., Benavidez, N., Bonci, A., & Wilbrecht, L.
- Affiliations
- Ernest Gallo Clinic and Research Center (US)
- University of California, San Francisco (US)
- National Institute on Drug Abuse (US)
- Corresponding author
- Wilbrecht, Linda
- Venue
- Nature Neuroscience
- Published
- 2012-08-19
- Volume
- 15
- Issue
- 9
- Pages
- 1281-1289
- ISSN
- 1097-6256 (ISSN-L)
- 1546-1726
- PMC
- PMC3951287
- OpenAlex
- W1971501199
- Cited by
- 399
- References
- 53
- Citations by year
- 2026: 17 · 2025: 31 · 2024: 48 · 2023: 26 · 2022: 34 · 2021: 30 · 2020: 21 · 2019: 36 · 2018: 27 · 2017: 16 · 2016: 32 · 2015: 26 · 2014: 37 · 2013: 16 · 2012: 1
- FWCI
- 10.54
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- National Institutes of Health (5rc2ns069350-02)
- National Institute of Mental Health (R01MH087542)
- National Institute on Drug Abuse (R01DA029150)
- National Institute of General Medical Sciences (T32GM007618)
- National Institute of Neurological Disorders and Stroke (RC2-NS-069350, 1RC2NS069350)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- dorsal striatum, action value, optogenetic stimulation, decision-making, choice bias, reward history, movement initiation
- MeSH terms
- Channelrhodopsins, Action Potentials, Dependovirus, Algorithms, Animals, Choice Behavior, Corpus Striatum, DNA, Mice, Inbred C57BL, Mice, Transgenic, Neurons, Photic Stimulation, Plasmids, Reward, Logistic Models, Receptors, Dopamine D1, Receptors, Dopamine D2, Mice, Optical Fibers, Electrophysiological Phenomena
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