Neuronal ensembles sufficient for recovery sleep and the sedative actions of α2 adrenergic agonists
Zhang, Zhe, Ferretti, Valentina, Güntan, İlke, Moro, Alessandro, Steinberg, Eleonora A, Ye, Zhiwen, Zecharia, Anna Y, Yu, Xiao +7 more·2015·Nature Neuroscience
DOI 10.1038/nn.3957
Cited by (275)
Items 201–275 of 275
- Dexmedetomidine Reduces Presynaptic γ-Aminobutyric Acid Release and Prolongs Postsynaptic Responses in Layer 5 Pyramidal Neurons in the Primary Somatosensory Cortex of MiceBo Tang, Jiali Tang, Yuguang Huang · 2025 · International Journal of Molecular Sciences
- Therapeutic Potential of Anesthesiology for Sleep Disorders in the Perioperative PeriodXiao-li Pan, Yanwanyu Xi, Peng Liang, Jiapeng Huang · 2025 · Current Neuropharmacology
- The Many Roads to SleepMila Halgren, Michael M. Halassa · 2019 · Neuron
- Evidence that loss of consciousness under anesthesia is not associated with impaired stimulus representation in auditory cortexMatthew I. Banks, Bryan M. Krause, Nicholas S. Moran, Sean M. Grady, Jeremiah Kakes, Daniel J. Uhlrich, Karen Manning · 2017 · bioRxiv (Cold Spring Harbor Laboratory)
- Hypothalamic NMDA receptors stabilize NREM sleep and are essential for REM sleepGiulia Miracca, Berta Anuncibay Soto, Kyoko Tossell, Raquel Yustos, Alexei L. Vyssotski, Nicholas P. Franks, William Wisden · 2020 · bioRxiv (Cold Spring Harbor Laboratory)
- Anesthesia unconsciousness recruits dynamic parabrachial activity within a distributed brain-wide ensembleKevin N. Schneider, Minke H.C. Nota, Hallie Lazaro, Daniel Ryskamp Rijsketic, Michelle Jin, Carlie Neiswanger, Asad I. Beck, Nick Ressler, Jason JQ Zhang, Amelia Li et al. · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
- Dexmedetomidine produces more sleep-like brain activity compared to propofolBryan M. Krause, Emily R. Dappen, Rashmi N. Mueller, Hiroto Kawasaki, Robert David Sanders, Kirill V. Nourski, Matthew I. Banks · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
- Mechanisms of Intravenous Anesthetic ActionHugh C. Hemmings, Karl F. Herold · 2017 · Springer eBooks
- The lateral habenula contributes to regulation of body temperatureXuxin Wang, Xiaowei Chen, Zehui Zhang, Xiaofeng Liu, Qianqian Lv, Meiying Song, Danyang Zhao, Jianjun Su, Yana Su, Guoyan Zhao et al. · 2025 · iScience
- Synergistic effects of combined hypnotic drugs on sleep in miceRui Bai, Chu Wang, Fanghui Wu, Yifeng Yin, Yanli Liu, Yuan Gao, Yun‐Yang Song · 2025 · Frontiers in Pharmacology
- Dexmedetomidine-Loaded Hydrogel Microneedles Alleviate Acute Inflammatory Visceral Pain in MicePeng Ke, Xin Tan, Yi Zhou, Xiaoyan Bao, Linjie Wu, Min Young Han, Xiaodan Wu · 2025 · Gels
- Disrupted temperature-sleep coupling mechanism in a Dravet syndrome mouse modelSaja Fadila, Georgii Krivoshein, Hala Majadly, Anat Mavashov, Shahak Ranen, Marina Brusel, Iria G. Dopeso‐Reyes, Bertrand Beucher, Eric J. Kremer, Else A. Tolner et al. · 2026 · Nature Communications
- Effects of different administration routes of dexmedetomidine on sleep quality in patients undergoing total knee arthroplastyZiqi Huang, Xiaomin Fan, Baojia Lin, Fang Liu, Shunqing Hu, Xiangyu Liu, Chenglong Li, Xinjian Zhang · 2026 · Scientific Reports
- Astrocytic α2A-adrenergic signalling in the hypothalamic paraventricular nucleus contributes to dexmedetomidine-induced sedation in miceRong Luo, Xiaojun Hu, Yuncheng Luo, Ping Liao, 张璠 Zhang Fan, Yu Shen, Hao-Di Tang, Qingran Li, Yunqing Yu, Limei Yi et al. · 2026 · British Journal of Anaesthesia
- Wake-active brainstem GABA neurons signal sleep pressure by upregulating AMPA receptors to drive recovery sleepWei Ba, Edward C. Harding, Mathieu Nollet, Kyoko Tossell, Lili Li, Sara Wong, Berta Anuncibay Soto, Raquel Yustos, Li Li, Jagoda Ostaszewska et al. · 2026 · Current Biology
- Dexmedetomidine produces more sleep-like brain activity compared with propofol in human participants. Comment on Br J Anaesth 2026; 136: 552–63Jiaojiao Shen, Xiangyang Mei · 2026 · British Journal of Anaesthesia
- Wake-activated neuronal populations that regulate sleep driveWilliam J. Joo, Clare M. Diester, Vassilis Bitsikas, Myrto Panopoulou, Amelia Hidalgo, Κωνσταντίνος Ντέμος, Rodrigo C. G. Pena, Fabia Imhof, Iris Odstrcil, Flavio Donato et al. · 2026 · Nature
- Isoliquiritigenin modulates the activity of LTS and non-LTS cells in the ventrolateral preoptic area via GABAA receptorsSumei Fan, Qiaoling Jin, Pingping Zhang, Dejiao Xu, Juan Cheng, Liecheng Wang · 2023 · Heliyon
- Chemogenetic approach to model hypofrontalityIke dela Peña, Wei‐Xing Shi · 2016 · Medical Hypotheses
- Anaesthetic management of patients undergoing deep brain simulation: A retrospective review of 8 cases from a tertiary care center of PakistanUsama Ahmed, Faraz Shafiq, Dileep Kumar, Khalid Ahsan, Waleed Bin Ghaffar, Muhammad Ehsan Bari · 2020 · Pakistan Journal of Medical Sciences
- Good night!2015 · BJPsych International
- Anesthetic Drug Concentration Rather Than Abrupt Behavioral Unresponsiveness Linearly Degrades Responses in the Rat Primary Auditory CortexLottem Bergman, Aaron J. Krom, Yaniv Sela, Amit Marmelshtein, Hanna Hayat, Noa Regev, Y. Nir · 2020 · bioRxiv
- Homeostatic regulation of REM sleep by the preoptic area of the hypothalamusJohn J. Maurer, Alex Lin, Xi Jin, Jiso Hong, Nicholas Sathi, Romain Cardis, Alejandro Osorio-Forero, Anita Lüthi, Franz Weber, Shinjae Chung · 2023 · eLife
- Synthetic torpor in the rat protects the heart from ischaemia-reperfusion injuryMeg Elley, Ludovico Taddei, Khan Ma, Una Rose Wilcox, Timna Hitrec, Martin Lewis, Anthony Edward Pickering, Michael T. Ambler · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
- Pharmakologie der SchlafendoskopieGünther M. Edenharter, Benedikt Gabriel Hofauer, Clemens Heiser · 2018 · Somnologie - Schlafforschung und Schlafmedizin
- Hypothalamic control of body temperature and sleepEdward C. Harding · 2016 · Spiral (Imperial College London)
- Memory trace superimposition impairs recall in a mouse model of ADStefanie Poll, Lena Schmid, Julia Steffen, Jens Wagner, Boris Schmidt, Walker S. Jackson, Susanne Schoch, Dan Ehninger, Martin Fuhrmann · 2018 · bioRxiv (Cold Spring Harbor Laboratory)
- Research progress and prospect of neural activity-dependent toolsJihua Wang, Hailan Hu · 2019 · Scientia Sinica Vitae
- New Insights into the Pharmacology of Dexmedetomidine and Open Issues for Neurosurgical ProceduresMariantonietta Scafuro, Francesca Gargano, Marco Fiore · 2019 · Neuromethods
- Tendencies and perspectives of central alpha2-adrenomimetic application in medicobiological researchNikolay G. Vengerovich, I. M. Ivanov, Yulia A. Proshina · 2019 · Pharmacy Formulas
- Exploration of neuronal ensembles responsible for sleep and body temperature regulationYing Ma · 2019 · Spiral (Imperial College London)
- Weak Coupling Between Spontaneous Local Cortical Activity State Switches Under Anesthesia Leads to Strongly Correlated Global Cortical StatesEthan B. Blackwood, Brenna P. Shortal, Alex Proekt · 2021 · bioRxiv (Cold Spring Harbor Laboratory)
- Notions de physiopathologie et de pharmacodynamique indispensables à la maîtrise des endoscopies du sommeil dans le cadre du Syndrome d’Apnées et d’Hypopnées Obstructives du Sommeil (SAHOS)Eric P. DEFLANDRE, Jean-François Brichant, Dan Benhamou · 2021 · Anesthésie & Réanimation
- α-Adrenergic SystemLutz Hein · 2021 · Springer eBooks
- α-Adrenergic SystemLutz Hein · 2021 · Springer eBooks
- Faculty Opinions recommendation of A neuronal hub binding sleep initiation and body cooling in response to a warm external stimulus.Douglas A. Bayliss, Yingtang Shi · 2018 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
- PANDORA'S BOX.2015 · PubMed Central
- Defective engram allocation contributes to impaired fear memory performance in Down syndromeÁlvaro Fernández‐Blanco, Alfonsa Zamora‐Moratalla, Miguel Sabariego-Navarro, Mara Dierssen · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
- Research Progress of Dexmedetomidine in Analgesia during Labor小波 杨 · 2023 · Advances in Clinical Medicine
- Comparison of the effects of dexmedetomidine and remifentanil in sedation, analgesia, and vital signs in patients undergoing stereotactic brain biopsy: a single-blind control trialFaranak Behnaz, Sogol Asgari, Narges Bazgir, Mohammadsmaeil Kordjazi, Parisa Sezari · 2023 · Research Square
- Reviewer #2 (Public Review): Homeostatic regulation of REM sleep by the preoptic area of the hypothalamus2023 · eLife
- eLife Assessment: Homeostatic regulation of REM sleep by the preoptic area of the hypothalamusAdrien Peyrache · 2023 · eLife
- Assessing Susceptibility to Carbon Dioxide Gas in Three Rat Strains Using the Loss of Righting ReflexDexter R Merenick, Brittany A Munro, Julia M.W. Gee, Daniel Pang · 2024 · Journal of the American Association for Laboratory Animal Science
- Dexmedetomidine Improves Sleep Quality of Chronic Insomnia Patients: A Prospective Randomized Controlled TrialMiaoyun Xia, Zhihong Xu, Xiaoxuan Yang, Yanru Zou, Yiqiong Xu, Yongchang Tan, Renyu Yan, Jiashi Xu, Yifan Song, Yifei Liu et al. · 2024 · SSRN Electronic Journal
- Research Progress on the Effect of Dexmedetomidine on Postoperative Sleep Quality港 罗 · 2024 · Advances in Clinical Medicine
- RGAST: A Relational Graph Attention Network for Multi-Scale Cell-Cell Communication Inference from Spatial TranscriptomicsYuqiao Gong, Zhangsheng Yu · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
- Cognitive clarity in colon surgery: The dexmedetomidine advantageAsad Gul Rao, Abdulqadir J. Nashwan · 2024 · World Journal of Gastrointestinal Surgery
- Abnormal c-Fos expression in TetTag mice containing fos-EGFPJacob H. Wilmot, Tracy L. Warren, Cassiano R.A.F. Diniz, Deger Carda, Marrisa M. Lafreniere, Alex S. Nord, Brian Joseph Wiltgen · 2024 · Frontiers in Behavioral Neuroscience
- Genetic capture for conscious state transitionsMitra Heshmati, Hallie Lazaro, Kevin N. Schneider, Michelle Jin, Asad I. Beck, Daniel Ryskamp Rijsketic, Alexandria D. Murry, Jovana S. Navarrete, Cole C. Shin, Ainsley C. Barrow et al. · 2025 · Research Square
- The Crunchometer: A Low-Cost, Open-Source Acoustic Analysis of Feeding MicrostructureElvi Gil-Lievana, Benjamin Arroyo, Jesús Pérez-Ortega, Axl Lopez, Luis Alfredo Rodriguez Blanco, Xarenny Diaz, Gustavo Hernandez, Alam Coss, Emily Alway, Naama Reicher et al. · 2025 · eLife
- Early time window for memory ensemble allocation specifically depending on activity in Syt2+ early-born parvalbumin interneuronsSergio Valbuena, Komal Bhandari, Annapoorani Udhayachandran, Matteo Tripodi, Pico Caroni · 2025 · Cell Reports
- The Crunchometer: A Low-Cost, Open-Source Acoustic Analysis of Feeding MicrostructureElvi Gil-Lievana, Benjamin Arroyo, Jesús Pérez-Ortega, Axl Lopez, Luis Alfredo Rodriguez Blanco, Xarenny Diaz, Gustavo Hernandez, Alam Coss, Emily Alway, Naama Reicher et al. · 2025 · eLife
- The Crunchometer, a low-cost, open-source acoustic analysis of feeding microstructureElvi Gil-Lievana, Benjamin Arroyo, Jesús Pérez-Ortega, Axel Lopez, Luis Alfredo Rodriguez Blanco, Xarenny Diaz, Gustavo Hernandez, Alam Coss, Emily Alway, Naama Reicher et al. · 2025 · eLife
- The systems biology of sleep: toward integrative understanding of molecular and circuit-based mechanisms of sleepHiroyuki J. Kanaya, Koji L. Ode, Hiroki R. Ueda · 2026 · Current Opinion in Biotechnology
- Edinger-Westphal Neurons Contribute to Emergence from Desflurane and Sevoflurane Anesthesia in MiceYiwen Hu(胡译文), Jing Huang(黄静), Fuhai Bai, Jing Yang(杨静), Zonghong Long, Yu Li (李钰), Min Zhang(张敏), Lu Huang(黄露), Zhuoxi Wu(吴卓熙), Tingting Yi et al. · 2026 · Journal of Neuroscience
- Etude du rôle des altérations des cycles éveil/sommeil dans la progression de la maladie de Parkinson et de l'atrophie multisystématiséeMarine Persillet · 2021
- On the developmental origin of CA1 pyramidal neuron diversity in the adult mouse hippocampusDavide Cavalieri · 2021 · theses.fr (ABES)
- Régulation du sommeil paradoxal en condition de stress : implication des projections corticales au noyau préoptique ventrolatéralMathilde Chouvaeff · 2024
- A Novel Conditional Adra2a-Knockout Mouse Line Reveals Cell-specific Contributions to Specific Dimensions of SedationNoah L Fryou, Timothy Jiang, Nathan Frick, Paula Kwasniewska, Mikhail Y. Lipin, Max B. Kelz, STEVEN A. THOMAS, Andrew R. McKinstry-Wu · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
- Astrocyte-neurone crosstalk mediates dexmedetomidine sedationBeverley Anne Orser, Connor T. A. Brenna, Mervyn Maze · 2026 · British Journal of Anaesthesia
- Hippocampal recruitment of cortical engrams underlies remote memory generalizationGabriel Berdugo‐Vega, Irene Ferreres, Jules Orsat, Myriam Schioppa, Johannes Gräff · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
- Efficacy and safety of preoperative intranasal dexmedetomidine in adults: a systematic review and meta-analysis of randomized controlled trialsVitaliy Voznyy, Mouad Elganga, Leya Tawfik, Tony Tan, Sammie Yu, Ellene Yan, Aparna Saripella, Marina F Englesakis, Frances F. Chung · 2026 · Brazilian Journal of Anesthesiology (English Edition)
- Exploring the synergistic mechanism of combined hypnotic drugs on sleep in mice based on transcriptomicsRui Bai, Yanli Liu, Yifeng Yin, Fanghui Wu, Yunyang Song, Yuan Gao · 2026 · Neuropharmacology
- Lateral septum GABAergic neurons mediate the effects of dexmedetomidine on allodynia and sleep in a male mouse model of neuropathic painHaiting Fan, Yingying Su, Jie Deng, Zhengkai LIANG, Meiying Chen, Kaibin Wu, Peiwen Tang, Chen Wang, Deyi Kong, Ting Xu et al. · 2026 · Nature Communications
- Catecholamine modulation of frontal cortical ignition during wakefulness, sleep and anesthesiaBing Li, Jia Zhao, Yang Dan · 2026 · National Science Review
- Synthetic torpor in the rat protects the heart from ischaemia-reperfusion injuryMeg Elley, Ludovico Taddei, Muz Ali Khan, Una Rose Wilcox, Timna Hitrec, Martin Lewis, Anthony Edward Pickering, Michael T. Ambler · 2026 · eLife
- Synthetic torpor in the rat protects the heart from ischaemia-reperfusion injuryMeg Elley, Ludovico Taddei, Muz Ali Khan, Una Rose Wilcox, Timna Hitrec, Anthony Edward Pickering, Michael T. Ambler · 2026 · eLife
- Dexmedetomidine versus remifentanil in sedation, analgesia, and vital signs in stereotactic brain biopsy: A randomized, single-blind, active-controlled clinical trialFaranak Behnaz, Parisa Sezari, Mohammad Mirahmadi Eraghi, Narges Bazgir, Sogol Asgari · 2026 · Journal of International Medical Research
- Microelectrode array-based detection and modulation of sleep–wake neuroinformation in the mouse preoptic areaYiming Duan, Qianli Jia, Jinping Luo, Yu Wang, Yu Liu, Xingcheng Lu, Jin Shan, Jiangbei Cao, Yulong Ma, Weidong Mi et al. · 2026 · Nanotechnology and Precision Engineering
- The Central Medial Thalamus Serves as a Critical Hub for Preserved Arousability During Dexmedetomidine SedationYunyun Zhang, Sa Wang, Haonan Li, Xinxin Zhang, Dan Wang, Ye Wang, Weichao Bai, Zefei Zhang, Guangchao Zhao, Tingting Gu et al. · 2026 · Neuroscience Bulletin
- A male-biased hypothalamic circuit modulates postmating sleep suppression in miceJin Zhao, Linhao Jiang, Qian Zhang, Shajin Huang, Xueping Gao, Minghui Song, Lu Xue, Siwen Pan, Xi Zha, Lei Jin et al. · 2026 · Science Advances
- Synthetic torpor in the rat protects the heart from ischaemia-reperfusion injuryMeg Elley, Ludovico Taddei, Muz Ali Khan, Una Rose Wilcox, Timna Hitrec, Martin Lewis, Anthony Edward Pickering, Michael T. Ambler · 2026 · eLife
- Recent perspectives regarding dexmedetomidine: highlights from anesthesiology and perioperative scienceXian Zou, Cheng Zhou, Donghang Zhang · 2026 · Anesthesiology and Perioperative Science
- Recovery sleep induces analgesia via sleep ensembles of the zona incerta acting through distinct neural circuits in miceHaiyan Sun, Xin Liu, Xu Zhao, Yanqin Zhou, Han Sun, Jiayi Zhang, Yan Li, Jun-Li Cao, Shuming An · 2026 · Neuron
- Trends in Supportive Medication Use Before, During, and After Dexmedetomidine Initiation in End-of-Life Palliative Care: A Descriptive Follow-up StudyJamie Kneebusch, Michael Ley, Kyle P. Edmonds, Paula Mesarwi, Jeremy M. Hirst, Jennifer M. Byrne, Rabia Samady Atayee · 2026 · Journal of Pain & Palliative Care Pharmacotherapy