Cited by 324Neurotransmitter Receptor Influence on BehaviorSubstance Abuse Treatment and OutcomesCannabis and Cannabinoid Research

The neuroscience of addiction

Volkow, Nora, Li, Ting-Kai·2005·Nature Neuroscience

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Crossref · 10.1038/nn1105-1429

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  • Drug-addicted individuals often engage in extreme behaviours to obtain drugs even when these entail known severe adverse consequences and may require sustained complex behaviours.

    “Dysregulated DA signalling is associated with enhanced motivation to procure drugs, a hallmark of addiction, which is why drug-addicted individuals often engage in extreme behaviours to obtain drugs, even when they entail known severe and adverse consequences and may require sustained and complex behaviours to obtain them (109).”

    From Obesity and addiction: Neurobiological overlaps (2013) · cites this paper as [109]

  • Dysregulated dopamine signalling is associated with enhanced motivation to procure drugs, a hallmark of addiction.

    “Dysregulated DA signalling is associated with enhanced motivation to procure drugs, a hallmark of addiction, which is why drug-addicted individuals often engage in extreme behaviours to obtain drugs, even when they entail known severe and adverse consequences and may require sustained and complex behaviours to obtain them (109).”

    From Obesity and addiction: Neurobiological overlaps (2013) · cites this paper as [109]

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References 18 · Cited by 324

Authors
Volkow, N., & Li, T.-K.
Affiliations
  • National Institute on Drug Abuse (US)
  • National Institute on Alcohol Abuse and Alcoholism (US)
Venue
Nature Neuroscience
Published
2005-11
Volume
8
Issue
11
Pages
1429-1430
ISSN
  • 1097-6256 (ISSN-L)
  • 1546-1726
OpenAlex
W2061573840
Cited by
324
References
18
Citations by year
2026: 5 · 2025: 6 · 2024: 6 · 2023: 33 · 2022: 8 · 2021: 18 · 2020: 13 · 2019: 7 · 2018: 9 · 2017: 18 · 2016: 20 · 2015: 14 · 2014: 17 · 2013: 34 · 2012: 22
FWCI
3.60
Type
journal article
Language
en
Open access
closed
Locations
  • Nature Neuroscience (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
  • Health Sciences › Medicine › Pharmacology › Cannabis and Cannabinoid Research
Keywords
addiction, neurobiology of addiction, cocaine dependence, endocannabinoids, metabotropic glutamate receptor 5, alcohol and tobacco use, mental health, methamphetamine dependence, PICK1, brain-derived neurotrophic factor, genetic risk variants
MeSH terms
Humans, Neurobiology, Substance-Related Disorders

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