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19F and 1H MRI detection of amyloid β plaques in vivo
Abstract
Formation of senile plaques composed of amyloid beta peptide, a pathological hallmark of Alzheimer disease, in human brains precedes disease onset by many years. Noninvasive detection of such plaques could be critical in presymptomatic diagnosis and could contribute to early preventive treatment strategies. Using amyloid precursor protein (APP) transgenic mice as a model of amyloid beta amyloidosis, we demonstrate here that an intravenously administered (19)F-containing amyloidophilic compound labels brain plaques and allows them to be visualized in living mice by magnetic resonance imaging (MRI) using (19)F and (1)H. Our findings provide a new direction for specific noninvasive amyloid imaging without the danger of exposure to radiation. This approach could be used in longitudinal studies in mouse models of Alzheimer disease to search for biomarkers associated with amyloid beta pathology as well as to track disease course after treatment with candidate medications.
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“The plaques showed hypointensity in MRI images and increased with age in both cortex and hippocampus regions, which is consistent with several previous findings (Higuchi et al., 2005; Meadowcroft et al., 2009).”
From Age-dependent microstructure alterations in 5xFAD mice by high-resolution diffusion tensor imaging (2022) · cites this paper as Higuchi et al., 2005
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Metadata
- Authors
- Higuchi, M., Iwata, N., Matsuba, Y., Sato, K., Sasamoto, K., & Saido, T. C.
- Affiliations
- RIKEN Center for Brain Science (JP)
- Corresponding author
- Higuchi, Makoto
- Saido, Takaomi C
- Venue
- Nature Neuroscience
- Published
- 2005-03-13
- Volume
- 8
- Issue
- 4
- Pages
- 527-533
- ISSN
- 1097-6256 (ISSN-L)
- 1546-1726
- OpenAlex
- W1989252530
- Cited by
- 339
- References
- 32
- Citations by year
- 2026: 3 · 2025: 6 · 2024: 9 · 2023: 8 · 2022: 14 · 2021: 14 · 2020: 7 · 2019: 3 · 2018: 15 · 2017: 13 · 2016: 15 · 2015: 16 · 2014: 17 · 2013: 27 · 2012: 15
- FWCI
- 17.38
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Funders
- RIKEN
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
- Keywords
- amyloid plaques, Alzheimer's disease, 19F MRI, 1H MRI, amyloid imaging, amyloid precursor protein transgenic mice, non-invasive brain imaging, presymptomatic diagnosis, disease biomarkers
- MeSH terms
- Age Factors, Alzheimer Disease, Amyloidosis, Animals, Brain, Brain Chemistry, Cell Count, Disease Models, Animal, Dose-Response Relationship, Drug, Fluorescent Dyes, Humans, Immunohistochemistry, Magnetic Resonance Imaging, Memantine, Mice, Transgenic, Phosphopyruvate Hydratase, Radionuclide Imaging, Staining and Labeling, Time Factors, Tritium, Amyloid beta-Peptides, Amyloid beta-Protein Precursor, Imaging, Three-Dimensional, Mice, Plaque, Amyloid
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