Lmx1b is essential for the development of serotonergic neurons
Abstract
The specification and differentiation of serotonergic (5-HT) neurons require both extrinsic signaling molecules and intrinsic transcription factors to work in concert or in cascade. Here we identify the genetic cascades that control the specification and differentiation of 5-HT neurons in mice. A major determinant in the cascades is an LIM homeodomain-containing gene, Lmx1b, which is required for the development of all 5-HT neurons in the central nervous system. Our results suggest that, during development of 5-HT neurons, Lmx1b is a critical intermediate factor that couples Nkx2-2-mediated early specification with Pet1-mediated terminal differentiation. Moreover, our data indicate that genetic cascades controlling the caudal and rostral 5-HT neurons are distinct, despite their shared components.
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Lmx1a and Lmx1b are co-expressed in hindbrain glutamatergic and midbrain dopaminergic cell types, and Lmx1b is also specifically expressed in serotonergic types.
“Lmx1a and Lmx1b are co-expressed in hindbrain glutamatergic and midbrain dopaminergic cell types112, and Lmx1b is also specifically expressed in serotonergic types113,114.”
From A high-resolution transcriptomic and spatial atlas of cell types in the whole mouse brain (2023) · cites this paper as [114]
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References 28 · Cited by 262
- Authors
- Ding, Y.-Q., Marklund, U., Yuan, W., Yin, J., Wegman, L., Ericson, J., Deneris, E., Johnson, R. L., & Chen, Z.-F.
- Affiliations
- Washington University in St. Louis (US)
- Karolinska Institutet (SE)
- Case Western Reserve University (US)
- The University of Texas MD Anderson Cancer Center (US)
- Corresponding author
- Chen, Zhou-Feng
- ORCID
- Venue
- Nature Neuroscience
- Published
- 2003-08-03
- Volume
- 6
- Issue
- 9
- Pages
- 933-938
- ISSN
- 1097-6256 (ISSN-L)
- 1546-1726
- OpenAlex
- W2167244529
- Cited by
- 262
- References
- 28
- Citations by year
- 2026: 1 · 2025: 7 · 2024: 5 · 2023: 4 · 2022: 7 · 2021: 4 · 2020: 10 · 2019: 6 · 2018: 11 · 2017: 11 · 2016: 15 · 2015: 11 · 2014: 9 · 2013: 12 · 2012: 16
- FWCI
- 3.97
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Health Sciences › Medicine › Surgery › Congenital gastrointestinal and neural anomalies
- Keywords
- Lmx1b, serotonergic neurons, neuronal differentiation, LIM-homeodomain transcription factor, Nkx2.2, central nervous system development
- MeSH terms
- Homeobox Protein Nkx-2.2, Animals, Cell Differentiation, Female, Mice, Mutant Strains, Neurons, Pregnancy, Serotonin, Transcription Factors, Homeodomain Proteins, Gene Expression Regulation, Developmental, Mice, LIM-Homeodomain Proteins
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