A rapidly acting glutamatergic ARC→PVH satiety circuit postsynaptically regulated by α-MSH

Fenselau, Henning; Campbell, John N; Verstegen, Anne M J; Madara, Joseph C; Xu, Jie; Shah, Bhavik P; Resch, Jon M; Yang, Zongfang; Mandelblat-Cerf, Yael; Livneh, Yoav; Lowell, Bradford B

doi:10.1038/nn.4442

A rapidly acting glutamatergic ARC→PVH satiety circuit postsynaptically regulated by α-MSH

Arcuate nucleus (ARC) neurons sense the fed or fasted state and regulate hunger. Agouti-related protein (AgRP) neurons in the ARC (ARCAgRP neurons) are stimulated by fasting and, once activated, they rapidly (within minutes) drive hunger. Pro-opiomelanocortin (ARCPOMC) neurons are viewed as the c…