The DOI matches its Crossref record; 45 of the 45 references it cites were found in a registry or an index.
Genome-wide identification and characterization of functional neuronal activity–dependent enhancers
Open accessAbstract
Experience-dependent gene transcription is required for nervous system development and function. However, the DNA regulatory elements that control this program of gene expression are not well defined. Here we characterize the enhancers that function across the genome to mediate activity-dependent transcription in mouse cortical neurons. We find that the subset of enhancers enriched for monomethylation of histone H3 Lys4 (H3K4me1) and binding of the transcriptional coactivator CREBBP (also called CBP) that shows increased acetylation of histone H3 Lys27 (H3K27ac) after membrane depolarization of cortical neurons functions to regulate activity-dependent transcription. A subset of these enhancers appears to require binding of FOS, which was previously thought to bind primarily to promoters. These findings suggest that FOS functions at enhancers to control activity-dependent gene programs that are critical for nervous system function and provide a resource of functional cis-regulatory elements that may give insight into the genetic variants that contribute to brain development and disease.
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Cites
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MEME SUITE: tools for motif discovery and searching
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Self-citationWidespread transcription at neuronal activity-regulated enhancers
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Metadata
- Authors
- Malik, A. N., Vierbuchen, T., Hemberg, M., Rubin, A. A., Ling, E., Couch, C. H., Stroud, H., Spiegel, I., Farh, K. K.-H., Harmin, D. A., & Greenberg, M. E.
- Venue
- Nature Neuroscience
- Published
- 2014-09-07
- Volume
- 17
- Issue
- 10
- Pages
- 1330-1339
- ISSN
- 1097-6256 (ISSN-L)
- 1546-1726
- OpenAlex
- W1977419289
- Cited by
- 275
- References
- 45
- FWCI
- 7.67
- Type
- journal article
- Language
- en
- Open access
- green
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- Malik, A. N., Vierbuchen, T., Hemberg, M., Rubin, A. A., Ling, E., Couch, C. H., Stroud, H., Spiegel, I., Farh, K. K.-H., Harmin, D. A., & Greenberg, M. E. (2014). Genome-wide identification and characterization of functional neuronal activity–dependent enhancers. Nature Neuroscience. https://doi.org/10.1038/nn.3808
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