SHANK3 controls maturation of social reward circuits in the VTA
Bariselli, Sebastiano, Tzanoulinou, Stamatina, Glangetas, Christelle, Prévost-Solié, Clément, Pucci, Luca, Viguié, Joanna, Bezzi, Paola, O'Connor, Eoin C, Georges, François, Lüscher, Christian, Bellone, Camilla·2016·Nature Neuroscience
DOI 10.1038/nn.4319
Cited by (168)
Items 101–168 of 168
- Potential role of primed microglia during obesity on the mesocorticolimbic circuit in autism spectrum disorderLuis A. Trujillo-Villarreal, Marcela Cárdenas‐Tueme, Roger Maldonado‐Ruiz, Diana Reséndez‐Pérez, Alberto Camacho‐Morales · 2020 · Journal of Neurochemistry
- Altered Neural Activity in the Mesoaccumbens Pathway Underlies Impaired Social Reward Processing in Shank3 ‐Deficient RatsMarie Barbier, Keerthi Thirtamara Rajamani, Shai Netser, Shlomo Wagner, Hala Harony‐Nicolas · 2025 · Advanced Science
- The PFC-LH-VTA pathway contributes to social deficits in IRSp53-mutant miceYoung Woo Noh, Yangsik Kim, Soowon Lee, Yeonghyeon Kim, Jae Jin Shin, Hyojin Kang, Il Hwan Kim, Eunjoon Kim · 2023 · Molecular Psychiatry
- Shank3 deficits in the anteromedial bed nucleus of the stria terminalis trigger an anxiety phenotype in miceAlessandro Contestabile, Giulia Casarotto, Stefano Musardo, Pedro Espinosa, Federica Maltese, Yong‐hui Jiang, Camilla Bellone, Christelle Glangetas · 2023 · European Journal of Neuroscience
- Distinct cell populations of ventral tegmental area process motivated behaviorMin Jung Kim, Bong‐Kiun Kaang · 2022 · Korean Journal of Physiology and Pharmacology
- Embryonic Valproate Exposure Alters Mesencephalic Dopaminergic Neurons Distribution and Septal Dopaminergic Gene Expression in Domestic ChicksAlice Adiletta, Alessandra Pross, Nicolò Taricco, Paola Sgadó · 2022 · Frontiers in Integrative Neuroscience
- The microbial metabolite p -Cresol induces autistic-like behaviors in mice by remodeling the gut microbiotaPatricia Bermudez-Martin, Jérôme A. J. Becker, Nicolas Caramello, S. P. Fernandez, Renan Costa Campos, Juliette Canaguier, Susana Barbosa, L. Martinez-Gili, A. Myridakis, Marc‐Emmanuel Dumas et al. · 2020 · bioRxiv (Cold Spring Harbor Laboratory)
- AST-001 Improves Social Deficits and Restores Dopamine Neuron Activity in a Mouse Model of AutismKi Bum Um, Soyoung Kwak, Sun-Ha Cheon, JuHyun Kim, Su‐Kyeong Hwang · 2023 · Biomedicines
- Deciphering the Role of Shank3 in Dendritic Morphology and Synaptic Function Across Postnatal Developmental Stages in the Shank3B KO MouseJing Yang, Guaiguai Ma, Xiaohui Du, Jinyi Xie, Mengmeng Wang, Wenting Wang, Baolin Guo, Shengxi Wu · 2024 · Neuroscience Bulletin
- Taste processing in autism spectrum disorder: A translational scoping reviewJess Goldschlager, Coralys Cintron, Rosangele Hall, Tracy Shields, Genesis Lucia Tolbert, Rama Woldebirhan, Khushbu Agarwal, Paule V. Joseph · 2025 · Neuroscience & Biobehavioral Reviews
- Degradation of Perineuronal Nets in the Cerebellar Interpositus Nucleus Ameliorated Social Deficits in Shank3-deficient MicePeng Liu, Yulu Zhao, Wen‐Cheng Xiong, Yida Pan, Minzhen Zhu, Xinhong Zhu · 2022 · Neuroscience
- VTA multifaceted modulation of CA1 local circuitsTolulope Tosin Adeyelu, Olalekan Michael Ogundele · 2023 · Neurobiology of Learning and Memory
- Optogenetic and chemogenetic approaches reveal differences in neuronal circuits that mediate initiation and maintenance of social interactionKarolina Rojek-Sito, Ksenia Z. Meyza, Karolina Ziegart-Sadowska, Kinga Nazaruk, Alicja Puścian, Adam Hamed, Michał Kiełbiński, Wojciech Solecki, Ewelina Knapska · 2023 · PLoS Biology
- VTA DA neuron excitatory synapses in Shank3 Δex4–9 mouse lineSebastiano Bariselli, Camilla Bellone · 2016 · Synapse
- Reduced Neurite Arborization in Primary Dopaminergic Neurons in Autism-Like Shank3B-Deficient MiceZuzana Bačová, Tomáš Havránek, Denisa Mihalj, Veronika Borbélyová, Kristina Kostrubanicova, Michaela Kramarova, Daniela Ostatníková, Ján Bakoš · 2024 · Molecular Neurobiology
- Neural Basis of Dysregulation of Palatability-Driven Appetite in AutismAnica Klockars, Tapasya Pal, Allen S. Levine, Pawel K. Olszewski · 2021 · Current Nutrition Reports
- A perspective on molecular signalling dysfunction, its clinical relevance and therapeutics in autism spectrum disorderSushmitha S. Purushotham, Neeharika M. N. Reddy, Michelle Ninochka D’Souza, Nilpawan Roy Choudhury, Anusa Ganguly, Niharika Gopalakrishna, Ravi Sondekoppa Muddashetty, James Premdoss Clement · 2022 · Experimental Brain Research
- Adolescent sleep defects and dopaminergic hyperactivity in mice with a schizophrenia-linked Shank3 mutationWen-Jie Bian, Oscar Christian Gonzalez, Luı́s de Lecea · 2023 · SLEEP
- Circuits underlying social function and dysfunctionZiwen Wang, Hannah Yueh, Mirabella Chau, Jeremy M. Veenstra-VanderWeele, Kally C. O’Reilly · 2023 · Autism Research
- The Cerebellum–Ventral Tegmental Area Microcircuit and Its Implications for Autism Spectrum Disorder: A Narrative ReviewPeiling Zhou, Shiyu Peng, Sizhe Wen, Qinghui Lan, Yingyin Zhuang, Xuyan Li, Mengliang Shi, Changzheng Zhang · 2024 · Neuropsychiatric Disease and Treatment
- Selective loss of Scn2a in ventral tegmental area dopaminergic neurons leads to dopamine system hypofunction and autistic-like behaviorsLiang Li, Qi Quan Huang, Jiahao Hu, Mengmeng Jin, Yizhou Zhuo, Ke Wei, Quansheng He, Yujie Xiao, Xiaoxue Zhang, Weisheng Wang et al. · 2025 · Neuron
- Neonatal programming with sex hormones: Effect on expression of dopamine D1 receptor and neurotransmitters release in nucleus accumbens in adult male and female ratsMaximiliano Elgueta-Reyes, Jonathan Martínez-Pinto, Georgina M. Renard, Ramón Sotomayor‐Zárate · 2021 · European Journal of Pharmacology
- How dopamine guides our social worldNancy Padilla-Coreano, Freddyson J. Martínez-Rivera · 2025 · Pharmacological Reviews
- Synergistic photoactivation of VTA-catecholaminergic and BLA-glutamatergic projections induces long-term potentiation in the insular cortexLuis F. Rodríguez-Durán, Diana L. López-Ibarra, Gabriela Herrera-Xithe, Federico Bermúdez‐Rattoni, Daniel Osorio‐Gómez, Martha Lilia Escobar · 2023 · Neurobiology of Learning and Memory
- Increased social interaction in Shank2-deficient mice following acute social isolationJa Eun Choi, Bong‐Kiun Kaang · 2023 · Molecular Brain
- The Enigmatic CA2: Exploring the Understudied Region of the Hippocampus and Its Involvement in Parkinson’s DiseaseFang Zhao, Thomas Behnisch · 2023 · Biomedicines
- The NMDA receptor modulator zelquistinel durably relieves behavioral deficits in three mouse models of autism spectrum disorderMathieu Fonteneau, Agathe Brugoux, Déborah Jaccaz, John E. Donello, Pradeep Banerjee, Julie Le Merrer, Jérôme A. J. Becker · 2024 · Neuropharmacology
- NMDAR dysfunction in autism spectrum disorders: Lessons learned from 10 years of studySoowon Lee, Heera Moon, Eunjoon Kim · 2025 · Current Opinion in Neurobiology
- Social stress and affiliative touch: A tale of two affective statesLito Parapera Papantoniou, Orysia Vityk, Stamatina Tzanoulinou · 2026 · iScience
- Postnatal ethanol exposure impairs social behavior and operant extinction in the adult female mouse offspringSebastiano Bariselli, Noa Reuveni, Nina Westcott, Yolanda Mateo, David M. Lovinger · 2023 · Frontiers in Neuroscience
- VTA µ-Opioidergic Neurons Facilitate Low Sociability in Protracted Opioid AbstinenceAdrienne Y. Jo, Yihan Xie, Lisa M. Wooldridge, Sophie A. Rogers, Blake A. Kimmey, Amrith Rodrigues, Raquel Adaia Sandoval Ortega, Kate Townsend Creasy, Kevin T. Beier, Julie A. Blendy et al. · 2025 · Journal of Neuroscience
- Deficiency of Shank3 in the nucleus accumbens reveals a loss of social-specific motivationOakleigh M. Folkes, Meaghan Donahue, Sung Eun Wang, Paola N. Negrón-Moreno, Nicole Xinyen Oo, Sheng-Nan Qiao, Xiaoming Wang, Yong‐hui Jiang · 2025 · Communications Biology
- Neurobiology of Autism Spectrum DisordersGabriela Joca Martins · 2017 · Springer eBooks
- VTA μ–opioidergic neurons facilitate low sociability in protracted opioid withdrawalAdrienne Y. Jo, Yihan Xie, Amrith Rodrigues, Raquel Adaia Sandoval Ortega, Kate Townsend Creasy, Kevin Thomas Beier, Julie A. Blendy, Gregory F. Corder · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
- Early Postnatal Shank3 Downregulation in the Nucleus Accumbens Impairs Performance in Social Conditioning Paradigms in Male MiceAlessandro Contestabile, Giulia Casarotto, Benoît J. T. Girard, Beatrice Righetti, Clément Solié, Camilla Bellone, Stamatina Tzanoulinou · 2025 · European Journal of Neuroscience
- Alterations in the social-conditioned place preference and density of dopaminergic neurons in the ventral tegmental area in Clsnt2-KO miceИ. Н. Рожкова, S. V. Okotrub, Eugeny Yu. Brusentsev, K. E. Uldanova, E. А. Chuyko, В. А. Напримеров, Tatiana V. Lipina, Tamara G. Amstislavskaya, Sergei Ya Amstislavsky · 2023 · Vavilov Journal of Genetics and Breeding
- Ketamine restores escape behavior by re-engaging dopamine systems to drive cortical spinogenesisMingzheng Wu, Samuel Minkowicz, Vasin Dumrongprechachan, Peter J. Hamilton, L Xiao, Yevgenia Kozorovitskiy · 2020 · bioRxiv (Cold Spring Harbor Laboratory)
- Potentiation of Nigra–Striatal Dopaminergic Projection Underpins Core Autism-Like Behaviors in Valproate-Exposed MiceQi Zheng, Yongsi Zhao, Qiangqiang Cheng, Hao Wang, Fuhong Liu, Jingru Lai, Yaqi Liu, Xinyuan Zhang, Yifan Kang, Zhongqi Li et al. · 2025 · Journal of Neuroscience
- Genetic and Pharmacological Reversibility of Phenotypes in Mouse Models of Autism Spectrum DisorderJan C. Schroeder, Elena Deliu, Gaia Novarino, Michael J. Schmeißer · 2017 · Advances in anatomy, embryology and cell biology
- Excessive self-grooming, gene dysregulation and imbalance between the striosome and matrix compartments in the striatum of Shank3 mutant miceAllain-Thibeault Le Sourd Ferhat, Elisabeth Verpy, Anne Biton, Benoît Forget, Fabrice de Chaumont, Florian Mueller, Le Sourd Anne-Marie, Sabrina Coqueran, Julien Schmitt, Christelle Rochefort et al. · 2022 · bioRxiv (Cold Spring Harbor Laboratory)
- A homecage operant paradigm reveals behavioral dynamics of social motivation in miceYiru Chen, Susan E. Maloney, Alexxai V. Kravitz · 2026 · Cell Reports Methods
- SHANK3 mutations disrupt olfactory valence coding across species, with cortical amygdala mechanisms identified in miceYu Hu, Yuli Wu, Mingyu Wei, Jingchao Ma, Jianbang Lin, Gaowei Chen, Qi Li, Jianqing Zhang, Ruiqi Wang, Yingjie Zhu et al. · 2026 · Science Advances
- Late onset and regional heterogeneity of synaptic deficits in cortical PV interneurons of Shank3B −/− miceYi-Chun Shih, Lars Nelson, Michael Janeček, Rui T. Peixoto · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
- A Novel Homecage Operant Paradigm Reveals Circadian and Behavioral Dynamics of Social Motivation in MiceYiru Chen, Susan E. Maloney, Alexxai V. Kravitz · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
- PAM helps solve VTA's SHANKless problemMichael F. Priest, Yevgenia Kozorovitskiy · 2016 · Nature Neuroscience
- Optogenetic stimulation of BLA terminals in the BNST elicits long term synaptic plasticity and restores synaptic alterations induced by adolescent Shank3 downregulationChristelle Glangetas, Alessandro Contestabile, Pedro Espinosa, Giulia Casarotto, Stefano Musardo, Camilla Bellone · 2021 · bioRxiv (Cold Spring Harbor Laboratory)
- Corticostriatal deficits underlying cognitive impairments induced by fetal exposure to alcoholSebastiano Bariselli, David M. Lovinger · 2020
- Living on the edgeNicky Scheefhals · 2022 · Utrecht University Repository (Utrecht University)
- Sociability genetically separable from social hierarchy in amniotesXin Lin, Guangyi Dai, Sumei Zhou, Yangyang Li, Ben Zhou, Yi-Hsuan Pan, Haipeng Li · 2025 · iScience
- Shank3 establishes AMPA receptor subunit composition at cerebellar mossy fiber-granule cell synapses and shapes regional microglia activationRajaram Kshetri, Ben D Richardson · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
- Brain-Wide Subnetworks within and between Naturally Socializing Typical and Autism Model MiceOdeya Marmor, Renana Terner, Vivian Khuory, Shelly Ginzburg, Haitham Amal, Ariel Gilad · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
- Shank3 establishes AMPA receptor subunit composition at cerebellar mossy fiber-granule cell synapses and is associated with altered regional microglial morphologyRajaram Kshetri, Raheem F. H. Al Aameri, Ben D. Richardson · 2025 · Neurobiology of Disease
- Additional file 1 of Increased social interaction in Shank2-deficient mice following acute social isolationJa Eun Choi, Bong‐Kiun Kaang · 2024 · Figshare
- Additional file 2 of Increased social interaction in Shank2-deficient mice following acute social isolationJa Eun Choi, Bong‐Kiun Kaang · 2024 · Figshare
- Additional file 2 of The microbial metabolite p-Cresol induces autistic-like behaviors in mice by remodeling the gut microbiotaPatricia Bermudez-Martin, Jérôme A. J. Becker, Nicolas Caramello, Sebastián P. Fernández, Renan Costa Campos, Juliette Canaguier, Susana Barbosa, Laura Martínez-Gili, Myridakis, Antonis, Marc‐Emmanuel Dumas et al. · 2021 · Figshare
- Identification of an engram ensemble mediating memory forgetting in the dentate gyrusShiqiang Hu, Jianfan Yang, Siqi Yin, Yijie Zhong, Yanzun An, Yuyang Guo, Zihan Zhai, Yi Zhong · 2026 · Neuron
- Prenatal valproate exposure alters midbrain and striatal neuronal morphology along with dopamine levelsBarbora Bugar Bodorova, Tomáš Havránek, Denisa Mihalj, Kristina Kupkova, Ema Bogyova, H. El Falougy, Zuzana Bačová, Ján Bakoš · 2026 · Brain Structure and Function
- Preserved autism-associated behaviors and dopaminergic neuron hyperactivity in DAT-IRES-Cre mice after valproate exposureQi Zheng, Yumei Tian, Yuzi Wu, Hao Wang, Yue Zhang, Yue Zhang, Yitong Wang, Yongsi Zhao, Yuanyuan Di, Juan Fan et al. · 2026 · Behavioural Brain Research
- Caractérisation de la co-organisation nanoscopique des récepteurs glutamatergiques à l'état basal et dans un modèle d'autismeJulia Goncalves · 2018 · theses.fr (ABES)
- Rôle du système CRF dans les effets de récompense cérébrale et les troubles de la motivation induits par la morphineAlessandro Piccin · 2018 · theses.fr (ABES)
- Peripheral and intestinal microbiota alterations in Autism Spectrum Disorders : The specific role of p-CresolPatricia Bermudez-Martin · 2020 · theses.fr (ABES)
- Influence of proximal social factors on cocaine consumption and the role played by the subthalamic nucleusCassandre Vielle · 2022 · theses.fr (ABES)
- Evaluating the cannabinoid CB1 receptor as a therapeutic target in a Shank3 mouse model of autism and Phelan-McDermid syndromeFlavio Tomasi · 2023 · theses.fr (ABES)
- Les troubles du spectre autistique au Liban : une étude épidémiologique et génétiquePerla Gerges · 2022 · theses.fr (ABES)
- Rôle et mécanismes d'action du métabolite microbien p-crésol dans les déficits d'interaction sociale associés à l'autismeJuliette Canaguier · 2023 · theses.fr (ABES)
- Social Novelty Recruits a Dysfunctional Nucleus Accumbens Ensemble That Drives Social Avoidance in a Shank3 −/− Autism ModelOakleigh M. Folkes, Meaghan Donahue, Rafael E. Perez, Angelica M. Minier-Toribio, Paola N. Negrón-Moreno, Marina R. Picciotto, Yong-Hui Jiang · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
- Reduced volume of neuromodulatory brainstem nuclei is associated with early hallucination-related vulnerability in Parkinson’s diseaseGabriella Monopoli, Federica Tomaiuolo, Carlo Sestieri, Miriam Punzi, Simone Marino, Francesco Gambi, Mauro Gianni Perrucci, Antonio Ferretti, Stefano Luca Sensi, Stefano Delli Pizzi · 2026 · Brain Communications
- The medial prefrontal cortex‐ventral tegmental area dopaminergic circuit regulates the pleasure of tactile contact by releasing dopamine in the nucleus accumbensJinhe Zhai, Zihan Xu, Xinran Yu, Keqing Shi, Xiaoyan Zhang, Hiroshi Kuniishi, Min Jue Xie, Yuying Zhang, Xueke Yao, Xinxin Wang et al. · 2026 · British Journal of Pharmacology