Progress in the use of microarray technology to study the neurobiology of disease
Abstract
The diverse functions of the brain are mediated by neurons and glia whose phenotype is defined by a dynamically maintained set of gene transcripts, or 'transcriptome'. Large-scale analysis of gene expression in postmortem brain using microarray technology has the potential to elucidate molecular changes that occur in disease states. There are unique challenges associated with studies of postmortem brain, including limited sample sizes and variable clinical phenotypes that are typical of complex disorders. Nevertheless, recent microarray-based studies have implicated both individual dysregulated genes and abnormal patterns of gene expression in brain disorders.
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Regional and cellular heterogeneity pose obstacles for transcriptomic studies in the CNS.
“Regional and cellular heterogeneity pose obstacles for transcriptomic studies in the central nervous system (CNS)100,200”
From Systems biology and gene networks in neurodevelopmental and neurodegenerative disorders (2015) · cites this paper as [100]
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References 69 · Cited by 150
- Authors
- Mirnics, K., & Pevsner, J.
- Affiliations
- University of Pittsburgh (US)
- Kennedy Krieger Institute (US)
- Venue
- Nature Neuroscience
- Published
- 2004-04-27
- Volume
- 7
- Issue
- 5
- Pages
- 434-439
- ISSN
- 1097-6256 (ISSN-L)
- 1546-1726
- OpenAlex
- W2044291712
- Cited by
- 150
- References
- 69
- Citations by year
- 2025: 1 · 2022: 1 · 2021: 2 · 2018: 5 · 2017: 4 · 2016: 5 · 2015: 2 · 2014: 5 · 2013: 6 · 2012: 8
- FWCI
- 1.90
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Funders
- University of California, Davis
- University of California, Irvine
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gene expression and cancer classification
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bioinformatics and Genomic Networks
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Molecular Biology Techniques and Applications
- Keywords
- microarray, postmortem brain, transcriptome, gene expression, neurobiology of disease, brain disorders, glia, neurons, dysregulated genes
- MeSH terms
- Animals, Brain, Cooperative Behavior, Humans, Nervous System Diseases, Neurobiology, Postmortem Changes, Sensitivity and Specificity, Statistics as Topic, Transcription, Genetic, Reproducibility of Results, Databases, Factual, Oligonucleotide Array Sequence Analysis, Gene Expression Profiling
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