Polycomb repressive complex 2 (PRC2) silences genes responsible for neurodegeneration

von Schimmelmann, Melanie, Feinberg, Philip A, Sullivan, Josefa M, Ku, Stacy M, Badimon, Ana, Duff, Mary Kaye, Wang, Zichen, Lachmann, Alexander +5 more·2016·Nature Neuroscience
DOI 10.1038/nn.4360

Cited by (225)

Items 101–200 of 225

  1. Recent advances in neuroepigenetic editing
    Song‐Jun Xu, Elizabeth A. Heller · 2019 · Current Opinion in Neurobiology
  2. Neurons and Astrocytes Elicit Brain Region Specific Transcriptional Responses to Prion Disease in the Murine CA1 and Thalamus
    Slota, Jessy A., Medina, Sarah J., Frost, Kathy L., Booth, Stephanie A. · 2022 · Frontiers in Neuroscience
  3. Coordination of EZH2 and SOX2 specifies human neural fate decision
    Yuan Zhao, Tianyu Wang, Yanqi Zhang, Liang Shi, Cong Zhang, Jingyuan Zhang, Yao Jiao, Qianyu Chen, Xiaofen Zhong, Yanxing Wei et al. · 2021 · Cell Regeneration
  4. TSPYL2 Regulates the Expression of EZH2 Target Genes in Neurons
    Hang Liu, Lei Peng, J. So, Ka-Hing Tsang, Chi H. Chong, P. Mak, Kui-Ming Chan, Siu Y. Chan · 2018 · Molecular Neurobiology
  5. Temporal analysis of hippocampal CA3 gene coexpression networks in a rat model of febrile seizures
    Hatylas F. Z de Azevedo, Nathália Amato Khaled, Paula Santos, Fernanda Bernardi Bertonha, Carlos Alberto Moreira‐Filho · 2018 · Disease Models & Mechanisms
  6. Polycomb repressive complex 2 inhibitors: emerging epigenetic modulators
    Mohd Danishuddin, Naidu Subbarao, Mohammad Faheem, Shahper N. Khan · 2018 · Drug Discovery Today
  7. The Dynamic Partnership of Polycomb and Trithorax in Brain Development and Diseases
    Janise N. Kuehner, Bing Yao · 2019 · Epigenomes
  8. KDM2B regulates hippocampal morphogenesis by transcriptionally silencing Wnt signaling in neural progenitors
    Bo Zhang, Chen Ning Zhao, Wenchen Shen, Wei Li, Yue Zheng, Xiangfei Kong, Junbao Wang, Xudong Wu, Tao Zeng, Ying Liu et al. · 2023 · Nature Communications
  9. EZH2 Influences mdDA Neuronal Differentiation, Maintenance and Survival
    Iris Wever, Lars von Oerthel, Cindy M. R. J. Wagemans, Marten P. Smidt · 2019 · Frontiers in Molecular Neuroscience
  10. RINGs, DUBs and Abnormal Brain Growth—Histone H2A Ubiquitination in Brain Development and Disease
    Lucy Anne Doyle, Firuze Ünlü Bektaş, Eleftheria Chatzantonaki, Charlotte Repton, Alexandra Derrien, Robert Scott Illingworth · 2022 · Epigenomes
  11. A conserved switch to less catalytically active Polycomb repressive complexes in non-dividing cells
    Rachel McCole, James Nolan, David M Reck, Craig Monger, Samantha Rustichelli, Eric Conway, Gerard L. Brien, Cheng Wang, Orla Deevy, Hannah K. Neikes et al. · 2025 · Cell Reports
  12. Msh3 and Pms1 Set Neuronal CAG-repeat Migration Rate to Drive Selective Striatal and Cortical Pathogenesis in HD Mice
    Nan Wang, Shasha Zhang, Peter Langfelder, Lalini Ramanathan, Mary Plascencia, Fuying Gao, Raymond Vaca, Xiaofeng Gu, Linna Deng, Leonardo E. Dionisio et al. · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
  13. Systemic epigenetic dysregulation as a driver of ageing and a therapeutic target
    Ali Doğa Yücel, Vadim N. Gladyshev · 2026 · Nature Reviews Molecular Cell Biology
  14. Neuronal Dot1l Activity Acts as a Mitochondrial Gene-Repressor Associated with Human Brain Aging via H3K79 Hypermethylation
    Van Heesbeen, Hendrikus J., Von Oerthel, Lars, De Vries, Paul M., Wagemans, Cindy M. R. J., Smidt, Marten P. · 2023 · International Journal of Molecular Sciences
  15. Hallmark Molecular and Pathological Features of POLG Disease are Recapitulated in Cerebral Organoids
    Anbin Chen, Tsering Yangzom, Yu Hong, Bjørn Christian Lundberg, Gareth J. Sullivan, Charalampos Tzoulis, Laurence Albert Bindoff, Kristina Xiao Liang · 2024 · Advanced Science
  16. Targeting neuronal epigenomes for brain rejuvenation
    Sara Zocher · 2024 · The EMBO Journal
  17. Shaking up the silence: consequences of HMGN1 antagonizing PRC2 in the Down syndrome brain
    Sean J. Farley, Alla Grishok, Ella Zeldich · 2022 · Epigenetics & Chromatin
  18. Histone methylation in Huntington’s disease: are bivalent promoters the critical targets?
    László Bodai, Nóra Zsindely · 2018 · Neural Regeneration Research
  19. Epigenetic regulation and signalling pathways in Merkel cell development
    Liat Oss-Ronen, Idan Cohen · 2021 · Experimental Dermatology
  20. From compartments to loops: understanding the unique chromatin organization in neuronal cells
    Diana Zagirova, Anna D. Kononkova, Nikita Vaulin, Ekaterina E. Khrameeva · 2024 · Epigenetics & Chromatin
  21. OnTarget: in silico design of MiniPromoters for targeted delivery of expression
    Oriol Fornés, Tamar V. Av‐Shalom, Andrea J. Korecki, Rachelle A. Farkas, David J. Arenillas, Anthony Mathelier, Elizabeth M. Simpson, Wyeth W. Wasserman · 2023 · Nucleic Acids Research
  22. PRC1 chromatin factors strengthen the consistency of neuronal cell fate specification and maintenance in C. elegans
    Guillaume Bordet, Carole Couillault, Fabien Soulavie · 2022 · PLoS Genetics
  23. Epigenomic Remodeling in Huntington’s Disease—Master or Servant?
    Geraldine Zimmer‐Bensch · 2020 · Epigenomes
  24. Polycomb repressive complex 2 is critical for mouse cortical glutamatergic neuron development
    Laura Currey, Benjamin Mitchell, Majd Al-Khalily, Sarah-Jayne McElnea, Peter Kozulin, Danyon Harkins, Alexandra Pelenyi, Laura R. Fenlon, Rodrigo Suárez, N. Kurniawan et al. · 2024 · Cerebral Cortex
  25. Epigenetic Modifiers: Exploring the Roles of Histone Methyltransferases and Demethylases in Cancer and Neurodegeneration
    L Reed, Janak Abraham, Shay Patel, Shilpa S. Dhar · 2024 · Biology
  26. HTT loss-of-function contributes to RNA deregulation in developing Huntington’s disease neurons
    Emilia Kozłowska, Agata Ciołak, Grażyna Adamek, Julia Szcześniak, Agnieszka Fiszer · 2025 · Cell & Bioscience
  27. Switch-Like Roles for Polycomb Proteins from Neurodevelopment to Neurodegeneration
    Anke Hoffmann, Vincenza Sportelli, Michael J. Ziller, Dietmar Spengler · 2017 · Epigenomes
  28. Single sample sequencing (S3EQ) of epigenome and transcriptome in nucleus accumbens
    Song‐Jun Xu, Elizabeth A. Heller · 2018 · Journal of Neuroscience Methods
  29. Non-Coding RNAs and Neurodegenerative Diseases: Information of their Roles in Apoptosis
    Mehrdad Valizadeh, Ehsan Derafsh, Fahimeh Abdi Abyaneh, Sayedeh Kiana Parsamatin, Fatemeh Zahra Rashidi Noshabad, Azam Alinaghipour, Zahra Yaghoobi, Abdolkarim Talebi Taheri, Ehsan Dadgostar, Michael Aschner et al. · 2023 · Molecular Neurobiology
  30. Immunomodulator-Derived Nanoparticles Induce Neuroprotection and Regulatory T Cell Action to Alleviate Parkinsonism
    Mohammed Nadim Sardoiwala, Liku Biswal, Subhasree Roy Choudhury · 2024 · ACS Applied Materials & Interfaces
  31. Genomic context– and H2AK119 ubiquitination–dependent inheritance of human Polycomb silencing
    Tiasha A. Shafiq, Juntao Yu, Wenzhi Feng, Yizhe Zhang, Haining Zhou, João A. Paulo, Steven P. Gygi, Danesh Moazed · 2024 · Science Advances
  32. The Transcriptome and Methylome of the Developing and Aging Brain and Their Relations to Gliomas and Psychological Disorders
    Henry Loeffler‐Wirth, Lydia Hopp, Maria Schmidt, Roksana Zakharyan, Arsen Arakelyan, Hans Binder · 2022 · Cells
  33. Key questions on the epigenetics of herpes simplex virus latency
    Abigail L. Whitford, Anna Ruth Cliffe · 2022 · PLoS Pathogens
  34. Regulation of Social Stress and Neural Degeneration by Activity-Regulated Genes and Epigenetic Mechanisms in Dopaminergic Neurons
    Clement F. Kent, Pavan Agrawal · 2020 · Molecular Neurobiology
  35. Histone bivalency in CNS development
    Kärt Mätlik, Eve‐Ellen Govek, Mary E. Hatten · 2025 · Genes & Development
  36. p53-mediated neurodegeneration in the absence of the nuclear protein Akirin2
    Stacey L. Peek, Peter J. Bosch, Ethan Bahl, Brianna J. Iverson, Mrutyunjaya Parida, Preeti Bais, John Robert Manak, Jacob J. Michaelson, Robert W. Burgess, Joshua A. Weiner · 2022 · iScience
  37. Control of striatal circuit development by the chromatin regulator Zswim6
    Kyuhyun Choi, Nathan T. Henderson, Emily R. Feierman, Sean Louzon, Jamie Galanaugh, M. Felicia Davatolhagh, Isha Bhandaru, David J. Tischfield, Stewart A. Anderson, Erica Korb et al. · 2025 · Science Advances
  38. Overcoming the therapeutic limitations of EZH2 inhibitors in Burkitt’s lymphoma: a comprehensive study on the combined effects of MS1943 and Ibrutinib
    Yurim Jeong, Se Been Kim, Chae Eun Yang, Min Seo Yu, Wan-Su Choi, Young‐Woo Jeon, Jung-Yeon Lim · 2023 · Frontiers in Oncology
  39. From Environment to Gene Expression: Epigenetic Methylations and One-Carbon Metabolism in Amyotrophic Lateral Sclerosis
    Marina Hernán-Godoy, Caroline Rouaux · 2024 · Cells
  40. Selective Vulnerability to Neurodegenerative Disease: Insights from Cell Type-Specific Translatome Studies
    Walker S. Jackson, Susanne Bauer, Lech Kaczmarczyk, Srivathsa Subramanya Magadi · 2024 · Biology
  41. Ezh1 regulates expression of Cpg15/Neuritin in mouse cortical neurons
    Shun Utsunomiya, Yusuke Kishi, Masafumi Tsuboi, Daichi Kawaguchi, Yukiko Gotoh, Manabu Abe, Kenji Sakimura, Kazuma Maeda, Hiroshi Takemoto · 2021 · Drug Discoveries & Therapeutics
  42. Camk2a-Cre and Tshz3 Expression in Mouse Striatal Cholinergic Interneurons: Implications for Autism Spectrum Disorder
    Xavier Caubit, Elise Arbeille, Dorian Chabbert, Florence Desprez, Imane Messak, Ahmed Fatmi, Bianca Hermine Habermann, Paolo Gubellini, Laurent Fasano · 2021 · Frontiers in Genetics
  43. SNIP1 and PRC2 coordinate cell fates of neural progenitors during brain development
    Yurika Matsui, Mohamed Nadhir Djekidel, Katherine Lindsay, Parimal Samir, Nina Connolly, Gang Wu, Xiaoyang Yang, Yiping Fan, Beisi Xu, Jamy C. Peng · 2023 · Nature Communications
  44. Lineage specification in glioblastoma is regulated by METTL7B
    Myrianni Constantinou, James Nicholson, Xinyu Zhang, Eleni Maniati, Sara Lucchini, Gabriel Rosser, Claire Vinel, Jun Wang, Yau Mun Lim, Sebastian Brandner et al. · 2024 · Cell Reports
  45. Huntingtin Is Required for Neural But Not Cardiac/Pancreatic Progenitor Differentiation of Mouse Embryonic Stem Cells In vitro
    Man Shan Yu, Naoko Tanese · 2017 · Frontiers in Cellular Neuroscience
  46. Cerebellar granule neurons induce Cyclin D1 before the onset of motor symptoms in Huntington’s disease mice
    Susanne Bauer, Chwen-Yu Chen, Maria Jonson, Lech Kaczmarczyk, Srivathsa Subramanya Magadi, Walker S. Jackson · 2023 · Acta Neuropathologica Communications
  47. Neuronal histone methyltransferase EZH2 regulates neuronal morphogenesis, synaptic plasticity, and cognitive behavior of mice
    Mei Zhang, Yong Zhang, Qian Xu, Joshua A. Crawford, Cheng Qian, Guohua Wang, Eastman M. Lewis, Philip Hall, Gül Dölen, Richard L. Huganir et al. · 2019 · bioRxiv (Cold Spring Harbor Laboratory)
  48. Polycomb repressive complexes 1 and 2 independently and dynamically regulate euchromatin during cerebellar neurodevelopment
    Aditya Parmar, Anjali Srinivasan, Lena Krockenberger, Abijith Augustine, Owin Gong, Addison C. Bullard, Riya Kalra, Leya Ledvin, Dylan A. Pilz, Jonathan Tawil et al. · 2025 · PLoS Genetics
  49. The relevance of polycomb group proteins to the development of psychiatric disorders
    Jacob Peedicayil · 2022 · Frontiers in Cell and Developmental Biology
  50. PRC2 promotes canalisation during endodermal differentiation
    Jurriaan Hölzenspies, Dipta Sengupta, Wendy A. Bickmore, Joshua M. Brickman, Robert Scott Illingworth · 2025 · PLoS Genetics
  51. Altered huntingtin−chromatin interactions predict transcriptional and epigenetic changes in Huntington's disease
    Jocelynn R. Pearl, Amol Carl Shetty, Jeffrey P. Cantle, Dani E. Bergey, Robert M. Bragg, Sydney R. Coffey, Holly B. Kordasiewicz, Leroy Hood, Nathan D. Price, Seth A. Ament et al. · 2025 · Disease Models & Mechanisms
  52. Shining a light on early stress responses and late-onset disease vulnerability
    Mark F. Mehler · 2017 · Proceedings of the National Academy of Sciences
  53. The Essential Role of Epigenetic Modifications in Neurodegenerative Diseases with Dyskinesia
    Zhipeng Qi, Jiashuo Li, Minghui Li, Xianchao Du, Lei Zhang, Shuang Wang, Bin Xu, Wei Liu, Zhaofa Xu, Yu Lin Deng · 2021 · Cellular and Molecular Neurobiology
  54. Tau protein modulates an epigenetic mechanism of cellular senescence in human SH-SY5Y neuroblastoma cells
    Claudia Magrin, Martina Bellafante, Martina Sola, Ester Piovesana, Marco Bolis, Luciano Cascione, Sara Napoli, Andrea Rinaldi, Stéphanie Papin, Paolo Paganetti · 2023 · Frontiers in Cell and Developmental Biology
  55. Chromatin Changes Associated with Neuronal Maintenance and Their Pharmacological Application
    Jang Ho Lee, Jeong‐Hoon Kim, Sunhong Kim, Kyoung Sang Cho, Sung Bae Lee · 2017 · Current Neuropharmacology
  56. Altered Huntingtin-Chromatin Interactions Predict Transcriptional and Epigenetic Changes in Huntington’s Disease Mouse Models
    Jocelynn R. Pearl, Amol Carl Shetty, Jeffrey P. Cantle, Dani E. Bergey, Robert M. Bragg, Sydney R. Coffey, Holly B. Kordasiewicz, Leroy Hood, Nathan D. Price, Seth A. Ament et al. · 2020 · bioRxiv (Cold Spring Harbor Laboratory)
  57. Life and death rest on a bivalent chromatin state
    Xueping Yang · 2016 · Nature Neuroscience
  58. Geometrically Encoded Positioning of Introns, Intergenic Segments, and Exons in the Human Genome
    Luay Matthew Almassalha, Kyle L. MacQuarrie, Marcelo A. Carignano, Cody L. Dunton, Ruyi Gong, Joe Ibarra, Lucas M. Carter, Wing Shun Li, Rikkert J. Nap, Parambir Singh Dulai et al. · 2025 · Advanced Science
  59. A human CAGinSTEM platform for decoding HTT repeats’ somatic instability links CAG interruption to HD pathology in neurons
    Martina Zobel, Gianluca Damaggio, Maria Lidia Mignogna, Dario Besusso, Davide Scalzo, Andrea Cossu, Camilla Trovesi, Mariacristina Crosti, Francesco Cortina, Ilaria Campus et al. · 2025 · Cell Reports
  60. Epigenetic regulation in atherosclerosis and its therapeutic potential
    Donato Santovito, Dorothee Atzler, Christian Weber · 2026 · Nature Reviews Cardiology
  61. Cross-species single-cell atlas of the striatum defines cell-type and subregion disease vulnerabilities
    Raleigh M. Linville, Benjamin T. James, Kyriaki Galani, Li‐Lun Ho, Jung Hoon Shin, Esaria Oliver, Stuart B. Fass, James C. Cameron, Brent E. Fitzwalter, Roland Bock et al. · 2026 · Cell
  62. Loss of Ezh2 in the medial ganglionic eminence alters interneuron fate, cell morphology and gene expression profiles
    Christopher T. Rhodes, Dhanya Asokumar, Mira Sohn, Shovan Naskar, Lielle Elisha, Parker K. Stevenson, Dongjin R. Lee, Yajun Zhang, Pedro P. Rocha, Ryan Dale et al. · 2024 · Frontiers in Cellular Neuroscience
  63. New MiniPromoter Ple389 (ADORA2A) drives selective expression in medium spiny neurons in mice and non-human primates
    Alissandra de Moura Gomes, Terri L. Petkau, Andrea J. Korecki, Oriol Fornés, Adriana Galván, Ge Lu, Austin M. Hill, Siu Ling Lam, Anqi Yao, Rachelle A. Farkas et al. · 2024 · Scientific Reports
  64. Integrative Proteome Analysis Revels 3-Hydroxybutyrate Exerts Neuroprotective Effect by Influencing Chromatin Bivalency
    Xinliang Zhu, Huan Du, Lei-Lei Wang, Erling Hu, Ning Li, Haixia Lü, Guo‐Qiang Chen, Xiaoyun Lu · 2023 · International Journal of Molecular Sciences
  65. Epigenetic Regulation of the Cerebellum
    Yue Yang, Tomoko Yamada, Azad Bonni · 2019 · Springer eBooks
  66. Chromatin dynamics underlying latent responses to xenobiotics
    Jonathan G. Moggs, Rémi Terranova · 2018 · Toxicology Research
  67. High density SNP array and reanalysis of genome sequencing uncovers CNVs associated with neurodevelopmental disorders in KOLF2.1J iPSCs
    Carolina Gracia-Diaz, Jonathan Elliot Perdomo, Munir E. Khan, Brianna Disanza, Gregory G. Cajka, Sunyimeng Lei, Alyssa L. Gagne, Jean Ann Maguire, Thomas Roulé, Ophir Shalem et al. · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
  68. Single-cell Multiome Analysis of Chromatin State and Transcriptome in the Human Basal Ganglia
    Lei Chang, Kai Li, Yang Xie, Guojie Zhong, Jonathan A. Rink, Cindy Tatiana Báez-Becerra, Anita Lie, Hannah S. Indralingam, Keyi Dong, Timothy H. Loe et al. · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
  69. From aging to Alzheimer’s disease: concordant brain DNA methylation changes in late life
    David Lukacsovich, Juan I. Young, Lissette Gomez, Michael A. Schmidt, Wei Yan Zhang, Brian W. Kunkle, X. Steven Chen, Eden R. Martin, Lily Wang, Alzheimer’s Disease Neuroimaging Initiative · 2026 · Genome Medicine
  70. PRC2 Diversity in Neuronal Differentiation and Developmental Disorders
    Jasmine Akoto, Thomas Roulé, Naiara Akizu · 2025 · Genes
  71. Liver-derived Indian hedgehog (Ihh) couples fast-feed transition to thermogenic and metabolic homeostasis
    Raffaele Teperino, Marketa Adamová, Shefa’ Muneer Aljabali, Shruta Sandesh Pai, Raffaele Gerlini, Irene Paez-Perez, Madlen Matz‐Soja, Steffen Heyne, Adelheid M. Lempradl, Maria Felicia Basilicata et al. · 2026 · Molecular Metabolism
  72. An EED/PRC2‐H19 Loop Regulates Cerebellar Development
    Peipei Liu, Xiao Han, Xiao Li, Shang‐Kun Dai, Yajie Xu, Lin‐Fei Jiao, Hong‐Zhen Du, Lihua Zhao, R. Li, Zhao‐Qian Teng et al. · 2024 · Advanced Science
  73. DNA glycosylases Ogg1 and Mutyh influence gene expression of PRC2 targets associated with cognition
    Andreas Abentung, Teri Sakshaug, Rabina Dumaru, Nina‐Beate Liabakk, Mingyi Yang, Junbai Wang, Magnar Bjørås, Katja Scheffler · 2025 · Cellular and Molecular Life Sciences
  74. The role of EZH1 and EZH2 in development and cancer
    Chul‐Hwan Lee, Yingying Li, Hanbyeol Kim, Seounghyun Eum, Kyumin Park, Soo Hyun Lee · 2022 · BMB Reports
  75. A decade of questions about the fluidity of cell identity
    Giacomo Masserdotti, Magdalena Götz · 2020 · Nature
  76. Genome-wide scan of Flortaucipir PET levels finds JARID2 associated with cerebral tau deposition
    Tamil Iniyan Gunasekaran, Devendra Meena, Annie Lee, Siwei Wu, Logan C. Dumitrescu, Reisa Anne Sperling, Timothy J. Hohman, Alzheimer’s Disease Neuroimaging Initiative, Jingxian Huang, Abbas Dehghan et al. · 2024 · medRxiv
  77. The epigenetics of aging
    Athanasios Metaxakis, Ilias Gkikas, Nektarios Tavernarakis · 2022 · Elsevier eBooks
  78. Overexpression of KDM6A in Hepatoma Cells Induces Hepatocytic Differentiation and Attenuates Proliferation Rate, Colony Formation, and Migration Capacities
    Mahdieh Hashemi, Mahdi Hesaraki, Roya Ramezankhani · 2025 · BioMed Research International
  79. TDP-43 controls RNA structure through high affinity lattice interactions
    Rahul Vivek, Takuma Kume, Saeed Roschdi, M. Thomas Record, Aaron A. Hoskins, Samuel E. Butcher · 2026 · Nature Communications
  80. Polycomb Repressive Complex 2 (PRC2): A Context-Dependent Epigenetic Regulator of Brain Aging
    Maria A. Katsianou, Eleni‐Kyriaki Vetsika, Mariam Markouli, Christina Piperi, Antonios N. Gargalionis · 2026 · Biomolecules
  81. Systems biology study of Huntington's disease
    Leonardo E. Dionisio, Peter Langfelder, Jeffrey S. Aaronson, Jim Rosinski, X. William Yang · 2024 · Elsevier eBooks
  82. Challenges in Polyglutamine Diseases: From Dysfunctional Neuronal Circuitries to Neuron-Specific CAG Repeat Instability
    Roxana Deleanu · 2025 · International Journal of Molecular Sciences
  83. Rb deficiency induces p21cip1 expression and delays retinal degeneration in rd1 mice
    Zhongping Lv, Lirong Xiao, Yunjing Tang, Yongjiang Chen, Danian Chen · 2021 · Experimental Eye Research
  84. Snip1 and PRC2 coordinate intrinsic apoptosis, cell division, and neurogenesis in the developing brain
    Yurika Matsui, Mohamed Nadhir Djekidel, Katherine Lindsay, Parimal Samir, Nina Connolly, Hongfeng Chen, Yiping Fan, Beisi Xu, Jamy C. Peng · 2022 · bioRxiv (Cold Spring Harbor Laboratory)
  85. Gain and loss of function variants in EZH1 disrupt neurogenesis timing and cause overlapping neurodevelopmental disorders
    Carolina Gracia-Diaz, Yijing Zhou, Qian Yang, Chul‐Hwan Lee, Paula Espana-Bonilla, Shuo Zhang, Natàlia Padilla, Raquel Fueyo, Garrett Otrimski, Dong Li et al. · 2022 · medRxiv
  86. Three rules for epigenetic inheritance of human Polycomb silencing
    Tiasha A. Shafiq, Danesh Moazed · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
  87. Increased EZH2 function in regulatory T cells promotes their capacity to suppress autoimmunity by driving effector differentiation prior to activation
    Janneke G. C. Peeters, Stephanie L. Silveria, Merve Özdemir, Srinivas Ramachandran, Michel J.P. DuPage · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
  88. DNA glycosylases Ogg1 and Mutyh mediate gene expression of PRC2 target genes important for neuronal processes underlying memory formation
    Andreas Abentung, Teri Sakshaug, Rabina Dumaru, N. Liabakk, Ming-Yi Yang, Junbai Wang, Magnar Bjørås, K. Scheffler · 2024 · bioRxiv
  89. NeuID, a novel neuron-specific lncRNA, resolves a key epigenetic mechanism linking gene silencing to Alzheimer’s disease
    Ranjit Pradhan, Zorica Petrovic, M. Sadman Sakib, Sophie Schröder, Dennis Manfred Krüger, Tonatiuh Peña, Eren Diniz, Susanne Burckhardt, Anna‐Lena Schütz, Iga Grządzielewska et al. · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
  90. Ultra-long-range Polycomb-coupled interactions underlie subtype identity of human cortical neurons
    Ilya A Pletenev, Nikita Vaulin, Maria N. Molodova, Ekaterina Kuznechenkova, Anastasia Soldatenkova, Olga Efimova, Anna V. Tvorogova, Philipp Khaitovich, Sergey V. Razin, Sergey V. Ulianov et al. · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
  91. Alterações transcriptômicas no hipocampo de ratos submetidos a um modelo experimental de epilepsia com insulto precipitante febril
    Hátylas Felype Zaneti de Azevedo · 2017
  92. Epigenetic regulators sculpt the plastic brain
    Ji‐Song Guan, Hong Bo Xie, Sanxiong Liu · 2017 · Frontiers in Biology
  93. Epigenetikai faktorok hatásának vizsgálata a Huntington-kór patomechanizmusában Drosophila modellben
    Júlia Varga · 2020
  94. From compartments to gene loops: Functions of the 3D genome in the human brain
    Panos Roussos, Samir Rahman, Pengfei Dong, Pasha Apontes, Michael B. Fernando, Kayla G. Townsley, Kiran Girdhar, Jaroslav M. Bendl, Zhiping Shao, Ruth Misir et al. · 2021 · Research Square
  95. Epigenetic Regulation of the Cerebellum
    Yue Yang, Tomoko Yamada, Azad Bonni · 2021 · Springer eBooks
  96. Epigenomic and transcriptomic analysis of developing, adult and aging brain: mechanisms of brain folding, neuronal function and finding novel therapy for dementia
    M. Sadman Sakib · 2021
  97. Autism spectrum disorder: understanding the impact of SNPs on biological pathways in the fetal and adult cortex
    Evgeniia Golovina, Tayaza Fadason, Thierry Lints, Caroline G. Walker, Mark Hedley Vickers, Justin Martin O'Sullivan · 2021 · bioRxiv (Cold Spring Harbor Laboratory)
  98. Faculty Opinions recommendation of Intrinsic mechanisms of neuronal axon regeneration.
    Phillip G. Popovich · 2019 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
  99. Faculty Opinions recommendation of JMJD3 and UTX determine fidelity and lineage specification of human neural progenitor cells.
    Vijay Kumar Tiwari, Arun Mariappan · 2020 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
  100. Cerebellar granule neurons induce Cyclin D1 in an early stage of Huntington’s disease
    Susanne Bauer, Chwen-Yu Chen, Maria Jonson, Lech Kaczmarczyk, Srivathsa Subramanya Magadi, Walker S. Jackson · 2022 · bioRxiv (Cold Spring Harbor Laboratory)