Cocaine-induced structural plasticity in frontal cortex correlates with conditioned place preference.
Open accessAbstract
Contextual cues associated with previous drug exposure can trigger drug craving and seeking, and form a substantial obstacle in substance use recovery. Using in vivo imaging in mice, we found that cocaine administration induced a rapid increase in the formation and accumulation of new dendritic spines, and that measures of new persistent spine gain correlated with cocaine conditioned place preference. Our data suggest that new persistent spine formation in the frontal cortex may be involved in stimulant-related learning driving appetitive behavior.
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The amount of new persistent spines after initial cocaine exposure correlated with the preference for the cocaine-paired context.
“Using a cocaine-conditioned place preference paradigm, a recent imaging study showed that initial cocaine exposure promoted spine formation in the frontal cortex, and that the amount of new persistent spines correlated with the preference for the cocaine-paired context (Munoz-Cuevas et al., 2013).”
From Spatiotemporal dynamics of dendritic spines in the living brain (2014) · cites this paper as Munoz-Cuevas et al., 2013
Initial cocaine exposure promoted spine formation in the frontal cortex.
“Using a cocaine-conditioned place preference paradigm, a recent imaging study showed that initial cocaine exposure promoted spine formation in the frontal cortex, and that the amount of new persistent spines correlated with the preference for the cocaine-paired context (Munoz-Cuevas et al., 2013).”
From Spatiotemporal dynamics of dendritic spines in the living brain (2014) · cites this paper as Munoz-Cuevas et al., 2013
Addiction elicits similar temporal changes in spine dynamics as motor learning does.
“Addiction, which has been considered as pathological learning (Hyman, 2005), elicits similar temporal changes in spine dynamics as motor learning does.”
From Spatiotemporal dynamics of dendritic spines in the living brain (2014) · cites this paper as Munoz-Cuevas et al., 2013
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References 17 · Cited by 85
- Authors
- Muñoz-Cuevas, F. J., Athilingam, J., Piscopo, D., & Wilbrecht, L.
- Affiliations
- University of California, San Francisco (US)
- Corresponding author
- Wilbrecht, Linda
- Venue
- Nature Neuroscience
- Published
- 2013-08-25
- Volume
- 16
- Issue
- 10
- Pages
- 1367-1369
- ISSN
- 1097-6256 (ISSN-L)
- 1546-1726
- PMC
- PMC3940437
- OpenAlex
- W1970077425
- Cited by
- 85
- References
- 17
- Citations by year
- 2026: 3 · 2025: 1 · 2024: 1 · 2023: 11 · 2022: 4 · 2021: 7 · 2020: 4 · 2019: 8 · 2018: 5 · 2017: 7 · 2016: 13 · 2015: 12 · 2014: 9
- FWCI
- 5.56
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- National Institute on Drug Abuse (R01DA029150)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- cocaine, dendritic spines, structural plasticity, conditioned place preference, dorsomedial frontal cortex, layer 5 pyramidal neurons, spine formation, drug craving, drug-seeking behavior, locomotor activity, in vivo imaging
- MeSH terms
- Animals, Cocaine, Conditioning, Operant, Frontal Lobe, Male, Mice, Inbred C57BL, Mice, Transgenic, Motor Activity, Neuronal Plasticity, Dendritic Spines, Mice
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