Transient incorporation of native GluR2-lacking AMPA receptors during hippocampal long-term potentiation
Abstract
Postnatal glutamatergic principal neuron synapses are typically presumed to express only calcium-impermeable (CI), GluR2-containing AMPARs under physiological conditions. Here, however, we demonstrate that long-term potentiation (LTP) in CA1 hippocampal pyramidal neurons causes rapid incorporation of GluR2-lacking calcium-permeable (CP)-AMPARs: CP-AMPARs are present transiently, being replaced by GluR2-containing AMPARs approximately 25 min after LTP induction. Thus, CP-AMPARs are physiologically expressed at CA1 pyramidal cell synapses during LTP, and may be required for LTP consolidation.
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The finding that LTP in WT mice was insensitive to IEM1460 is consistent with earlier studies that observed recruitment of GluA2-lacking AMPARs in WT rodents <2 weeks-old and >4 weeks-old but not in the ~3 week-old age range studied.
“This finding is consistent with several earlier studies using a variety of different protocols to induce LTP that have in general observed recruitment of GluA2-lacking AMPARs in WT rodents <2 weeks-old and >4 weeks-old but not in the ~3 week-old age range that we studied”
From AKAP150-Anchored Calcineurin Regulates Synaptic Plasticity by Limiting Synaptic Incorporation of Ca<sup>2+</sup>-Permeable AMPA Receptors (2012) · cites this paper as Plant et al., 2006
Hippocampal LTP in very young neurons may preferentially recruit CP-AMPARs.
“Hippocampal LTP in very young neurons may preferentially recruit CP-AMPARs (Plant et al., 2006, Sanderson et al., 2016).”
From The AMPA Receptor Code of Synaptic Plasticity (2018) · cites this paper as Plant et al., 2006
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References 15 · Cited by 542
- Authors
- Plant, K., Pelkey, K. A., Bortolotto, Z. A., Morita, D., Terashima, A., McBain, C. J., Collingridge, G. L., & Isaac, J. T. R.
- Affiliations
- University of Bristol (GB)
- National Institutes of Health (US)
- Corresponding author
- Isaac, John T R
- Venue
- Nature Neuroscience
- Published
- 2006-04-02
- Volume
- 9
- Issue
- 5
- Pages
- 602-604
- ISSN
- 1097-6256 (ISSN-L)
- 1546-1726
- OpenAlex
- W1993782794
- Cited by
- 542
- References
- 15
- Citations by year
- 2026: 10 · 2025: 19 · 2024: 21 · 2023: 14 · 2022: 16 · 2021: 30 · 2020: 17 · 2019: 23 · 2018: 44 · 2017: 20 · 2016: 18 · 2015: 20 · 2014: 26 · 2013: 43 · 2012: 38
- FWCI
- 14.18
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Bristol Research (University of Bristol) (publishedVersion)
- Explore Bristol Research (submittedVersion)
- Funders
- Wellcome Trust
- National Institutes of Health
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Keywords
- AMPA receptors, GluR2, calcium-permeable AMPA receptors, long-term potentiation, hippocampus, CA1 pyramidal neurons, synaptic plasticity
- MeSH terms
- Animals, Animals, Newborn, Calcium, Dose-Response Relationship, Radiation, Electric Stimulation, Hippocampus, Polyamines, Time Factors, Long-Term Potentiation, Pyramidal Cells, Receptors, AMPA, Patch-Clamp Techniques, Nicotinic Antagonists, Excitatory Postsynaptic Potentials, Mice, Rats, In Vitro Techniques
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