Central role for PICALM in amyloid-β blood-brain barrier transcytosis and clearance

Zhao, Zhen, Sagare, Abhay P, Ma, Qingyi, Halliday, Matthew R, Kong, Pan, Kisler, Kassandra, Winkler, Ethan A, Ramanathan, Anita +14 more·2015·Nature Neuroscience

DOI 10.1038/nn.4025

Cited by (410)

Items 201–300 of 410

Modeling Neurovascular Disorders and Therapeutic Outcomes with Human-Induced Pluripotent Stem Cells
Allison M. Bosworth, Shannon L. Faley, Leon M. Bellan, Ethan S. Lippmann · 2018 · Frontiers in Bioengineering and Biotechnology
A functional variant in the miR‐142 promoter modulating its expression and conferring risk of Alzheimer disease
Mohsen Ghanbari, Shashini T. Munshi, Buyun Ma, Bas Lendemeijer, Sakshi Bansal, Hieab H.H. Adams, Wenshi Wang, Kerstin Goth, Denise E. Slump, Mirjam C. G. N. van den Hout et al. · 2019 · Human Mutation
The first Antechinus reference genome provides a resource for investigating the genetic basis of semelparity and age-related neuropathologies
Parice A. Brandies, Simon S. K. Tang, Robert Johnson, Carolyn J. Hogg, Katherine Belov · 2020 · Gigabyte
Translating Alzheimer’s disease-associated polymorphisms into functional candidates: a survey of IGAP genes and SNPs
Katsumata, Yuriko, Nelson, Peter T., Estus, Steven, Fardo, David W. · 2019 · Neurobiology of Aging
Microglia and its Genetics in Alzheimer's Disease
Xinyan Liang, Haijian Wu, Mark Colt, Xinying Guo, Brock R. Pluimer, Jianxiong Zeng, Shupeng Dong, Zhen Zhao · 2021 · Current Alzheimer Research
Genetic insights into immune mechanisms of Alzheimer’s and Parkinson’s disease
Alexi Nott, Inge R. Holtman · 2023 · Frontiers in Immunology
Clearance of interstitial fluid (ISF) and CSF (CLIC) group‐part of Vascular Professional Interest Area (PIA), updates in 2022‐2023. Cerebrovascular disease and the failure of elimination of Amyloid‐β from the brain and retina with age and Alzheimer's disease: Opportunities for therapy
Louise Kelly, Christopher Brown, Daniel Michalik, Cheryl A. Hawkes, Roxana Aldea, Nivedita Agarwal, Rami J. Salib, Aiman Alzetani, Douglas W. Ethell, Scott Counts et al. · 2023 · Alzheimer s & Dementia
Microvascular Contributions to Alzheimer Disease Pathogenesis: Is Alzheimer Disease Primarily an Endotheliopathy?
Tarawneh, Rawan · 2023 · Biomolecules
Development of a Multicomponent Intervention to Prevent Alzheimer's Disease
Satoshi Saitô, Yumi Yamamoto, Masafumi Ihara · 2019 · Frontiers in Neurology
Therapeutic TVs for Crossing Barriers in the Brain
Zhen Zhao, Berislav V. Zloković · 2020 · Cell
Blood-Brain Barrier (BBB) Permeability and Transport Measurement In Vitro and In Vivo
Bingmei M. Fu, Zhen Zhao, Donghui Zhu · 2020 · Methods in molecular biology
Levetiracetam Treatment Normalizes Levels of Presynaptic Endocytosis Machinery and Restores Nonamyloidogenic APP Processing in App Knock-in Mice
Nalini R. Rao, Jeffrey N. Savas · 2021 · Journal of Proteome Research
Selective endocytosis of Ca 2+ -permeable AMPARs by the Alzheimer’s disease risk factor CALM bidirectionally controls synaptic plasticity
Domenico Azarnia Tehran, Gaga Kochlamazashvili, Niccolò Paolo Pampaloni, Silvia Sposini, Jasmeet Kaur Shergill, Martin Lehmann, Natalya Pashkova, Claudia Schmidt, Delia Löwe, Hanna Napieczyńska et al. · 2022 · Science Advances
Anti-malaria drug artesunate prevents development of amyloid-β pathology in mice by upregulating PICALM at the blood-brain barrier
Kassandra Kisler, Abhay P. Sagare, Divna Lazić, Sam A. Bazzi, Erica J. Lawson, Ching-Ju Hsu, Yaoming Wang, Anita Ramanathan, Amy R. Nelson, Zhen Zhao et al. · 2023 · Molecular Neurodegeneration
Meox2 haploinsufficiency increases neuronal cell loss in a mouse model of Alzheimer's disease
Ileana Soto, Weronika A. Grabowska, Kristen D. Onos, Leah C. Graham, Harriet M. Jackson, Stephen N. Simeone, Gareth R. Howell · 2016 · Neurobiology of Aging
How does the brain remove its waste metabolites from within?
Yiming Cheng, James Haorah · 2019 · PubMed Central
Alcohol promotes waste clearance in the CNS via brain vascular reactivity
Yiming Cheng, Xinglei Liu, Xiaotang Ma, Ricardo Juan Bosch García, Kevin D. Belfield, James Haorah · 2019 · Free Radical Biology and Medicine
Reduced binding of apoE4 to complement factor H promotes amyloid‐β oligomerization and neuroinflammation
Larisa Chernyaeva, Giorgio Ratti, Laura Teirilä, Satoshi Fudo, Uni Rankka, Anssi Pelkonen, Paula Korhonen, Katarzyna Leskinen, Salla Keskitalo, Kari Salokas et al. · 2023 · EMBO Reports
Challenges in the treatment of Alzheimer’s disease: recent progress and treatment strategies of pharmaceuticals targeting notable pathological factors
Yung‐Chih Kuo, Rajendiran Rajesh · 2019 · Expert Review of Neurotherapeutics
The Blood–Brain Barrier: Much More Than a Selective Access to the Brain
Fredy Sánchez-Cano, Luisa C. Hernández‐Kelly, Arturo Ortega · 2021 · Neurotoxicity Research
Partial loss of CALM function reduces Aβ42 production and amyloid depositionin vivo
Kunihiko Kanatsu, Yukiko Hori, Sho Takatori, Toshio Watanabe, Takeshi Iwatsubo, Taisuke Tomita · 2016 · Human Molecular Genetics
Apolipoprotein E2 and E3, but Not E4, Promote Retinal Pathologic Neovascularization
Tomomi Masuda, Masamitsu Shimazawa, Yuhei Hashimoto, Atsushi Kojima, Shinsuke Nakamura, Shinsuke Suemori, Kiyofumi Mochizuki, Hideaki Kawakami, Kazuhide Kawase, Hideaki Hara · 2017 · Investigative Ophthalmology & Visual Science
Impaired autophagy in amyloid-beta pathology: A traditional review of recent Alzheimer's research
Minghao Yuan, Yangyang Wang, Zhenting Huang, Feng Jing, Peifeng Qiao, Qian Zou, Jing Li, Zhiyou Cai · 2022 · Journal of Biomedical Research
rs3851179 Polymorphism at 5′ to the PICALM Gene is Associated with Alzheimer and Parkinson Diseases in Brazilian Population
Cíntia Barros Santos-Rebouças, Andressa Pereira Gonçalves, Jussara Mendonça dos Santos, Bianca Barbosa Abdala, Luciana Branco da Motta, Jerson Laks, Margarete Borges de Borges, Ana Lúcia Zuma de Rosso, João Santos Pereira, Denise Hack Nicaretta et al. · 2017 · NeuroMolecular Medicine
Vascular dysfunction in Alzheimer’s disease: a biomarker of disease progression and a potential therapeutic target
Karan Govindpani, Chitra Vinnakota, Henry J. Waldvogel, Richard L. Faull, Andrea Kwakowsky · 2019 · Neural Regeneration Research
Pericytes in Alzheimer's disease: Key players and therapeutic targets
Yu Zhang, Benrong Mu, Ran Zhao, Tao Zhu, Xin Huang, Xiong Yang, Dongmei Wang, Quanhong Ma, Mei‐Hong Lu · 2024 · Experimental Neurology
Bidirectional apical–basal traffic of the cation-independent mannose-6-phosphate receptor in brain endothelial cells
Piotr Siupka, Maria Hersom, Karin Lykke‐Hartmann, Kasper Bendix Johnsen, Louiza Bohn Thomsen, Thomas Lars Andresen, Torben Moos, N. Joan Abbott, Birger Brodin, Morten Schallburg Nielsen · 2017 · Journal of Cerebral Blood Flow & Metabolism
Single-cell-led drug repurposing for Alzheimer’s disease
Silvia Parolo, Federica Mariotti, Pranami Bora, Lucia Carboni, Enrico Domenici · 2023 · Scientific Reports
Clusterin/apolipoprotein J, its isoforms and Alzheimer's disease
Giedre Milinkeviciute, Kim N. Green · 2023 · Frontiers in Aging Neuroscience
The role of LRP1 in Aβ efflux transport across the blood-brain barrier and cognitive dysfunction in diabetes mellitus
Xue Pan, Long Zz, Jiang Gg, Wang Lp, Bian Cm, Wang Yl, M.F. Chen, Wei Li · 2022 · Neurochemistry International
PICALM mRNA Expression in the Blood of Patients with Neurodegenerative Diseases and Geriatric Depression
Hiroshi Kumon, Yuta Yoshino, Yu Funahashi, Hiroaki Mori, Mariko Ueno, Yuki Ozaki, Kiyohiro Yamazaki, Shinichiro Ochi, Takaaki Mori, Jun‐ichi Iga et al. · 2020 · Journal of Alzheimer s Disease
Cell type-specific functions of Alzheimer's disease endocytic risk genes
Johanna‐Katharina Maninger, Karolina Nowak, Srilakshmi Goberdhan, Rachel O’Donoghue, Natalie Connor‐Robson · 2024 · Philosophical Transactions of the Royal Society B Biological Sciences
Microglia internalize tau monomers and fibrils using distinct receptors but similar mechanisms
Kristian F. Falkon, Liliana Danford, Eduardo Gutierrez Kuri, Paulina Esquinca‐Moreno, Yaren L. Peña Señeriz, Sabrina A. Smith, Jessica L. Wickline, Ariel Louwrier, Jacob Alec McPhail, Naomi L. Sayre et al. · 2024 · Alzheimer s & Dementia
Effects of cerebral amyloid angiopathy on the brain vasculome
Wenjun Deng, Shuzhen Guo, Susanne J. van Veluw, Zhanyang Yu, Su Jing Chan, Hajime Takase, Ken Arai, MingMing Ning, Steven Mark Greenberg, Eng H. Lo et al. · 2022 · Aging Cell
Polarized trafficking of the sorting receptor Sor LA in neurons and MDCK cells
Stine Christensen Klinger, Anne Højland, Shweta Jain, Mads Kjølby, Peder Madsen, Anna Dorst Svendsen, Gunilla Olivecrona, Juan S. Bonifacino, Morten Schallburg Nielsen · 2016 · FEBS Journal
Neurological diseases at the blood-brain barrier: Stemming new scientific paradigms using patient-derived induced pluripotent cells
Shyanne Page, Ronak Patel, Snehal Raut, Abraham Jacob Al-Ahmad · 2018 · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
Genetic discoveries and advances in late‐onset Alzheimer’s disease
Maryam Rezazadeh, Hassan Hosseinzadeh, Mohsen Moradi, Behnaz Salek Esfahani, Shahrzad Talebian, Shaho Parvin, Jalal Gharesouran · 2019 · Journal of Cellular Physiology
Differential Sensitivity of Two Endothelial Cell Lines to Hydrogen Peroxide Toxicity: Relevance for In Vitro Studies of the Blood–Brain Barrier
Olufemi A. Alamu, Mariam Rado, Okobi Eko Ekpo, David Fisher · 2020 · Cells
Pathology of Amyloid-β (Aβ) Peptide Peripheral Clearance in Alzheimer’s Disease
Andrey Tsoy, Bauyrzhan A. Umbayev, Aliya Kassenova, Bibifatima Kaupbayeva, Sholpan Askarova · 2024 · International Journal of Molecular Sciences
Peripheral Pathways to Neurovascular Unit Dysfunction, Cognitive Impairment, and Alzheimer’s Disease
Amy R. Nelson · 2022 · Frontiers in Aging Neuroscience
Rab11 and Its Role in Neurodegenerative Diseases
Pinky Sultana, Jiřı́ Novotný · 2022 · ASN NEURO
Regulation of beta‐amyloid for the treatment of Alzheimer's disease: Research progress of therapeutic strategies and bioactive compounds
Weimin Qiu, Hui Liu, Yijun Liu, Xin Lü, Lei Wang, Yanyu Hu, Feng Feng, Qi Li, Haopeng Sun · 2023 · Medicinal Research Reviews
Improvement of Electroacupuncture on APP/PS1 Transgenic Mice in Spatial Learning and Memory Probably due to Expression of A β and LRP1 in Hippocampus
Xin Wang, Yanhuan Miao, Jiawula Abulizi, Li Fu, Yuping Mo, Xue Wei-guo, Zhigang Li · 2016 · Evidence-based Complementary and Alternative Medicine
C-type natriuretic peptide functions as an innate neuroprotectant in neonatal hypoxic-ischemic brain injury in mouse via natriuretic peptide receptor 2
Qingyi Ma, Li Zhang · 2018 · Experimental Neurology
The blood–brain barrier as a treatment target for neurodegenerative disorders
Ruslan Rust, Abhay P. Sagare, Mingzi Zhang, Berislav V. Zloković, Kassandra Kisler · 2025 · Expert Opinion on Drug Delivery
Quantifying Serum Derived Differential Expressed and Low Molecular Weight Protein in Breast Cancer Patients
Ayesha Zafar, Maryum Jabbar, Yasmeen Manzoor, Huma Gulzar, Shahzad Gul Hassan, Muniba Anum Nazir, Ain-ul-Haq, Ghazala Mustafa, Romana Sahar, Aqeel Masood et al. · 2020 · Protein and Peptide Letters
Current Management and Therapeutic Strategies for Cerebral Amyloid Angiopathy
Yasuteru Inoue, Yukio Ando, Yohei Misumi, Mitsuharu Ueda · 2021 · International Journal of Molecular Sciences
Endothelial LRP1-ICD Accelerates Cognition-Associated Alpha-Synuclein Pathology and Neurodegeneration through PARP1 Activation in a Mouse Model of Parkinson’s Disease
Rui Huang, Yuyuan Gao, Qingrui Duan, Qingxi Zhang, Peikun He, Jianing Chen, Guixian Ma, Limin Wang, Yuhu Zhang, Kun Nie et al. · 2022 · Molecular Neurobiology
Genome-wide association study in Alzheimer’s disease: a bibliometric and visualization analysis
Junyao Zhang, Yinuo Wang, Yingying Zhang, Junyan Yao · 2023 · Frontiers in Aging Neuroscience
Counteracting Alzheimer's disease via normalizing neurovascular unit with a self-regulated multi-functional nano-modulator
Xue Xia, Ya Wei, Qianqian Huang, Yang Zhou, Xiaorong Wang, Yulong Shi, Xiaotong Yang, Wenqin Yang, Yiwei Zhang, Ting Lei et al. · 2024 · Acta Pharmaceutica Sinica B
Diet Associated with Inflammation and Alzheimer’s Disease
Maryam Vasefi, Mackenzie Hudson, Ehsan Ghaboolian-Zare · 2019 · Journal of Alzheimer s Disease Reports
Uncovering the Potential Differentially Expressed miRNAs and mRNAs in Ischemic Stroke Based on Integrated Analysis in the Gene Expression Omnibus Database
Xiao-Tun Zhu, Xiao Liu, Ying Min Liu, Wansheng Chang, Yanfeng Song, Shulai Zhu · 2020 · European Neurology
Structural Covariance Network as an Endophenotype in Alzheimer’s Disease-Susceptible Single-Nucleotide Polymorphisms and the Correlations With Cognitive Outcomes
Hsin‐I Chang, Yu‐Tzu Chang, Chi‐Wei Huang, Kuo‐Lun Huang, Jung‐Lung Hsu, Shih‐Wei Hsu, Shih‐Jen Tsai, Wen‐Neng Chang, Chen‐Chang Lee, Shu‐Hua Huang et al. · 2021 · Frontiers in Aging Neuroscience
Transcriptomic Analysis of Rat Cerebral Cortex Reveals the Potential Mechanism of Electroacupuncture Opening Blood Brain Barrier
Congcong Ma, Lin Gan, Hao Wang, Li Ren, Yubo Lin, Yibin Zhao, Shanshan Zhang, Peng Gong, Xianming Lin · 2022 · Frontiers in Neuroscience
The Role of Astrocytes and Blood–Brain Barrier Disruption in Alzheimer’s Disease
J. V. R. Cruz, C. Batista, L. Diniz, F. Mendes · 2023 · Neuroglia
High glucose‐mediated PICALM and mTORC1 modulate processing of amyloid precursor protein via endosomal abnormalities
Chang Woo Chae, Hyun Jik Lee, Gee Euhn Choi, Young Hyun Jung, Jun Sung Kim, Jae Ryong Lim, Seo Yihl Kim, In Koo Hwang, Je Kyung Seong, Ho Jae Han · 2020 · British Journal of Pharmacology
Pseudogene ACTBP2 increases blood–brain barrier permeability by promoting KHDRBS2 transcription through recruitment of KMT2D/WDR5 in Aβ1–42 microenvironment
Qianshuo Liu, Xiaobai Liu, Defeng Zhao, Xuelei Ruan, Rui Jun Su, Xiuli Shang, Di Wang, Chunqing Yang, Yixue Xue · 2021 · Cell Death Discovery
Monocytes Release Pro-Cathepsin D to Drive Blood-to-Brain Transcytosis in Diabetes
Dan Zhao, Zeng-Kang Huang, Liang Yu, Zhi-Jun Li, X Y Zhang, Kunhang Li, Hao Wu, Xudong Zhang, Chen-Sheng Li, Dong An et al. · 2024 · Circulation Research
PI3K activation prevents Aβ42-induced synapse loss and favors insoluble amyloid deposit formation
Mercedes Arnés, Ninovska Romero, Sergio Casas‐Tintó, Ángel Acebes, Alberto Ferrús · 2019 · Molecular Biology of the Cell
The role of PTB domain containing adaptor proteins on PICALM-mediated APP endocytosis and localization
Lisa Merthan, Amelie Haller, Dietmar Rudolf Thal, Bjoern von Einem, Christine A. F. Von Arnim · 2019 · Biochemical Journal
Molecular signature and functional properties of human pluripotent stem cell-derived brain pericytes
Ruslan Rust, Abhay P. Sagare, Kassandra Kisler, Youbin Kim, Mingzi Zhang, Casey Griffin, Yaoming Wang, Veronica A. Clementel, Arkadi Shwartz, Scott E Fraser et al. · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
Calmodulin and Amyloid Beta as Coregulators of Critical Events during the Onset and Progression of Alzheimer’s Disease
Danton H. O’Day · 2023 · International Journal of Molecular Sciences
Genetic Variants of PICALM rs541458 Modulate Brain Spontaneous Activity in Older Adults With Amnestic Mild Cognitive Impairment
Liying Zhuang, Xiaoyan Liu, Yongmei Shi, Xiaoli Liu, Benyan Luo · 2019 · Frontiers in Neurology
Association of PICALM with Cognitive Impairment in Parkinson's Disease
María Teresa Periñán, Daniel Macías‐García, Miguel Ángel Labrador‐Espinosa, Silvia Jesús, Dolores Buiza‐Rueda, Astrid Daniela Adarmes-Gómez, Laura Muñoz‐Delgado, Pilar Gómez‐Garre, Pablo Mir · 2020 · Movement Disorders
Removal of extracellular human amyloid beta aggregates by extracellular proteases in C. elegans
Elisabeth Jongsma, Anita Goyala, José Marı́a Mateos, Collin Y. Ewald · 2023 · eLife
Rab11-mediated recycling endosome role in nervous system development and neurodegenerative diseases
Jiajia Zhang, Gang Su, Qionghui Wu, Jifei Liu, Ye Tian, Xiaoyan Liu, Juanping Zhou, Juan Gao, Wei Chen, Deyi Chen et al. · 2020 · International Journal of Neuroscience
PICALM rescues glutamatergic neurotransmission, behavioural function and survival in a Drosophila model of Aβ42 toxicity
Yifan Yu, Teresa Niccoli, Ziyu Ren, Nathaniel S. Woodling, Benjamin Aleyakpo, György Szabadkai, Linda Partridge · 2020 · Human Molecular Genetics
Syndapin-2 mediated transcytosis of amyloid-β across the blood–brain barrier
Diana M. Leite, Mohsen Seifi, Lorena Ruiz‐Pérez, Filomain Nguemo, Markus Plomann, Jerome D. Swinny, Giuseppe Battaglia · 2022 · Brain Communications
The Expression of Major Facilitator Superfamily Domain-Containing Protein2a (Mfsd2a) and Aquaporin 4 Is Altered in the Retinas of a 5xFAD Mouse Model of Alzheimer’s Disease
Irena Jovanović Macura, Ana Živanović, Milka Perović, Jelena Ciric, Tamara Major, Selma Kanazir, Sanja Ivković · 2023 · International Journal of Molecular Sciences
The Intersection of cerebral cholesterol metabolism and Alzheimer's disease: Mechanisms and therapeutic prospects
Li-Cheng Liu, Jun-Yi Liang, Yan-Hong Liu, Bin Liu, Xiao-Hong Dong, Wen-Hui Cai, Ning Zhang · 2024 · Heliyon · Retracted
Differential Effects of Alzheimer’s Disease Aβ40 and 42 on Endocytosis and Intraneuronal Trafficking
Rajesh S. Omtri, Kevin J. Thompson, Xiaojia Tang, Chaitanya Chakravarthi Gali, Ute Panzenboeck, Michael W. Davidson, Krishna R. Kalari, Karunya K. Kandimalla · 2018 · Neuroscience
Comparative genomic analysis of embryonic, lineage-converted, and stem cell-derived motor neurons
Justin K. Ichida, Kim A. Staats, Brandi N. Davis‐Dusenbery, Kendell Clement, Kate E. Galloway, Kimberly Babos, Yingxiao Shi, Esther Son, Evangelos Kiskinis, Nicholas Atwater et al. · 2018 · Development
Classifying Alzheimer’s disease and normal subjects using machine learning techniques and genetic-environmental features
Yu-Hua Huang, Yi‐Chun Chen, Wei-Min Ho, Ren-Guey Lee, Ren‐Hua Chung, Yuli Liu, Pi-Yueh Chang, Shih‐Cheng Chang, Chaung-Wei Wang, Wen‐Hung Chung et al. · 2023 · Journal of the Formosan Medical Association
Genetic Association Between Alzheimer’s Disease Risk Variant of the PICALM Gene and EEG Functional Connectivity in Non-demented Adults
Н.В. Пономарева, Т. В. Андреева, Maria Protasova, Родион Николаевич Коновалов, М. В. Кротенкова, Daria D. Malina, Митрофанов Андрей Алексеевич, Vitaly Feodor Fokin, Sergey Nikolaevich Illarioshkin, Evgeny Ivanovich Rogaev · 2020 · Frontiers in Neuroscience
Reduced endothelial caveolin-1 underlies deficits in brain insulin signalling in type 2 diabetes
Aashutosh Shetti, Abhirami Ramakrishnan, Liudmila G. Romanova, Wenping Li, Khanh Vo, Ipsita Volety, Ishara S. Ratnayake, Terilyn K. L. Stephen, Richard D. Minshall, Stephanie M. Cologna et al. · 2023 · Brain
Rebuilding insight into the pathophysiology of Alzheimer's disease through new blood-brain barrier models
Kinya Matsuo, Hideaki Nishihara · 2023 · Neural Regeneration Research
The Lipid Invasion Model: Growing Evidence for This New Explanation of Alzheimer’s Disease
Jonathan D’Arcy Rudge · 2023 · Journal of Alzheimer s Disease
Developing Trojan horses to induce, diagnose and suppress Alzheimer’s pathology
Amal A. Aziz, Zareen Amtul · 2019 · Pharmacological Research
Single-cell dissection of the human cerebrovasculature in health and disease
F. García, Na Sun, Hyeseung Lee, Brianna R. Godlewski, Kyriaki Galani, Julio C. Mantero, David Alan Bennett, Mustafa Şahin, M Kellis, Myriam Heiman · 2021 · bioRxiv (Cold Spring Harbor Laboratory)
Therapeutic targeting of neuroimmune mechanisms in neurodegeneration
Kathryn M. Monroe, Soyon Youngae Hong, Joseph W. Lewcock, Andrew C. Yang · 2026 · Nature Reviews Drug Discovery
Differential Clearance of Aβ Species from the Brain by Brain Lymphatic Endothelial Cells in Zebrafish
Yun-Mi Jeong, Jae Geun Lee, Hyun-Ju Cho, Wang Sik Lee, Jinyoung Jeong, Jeong-Soo Lee · 2021 · International Journal of Molecular Sciences
Amylovis-201 is a new dual-target ligand, acting as an anti-amyloidogenic compound and a potent agonist of the σ1 chaperone protein
Laura García-Pupo, Lucie Crouzier, Alberto Bencomo-Martínez, Johann Meunier, Axelle Morilleau, Benjamin Delprat, Marquiza Sablón-Carrazana, Roberto Menéndez, Tangui Maurice, Chryslaine Rodríguez‐Tanty · 2024 · Acta Pharmaceutica Sinica B
Unraveling the transcriptomic landscape of brain vascular cells in dementia: A systematic review
Michael D.E. Sewell, Nela Fialova, Axel Montagne · 2025 · Alzheimer s & Dementia
Gene Ontology: A Resource for Analysis and Interpretation of Alzheimer’s Disease Data
Barbara Kramarz, Ruth C. Lovering · 2019 · Codon Publications eBooks
Sigma ligands as potent inhibitors of Aβ and AβOs in neurons and promising therapeutic agents of Alzheimer's disease
Wenhui Ma, Ai-Fang Chen, Xiaoyang Xie, Yun‐Sheng Huang · 2020 · Neuropharmacology
Influence of PICALM and CLU risk variants on beta EEG activity in Alzheimer’s disease patients
Aarón Maturana-Candelas, Carlos Gómez, Jesús Poza, Víctor Rodríguez-González, Víctor Gutiérrez-de Pablo, Alexandra M. Lopes, Nádia Pinto, Roberto Hornero · 2021 · Scientific Reports
Blood–Brain Barrier Transport of Alzheimer’s Amyloid β-Peptide
Amy R. Nelson, Abhay P. Sagare, Berislav V. Zloković · 2016 · Elsevier eBooks
The Interactive Effects of Age and PICALM rs541458 Polymorphism on Cognitive Performance, Brain Structure, and Function in Non-demented Elderly
Zhen Liu, Xiangwei Dai, Junying Zhang, Xin Li, Yaojing Chen, Chao Ma, Kewei Chen, Dantao Peng, Zhanjun Zhang · 2017 · Molecular Neurobiology
The Level of Plasma Amyloid-β40 Is Correlated with Peripheral Transport Proteins in Cognitively Normal Adults: A Population-Based Cross-Sectional Study
Ling Gao, Yu Jiang, Shan Wei, Suhang Shang, Pei Li, Chen Chen, Liangjun Dang, Jin Wang, Kang Huo, Meiying Deng et al. · 2018 · Journal of Alzheimer s Disease
Abeta peptides disrupt the barrier integrity and glucose metabolism of human induced pluripotent stem cell-derived brain microvascular endothelial cells
Snehal Raut, Ronak Patel, Iqra Pervaiz, Abraham Jacob Al-Ahmad · 2022 · NeuroToxicology
Explicating anti-amyloidogenic role of curcumin and piperine via amyloid beta (A β ) explicit pathway: recovery and reversal paradigm effects
Aimi Syamima Abdul Manap, Priya Madhavan, Shantini Vijayabalan, Adeline Yoke Yin Chia, Koji Fukui · 2020 · PeerJ
Upregulation of endocytic protein expression in the Alzheimer’s disease male human brain
Mouhamed Alsaqati, Rhian S. Thomas, Emma J. Kidd · 2023 · Aging Brain
Contextualizing the Role of Osteopontin in the Inflammatory Responses of Alzheimer’s Disease
Roshni C. Lalwani, Claude‐Henry Volmar, Claes Wahlestedt, Keith A. Webster, Lina A. Shehadeh · 2023 · Biomedicines
Genetic interaction is associated with lower metabolic connectivity and memory impairment in clinically mild Alzheimer's disease
Young‐Tae Chang, Cheng‐Wei Huang, Shu‐Hua Huang, Shih Wei Hsu, W.‐N. Chang, J.‐J. Lee, Chiung‐Chih Chang · 2018 · Genes Brain & Behavior
Molecular signature of penumbra in acute ischemic stroke: a pilot transcriptomics study
Zurab Nadareishvili, Devon Kelley, Marie L. Luby, Alexis Netis Simpkins, Richard J. Leigh, John K. Lynch, Amie W. Hsia, Richard T Benson, Kory R. Johnson, John M. Hallenbeck et al. · 2019 · Annals of Clinical and Translational Neurology
Computational analysis of functional SNPs in Alzheimer’s disease-associated endocytosis genes
Han Jieh Tey, Chong Han Ng · 2019 · PeerJ
Approaches for Increasing Cerebral Efflux of Amyloid-β in Experimental Systems
David A. Loeffler · 2024 · Journal of Alzheimer s Disease
LRP1 at the crossroads of Aβ clearance and therapeutic targeting in Alzheimer’s disease
Yuepeng Deng, Haolin Yin, Zihao Lu, Huan Lan, Wenxiong Liu, Chao Zuo, Nanfang Pan, Xiaohe Tian, Q. Gong · 2026 · Frontiers in Aging Neuroscience
The Role of RIN3 Gene in Alzheimer’s Disease Pathogenesis: a Comprehensive Review
Mostafa Mahmoud Meshref, Hazem S. Ghaith, Mohamed Ahmed Hammad, Mahmoud Mohamed Mohamed Shalaby, Faris Ayasra, Fatma Ahmed Monib, Mohamed S. Attia, Mahmoud Ahmed Ebada, Hanaa Elsayed, Ali Shalash et al. · 2023 · Molecular Neurobiology
The Impact of High-Dose Fish Oil Supplementation on Mfsd2a, Aqp4, and Amyloid-β Expression in Retinal Blood Vessels of 5xFAD Alzheimer’s Mouse Model
Irena Jovanović Macura, Desanka Milanović, Vesna Tešić, Tamara Major, Milka Perović, Miroslav Adžić, Sanja Ivković · 2024 · International Journal of Molecular Sciences