The synaptic Aβ hypothesis of Alzheimer disease
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Each is checked against this paper’s own text: does it say what the citing paper says it does?
Soluble Ab oligomers cause early memory problems by disrupting LTP and LTD mechanisms.
“The cognitive decline, however, starts well before this stage, and there is growing evidence that one of the toxic protein species believed to be etiologically related to AD, soluble Ab oligomers, causes early memory problems by disrupting LTP and LTD mechanisms (Walsh et al. 2002;Tanzi 2005;Shankar et al. 2008;Cisse et al. 2011).”
From NMDA receptor-dependent long-term potentiation and long-term depression (LTP/LTD). (2012) · cites this paper as Tanzi 2005
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References 14 · Cited by 206
- Authors
- Tanzi, R. E.
- Affiliations
- Harvard University (US)
- Corresponding author
- Tanzi, Rudolph E
- ORCID
- Tanzi, Rudolph E
- Venue
- Nature Neuroscience
- Published
- 2005-08
- Volume
- 8
- Issue
- 8
- Pages
- 977-979
- ISSN
- 1097-6256 (ISSN-L)
- 1546-1726
- OpenAlex
- W2030320815
- Cited by
- 206
- References
- 14
- Citations by year
- 2025: 3 · 2024: 4 · 2023: 5 · 2022: 7 · 2021: 13 · 2020: 4 · 2019: 9 · 2018: 8 · 2017: 14 · 2016: 14 · 2015: 10 · 2014: 12 · 2013: 7 · 2012: 11
- FWCI
- 8.93
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- amyloid-beta, Alzheimer's disease, NMDA receptor, synaptic dysfunction, receptor internalization, endocytosis, synaptic toxicity
- MeSH terms
- Alzheimer Disease, Brain, Endocytosis, Humans, Models, Neurological, Synapses, Receptors, N-Methyl-D-Aspartate, Amyloid beta-Peptides
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
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